A Critical Appraisal of Functional Hydrogels for Chronic Wound Healing: Recent Advances and Ongoing Research DOI
Tanmay S. Markandeywar, Dilpreet Singh, Raj Kumar Narang

et al.

Current Applied Materials, Journal Year: 2023, Volume and Issue: 2(1)

Published: June 12, 2023

Abstract: In diabetic wounds, reactive oxygen species (ROS) are developed in large quantities a consistently hyperglycemic and excessive biogenic environment. Inflammatory factors increased as result of impaired hematopoiesis. Because, subsequent infections obstruct the healing process result, most chronic wounds not healed properly. The majority worsened during inflammatory stage. Because ROS, it is still challenging for timely closure wounds. Wound dressings with anti-inflammatory ROS scavenging properties preferable treatment Hence, strategic required which facilitates both targeting myogenic potential. recent decades, production macroporous hydrogels via three-dimensional (3D) printing has gained popularity cutting-edge technique Multiple hydrogel subtypes have been formulated different states used 3D indicated better wound by enhancing expression adipose-derived stem cells (ASCs) activities scaffolds due to presence an ordered structure. Regenerative medicine undergone paradigm shift introduction inventive medicines based on use living organisms. New treatments skin subject several studies, bioactive peptides, nanoparticles, attracting lot attention their potential therapeutics. For healing, create angiogenesis microenvironment avoid infections. present review provides light superficial along healing.

Language: Английский

Multifunctional and theranostic hydrogels for wound healing acceleration: An emphasis on diabetic-related chronic wounds DOI
Pooya M. Tehrany, Parham Rahmanian,

Aryan Rezaee

et al.

Environmental Research, Journal Year: 2023, Volume and Issue: 238, P. 117087 - 117087

Published: Sept. 15, 2023

Language: Английский

Citations

24
Recent advancements in natural polymers‐based self‐healing nano‐materials for wound dressing DOI
Kumar Anand, Rishi Sharma, Neelima Sharma

et al.

Journal of Biomedical Materials Research Part B Applied Biomaterials, Journal Year: 2024, Volume and Issue: 112(6)

Published: June 1, 2024

The field of wound healing has witnessed remarkable progress in recent years, driven by the pursuit advanced dressings. Traditional dressing materials have limitations like poor biocompatibility, nonbiodegradability, inadequate moisture management, breathability, lack inherent therapeutic properties, and environmental impacts. There is a compelling demand for innovative solutions to transcend constraints conventional optimal care. In this extensive review, potential natural polymers as foundation development self-healing nano-materials, specifically applications, been elucidated. Natural offer multitude advantages, possessing exceptional biodegradability, bioactivity. intricate engineering strategies employed fabricate these into nanostructures, thereby imparting enhanced mechanical robustness, flexibility, critical efficacious management expounded. By harnessing properties polymers, including chitosan, alginate, collagen, hyaluronic acid, so on, integrating concept materials, comprehensive overview cutting-edge research emerging presented review. Furthermore, attributes wherein they exhibit innate capabilities autonomously rectify any damage or disruption upon exposure body fluids, reducing frequent replacements also explored. This review consolidates existing knowledge landscape, accentuating benefits challenges associated with pioneering while concurrently paving way future investigations translational applications realm healing.

Language: Английский

Citations

5
Antibacterial–Antioxidative Thiolated Gelatin/Methacrylated Silk Fibroin Hydrogels with Nitric Oxide Release Catalyzed by Metal–Polyphenol Nanoparticles for MRSA-Infected Wound Healing DOI
Zhiwen Zeng, Jiayi Guo,

Guangxin Shen

et al.

Biomacromolecules, Journal Year: 2023, Volume and Issue: 24(11), P. 5116 - 5131

Published: Oct. 27, 2023

Chronic wound infection often leads to irregular tissue closure and accompanies delayed healing economy issues. Developing an ideal dressing that can control the occurrence of antibacterial infections biological responses is highly desirable. In this study, a multifunctional hybrid hydrogel (GS@EG-Cu-CA NPs) containing synthesized thiolated gelatin, methacrylated silk fibroin, (-)-epigallocatechin gallate-copper ionic-carrageenan nanoparticles (EG-Cu-CA was engineered by thio-ene click reaction. The metal-polyphenol EG-Cu-CA NPs were encapsulated with kappa-carrageenan enhance its aqueous-soluble, mechanical, bioactive properties endowed fascinating antibacterial, antioxidation, nitric oxide (NO) generation catalyzing. hydrogels also illustrated favorable cytocompatibility. Benefiting from reaction, injected photocured rapidly in situ cover wound. SD rat full-thickness skin-wound-infected model, methicillin-resistant Staphylococcus aureus-infected covered GS@EG-Cu-CA almost completely healed after 10 days. This study presents facile design incorporating nanoparticles, which demonstrates promising potential way for dealing effective management other complicated healings.

Language: Английский

Citations

9
RESPONSIVE TO ADAPTIVE SUPRAMOLECULAR HYDROGELS FOR DIABETIC WOUND TREATMENT. DOI Creative Commons

Shalini Balakrishnan,

Revathy Remesh,

Kalathil K. Kartha

et al.

Supramolecular Materials, Journal Year: 2024, Volume and Issue: unknown, P. 100081 - 100081

Published: Nov. 1, 2024

Language: Английский

Citations

3
Driven metal organic frameworks based hydrogels as wound dressing for anti‐inflammatory and antibacterial DOI
Li Ning Yang, Jingqi Li, Liu Yang

et al.

Applied Organometallic Chemistry, Journal Year: 2023, Volume and Issue: 38(1)

Published: Dec. 4, 2023

Metal organic frameworks (MOFs) are porous crystalline materials composed of metal ions and ligands by coordinate bonds. They have adjustable structure ordered structure. As a porous, soft, extracellular matrix‐like polymer, hydrogel is strong competitor for wound dressings has attracted much attention in recent years. MOF‐based hydrogels (MOF–hydrogels), as new type intelligent dressing, breaks the limitations traditional gauze expands application range updates definition dressing. The combination MOF transcends function single component combines advantages hydrogel. In this paper, MOF–hydrogels dressing will be systematically comprehensively described from working principles anti‐inflammatory antibacterial. And prospect its development trend future made, which provides idea direction.

Language: Английский

Citations

7
Hydrogel Applications in the Diagnosis and Treatment of Glioblastoma DOI
S.H. Zhang, Renming Zhong, Muhammad Rizwan Younis

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 4, 2024

Glioblastoma multiforme (GBM), a common malignant neurological tumor, has boundaries indistinguishable from those of normal tissue, making complete surgical removal ineffective. The blood-brain barrier (BBB) further impedes the efficacy radiotherapy and chemotherapy, leading to suboptimal treatment outcomes heightened probability recurrence. Hydrogels offer multiple advantages for GBM diagnosis treatment, including overcoming BBB improved drug delivery, controlled release long-term efficacy, enhanced relaxation properties magnetic resonance imaging (MRI) contrast agents. Hydrogels, with their excellent biocompatibility customizability, can mimic

Language: Английский

Citations

1
A Critical Appraisal of Functional Hydrogels for Chronic Wound Healing: Recent Advances and Ongoing Research DOI
Tanmay S. Markandeywar, Dilpreet Singh, Raj Kumar Narang

et al.

Current Applied Materials, Journal Year: 2023, Volume and Issue: 2(1)

Published: June 12, 2023

Abstract: In diabetic wounds, reactive oxygen species (ROS) are developed in large quantities a consistently hyperglycemic and excessive biogenic environment. Inflammatory factors increased as result of impaired hematopoiesis. Because, subsequent infections obstruct the healing process result, most chronic wounds not healed properly. The majority worsened during inflammatory stage. Because ROS, it is still challenging for timely closure wounds. Wound dressings with anti-inflammatory ROS scavenging properties preferable treatment Hence, strategic required which facilitates both targeting myogenic potential. recent decades, production macroporous hydrogels via three-dimensional (3D) printing has gained popularity cutting-edge technique Multiple hydrogel subtypes have been formulated different states used 3D indicated better wound by enhancing expression adipose-derived stem cells (ASCs) activities scaffolds due to presence an ordered structure. Regenerative medicine undergone paradigm shift introduction inventive medicines based on use living organisms. New treatments skin subject several studies, bioactive peptides, nanoparticles, attracting lot attention their potential therapeutics. For healing, create angiogenesis microenvironment avoid infections. present review provides light superficial along healing.

Language: Английский

Citations

0