The Effects of Biomimetic Surface Topography on Vascular Cells: Implications for Vascular Conduits DOI Creative Commons
Abigail A. Conner, Dency David, Evelyn K. F. Yim

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: 13(27)

Published: June 27, 2024

Abstract Cardiovascular diseases (CVDs) are the leading cause of mortality worldwide and represent a pressing clinical need. Vascular occlusions predominant CVD necessitate surgical interventions such as bypass graft surgery to replace damaged or obstructed blood vessel with synthetic conduit. Synthetic small‐diameter vascular grafts (sSDVGs) desired vessels an inner diameter <6 mm yet have limited use due unacceptable patency rates. The incorporation biophysical cues topography onto sSDVG biointerface can be used mimic cellular microenvironment improve outcomes. In this review, utility surface in design is discussed. First, primary challenges that sSDVGs face rationale for utilizing biomimetic introduced. current literature surrounding effects topographical on cell behavior vitro reviewed, providing insight into which features optimal application sSDVGs. results studies utilized topographically‐enhanced vivo evaluated. Current barriers translation Based wealth evidence detailed here, substrate offers enormous potential outcome provide therapeutic solutions CVDs.

Language: Английский

Bioprinting: Mechanical Stabilization and Reinforcement Strategies in Regenerative Medicine DOI

Ashleigh Ballard,

Rebecca Patush,

Jenesis Perez

et al.

Tissue Engineering Part A, Journal Year: 2024, Volume and Issue: 30(13-14), P. 387 - 408

Published: Jan. 11, 2024

Bioprinting describes the printing of biomaterials and cell-laden or cell-free hydrogels with various combinations embedded bioactive molecules. It encompasses precise patterning cells to create scaffolds for different biomedical needs. There are many requirements that bioprinting face, it is ultimately interplay between scaffold's structure, properties, processing, performance will lead its successful translation. Among essential properties must possess—adequate appropriate application-specific chemical, mechanical, biological performance—the mechanical behavior hydrogel-based bioprinted key their stable in vivo at site implantation. Hydrogels typically constitute main scaffold material medium biomolecules very soft, often lack sufficient stability, which reduces printability and, therefore, potential. The aim this review article highlight reinforcement strategies used approaches achieve enhanced stability bioinks printed scaffolds. Enabling robust materials processes creation truly complex remarkable structures could accelerate application smart, functional settings. a powerful tool fabrication 3D applications. has gained tremendous attention recent years, bioink library expanding include more combinations. From practical perspective, need be considered, such as structure's performances. these, constructs critical translation into clinic. explore stabilization structures.

Language: Английский

Citations

4
Innovative Strategies in 3D Bioprinting for Spinal Cord Injury Repair DOI Open Access

Daniel Youngsuk Kim,

Yanting Liu,

Gyubin Kim

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(17), P. 9592 - 9592

Published: Sept. 4, 2024

Spinal cord injury (SCI) is a catastrophic condition that disrupts neurons within the spinal cord, leading to severe motor and sensory deficits. While current treatments can alleviate pain, they do not promote neural regeneration or functional recovery. Three-dimensional (3D) bioprinting offers promising solutions for SCI repair by enabling creation of complex tissue constructs. This review provides comprehensive overview 3D techniques, bioinks, stem cell applications in repair. Additionally, it highlights recent advancements bioprinted scaffolds, including integration conductive materials, incorporation bioactive molecules like neurotrophic factors, drugs, exosomes, design innovative structures such as multi-channel axial scaffolds. These strategies offer approach optimizing microenvironment, advancing understanding state repair, offering insights into future directions field regenerative medicine.

Language: Английский

Citations

4
Molecularly and ionically imprinted polymers-based chemical sensors in chemical assays DOI
Haiwen Su,

Haoyu Ren,

Xiayidan Maimaitikelimu

et al.

Chemical Engineering Journal, Journal Year: 2024, Volume and Issue: unknown, P. 156315 - 156315

Published: Sept. 1, 2024

Language: Английский

Citations

4
3D piezoelectric cellulose composites as advanced multifunctional implants for neural stem cell transplantation DOI Creative Commons
Vlad Jarkov, Davide Califano, Zois Michail Tsikriteas

et al.

Cell Reports Physical Science, Journal Year: 2025, Volume and Issue: unknown, P. 102368 - 102368

Published: Jan. 1, 2025

Citations

0
Potential for medico-biological applications of potassium sodium niobate: A review DOI
Myint Thu,

Caitlin M. Guzzo,

Julia Glaum

et al.

Progress in Materials Science, Journal Year: 2025, Volume and Issue: unknown, P. 101448 - 101448

Published: Jan. 1, 2025

Citations

0
Development and Evaluation of BDNF-Loaded PCL/PVA Two-Layer Nerve Guidance Conduit with Enhanced Biomechanical and Biological Properties for Peripheral Nerve Regeneration DOI Creative Commons
Massoumeh Jabbari Fakhr, Mohsen Eslami Farsani, Leyla Fath‐Bayati

et al.

Heliyon, Journal Year: 2025, Volume and Issue: 11(4), P. e42792 - e42792

Published: Feb. 1, 2025

The repair of damaged peripheral nerves and the following restoration functionality remain significant therapeutic challenges. Hollow nerve conduits currently available do not align with ideal human model. Successfully mending gaps requires incorporating biomimetic functional features into neural conduit design. In this research, a new two-layer that combines topographic support controlled growth factor release was developed. We used two-layered framework to amplify mechanical reinforcement reduce risk tissue collapse post-grafting. hollow were fabricated through three-dimensional printing, employing Polycaprolactone (PCL) slowly biodegradable nanofiber for intraluminal brain-derived neurotrophic factors (BDNF)-loaded polyvinyl alcohol (PVA)/PCL core-shell. contact angle indicated show hydrophilicity properties degradation rate biocompatibility. scanning electron microscope (SEM) images analyzed determine fiber's diameters, structure morphology, stem cell adhesion. performance core-shell investigated in dental pulp cells (hDPSC) culture their differentiation Schwann (SCs) invitro. vitality samples assessed using SEM, MTT assay, potential real-time Immunofluorescence staining techniques. Invitro cumulated BDNF followed Korsmeyer-Peppas model, demonstrating strong correlation coefficient 0.981. Real-time analysis showed after 14 days induction, expression S100 increased 5.89-fold. concluded PCL/PVA guidance can encourage adhesion proliferation hDPSCs create environment increasing survival. Also, sustained within walls promoted toward SC.

Language: Английский

Citations

0
Spinal cord conduits for spinal cord injury regeneration DOI Creative Commons
Yanyu Ma, Quanchi Chen, Wenhan Li

et al.

Engineered Regeneration, Journal Year: 2022, Volume and Issue: 4(1), P. 68 - 80

Published: Dec. 17, 2022

Spinal cord injury (SCI), which causes irreversible damage in both sensory and motor function, is considered an insurmountable challenge the field of medicine. The previous researchers have developed many kinds biomaterials for SCI, spinal conduits (SCCs) are important classification bridging tissues while performing their corresponding functions. In this review, we first describe original sources different polymers that determine properties SCCs. Afterwards, focus on types crosslinking methods used preparing Then, various practical applications therapeutic effects SCCs summarized discussed. Finally, conclude existing limitations current We hope paper will serve as a further inspiration development future.

Language: Английский

Citations

15
Aligned polycaprolactone/polyaniline electrospun nanofibers for directing neural stem cell differentiation and neuron arrangement DOI Creative Commons
Michela Licciardello,

Cecilia Traldi,

Matteo Bortolameazzi

et al.

Frontiers in Biomaterials Science, Journal Year: 2024, Volume and Issue: 3

Published: June 25, 2024

The use of engineered biomimetic substrates combined with neural stem cells (NSCs) constitutes a promising approach to develop reliable in vitro models the nervous tissue. fabrication scaffolds suitable compositional, topographical, and electrical properties is crucial for directing cell adhesion, differentiation, arrangement. Herein, we propose development electroconductive polycaprolactone/polyaniline (PCL/PANI) electrospun mats as functional NSC culture. A rotating drum collector was employed obtain fibers aligned geometry. According results, increase alignment contributed reduction fiber diameter scaffold mechanical terms elastic modulus tensile strength. In experiments demonstrated ability PCL/PANI membranes support attachment growth, well significantly foster neuronal differentiation. Furthermore, presence an pattern shown effectively influence arrangement NSC-derived neurons, confirming potential this substrate design physiologically relevant culture platform investigation

Language: Английский

Citations

3
Self-Healing Supramolecular Hydrogels with Antibacterial Abilities for Wound Healing DOI Creative Commons
Zhiwu Hong, Lei Wu, Zherui Zhang

et al.

Journal of Healthcare Engineering, Journal Year: 2023, Volume and Issue: 2023, P. 1 - 10

Published: Feb. 9, 2023

Wound healing due to skin defects is a growing clinical concern. Especially when infection occurs, it not only leads impair of the wound but even occurrence death. In this study, self-healing supramolecular hydrogel with antibacterial abilities was developed for healing. The hydrogels inherited excellent and mechanical properties are produced by polymerization N-acryloyl glycinamide monomers which carries lot amides. addition, obtained integrating silver nanoparticles (Ag NPs) into hydrogels. resultant has demonstrated ability in superior properties, including stretchability self-healing. Also, good biocompatibility have been proven Besides, prepared were employed as dressings treat wounds animals. It found that could significantly promote repair, relieving inflammation, promoting collagen deposition, enhancing angiogenesis. Therefore, such composite functional nanomaterials expected be used new field healthcare.

Language: Английский

Citations

7
Biomimetic Electrospun PLLA/PPSB Nanofibrous Scaffold Combined with Human Neural Stem Cells for Spinal Cord Injury Repair DOI
Yuan Dai, Weizhong Wang, Xiaojun Zhou

et al.

ACS Applied Nano Materials, Journal Year: 2023, Volume and Issue: 6(7), P. 5980 - 5993

Published: March 27, 2023

Spinal cord injury (SCI) treatment remains a worldwide challenge considering its limited self-repair capacity. The transplantation of neural stem cells (NSCs) has been proposed as potential approach to restoring neurological function by promoting axonal regeneration. While nanofibrous biomaterials provide the biomimetic microenvironment for immobilization and growth transplanted NSCs. In this study, poly(polyol sebacate)-based elastomeric scaffold developed with poly(l-lactic acid) (PLLA) poly(polycaprolactone triol-co-sebacic acid-co-BES sodium salt) (PPSB) was fabricated electrospinning combined human NSCs (hNSCs) SCI treatment. electrospun PLLA/PPSB containing 40 wt % PPSB demonstrated highly porous microstructure, sulfonate group modification, strong hydrophilicity, suitable degradation performance, good mechanical properties. promoted proliferation further differentiation hNSCs into neuronal cells. Moreover, hNSCs-loaded attenuated inflammatory response, enhanced regeneration neurons, inhibited astrocytes in lesion areas, thereby functional restoration spinal rats completely transected SCI. Thus, we conclude that composites could promote repair spine injury. findings insight strategies based on bioactive biomaterials.

Language: Английский

Citations

7