Mixed probiotics modulated gut microbiota to improve spermatogenesis in bisphenol A-exposed male mice

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 270, P. 115922 - 115922

Published: Jan. 1, 2024

Bisphenol A (BPA), an environmental endocrine disruptor (EDC), has been implicated in impairing intestinal and male reproductive dysfunction. The efficacy of gut microbiota modulation for BPA-exposed testicular dysfunction yet to be verified through research. Therefore, this study explored the potential mixed probiotics restoring spermatogenesis damage gut-testis axis under BPA exposure. We selected two strains (Lactobacillus rhamnosus Lactobacillus plantarum) with removal properties vitro mice model was established. mixture effectively reduced residue gut, serum, testis mice. Through 16 S rDNA-seq metabolomics sequencing, we uncovered that vitamin D metabolism bile acid levels abolished This perturbation linked increased abundance Faecalibaculum decreased Lachnospiraceae_NK4A136_group Ligilactobacillus. restored balance, enhancing barrier function reducing oxidative stress. improvement accompanied by a balance short-chain fatty acids (SCFAs). Remarkably, ameliorated repairing structures seminiferous tubules reversing arrested spermiogenesis. Further, enhanced testosterone-driven increases spermatogonial stem cells all stages sperm cells. Testicular transcriptome profiling these improvements degradation peroxisome pathways. These findings suggest significant interplay between microbiota, demonstrating probiotic intake could viable strategy combating subfertility issues caused

Language: Английский

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Dietary nobiletin regulated cefuroxime- and levofloxacin-associated “gut microbiota-metabolism” imbalance and intestinal barrier dysfunction in mice

Food & Function, Journal Year: 2024, Volume and Issue: 15(3), P. 1265 - 1278

Published: Jan. 1, 2024

Dietary nobiletin alleviated antibiotic-associated gut dysbiosis by maintaining the balance of intestinal microbiota and metabolism to enhance barrier function.

Language: Английский

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Pollutants, microbiota and immune system: frenemies within the gut

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: May 10, 2024

Pollution is a critical concern of modern society for its heterogeneous effects on human health, despite widespread lack awareness. Environmental pollutants promote several pathologies through different molecular mechanisms. Pollutants can affect the immune system and related pathways, perturbing regulation triggering pro-inflammatory responses. The exposure to also leads alterations in gut microbiota with decreasing abundance beneficial microbes, such as short-chain fatty acid-producing bacteria, an overgrowth species. subsequent intestinal barrier dysfunction, together oxidative stress increased inflammatory responses, plays role pathogenesis gastrointestinal diseases. Moreover, encourage inflammation-dysplasia-carcinoma sequence various mechanisms, stress, dysregulation cellular signalling cell cycle impairment genomic instability. In this narrative review, we will describe interplay between pollutants, microbiota, system, focusing their relationship bowel diseases colorectal cancer. Understanding biological mechanisms underlying health-to-disease transition may allow design public health policies aimed at reducing burden disease pollutants.

Language: Английский

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Bisphenol A exposure affects specific gut taxa and drives microbiota dynamics in childhood obesity

mSystems, Journal Year: 2024, Volume and Issue: 9(3)

Published: March 1, 2024

ABSTRACT Cumulative xenobiotic exposure has an environmental and human health impact which is currently assessed under the One Health approach. Bisphenol A (BPA) its potential link with childhood obesity that parallelly increased during last decades deserve special attention. It stands prenatal or early life could trigger comorbidities non-communicable diseases along life. Accumulation in nature of synthetic chemicals supports “environmental obesogen” hypothesis, such as BPA. This estrogen-mimicking shown endocrine disruptive obesogenic effects accompanied by gut microbiota misbalance not yet well elucidated. study aimed to investigate specific taxa isolated selected direct BPA reveal role on overall children community dynamics, driving toward dysbiosis. total 333 BPA-resistant species obtained through culturing after several conditions were evaluated for their interplay global microbial community. The BPA-cultured biomarkers showed a significant alpha diversity. Specifically, Clostridium Romboutsia positively associated promoting richness communities, while Intestinibacter , Escherichia-Shigella Bifidobacterium Lactobacillus negatively associated. Microbial dynamics networks analyses differences according groups. normal-weight group exhibited more enriched, structured, connected network compared overweight obese groups, represent resilient substances. In this sense, subnetwork analysis generated genera correlation between connectivity diverse enzymatic degradation capacities. IMPORTANCE Our findings indicate how capacity grow differentially represented within differential body mass index groups these affected patterns diversity generally recognized Community corroborated better connectedness stability profiles

Language: Английский

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Health risks of Bisphenol-A exposure: From Wnt signaling perspective

Environmental Research, Journal Year: 2024, Volume and Issue: 251, P. 118752 - 118752

Published: March 20, 2024

Language: Английский

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Toxic ties: Unraveling the complex relationship between endocrine disrupting chemicals and chronic kidney disease

Environmental Pollution, Journal Year: 2023, Volume and Issue: 338, P. 122686 - 122686

Published: Oct. 4, 2023

Language: Английский

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Impact of Ex Vivo Bisphenol A Exposure on Gut Microbiota Dysbiosis and Its Association with Childhood Obesity

Journal of Xenobiotics, Journal Year: 2025, Volume and Issue: 15(1), P. 14 - 14

Published: Jan. 17, 2025

Dietary exposure to the plasticiser bisphenol A (BPA), an obesogenic and endocrine disruptor from plastic epoxy resin industries, remains prevalent despite regulatory restriction food safety efforts. BPA can be accumulated in humans animals, potentially exerting differential health effects based on individual metabolic capacity. This pilot study examines impact of direct ex vivo gut microbiota obese normal-weight children, using 16S rRNA amplicon sequencing anaerobic culturing combined methods. Results showed that xenobiotic induced modifications microbial taxa relative abundance, community structure, diversity. Specifically, reduced abundance bacteria belonging phylum Bacteroidota, while Actinomycetota were promoted. Consistently, Bacteroides species classified as sensitive BPA, whereas class Clostridia identified resistant our culturomics analysis. Some altered bacterial patterns common for both BPA-exposed groups non-exposed group study. These findings also corroborated a larger cohort children. Future research will essential evaluate these potential biomarkers biomonitoring effect its role substance

Language: Английский

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Neutrophil Airfreighter Efficiently Delivers siRNA‐Loaded Nanocomplex to Mononuclear Phagocytes for Inhibition of mtDNA‐Induced Inflammation

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Abstract The extensive intercellular material and information flow in the immune microenvironment is instructive to development of targeted delivery strategies, but has received little attention previously. In this study, efferocytosis, an important link during inflammation, creatively used achieve a significant increase efficiency. A tailored “neutrophil airfreighter” strategy developed deliver plenty siRNA‐loaded nanocomplexes (FCM@siNPs) mtDNA‐releasing sentinel mononuclear phagocytes (MPs) vivo, providing them with immuno‐directed information. FCM@siNPs consist mesoporous silicon modified engineered NIH3T3 cell membranes. Based on innovative strategy, efficiency MPs improved by 360% vitro 120% vivo. could effectively inhibit periodontal inflammation mice precisely regulating mtDNA‐induced inflammatory response MPs. This study suggests potential organismal design efficient strategies.

Language: Английский

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Environmental contamination by bisphenols: from plastic production to modulation of the intestinal morphophysiology in experimental models

Food and Chemical Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 115280 - 115280

Published: Feb. 1, 2025

Language: Английский

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Correlation between the interleukin-36 subfamily and gut microbiota in patients with liver cirrhosis: Implications for gut-liver axis imbalance

World Journal of Hepatology, Journal Year: 2025, Volume and Issue: 17(4)

Published: April 25, 2025

Liver cirrhosis (LC) affect millions of people worldwide. The pathogenesis involves complex interactions between immune responses and gut microbiota. Recent studies have highlighted the role interleukin-36 (IL-36) subfamily in inflammation regulation. However, relationship serum IL-36 levels microbiota patients remains unclear. This study aimed to explore clinical significance their association with patients. To among Sixty-one were enrolled from Lihuili Hospital Ningbo University May 2022 November 2023 as LC group 29 healthy volunteers control (HC) group. expressions IL-36α, IL-36β, IL-36γ, IL-36Ra, IL-38 measured through ELISA, while 16S rRNA gene sequencing was employed rate microbial community human fecal samples. remarkably exceeded those HC (P < 0.05). related positively Child-Pugh score 0.05) prominently C absolute abundance harmful bacteria (Bacteroides, Bifidobacterium, Faecalibacterium) rose, beneficial (Firmicutes, Bacteroides, Escherichia-Shigella) notably decreased Lactobacillus 0.05), negatively Fusicatenibacter IL-36γ show promise potential biomarkers for progression, but further validation is required.

Language: Английский

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