Environmental Science & Technology,
Journal Year:
2016,
Volume and Issue:
50(18), P. 10245 - 10254
Published: Sept. 12, 2016
Synthetic
corticosteroids
may
pose
an
environmental
risk
to
fish.
Here,
we
describe
multiend
point
responses
of
adult
zebrafish
(8
months
old)
upon
21-day
exposure
a
commonly
prescribed
corticosteroid,
fludrocortisone
acetate
(FLU),
at
concentrations
between
0.006
and
42
μg/L.
No
remarkable
reproductive
impacts
were
observed,
while
physiological
effects,
including
plasma
glucose
level
blood
leukocyte
numbers
significant
altered
even
ng/L.
Ovary
parameters
transcriptional
analysis
hypothalamic-pituitary-gonadal-liver
axis
revealed
negligible
effects.
Significant
alterations
the
circadian
rhythm
network
observed
in
brain.
Transcripts
several
biomarker
genes,
per1a
nr1d1,
displayed
strong
changes,
which
occurred
relevant
6
ng/L
FLU.
Importantly,
development
behavior
F1
embryos
changed.
Heartbeat,
hatching
success
swimming
all
increased
All
effects
further
confirmed
by
eleuthero-embryos.
changes
genes
involved
gluconeogenesis,
immune
response
eleuthero-embryos
observations
Hatching
success,
heartbeat,
activity
81
higher,
as
with
embryos.
These
results
provide
novel
insights
into
understanding
potential
risks
corticosteroids.
The Science of The Total Environment,
Journal Year:
2021,
Volume and Issue:
792, P. 148306 - 148306
Published: June 16, 2021
Steroid
hormones
are
extremely
important
natural
in
all
vertebrates.
They
control
a
wide
range
of
physiological
processes,
including
osmoregulation,
sexual
maturity,
reproduction
and
stress
responses.
In
addition,
many
synthetic
steroid
widespread
general
use,
both
as
human
veterinary
pharmaceuticals.
Recent
advances
environmental
analytical
chemistry
have
enabled
concentrations
rivers
to
be
determined.
Many
different
hormones,
synthetic,
transformation
products,
been
identified
quantified,
demonstrating
that
they
aquatic
contaminants.
Laboratory
ecotoxicology
experiments,
mainly
conducted
with
fish,
but
also
amphibians,
shown
some
can
adversely
affect
when
present
the
water
at
low
concentrations:
even
sub-ng/L.
research
has
demonstrated
mixtures
inhibit
each
individual
hormone
is
concentration
below
which
it
would
not
invoke
measurable
effect
on
its
own.
Limited
field
studies
supported
conclusions
laboratory
may
pollutants
significant
concern.
Further
required
identify
main
sources
entering
environment,
better
describe
complex
now
known
ubiquitously
present,
determine
impacts
environmentally-realistic
vertebrates,
especially
fish.
Only
once
completed
robust
risk
assessment
concluded.
International Journal of Molecular Sciences,
Journal Year:
2022,
Volume and Issue:
23(14), P. 7989 - 7989
Published: July 20, 2022
Progesterone
is
a
steroid
hormone
traditionally
linked
with
female
fertility
and
pregnancy.
In
current
reproductive
medicine,
progesterone
its
analogues
play
crucial
roles.
While
the
discovery
of
effects
has
long
history,
over
recent
decades,
various
novel
actions
this
interesting
have
been
documented,
which
neuro-
immunoprotective
activities
are
most
widely
discussed.
Discoveries
biological
also
driven
research
development
in
field
used
human
medicine.
Progestogen
treatment
predominately
maintaining
pregnancy,
prevention
preterm
labor,
gynecological
pathologies,
lowering
negative
menopause.
However,
there
other
medical
fields
where
could
find
application
future.
The
aim
work
to
show
mechanisms
action
metabolites,
physiological
pharmacological
synthetic
as
well
impacts
production
use
on
environment.
Emerging contaminants,
Journal Year:
2023,
Volume and Issue:
9(2), P. 100210 - 100210
Published: Feb. 3, 2023
Steroid
hormones
are
micropollutants
that
contaminate
the
water
worldwide
and
exhibit
a
significant
threat
to
human
health
environment
even
at
low
concentrations.
among
most
common
endocrine
disruptors
investigated
due
their
widespread
use
as
active
ingredients
in
hormonal
treatments
natural
secretions.
Three
main
types
of
steroids
critical
for
development
multiorgan
homeostasis
estrogens,
progesterone,
androgens.
The
sources
steroid
livestock
excretion,
veterinary
medicines,
agricultural
runoff,
pharmaceuticals.
When
they
reach
environment,
effects
on
detrimental.
Therefore,
this
review
discusses
sources,
efficiency
available
wastewater
treatment
techniques
remove
these
from
wastewater,
potential
environmental
risks,
international
standards
regulate
them.
This
concludes
different
emerging
hybrid
approaches
show
best
efficiencies
hormone
removal
wastewater.
Moreover,
studies
have
focused
estrogen,
but
equal
attention
research
should
also
be
given
progesterone
androgen.
national
need
more
detailed
guidelines
encourage
advanced
systems.
Overall,
many
modern
technologies
treatments,
there
is
still
gap
make
them
sustainable,
environmentally
safe,
cost-efficient.
Environmental Science & Technology,
Journal Year:
2018,
Volume and Issue:
52(9), P. 5296 - 5307
Published: March 26, 2018
In
the
current
study
a
high
sensitive
analytical
method
was
developed
for
determination
of
60
steroids
including
glucocorticoids
(GC),
mineralocorticoids
(MC),
and
progestogens
(PG)
in
WWTP
effluents
surface
water
using
liquid
chromatography
with
tandem
mass
spectrometry
detection
(LC-MS/MS).
The
limits
quantification
(LOQ)
ranged
between
0.02
ng/L
(cortisone)
to
0.5
(drospirenone)
from
0.05
(betamethasone)
5
(chlormadinone)
treated
wastewater.
After
optimization,
applied
effluents,
rivers,
streams
around
Germany.
Numerous
have
been
detected
during
sampling
campaign
predominant
analytes
all
steroid
types
were
determined.
Moreover,
occurrence
dienogest,
mometasone
furoate,
flumethasone
pivalate,
metabolites
6β-hydroxy
triamcinolone
acetonide,
7α-thiomethyl
spironolactone,
11α-hydroxy
canrenone
is
reported
first
time.
addition,
this
revealed
ubiquitous
presence
topically
GC
monoesters
betamethasone
propionate,
valerate,
6α-methylprednisolone
propionate
water.
Environmental Research,
Journal Year:
2021,
Volume and Issue:
204, P. 112040 - 112040
Published: Sept. 9, 2021
Over
the
past
century,
evidence
has
emerged
that
endocrine
disrupting
chemicals
(EDCs)
have
an
impact
on
reproductive
health.
An
increased
frequency
of
disorders
been
observed
worldwide
in
both
wildlife
and
humans
is
correlated
with
accidental
exposures
to
EDCs
their
production.
Epidemiological
experimental
studies
highlighted
consequences
early
existence
key
windows
sensitivity
during
development.
Such
life
can
immediate
gonadal
tract
development,
as
well
long-term
health
males
females.
Traditionally,
were
thought
exert
effects
by
modifying
pathways
controlling
reproduction.
Advances
knowledge
mechanisms
regulating
sex
determination,
differentiation
development
fish
rodents
led
a
better
understanding
molecular
underlying
exposure
In
this
manuscript,
we
review
developmental
stages
sensitive
state
which
model
affect
these
processes,
based
roadmap
gonad
specific
mammals.
Environmental Science & Technology,
Journal Year:
2022,
Volume and Issue:
56(7), P. 4080 - 4090
Published: March 17, 2022
A
frequent
goal
of
chemical
forensic
analyses
is
to
select
a
panel
diagnostic
features─colloquially
termed
fingerprint─that
can
predict
the
presence
source
in
novel
sample.
However,
most
developed
fingerprinting
workflows
are
qualitative
nature.
Herein,
we
report
on
quantitative
machine
learning
workflow.
Grab
samples
(n
=
51)
were
collected
from
five
sources,
including
agricultural
runoff,
headwaters,
livestock
manure,
(sub)urban
and
municipal
wastewater.
Support
vector
classification
was
used
top
10,
25,
50,
100
features
that
best
discriminate
each
all
others.
The
cross-validation
balanced
accuracy
92-100%
for
sources
1,000
iterations).
When
screening
four
local
creeks,
probabilities
low
except
wastewater
at
two
downstream
locations
single
creek.
Upon
closer
investigation,
treatment
facility
located
∼3
km
upstream
nearest
sample
location.
In
addition,
using
simulated
silico
mixtures,
workflow
distinguish
absence
some
10,000-fold
dilutions.
These
results
strongly
suggest
this
subsets
be
quantitatively
presence/absence
various
trace
levels
environment.
Environmental Science & Technology,
Journal Year:
2017,
Volume and Issue:
51(11), P. 6498 - 6506
Published: May 9, 2017
Apart
from
estrogens,
the
occurrence
and
ecotoxicity
of
steroids
in
aquatic
environments
is
poorly
known.
Here,
we
analyzed
33
steroids,
including
androgens,
progestins,
glucocorticoids,
hospital
wastewaters,
river
water,
municipal
wastewater
treatment
plant
(WTP)
influents
effluents
at
different
sites
Switzerland.
In
addition,
steps
two
WTPs
with
advanced
treatment,
such
as
ozonation
or
pulverized
activated
carbon,
were
to
study
steroid's
behavior
during
treatment.
Considerable
levels
occurred
raw
wastewater,
but
they
low
(lower
than
1
ng/L)
below
detection
level
water.
WTP
influents,
estrogens
(estrone,
17β-estradiol,
estriol),
androgens
(androstenedione,
androsterone,
trans-androsterone,
testosterone),
progestins
metabolites
(progesterone,
medroxyprogesterone
acetate,
megestrol
mifepristone,
pregnanediol,
17α-hydroxypregnanolone,
17α-hydroxyprogesterone,
21α-hydroxyprogesterone)
detected
removed
effectively
biological
Ozonation
further
steroids.
Exposure
zebrafish
embryos
demonstrated
negligible
effects
pregnanediol
while
mixtures
that
mimic
water
composition
affected
embryo
development
led
alteration
steroidogenesis
gene
transcripts
nanogram
per
liter
concentrations.
Although
steroid
concentrations
are
Swiss
rivers,
possibility
additive
may
be
concern.
