Raman Microspectroscopy evidence of microplastics in human semen

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 901, P. 165922 - 165922

Published: July 31, 2023

The presence of microplastics (MPs) in human fluids and organs is a great concern, since, as highlighted by recent studies on animal models, they could cause alterations several physiological functions, including reproduction. In this study, semen samples collected from men living polluted area the Campania Region (Southern Italy), were analyzed to assess MPs. N. 16 pigmented microplastic fragments (ranging 2 6 μm size) with spheric or irregular shapes found six out ten samples. All detected MPs characterized terms morphology (size, colour, shape) chemical composition Raman Microspectroscopy. Chemical showed polypropylene (PP), polyethylene (PE), terephthalate (PET), polystyrene (PS), polyvinylchloride (PVC), polycarbonate (PC), polyoxymethylene (POM) acrylic, suggesting ingestion and/or inhalation route exposure environmental work, we propose for first time mechanism which pass into most likely through epididymis seminal vesicles, are susceptible inflammation.

Language: Английский

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First evidence of microplastics in human ovarian follicular fluid: An emerging threat to female fertility

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 291, P. 117868 - 117868

Published: Feb. 1, 2025

Language: Английский

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First evidence of microplastics in human ovarian follicular fluid: an emerging threat to female fertility

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: April 5, 2024

Abstract Plastic pollution is a pressing global issue, with over 400 million tons produced annually and projections of 1.1 billion by 2050. Microplastics (MPs), ranging from 5 mm to 1 µm, are pervasive in the environment. They found air, sea, freshwater, soils, food chains studies show that tiny MPs, smaller than 10 μm, can cross cellular membranes, posing potential health risks through oxidative stress, inflammation, immune dysfunction, neurotoxicity reprotoxicity. In recent years, research has shown microplastics have negative effects on female reproductive systems animals. However, there still lack evidence how accumulation affects human females. This study aimed examine presence ovarian follicular fluid 18 women undergoing assisted treatment whose samples were processed using patented method endorsed nationally internationally. particles <10 µm measured SEM EDX detection. Preventive measures taken avoid contamination during process. (dimensions µm) detected 14 out fluid, an average 2191 p/ml (0 - 7181p/ml) mean diameter MPs 4.48 (3.18-5.54 µm). A significant correlation was between microplastic concentration FSH (p-value <0.05), as well weak BMI, age Estradiol. There no fertilization outcomes, miscarriages, or live birth. first provide for microplastics’ treatment, representing threat function. Figure

Language: Английский

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Molecular Alterations in Spermatozoa of a Family Case Living in the Land of Fires—A First Look at Possible Transgenerational Effects of Pollutants

International Journal of Molecular Sciences, Journal Year: 2020, Volume and Issue: 21(18), P. 6710 - 6710

Published: Sept. 13, 2020

In our previous work, we reported alterations in protamines/histones ratio, DNA binding of these proteins and their involvement oxidative damage 84% the young men living Land Fires. present extended findings, evaluating any spermatozoa a family case, father son, this area, to also give first look at possibility transgenerational inherited effects environmental contaminants on molecular sperm nuclear basic (SNBP), semen parameters. found diverse excess copper chromium semen, different SNBP content low affinity proteins. addition, damage, presence CuCl2 H2O2, increased by adding both son SNBP. Interestingly, SNBP, unlike his father, showed an unstable were able produce even without external addition CuCl2, line with lower seminal antioxidant activity than father. The peculiarity some characteristics could be basis for possible future studies pollutants fertility.

Language: Английский

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Association between exposure to ambient air pollutants and the outcomes of in vitro fertilization treatment: A multicenter retrospective study

Environment International, Journal Year: 2021, Volume and Issue: 153, P. 106544 - 106544

Published: April 2, 2021

Exposure to ambient air pollution has been reported be inversely correlated with human reproductive health. However, the results of previous studies exploring association between and in vitro fertilization (IVF) outcomes are conflicting, further research is needed clarify this association. This study aimed investigate associations exposure pollutants IVF outcomes. We conducted a multicenter retrospective cohort involving 20,835 patients from four cities Northern China, contributing 11,787 fresh embryo transfer cycles, 9050 freeze-all 17,676 frozen-thawed (FET) cycles during 2014–2018. calculated daily average concentrations six criteria (PM2.5, PM10, O3, NO2, CO, SO2) different windows treatment timeline using data monitoring station nearest residential site as approximate individual exposure. Generalized estimation equation models were used assess CO most lower possibilities biochemical pregnancy, clinical live birth. An inverse O3 SO2 pregnancy was observed FET cycles. In addition, we found significant higher risk ectopic oocyte yield. Our provided large-scale evidence adverse population opting for IVF. Thus, should limited improve

Language: Английский

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Unraveling the interplay between environmental microplastics and salinity stress on Mytilus galloprovincialis larval development: A holistic exploration

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 927, P. 172177 - 172177

Published: April 3, 2024

Language: Английский

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Reproductive toxicity assessment of cellulose nanofibers, citric acid, and branched polyethylenimine in sea urchins: Eco-design of nanostructured cellulose sponge framework (Part B)

Environmental Pollution, Journal Year: 2024, Volume and Issue: 350, P. 123934 - 123934

Published: April 6, 2024

Language: Английский

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Herbicides glyphosate and glufosinate ammonium negatively affect human sperm mitochondria respiration efficiency

Reproductive Toxicology, Journal Year: 2020, Volume and Issue: 99, P. 48 - 55

Published: Nov. 26, 2020

Language: Английский

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Reproduction Under Stress: Acute Effect of Low Salinities and Heat Waves on Reproductive Cycle of Four Ecologically and Commercially Important Bivalves

Frontiers in Marine Science, Journal Year: 2021, Volume and Issue: 8

Published: Aug. 2, 2021

The impacts of climate change on the structure and functioning estuaries is a major focus concern, even more when affected species support important fisheries as bivalves Ruditapes decussatus , philippinarum Venerupis corrugata Cerastoderma edule in Europe. Their reproductive performance, context stressors, had not been investigated so far. Our objective was to experimentally evaluate acute stress effects over gonad development after 6 days low salinity autumn, winter spring well 4 heatwave during emersion summer. These are most probable extreme events that should face our latitudes. Four different ramps (5–20, 10–25, 15–30, 30–30) were created simulated tidal cycles mesocosms for experiments. Also four sediment heatwaves at (20–20, 20–27, 20–32, 20–37°C) done cycle. Both stresses such short periods compromised reproduction; response species-specific varied with time year, therefore, stage gametogenic In December, sexual resting beginning gametogenesis, delay gametogenesis lower salinities recorded species. However, peak period (March May), responses observed: abnormal oocytes R. resorption gametes haemocytic infiltration V. . Likewise temperatures higher than 32°C provoked gonadal severe invasion corrugata, C. but no effect both environmental stressors might be related allocation energy from reproduction toward defense repair mechanisms ensure survival. Contrastingly, triggered massive spawning could lead mismatch between presence larvae phytoplankton, causing potentially starvation thus reducing recruitment success. Reproduction theses would if episodes spring, those these experiments, followed by Furthermore impact magnified this situation happens consecutive years preventing replenishment shellfish beds.

Language: Английский

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Beneficial Effects of Antioxidants in Male Infertility Management: A Narrative Review

Oxygen, Journal Year: 2022, Volume and Issue: 2(1), P. 1 - 11

Published: Jan. 28, 2022

Background: Infertility, defined as the failure to conceive after one year of regular, unprotected intercourse, affects 50–80 million people worldwide. A male factor is involved in approximately 20–30% cases. In etiology infertility, association between poor semen quality and oxidative stress (OS) well known. High levels reactive oxygen species (ROS) allow oxidation DNA, proteins, lipids sperm cells, modifying their vitality, motility, morphology. Methods: To evaluate effects antioxidants on infertile men, we queried MEDLINE database (via PubMed interface) for published studies last 10 years (2011–2021). The following keywords were used: “infertility” -“inositol”, -“alpha-lipoic acid”, -“zinc”, -“folate”, -“coenzyme Q10”, -“selenium”, -“vitamin”. Results: Inositol regulates OS cells thanks its role mitochondrial reactions several processes favoring sperm–oocyte interactions. Alpha-lipoic acid (ALA) reduces ROS damage improves parameters terms spermatozoa’s morphology, count. Poor zinc nutrition may be related low sperm. Supplementation folate plus has a positive effect concentration with CoQ10 increases concentration, total progressive motility. Selenium (Se) supplementation overall higher ejaculated volume. Among vitamins, only vitamin B12 shows quality; it count motility DNA damage. Conclusions: men showing low-quality semen, diet improve by alleviating OS-induced enhancing hormone synthesis spermatozoa Future clinical trials should focused possible take advantage combined mechanisms action.

Language: Английский

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