Association between uric acid to high-density lipoprotein cholesterol ratio and chronic kidney disease in Chinese patients with type 2 diabetes mellitus: a cross-sectional study DOI Creative Commons
Xiangyu Chen, Jie Zhang, Feng Lü

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 14, 2025

Objectives To examine the association between uric acid (UA) to high-density lipoprotein cholesterol (HDL-C) ratio (UHR) and chronic kidney disease (CKD) in type 2 diabetes mellitus (T2DM) patients China. Methods The investigation stems from a survey conducted eastern Chinese province of Zhejiang, spanning March November 2018. A multivariable logistic regression model was employed assess relationship UHR CKD, while restricted cubic spline (RCS) analysis used evaluate dose–response relationship. Receiver operating characteristic (ROC) curve performed determine optimal cut-off value its diagnostic performance for CKD. Model further evaluated using net reclassification improvement (NRI) integrated discrimination (IDI) metrics. Sensitivity analyses, including propensity score matching (PSM) k-means clustering, were enhance robustness findings. Subgroup analyses across various demographic clinical categories consistency UHR-CKD association. Results This cross-sectional study included 1,756 with T2DM, among whom 485 (27.62%) identified Multivariable revealed significant positive Per standard deviation (SD) increase associated 40% higher odds CKD (OR = 1.40, 95% CI: 1.23–1.60) after adjusting potential covariates. When analyzed categorically, participants highest tertile (T3) had 1.82-fold compared lowest (T1) (95% 1.32–2.50). RCS demonstrated consistent linear all models (all p nonlinearity >0.05). ROC an 12.28 prediction, area under (AUC) 0.710 0.683–0.737) fully adjusted model. confirmed most variables, except younger age groups (18–44 45–59 years) smokers. Notably, BMI significantly modified relationship, nonlinear observed individuals lower (<24 kg/m ) those (≥24 ). Conclusion demonstrates highlighting as promising biomarker risk assessment. offers practical threshold early renal monitoring targeted interventions. Future research should explore UHR-targeted therapies integration into personalized stratification improve management T2DM.

Language: Английский

Hyperuricemia and its related diseases: mechanisms and advances in therapy DOI Creative Commons
Lin Du,

Zong Yao,

H. Li

et al.

Signal Transduction and Targeted Therapy, Journal Year: 2024, Volume and Issue: 9(1)

Published: Aug. 28, 2024

Abstract Hyperuricemia, characterized by elevated levels of serum uric acid (SUA), is linked to a spectrum commodities such as gout, cardiovascular diseases, renal disorders, metabolic syndrome, and diabetes, etc. Significantly impairing the quality life for those affected, prevalence hyperuricemia an upward trend globally, especially in most developed countries. UA possesses multifaceted role, antioxidant, pro-oxidative, pro-inflammatory, nitric oxide modulating, anti-aging, immune effects, which are significant both physiological pathological contexts. The equilibrium circulating urate hinges on interplay between production excretion, delicate balance orchestrated transporter functions across various epithelial tissues cell types. While existing research has identified involvement numerous biological processes signaling pathways, precise mechanisms connecting disease etiology remain be fully elucidated. In addition, influence genetic susceptibilities environmental determinants calls detailed nuanced examination. This review compiles data from global epidemiological studies clinical practices, exploring foundations transporters depth. Furthermore, we uncover complex induced inflammation influences individuals with association its relative disease, offering foundation innovative therapeutic approaches advanced pharmacological strategies.

Language: Английский

Citations

98
Uric acid in health and disease: From physiological functions to pathogenic mechanisms DOI
Shijie Wen,

Hiroshi Arakawa,

Ikumi Tamai

et al.

Pharmacology & Therapeutics, Journal Year: 2024, Volume and Issue: 256, P. 108615 - 108615

Published: Feb. 19, 2024

Language: Английский

Citations

73
Comorbidity of patients with noncommunicable diseases in general practice. Eurasian guidelines DOI Creative Commons
О. М. Драпкина, А. V. Kontsevaya, А. М. Калинина

et al.

CARDIOVASCULAR THERAPY AND PREVENTION, Journal Year: 2024, Volume and Issue: 23(3), P. 3696 - 3696

Published: April 1, 2024

Создание руководства поддержано Советом по терапевтическим наукам отделения клинической медицины Российской академии наук.

Language: Русский

Citations

19
Neutrophils and NETs in kidney disease DOI

Daigo Nakazawa,

Sakiko Masuda,

Yuka Nishibata

et al.

Nature Reviews Nephrology, Journal Year: 2025, Volume and Issue: unknown

Published: March 18, 2025

Language: Английский

Citations

2
Asymptomatic Hyperuricemia and the Kidney: Lessons from the URRAH Study DOI Creative Commons

Cecilia Barnini,

Elisa Russo, Giovanna Leoncini

et al.

Metabolites, Journal Year: 2025, Volume and Issue: 15(1), P. 11 - 11

Published: Jan. 2, 2025

Chronic kidney disease (CKD) is a prevalent global health concern affecting approximately 850 million people worldwide, with significant and rising mortality rate. CKD often coexists hyperuricemia (HSUA), which also increasingly common due to its association hypertension, obesity, diabetes. The interplay between complex; while in vitro studies animal models support role for uric acid mediating glomerular tubule-interstitial damage, HSUA has been shown predict the onset progression of CKD, expectations renal protection by use urate lowering treatment (ULT) are inconsistent. A challenge managing asymptomatic patients lies determining appropriate SUA threshold values. Recent research, including URRAH project, sought identify cut-offs predictive cardiovascular mortality, but these thresholds may vary depending on severity CKD. This variability complicates establishment universal guidelines treating HSUA, leading lack specific recommendations clinical practice. In conclusion, recognized as prognostic factor risk, more research needed refine values benefit from ULT. Stratification based filtration rate be necessary tailor treatments improve outcomes this population.

Language: Английский

Citations

1
Current Status of Gout Arthritis: Current Approaches to Gout Arthritis Treatment: Nanoparticles Delivery Systems Approach DOI Creative Commons
Yedi Herdiana, Yoga Windhu Wardhana, Insan Sunan Kurniawansyah

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 102 - 102

Published: Jan. 14, 2025

The deposition of monosodium urate (MSU) crystals within joint spaces produces a painful inflammatory condition known as gout, specific form arthritis. calls for combined curative and preventive management model. A new development in the approach to gout is that NLRP3-targeted biologic agents, such monoclonal therapies, provide more accurate treatment by blocking pro-inflammatory cytokines. Nanoparticle drug delivery enhances biological availability targets, which may increase therapeutic efficacy decrease general toxicity. again cannot be ignored, mainly keeping up certain modifications diet weight, along with pharmacological therapies reduce uric acid (UA) levels frequency acute attacks. advancement genetic profiling patients biomarker discoveries drives trend towards building individualized medicine care, quickly gaining ground most effective method delivering treatments individual patients, moving away from one-size-fits-all treatments. following paper aims an updated account focus on recent developments, order enhance these approaches, quality life standard treatment.

Language: Английский

Citations

1
Effects of Dietary Fiber Supplementation on Modulating Uremic Toxins and Inflammation in Chronic Kidney Disease Patients: A Systematic Review and Meta-Analysis of Randomized Controlled Trials DOI Creative Commons
Wannasit Wathanavasin, Wisit Cheungpasitporn, Charat Thongprayoon

et al.

Toxins, Journal Year: 2025, Volume and Issue: 17(2), P. 57 - 57

Published: Jan. 26, 2025

Emerging evidence supports the beneficial effects of dietary fiber supplementation in alleviating gut dysbiosis, which leads to a reduction uremic toxins and inflammatory markers chronic kidney disease (CKD) patients. However, current evidence-based renal nutrition guidelines do not provide recommendations regarding intake. We performed systematic review meta-analysis investigate highlight on modulating individuals with CKD, or without dialysis. The eligible randomized controlled trials (RCTs) were identified from PubMed, Scopus, Cochrane Central Register Controlled until 27 November 2024. results synthesized using random-effects model presented as standardized mean differences (SMDs) 95% confidence interval (CI). A total 21 studies 700 patients included. When compared control group, ranging 6 50 g/day, for typically more than 4 weeks, could significantly reduce levels serum toxins, including p-cresyl sulfate, indoxyl blood urea nitrogen (SMD -0.22, -0.34, -0.25, respectively, p-values < 0.05), well biomarkers inflammation, interleukin-6 tumor necrosis factor alpha -0.44, 0.05). These consistent across different types fibers CKD status (with dialysis). no significant trimethylamine N-oxide, uric acid, high-sensitivity C-reactive protein was observed intervention. This study would pave way prioritizing quality, particularly fiber-rich diet, beyond traditional focus quantities protein, energy, electrolyte restrictions among CKD.

Language: Английский

Citations

1
Association of obesity traits and uric acid levels with cardiovascular disease in Punjabi patients from Faisalabad, Pakistan DOI

Muhammad Umer Ghori,

Muhammad Shareef Masoud, Muhammad Shafique

et al.

Acta Cardiologica, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 10

Published: April 14, 2025

Cardiovascular diseases (CVDs) are one of the significant public health concerns worldwide. Understanding relationship between Body Mass Index (BMI), Waist Circumference (WC), Waist-to-Hip Ratio (WHR) and uric acid levels important in assessing cardiovascular risk. This study aimed to investigate associations BMI, WHR, WC several biochemical parameters including with disease patients from Faisalabad, Pakistan. is a Retrospective Observational Study. A total 403 were enrolled. Anthropometric measurements WHR recorded. Serum samples used measure various parameters. SPSS ver. 21 was perform statistical analyses. Results showed that BMI (29%↑), waist circumference (7%↑) hip (8%↑) higher obese CVD as compared non-obese patients. Additionally, high (11%↑) male female while cholesterol triglycerides (20%↑) Pearson correlation Linear regression analysis confirmed associated cholesterol, triglycerides, alanine transaminase, creatinine urea (p < 0.05). confirms WC, multiple status

Language: Английский

Citations

1
An Overview of Chronic Kidney Disease Pathophysiology: The Impact of Gut Dysbiosis and Oral Disease DOI Creative Commons
Serena Altamura, Davide Pietropaoli, Francesca Lombardi

et al.

Biomedicines, Journal Year: 2023, Volume and Issue: 11(11), P. 3033 - 3033

Published: Nov. 12, 2023

Chronic kidney disease (CKD) is a severe condition and significant public health issue worldwide, carrying the burden of an increased risk cardiovascular events mortality. The traditional factors that promote onset progression CKD are cardiometabolic like hypertension diabetes, but non-traditional contributors escalating. Moreover, gut dysbiosis, inflammation, impaired immune response emerging as crucial mechanisms in pathology. microbiome exert reciprocal influence commonly referred to "the gut-kidney axis" through induction metabolic, immunological, endocrine alterations. Periodontal diseases strictly involved axis for their impact on microbiota composition metabolic immunological alterations occurring reciprocally affecting both conditions. This review aims provide overview dynamic biological interconnections between oral status, gut, renal pathophysiology, spotlighting oral-gut-kidney raising whether periodontal can be modifiers CKD. By doing so, we try offer new insights into therapeutic strategies may enhance clinical trajectory patients, ultimately advancing our quest improved patient outcomes well-being.

Language: Английский

Citations

16
Gout and hyperuricaemia: modifiable cardiovascular risk factors? DOI Creative Commons
Michel Burnier

Frontiers in Cardiovascular Medicine, Journal Year: 2023, Volume and Issue: 10

Published: May 25, 2023

Gout and hyperuricaemia are two clinical situations associated with an elevated risk of developing cardiovascular (heart failure, myocardial infarction, stroke) metabolic renal complications. One reason is probably related to the fact that prevalence gout high in situations, which themselves involve a risk, such as hypertension, diabetes, chronic kidney disease or obesity. However, recent studies suggest may promote complications independently other factors, by inducing inflammation, oxidative stress, endothelial dysfunction. The questions arise today concern primarily treatment asymptomatic hyperuricaemia. Should it be treated decrease patients' if so, starting from level towards target? There now several pieces evidence indicating this might useful, but data large not unanimous. This review will discuss issue well new well-tolerated treatments, febuxostat SGLT2 inhibitors, lower uric acid levels, prevent cardio-renal events.

Language: Английский

Citations

14