Benzophenone-3 (oxybenzone) in zebrafish: histopathological and oxidative stress analysis DOI

Alfredo Carvalho,

Ana Clara Rodrigues de Oliveira,

Francisco de Sousa Holanda

et al.

Xenobiotica, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 10

Published: April 22, 2025

1. Benzophenone-3, commonly known as oxybenzone, is an organic compound widely used in sunscreens and personal care products for protection against UVA UVB rays. Due to its environmental persistence potential toxicity, this study evaluated the effects of BP-3 at environmentally relevant concentration (1 µg/L) on gills, kidney, antioxidant system zebrafish (Danio rerio).2. Adult male were randomly distributed into three groups, each with replicates (n = 10 per group): water control, solvent 1 µg/L BP-3, using a static exposure 96 hours. After experiment, histopathological analyses gills kidneys performed, along biochemical assessments enzymes superoxide dismutase (SOD) catalase (CAT).3. Exposure resulted significant alterations including vascular congestion, epithelial detachment, edema, lamellar aneurysm, indicating severe damage respiratory function. In kidneys, glomerular capillary dilation, tubular cell vacuolization, focal necrosis observed, suggesting renal dysfunction. Biochemical revealed impairment defense system: SOD activity decreased, while CAT remained unchanged, oxidative stress accumulation. significantly increased, enzymatic imbalance cumulative damage.4. These results demonstrate that even low concentrations, induces D. rerio, highlighting compromise organ function defenses. findings underscore need stricter regulation release aquatic environments mitigate ecotoxicological impacts protect biodiversity.

Language: Английский

The triple exposure nexus of microplastic particles, plastic-associated chemicals, and environmental pollutants from a human health perspective DOI Creative Commons
Andi Alijagić, Damir Suljević, Muhamed Fočak

et al.

Environment International, Journal Year: 2024, Volume and Issue: 188, P. 108736 - 108736

Published: May 10, 2024

The presence of microplastics (MPs) is increasing at a dramatic rate globally, posing risks for exposure and subsequent potential adverse effects on human health. Apart from being physical objects, MP particles contain thousands plastic-associated chemicals (i.e., monomers, chemical additives, non-intentionally added substances) captured within the polymer matrix. These are often migrating MPs can be found in various environmental matrices food chains; health effects. In addition to attributes MPs, plastic surfaces effectively bind exogenous chemicals, including pollutants (e.g., heavy metals, persistent organic pollutants). Therefore, act as vectors pollution across air, drinking water, food, further amplifying posed by exposure. Critically, fragmentation plastics environment increases risk interactions with cells, available leach adsorb transfer pollutants. This review proposes so-called triple nexus approach comprehensively map existing knowledge interconnected particles, Based data, there large gap regard cumulative nexus. Each component known induce genotoxicity, inflammation, endocrine disruption, but about long-term inter-individual lacking. Furthermore, not readily excreted organisms after ingestion they have been accumulated blood, cardiac tissue, placenta, etc. Even though number studies MPs-associated impacts rapidly, this underscores that pressing necessity achieve an integrated assessment MPs' order address future gaps.

Language: Английский

Citations

35
A review of sources, pathways, and toxic effects of human exposure to benzophenone ultraviolet light filters DOI Creative Commons
Yan‐an Yao, You Wang,

Hengling Zhang

et al.

Eco-Environment & Health, Journal Year: 2023, Volume and Issue: 3(1), P. 30 - 44

Published: Oct. 19, 2023

Benzophenone ultraviolet light filters (BPs) are high-production-volume chemicals extensively used in personal care products, leading to widespread human exposure. Given their estrogenic properties, the potential health risks associated with exposure BPs have become a public concern. This review aims summarize sources and pathways of risks. Dermal exposure, primarily through use sunscreens, constitutes major pathway for BP At recommended application rate, dermal BP-3 via sunscreens may reach or exceed suggested reference dose. Other BPs, such as drinking water, seafood, packaged foods, contribute minimal overall Inhalation is minor exposure; however, its contribution cannot be ignored. Human an order magnitude higher North America than Asia Europe. Studies conducted on laboratory animals cells consistently demonstrated toxic effects elicit reproductive developmental toxicities. Furthermore, neurotoxicity, hepatotoxicity, nephrotoxicity, carcinogenicity been reported from chronic In addition animal cell studies, epidemiological investigations identified associations between couples' fecundity other disorders, well adverse birth outcomes. Further studies urgently needed understand posed by health.

Language: Английский

Citations

25
ChlorTox scale assessment, greenness, and whiteness evaluation of selective spectrophotometric analysis of dimenhydrinate and cinnarizine DOI
Eman M. Morgan,

Yasmin M. Fayez,

Shereen A. Boltia

et al.

Spectrochimica Acta Part A Molecular and Biomolecular Spectroscopy, Journal Year: 2024, Volume and Issue: 321, P. 124740 - 124740

Published: June 30, 2024

Language: Английский

Citations

11
Single and combined exposures to bisphenol A and benzophenone-3 during early mouse pregnancy have differential effects on fetal and placental development DOI Creative Commons
Florence Fischer, Tobias Kretschmer,

Paulina Seifert

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 922, P. 171386 - 171386

Published: Feb. 29, 2024

Endocrine disrupting chemicals (EDCs) possess the capability to interfere with endocrine system by binding hormone receptors, for example on immune cells. Specific effects have already been described individual substances, but impact of exposure chemical mixtures during pregnancy maternal regulation, placentation and fetal development is not known. In this study, we aimed investigate combined two widespread EDCs bisphenol A (BPA) benzophenone-3 (BP-3) at allowed concentrations crucial processes such as implantation, placentation, uterine cell populations growth. From gestation day (gd) 0 gd10, female mice were exposed 4 μg/kg/d BPA, 50 mg/kg/d BP-3 or a BPA/BP-3 mixture. High frequency ultrasound Doppler measurements used determine intrauterine hemodynamic parameters. Furthermore, spiral artery remodeling placental mRNA expression studied via histology CHIP-RT-PCR, respectively. Effects EDC multiple investigated using flow cytometry. We found that caused growth restriction in offspring gd14, while BPA mixture varying effects. Moreover, morphology gd12 efficiency gd14 altered upon exposure. Placental gene transcription was particularly after utero BP-3. Flow cytometry analyses revealed an increase T cells NK BPA/BP-3-treated dams gd14. no effect parameters affected following Our results provide evidence early affects sex-dependent manner, function frequencies feto-maternal interface. These call inclusion studies addressing risk assessment environmental chemicals.

Language: Английский

Citations

9
The Toxicological Impact of the Ultraviolet Filter Oxybenzone on Antioxidant Profiles in In Virto Cultures of Lentinula edodes DOI Creative Commons
Agata Kryczyk‐Poprawa,

Adrián Sánchez-Hidalgo,

Wojciech Baran

et al.

Toxics, Journal Year: 2025, Volume and Issue: 13(3), P. 145 - 145

Published: Feb. 20, 2025

A detailed understanding of the toxic effects organic UV filters, such as oxybenzone, on living organisms is crucial for assessing feasibility bioremediation methods. Due to widespread use oxybenzone an ultraviolet filter in sunscreens, it has become emerging contaminant concern environment. This extends fungi, which have potential neutralize a wide variety xenobiotics released into The primary objective study was elucidate alterations antioxidant profiles white-rot fungus Lentinula edodes response exposure. Samples with at final concentration 0.1 mg mL−1 were cultured vitro mycelium L. 14 days. contents following compounds assessed: indole derivatives (6-methyl-D,L-tryptophan, tryptophan), ergothioneine, and phenolic acid (p-hydroxybenzoic acid), well lovastatin ergosterol. addition negatively affected biomass growth, reducing from 3.205 ± 0.4022 g 0.5803 0.1019 g. considerable reduction amounts found medium after incubation (from 25 0.2993 0.1934 mg). After lyophilization, contained 1.1591 0.0323 oxybenzone. Additionally, eleven biotransformation products assessed samples using UPLC-Q ToF. incubation, transformation identified based monoisotopic molecular mass fragmentation spectra. observed increase content some antioxidants, e.g., while others, lovastatin, suggests that impact profile cultures complex. Marked growth suggest toxicological risk associated contributes environmental filters emphasizes need safer alternatives.

Language: Английский

Citations

1
The Potential of Natural Compounds in UV Protection Products DOI Creative Commons
Jovana Milutinov, Nebojša Pavlović, Dejan Ćirin

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(22), P. 5409 - 5409

Published: Nov. 16, 2024

Overexposure to ultraviolet radiation mainly leads skin disorders (erythema, burns, immunosuppression), aging, and cancer as the most serious side effect. It has been widely accepted that using sunscreen products is an important way protect against harmful effects of UV rays. Although commercial sunscreens have constantly changed improved over time, there are emerging concerns about safety conventional, organic, filters due adverse on humans (such photoallergic dermatitis, contact sensitivity, endocrine-disrupting effects, etc.) well accumulation in environment aquatic organisms. This why natural compounds increasingly being investigated used cosmetic pharmaceutical sunscreens. Some these available, non-toxic, safer for use, considerable protective properties less effects. Plant-based such flavonoids can absorb UVA UVB rays possess antioxidant, anticarcinogenic, anti-inflammatory contribute photoprotection. Apart from flavonoids, other certain vegetable oils, carotenoids, stilbenes, ferulic acid also UV-absorbing properties. vitamins might be beneficial protection their antioxidant activity. Therefore, aim this research was gain insight into potential replace or reduce amount conventional filters, based recent research.

Language: Английский

Citations

7
Evaluation of the anti-androgenic and cytotoxic effects of benzophenone-3 in male Sprague-Dawley rats DOI

Chi Rim Sung,

Byeong Jun Kim,

Chan Ju Park

et al.

Journal of Toxicology and Environmental Health, Journal Year: 2024, Volume and Issue: 87(6), P. 266 - 273

Published: Jan. 3, 2024

Benzophenone-3 (BP-3, 2-hydroxy-4-methoxybenzophenone, oxybenzone) is one of the most widely used types benzophenone organic sunscreen. However, this compound a potentially harmful toxicant. The aim study was 2-fold to: (1) utilize Hershberger bioassay in vivo castrated male Sprague-Dawley rats to investigate anti-androgenic activities BP-3, and (2) use vitro methyl tetrazolium assay compare toxicity between Leydig cells (TM3 cells) mouse fibroblast (NIH-3T3) cell lines. In assay, were divided into 6 groups (each n = 7): vehicle control, negative positive PB-3 low (40 mg/kg), BP-3 intermediate (200 high (1000 mg/kg)-dose. weight ventral prostate significantly decreased at doses 200 or 1,000 mg/kg/day. addition, levator anibulbocavernosus muscle weights also reduced 40, 200, MTT viability NIH-3T3 within normal range. TM3 testis lowered concentration-dependent manner. Therefore, data indicate that might exert cytotoxic effects associated with reproductive system compared non-reproductive cells.

Language: Английский

Citations

6
Implementation of effect biomarkers in human biomonitoring studies: A systematic approach synergizing toxicological and epidemiological knowledge DOI Creative Commons
Andrea Rodríguez‐Carrillo, Vicente Mustieles, Elena Salamanca‐Fernández

et al.

International Journal of Hygiene and Environmental Health, Journal Year: 2023, Volume and Issue: 249, P. 114140 - 114140

Published: Feb. 24, 2023

Human biomonitoring (HBM) studies have highlighted widespread daily exposure to environmental chemicals. Some of these are suspected contribute adverse health outcomes such as reproductive, neurological, and metabolic disorders, among other developmental chronic impairments. One the objectives H2020 European Biomonitoring Initiative (HBM4EU) was development informative effect biomarkers for application in a more systematic harmonized way large-scale HBM studies. The inclusion would complement data with mechanistically-based information on early late effects. For this purpose, stepwise strategy developed identify implement panel validated This work offers an overview complete procedure followed, from comprehensive literature search strategies, selection criteria their classification prioritization, based toxicological outcomes, pilot analytical, physiological, epidemiological validation. We present example one study that demonstrated mediating role biomarker status brain-derived neurotrophic factor BDNF longitudinal association between infant bisphenol A (BPA) behavioral function adolescence. has been implemented HBM4EU Aligned Studies main including traditional oxidative stress, thyroid hormone biomarkers. Novel effect, DNA methylation kisspeptin (KISS) genes were also evaluated molecular markers neurological reproductive health, respectively. applied occupational studies, micronucleus analysis lymphocytes reticulocytes, whole blood comet assay, malondialdehyde, 8-oxo-2'-deoxyguanosine untargeted metabolomic profile urine, investigate, example, biological changes response hexavalent chromium Cr(VI) exposure. use ability detect effects chemical subgroups at higher risk. roadmap confirms utility biomarkers, support research, which is link mechanistically susceptibility order better understand public implications human

Language: Английский

Citations

14
Hazard identification of endocrine-disrupting carcinogens (EDCs) in relation to cancers in humans DOI
Neha Sharma, Vinay Kumar, S. Vimal

et al.

Environmental Toxicology and Pharmacology, Journal Year: 2024, Volume and Issue: 109, P. 104480 - 104480

Published: May 31, 2024

Language: Английский

Citations

5
Prenatal exposure to benzophenone-type UV filters and the associations with neonatal birth outcomes and maternal health in south China DOI Creative Commons

Jinfeng Fu,

Yao Yao, Zhihong Huang

et al.

Environment International, Journal Year: 2024, Volume and Issue: 189, P. 108797 - 108797

Published: June 1, 2024

Benzophenone (BP)-type UV filters are commonly added to sunscreens and cosmetics protect against radiation for human skin hair. As a result, BPs ubiquitous in the environment body, their endocrine-disrupting characteristics have been hot topic of discussion. However, our knowledge regarding detrimental effects prenatal exposure on pregnant women offspring remains limited. To fill this gap, we determined five BP derivatives 600 serum samples obtained from women. All target analytes, except 2,4-dihydroxybenzophenone (BP-1), achieved 100 % detection rate. The most prevalent compound was 2-hydroxy-4-methoxybenzophenone (BP-3), with median concentration 0.545 ng/mL. Significant positive correlations were observed among derivatives, indicating both endogenous metabolism common external sources. Utilizing Bayesian kernel machine regression (BKMR) quantile-based g-computation (QGC) models, found relationships between reduced neonatal birth weight (BW) chest circumference (BC) during third trimester. Notably, adverse effect size sex-specific. Moreover, triglyceride (TG) identified as potential mediator blood pressure, co-exposure linked disruptions thyroid hormone levels glucose regulation. Further research is warranted unravel toxicity fetuses.

Language: Английский

Citations

5