EFSA Supporting Publications,
Journal Year:
2024,
Volume and Issue:
21(7)
Published: July 1, 2024
Abstract
The
European
Food
Safety
Authority
(EFSA)
has
a
goal
to
efficiently
conduct
aggregate
exposure
assessments
(AEAs)
for
chemicals
using
both
models
and
human
biomonitoring
(HBM)
data
by
2030.
To
achieve
EFSA's
vision,
roadmap
action
advancing
(AE)
in
the
EU
was
developed.
This
created
performing
series
of
engagement
collection
activities
map
currently
available
methods,
data,
tools
assessing
AE
chemicals,
against
needs
priorities
EFSA.
allowed
creation
AEA
framework,
identification
knowledge
gaps
our
current
capabilities,
challenges
blockers
that
would
hinder
efforts
fill
gaps.
identifies
interdependent
working
areas
(WAs)
where
additional
research
development
are
required
goal.
It
also
proposes
future
collaboration
opportunities
recommends
several
project
proposals
meet
goals.
Eight
proposal
projects
supported
SWOT
analysis
presented
consideration.
inform
high‐level
recommendations
multi‐annual
multi‐partner
projects.
Recommendations
improve
stakeholder
communication
work
on
were
gathered
surveying
stakeholders
specific
actions
AE,
including
webinars,
virtual
training,
social
media
channels,
newsletters.
Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
96(9), P. 3707 - 3716
Published: Feb. 21, 2024
Recent
advances
in
high-resolution
mass
spectrometry
(HRMS)
have
enabled
the
detection
of
thousands
chemicals
from
a
single
sample,
while
computational
methods
improved
identification
and
quantification
these
absence
reference
standards
typically
required
targeted
analysis.
However,
to
determine
presence
interest
that
may
pose
an
overall
impact
on
ecological
human
health,
prioritization
strategies
must
be
used
effectively
efficiently
highlight
for
further
investigation.
Prioritization
can
based
chemical's
physicochemical
properties,
structure,
exposure,
toxicity,
addition
its
regulatory
status.
This
Perspective
aims
provide
framework
chemical
implemented
facilitate
high-quality
research
communication
results.
These
are
categorized
as
either
"online"
or
"offline"
techniques.
Online
techniques
trigger
isolation
fragmentation
ions
low-energy
spectra
real
time,
with
user-defined
parameters.
Offline
techniques,
contrast,
after
data
has
been
acquired;
detected
features
filtered
ranked
relative
abundance
predicted
concentration
imputed
tandem
spectrum
(MS
Current Research in Toxicology,
Journal Year:
2024,
Volume and Issue:
6, P. 100156 - 100156
Published: Jan. 1, 2024
Open
access
new
approach
methods
(NAM)
in
the
US
EPA
ToxCast
program
and
NTP
Integrated
Chemical
Environment
(ICE)
were
used
to
investigate
activities
of
four
neurotoxic
pesticides:
endosulfan,
fipronil,
propyzamide
carbaryl.
Concordance
vivo
regulatory
points
departure
(POD)
adjusted
for
interspecies
extrapolation
(AdjPOD)
modelled
human
Administered
Equivalent
Dose
(AEDHuman)
was
assessed
using
3-compartment
or
Adult/Fetal
PBTK
vitro
extrapolation.
Model
inputs
from
Tier
1
(High
throughput
transcriptomics:
HTTr,
high
phenotypic
profiling:
HTPP)
2
(single
target:
ToxCast)
assays.
HTTr
identified
gene
expression
signatures
associated
with
potential
neurotoxicity
carbaryl
non-neuronal
MCF-7
HepaRG
cells.
The
HTPP
assay
U-2
OS
cells
detected
potent
effects
on
DNA
endpoints
endosulfan
carbaryl,
mitochondria
fipronil
(propyzamide
inactive).
most
assays
concordant
specific
components
each
chemical
mode
action
(MOA).
Predictive
adult
IVIVE
models
produced
fold
differences
(FD)
<
10
between
AEDHuman
measured
AdjPOD.
model
(i.e.,
smallest
FD)
propyzamide.
predictions
showed
mainly
AdjPODs
but
less
MOAs.
This
likely
due
cell
types
testing
and/or
lack
metabolic
capabilities
pathways
available
vivo.
Fetal
had
larger
FDs
than
predictive
overall.
Birth Defects Research,
Journal Year:
2024,
Volume and Issue:
116(9)
Published: Sept. 1, 2024
ABSTRACT
Background
The
paper
analyzes
opportunities
for
integrating
Open
access
resources
(Abstract
Sifter,
US
EPA
and
NTP
Toxicity
Value
Reference
[ToxVal/ToxRefDB])
New
Approach
Methodologies
(NAM)
integration
into
Community
Engaged
Research
(CEnR).
Methods
CompTox
Chemicals
Dashboard
Integrated
Chemical
Environment
with
in
vivo
ToxVal/ToxRef
NAMs
(in
vitro)
databases
are
presented
three
case
studies
to
show
how
these
could
be
used
Pilot
Projects
involving
(CEnR)
from
the
University
of
California,
Davis,
Environmental
Health
Sciences
Center.
Results
Case
#1
developed
a
novel
assay
methodology
testing
pesticide
toxicity.
#2
involved
detection
water
contaminants
wildfire
ash
#3
on
Tribal
Lands.
Abstract
Sifter/ToxVal/ToxRefDB
regulatory
data
screen/prioritize
risks
exposure
metals,
PAHs
PFAS
leached
investigate
activities
environmental
toxins
(e.g.,
pesticides)
lands.
computational
tools
can
apply
sensitive
biological
potential
or
known
adverse
outcome
pathways
predict
points
departure
(POD)
comparison
values
hazard
identification.
Systematic
Empirical
Evaluation
Models
biomonitoring
exposures
available
human
subpopulations
determine
bioactivity
ratio
facilitate
mitigation.
Conclusions
These
help
prioritize
chemical
toxicity
decisions
health
protective
policies
that
aid
stakeholders
deciding
needed
research.
Insights
justice
equity
advocates.
