Study on Quality Germplasm Screening and Drought Resistance of <i>Trollius chinensis</i> Bunge in Hulunbuir
慧 智
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Botanical Research,
Journal Year:
2025,
Volume and Issue:
14(01), P. 58 - 67
Published: Jan. 1, 2025
Language: Английский
Integrating metabolomics, network pharmacology and pharmacological verification analysis provides new insights into the anti-inflammatory and anti-tussive properties of Fritillaria cirrhosa bulbs
Can Zhao,
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Jianyun Zhang,
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Zhihuang Zhao
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et al.
Journal of Ethnopharmacology,
Journal Year:
2025,
Volume and Issue:
unknown, P. 119460 - 119460
Published: Feb. 1, 2025
Fritillaria
cirrhosa
bulbs,
referred
to
as
Chuanbeimu
in
traditional
Chinese
medicine
(TCM),
are
extensively
used
for
recognized
anti-inflammatory
and
anti-tussive
effects.
Both
Songbei
(SB)
Qingbei
(QB),
which
from
this
plant,
have
been
separately
medicine.
However,
the
differences
similarities
their
bioactive
components
effects
remain
unclear.
We
aimed
analyse
metabolic
profiles
of
F.
bulbs
across
different
growth
years
explore
properties
two
distinct
medicinal
materials.
With
nontargeted
technology,
main
were
detected.
Principal
component
analysis
(PCA)
pathway
enrichment
carried
out
determine
differentially
expressed
metabolites
between
years.
Network
pharmacology
was
subsequently
relationships
among
components,
diseases,
key
targets,
pathways
by
constructing
a
network
model.
The
drug-containing
serum
on
cellular
inflammatory
factors
analysed
through
vitro
assays.
A
total
1349
compounds
identified
bulb
samples.
PCA
revealed
SB
(1-
2-year-old)
QB
(3-,
4-,
5-year-old).
Notably,
4-methoxycinnamaldehyde,
tenuifoliside
A,
LysoPC
20:4,
morpholine-4-carboximidamide
hydrobromide
potential
distinguishing
QB.
more
common
targets
related
(PPARG,
PPARA,
PTGS1,
XDH)
OPRM1,
DRD2,
SLC6A4,
HTR2A)
than
KEGG
that
inflammation
cough,
including
tryptophan
metabolism
arachidonic
acid
metabolism,
enriched
group.
Cellular
assays
effects,
with
having
greater
IL-6
TNF-α
IL-1β
overall
By
integrating
metabolomic
analyses,
classification
into
based
characteristics
observed
justified
certain
extent.
This
study
provides
new
insights,
guiding
clinical
use
these
treatments
cough.
Language: Английский
Manipulation of artificial light environment improves tropane alkaloids content in Atropa belladonna L.
Xupeng Gu,
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Linlin Yang,
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Di Zhang
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et al.
Plant Physiology and Biochemistry,
Journal Year:
2025,
Volume and Issue:
unknown, P. 109828 - 109828
Published: March 1, 2025
Language: Английский
Light quality modulates yields and secondary metabolite accumulation in Fritillaria cirrhosa: Insights from rhizosphere metabolomics and microbiomics
Yi Lu,
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Dan Gao,
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Xusheng Gao
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et al.
Industrial Crops and Products,
Journal Year:
2025,
Volume and Issue:
229, P. 120967 - 120967
Published: April 10, 2025
Language: Английский
Effects of long-term continuous cultivation on the structure and function of soil bacterial and fungal communities of Fritillaria Cirrhosa on the Qinghai-Tibetan Plateau
Dan Gao,
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Xusheng Gao,
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Ye Wang
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et al.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: Sept. 12, 2024
Language: Английский