Innovative Pharmaceutical Techniques for Paediatric Dosage Forms: A Systematic Review on 3D Printing, Prilling/Vibration and Microfluidic Platform

Journal of Pharmaceutical Sciences, Journal Year: 2024, Volume and Issue: 113(7), P. 1726 - 1748

Published: April 4, 2024

The production of paediatric pharmaceutical forms represents a unique challenge within the industry. primary goal these formulations is to ensure therapeutic efficacy, safety, and tolerability in patients, who have specific physiological needs characteristics. In recent years, there has been significant increase attention towards this area, driven by need improve drug administration children optimal treatments. Technological innovation played crucial role meeting requirements, opening new frontiers design forms. particular, three emerging technologies garnered considerable interest scientific industrial community: 3D printing, prilling/vibration, microfluidics. These offer advanced approaches for design, production, customization forms, allowing more precise dosage modulation, improved solubility, greater acceptability. review, we delve into cutting-edge their impact on We analyse potential, associated challenges, developments, providing comprehensive overview opportunities that innovative methodologies sector. examine different generated using techniques, evaluating advantages disadvantages.

Language: Английский

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Microspheres: Preparation Methods, Advances, Applications, and Challenges in Drug Delivery

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 6, 2025

Language: Английский

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Artificial intelligence-aided endoscopic in-line particle size analysis during the pellet layering process

Journal of Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 101227 - 101227

Published: Feb. 1, 2025

Language: Английский

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Polymer Microspheres and Their Application in Cancer Diagnosis and Treatment

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(12), P. 6556 - 6556

Published: June 14, 2024

Cancer is a significant global public health issue with increasing morbidity and mortality rates. To address this challenge, novel drug carriers such as nano-materials, liposomes, hydrogels, fibers, microspheres have been extensively researched utilized in oncology. Among them, polymer are gaining popularity due to their ease of preparation, excellent performance, biocompatibility, drug-release capabilities. This paper categorizes commonly used materials for microsphere summarizes various preparation methods (emulsification, phase separation, spray drying, electrospray, microfluidics, membrane emulsification), reviews the applications cancer diagnosis, therapy, postoperative care. The current status future development directions treatment analyzed, highlighting importance potential improving patient outcomes.

Language: Английский

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Enhancing Magnetic Micro- and Nanoparticle Separation with a Cost-Effective Microfluidic Device Fabricated by Laser Ablation of PMMA

Micromachines, Journal Year: 2024, Volume and Issue: 15(8), P. 1057 - 1057

Published: Aug. 22, 2024

Superparamagnetic iron oxide micro- and nanoparticles have significant applications in biomedical chemical engineering. This study presents the development evaluation of a novel low-cost microfluidic device for purification hyperconcentration these magnetic particles. The device, fabricated using laser ablation polymethyl methacrylate (PMMA), leverages precise control over fluid dynamics to efficiently separate particles from non-magnetic ones. We assessed device’s performance through Multiphysics simulations empirical tests, focusing on separation magnetite blue carbon dots microparticles polystyrene at various total flow rates (TFRs). For nanoparticle separation, achieved recall up 93.3 ± 4% precision 95.9 1.2% an optimal TFR 2 mL/h, significantly outperforming previous models, which only 50% recall. Microparticle demonstrated accuracy 98.1 1% mL/h both experimental conditions. Lagrangian model effectively captured microparticle microparticles, with close agreement between simulated results. Our findings underscore robust capability distinguishing nanoscales. highlights potential low-cost, non-cleanroom manufacturing techniques produce high-performance devices, thereby expanding their accessibility applicability industrial research settings. integration continuous magnet, as opposed segmented magnets designs, was identified key factor enhancing efficiency.

Language: Английский

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Current research status, applications and challenges of ketorolac-based sustained-release and controlled-release formulations

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: 670, P. 125162 - 125162

Published: Jan. 8, 2025

Language: Английский

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Design and Characterization of Aceclofenac-Loaded Microballoons using Eudragit with Hydroxypropyl Methylcellulose

Journal of Drug Delivery and Therapeutics, Journal Year: 2025, Volume and Issue: 15(1), P. 130 - 141

Published: Jan. 15, 2025

Background: Drug delivery systems based on microballoons are one of the promising approaches for gastric retention, especially useful drugs with site-specific absorption in stomach. The hollow, spherical particles under 200 micrometers, designed to float environment. Aceclofenac formulation an NSAID is helpful a half-life 4–4.3 hours; this form gives sustained release and maintains constant plasma levels enhanced bioavailability decrease dosing frequency. Methodology: Microballoons were prepared using Eudragit RS 100 Hydroxy Propyl Methyl Cellulose as polymers from emulsion–solvent diffusion method. In this, impart stability along profile controlled release. Here, was evaluated physical parameter regarding average particle size, floatation percentage, entrapment efficiency, true tapped density, percentage yield, FTIR will be carried out complexes drug polymer. Results Discussion: exhibit excellent floating properties uniformity which aided long retention. High efficiency extended period obtained. studies indicated that remained stable polymer matrix no considerable chemical interaction between polymers. Conclusion: This research shows promise microballoons-based could maintain longer duration device respect Aceclofenac, enhances reduces frequencies. Keywords: Microballoons, NSAID, Sustain Release Medication, RS100, HPMC

Language: Английский

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Designing & optimisation of dual Ca ²⁺ and SO ₄ ^2– ionic cross-linked sericin/pectin microbeads using response surface methodology for colon-specific delivery

Journal of Biomaterials Science Polymer Edition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 26

Published: Jan. 15, 2025

Ulcerative colitis, a chronic inflammatory condition of the colon, requires precise and targeted treatment, polysaccharides, with their pH responsiveness biodegradability, offer an innovative approach for colon-specific drug delivery. This study aims to develop highly delivery system enhanced therapeutic targeting efficiency ulcerative focusing on preparation, optimisation, evaluation dual cross-linked mesalamine-loaded sericin-pectin (DCLSPs) micro-beads. These beads utilise pH-responsive microflora biodegradability properties polysaccharides colon delivery, employing Response Surface Methodology. Formulated via ionotropic gelation method divalent cross-linking ions (Ca2+ SO42–), DCLSPs were optimised using Box-Behnken design assess impact varying drug, pectin, sericin polymer proportions. The evaluated entrapment efficiency, thermal behaviour, surface morphology, water uptake, swelling, in-vitro release. Results indicated that spherical successfully developed, encapsulation ranging from 65.1% 95.5%, loading between 32.5% 49.9%, bead sizes 0.75 mm 0.92 mm, degrees swelling 1.82. Drug release was controlled by both diffusion mechanisms, as supported Higuchi Korsmeyer-Peppas models. formulation demonstrated high strong adhesion ensuring extended retention at site. Additionally, incorporation accuracy Gaussian fitting particle size distribution. Overall, show potential mucoadhesive carriers delivering drugs specifically colon.

Language: Английский

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Inulin: A Versatile Polymer in Colon Drug Targeting

Published: Jan. 1, 2025

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Modeling the Analysis Process of a Lipid-Based, Multi-Compartment Drug Delivery System

Processes, Journal Year: 2025, Volume and Issue: 13(2), P. 460 - 460

Published: Feb. 8, 2025

Solid lipid microparticles (SLMs) are multi-compartment drug carriers that can be used in various forms via many routes of administration, primarily to obtain prolonged release, protect the substance or mask its taste. It is practically impossible theoretically predict effectiveness incorporation and distribution active pharmaceutical ingredients (APIs) SLMs, these fundamental features determine key properties dosage form. The possibility an effective assessment by selecting developing sensitive, universal methods, therefore, conditions further development practical use this carrier. Therefore, unlike already available review papers on aim mini-review focus solely issues API SLMs their release. For purpose, most important observations results our own research were collected summarized, then attempt was made confront them with literature data. Among methods describing critical attributes instrumental (DSC, AFM, Raman spectroscopy NMR), quantitative studies for assessing (including entrapment efficiency drug-loading parameters) as well different release techniques (without a membrane, dialysis bag horizontal chambers, taking into account physiological factors) characterized compared. facilitate understanding SLM assess ability achieve intended effect vivo, standardize such carriers, facilitating comparison between centers.

Language: Английский

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