Diet and Male Fertility: The Impact of Nutrients and Antioxidants on Sperm Energetic Metabolism

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(5), P. 2542 - 2542

Published: Feb. 25, 2022

Diet might affect male reproductive potential, but the biochemical mechanisms involved in modulation of sperm quality remain poorly understood. While a Western diet is considered risk factor for infertility, Mediterranean seems to protect against infertility; moreover, role vegetarian habitus preservation controversial. The aim this review analyze molecular effects single nutrients on quality, focusing their involvement related bioenergetics. It appears that diets rich saturated fatty acids (SFA) and low polyunsaturated (PUFA) negatively whereas unsaturated supplementation ameliorates quality. In fact, administration PUFA, especially omega-3 determined an increase mitochondrial energetic metabolism reduction oxidative damage. Carbohydrates proteins are also nutritional modulators stress testosterone levels, which strictly linked function, key element Moreover, many dietary natural polyphenols differentially (positively or negatively) depending concentration. We believe understanding responsible will lead more targeted effective therapeutics infertility.

Language: Английский

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Mitochondria Quality Control and Male Fertility

Biology, Journal Year: 2023, Volume and Issue: 12(6), P. 827 - 827

Published: June 6, 2023

Mitochondria are pivotal to cellular homeostasis, performing vital functions such as bioenergetics, biosynthesis, and cell signalling. Proper maintenance of these processes is crucial prevent disease development ensure optimal function. Mitochondrial dynamics, including fission, fusion, biogenesis, mitophagy, apoptosis, maintain mitochondrial quality control, which essential for overall health. In male reproduction, mitochondria play a role in germ any defects can have serious consequences on fertility. Reactive oxygen species (ROS) also sperm capacitation, but excessive ROS levels trigger oxidative damage. Any imbalance between caused by non-communicable diseases or environmental factors, lead an increase stress, damage, turn affect concentration, quality, motility. Therefore, assessing functionality control gain valuable insights into infertility. sum, proper health, particularly important The assessment provide information the study management infertility may new strategies its management.

Language: Английский

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Glyphosate: Hepatotoxicity, Nephrotoxicity, Hemotoxicity, Carcinogenicity, and Clinical Cases of Endocrine, Reproductive, Cardiovascular, and Pulmonary System Intoxication

ACS Pharmacology & Translational Science, Journal Year: 2024, Volume and Issue: 7(5), P. 1205 - 1236

Published: April 8, 2024

Glyphosate (GLP) is an active agent of GLP-based herbicides (GBHs), i.e., broad-spectrum and postemergent weedkillers, commercialized by Monsanto as, e.g., Roundup RangerPro formulants. The GBH crop spraying, dedicated to genetically engineered GLP-resistant crops, has revolutionized modern agriculture increasing the production yield. However, abusively administered GBHs' ingredients, GLP, polyoxyethyleneamine, heavy metals, have polluted environmental industrial areas far beyond farmlands, causing global contamination life-threatening risk, which led recent local bans use. Moreover, preclinical clinical reports demonstrated harmful impacts GLP other ingredients on gut microbiome, gastrointestinal tract, liver, kidney, endocrine, as well reproductive, cardiopulmonary systems, whereas carcinogenicity these remains controversial. Occupational exposure dysregulates hypothalamic–pituitary–adrenal axis, responsible for steroidogenesis endocrinal secretion, thus affecting hormonal homeostasis, functions reproductive organs, fertility. On hand, acute intoxication with GBH, characterized dehydration, oliguria, paralytic ileus, hypovolemic cardiogenic shock, pulmonary edema, hyperkalemia, metabolic acidosis, may occur fatally. As no antidote been developed poisoning so far, detoxification mainly symptomatic supportive requires intensive care based gastric lavage, extracorporeal blood filtering, intravenous lipid emulsion infusion. current review comprehensively discusses molecular physiological basics GLP- and/or GBH-induced diseases endocrine cardiopulmonary-, nephro-, hepatotoxicities, presented in studies case accidental or intentional ingestions most popular GBHs. Finally, they briefly describe future healthcare methods tools detection, determination, detoxification. Future electronically powered, decision-making, user-friendly devices targeting major GLP/GBH's modes actions, dysbiosis inhibition AChE, shall enable self-handled point-of-care professional-assisted evaluation harm followed rapid capturing xenobiotics body precise determining pathology-associated biomarkers levels.

Language: Английский

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Glyphosate presence in human sperm: First report and positive correlation with oxidative stress in an infertile French population

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 278, P. 116410 - 116410

Published: May 1, 2024

Environmental exposure to endocrine disruptors, such as pesticides, could contribute a decline of human fertility. Glyphosate (GLY) is the main component Based Herbicides (GBHs), which are most commonly herbicides used in world. Various animal model studies demonstrated its reprotoxicity. In Europe, GLY authorization agriculture has been extended until 2034. Meanwhile toxicity humans still debate. The aims our study were firstly analyse concentration and metabolite, amino-methyl-phosphonic acid (AMPA) by LC/MS-MS seminal blood plasma an infertile French men population (n=128). We secondly determined Total Antioxidant Status (TAS) Oxidant (TOS) using commercial colorimetric kits some oxidative stress biomarkers including malondialdehyde (MDA) 8-hydroxy-2′-deoxyguanosine (8-OHdG) ELISA assays. next analysed potential correlations between sperm parameters (sperm concentration, progressive speed, anormal forms). Here, we detected for first time significant proportions showed that was four times higher than those observed plasma. At opposite, AMPA undetectable. also strong positive correlation concentrations 8-OHdG concentrations, latter reflecting DNA impact. addition, TOS, Oxidative Stress Index (OSI) (TOS/TAS), MDA significantly with glyphosate plasma, respectively. Taken together, results suggest negative impact on reproductive health possibly his progeny. A precaution principle should be applied at actual discussion GBHs formulants uses Europe authorities.

Language: Английский

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Counterion Lewis Acidity Determines the Rate of Hexafluorophosphate Hydrolysis in Nonaqueous Battery Electrolytes

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

The decomposition of LiPF6 in nonaqueous battery electrolytes is a well-studied, deleterious process that leads to hydrofluoric acid (HF) driven transition metal dissolution at the positive electrode and gas production (H2) anode, often attributed inherent moisture sensitivity hexafluorophosphate anion. In this work, we use situ nuclear magnetic resonance (NMR) spectroscopy demonstrate rate PF6- hydrolysis significantly decreases Na K systems, where Lewis acidity cation dictates according Li+ > Na+ K+. Despite remarkable stability electrolytes, show they are still susceptible presence protons, which can catalyze breakdown PF6-, indicating these chemistries not immune from when paired with solvent/cathode combinations generate H+ high voltage. Quantitative multinuclear multidimensional NMR decomposed shows after long-term degradation, systems contain HF, HPO2F2, H2PO3F as well variety defluorinated byproducts, such organophosphates phosphonates, structurally similar herbicides/insecticides may pose health environmental risks. Taken together, results have important implications for Na- K-ion batteries hazardous harmful byproducts like soluble metals, organophosphates, phosphonates be greatly reduced through cell design. Our also suggest next-generation present pathway safer lower quantities flammable gases, H2, if properly engineered.

Language: Английский

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Review: Mechanisms of Glyphosate and Glyphosate-Based Herbicides Action in Female and Male Fertility in Humans and Animal Models

Cells, Journal Year: 2021, Volume and Issue: 10(11), P. 3079 - 3079

Published: Nov. 8, 2021

Glyphosate (G), also known as N-(phosphonomethyl)glycine is the declared active ingredient of glyphosate-based herbicides (GBHs) such Roundup largely used in conventional agriculture. It always mixed with formulants. G acts particular on shikimate pathway, which exists bacteria, for aromatic amino acids synthesis, but this pathway does not exist vertebrates. In recent decades, researchers have shown by using various animal models that GBHs are endocrine disruptors might alter reproductive functions. Our review describes effects exposure to or hypothalamic–pituitary–gonadal (HPG) axis males and females terms disruption, cell viability, proliferation. Most main regulators (GPR54, GnRH, LH, FSH, estradiol, testosterone) altered at all levels HPG (hypothalamus, pituitary, ovaries, testis, placenta, uterus) considered more toxic than alone due presence formulants polyoxyethylene tallow amine (POEA).” addition, we report intergenerational impacts and, finally, discuss different strategies reduce negative fertility.

Language: Английский

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Glyphosate-induced mitochondrial reactive oxygen species overproduction activates parkin-dependent mitophagy to inhibit testosterone synthesis in mouse leydig cells

Environmental Pollution, Journal Year: 2022, Volume and Issue: 314, P. 120314 - 120314

Published: Sept. 29, 2022

Language: Английский

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Modulation of Human Sperm Mitochondrial Respiration Efficiency by Plant Polyphenols

Antioxidants, Journal Year: 2021, Volume and Issue: 10(2), P. 217 - 217

Published: Feb. 2, 2021

Plant bioactives, such as polyphenols, can differentially affect (positively or negatively) sperm quality, depending on their concentration. These molecules have been proposed natural scavengers of reactive oxygen species (ROS) for male infertility treatment. However, few data are available about effects the molecular mechanisms related to quality and, in particular, mitochondrial function. We investigated quercetin, naringenin, genistein, apigenin, luteolin, and resveratrol at concentration 0.1–1000 nM respiration efficiency. Upon chemical exposure, spermatozoa were swollen a hypotonic solution used polarographic assays respiration. All tested compounds, except caused significant increase efficiency 0.1 nM, decrease starting from concentrations 10 nM. The analysis consumption rate active resting state suggested different by which compounds modulate Therefore, virtue ability stimulate state, luteolin found improve function asthenozoospermic samples. Our results relevant debate promises perils antioxidants nutraceutical supplementation.

Language: Английский

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Effects of glyphosate-based herbicides and glyphosate exposure on sex hormones and the reproductive system: From epidemiological evidence to mechanistic insights

Environmental Toxicology and Pharmacology, Journal Year: 2023, Volume and Issue: 102, P. 104252 - 104252

Published: Aug. 20, 2023

Language: Английский

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Sex-specific reproductive toxicity of subacute exposure to glufosinate-ammonium in zebrafish (Danio rerio)

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 963, P. 178489 - 178489

Published: Jan. 17, 2025

Language: Английский

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