m6A Ribonucleic Acid Methylation in Fibrotic Diseases of Visceral Organs DOI Creative Commons

Xiaoniu Dai,

Yusi Cheng, Wei Luo

et al.

Small Science, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Fibrosis is a pathological process characterized by the excessive deposition of extracellular matrix in tissue's space, leading to structural injury and organ dysfunction, even failure, posing threat human life. Despite mounting evidence suggesting that fibrosis reversible, effective treatments for fibrotic diseases are lacking. Accumulating has elucidated ribonucleic acid (RNA) modifications have emerged as novel mechanisms regulating gene expression. N6‐methyladenosine (m6A) modification well‐known prevalent RNA posttranscriptional participates essential biological processes such splicing, translation, degradation. It tightly implicated wide range cellular various diseases, particularly fibrosis. The m6A dynamic reversible regulated methylases, commonly known “writers,” demethylases referred “erasers,” while recognized “readers.” suggests on RNAs associated with visceral organs including lungs, heart, liver, kidney. In this review, recent advances impact methylation highlighted potential prospects therapy treating discussed.

Language: Английский

Ferroptosis-Related Oxaliplatin Resistance in Multiple Cancers: Potential Roles and Therapeutic Implications DOI Creative Commons

Si-Jia Zhong,

Zihan Wang,

Jiaxi Yang

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(18), P. e37613 - e37613

Published: Sept. 1, 2024

Oxaliplatin (OXA)-based therapy is effective in the treatment of multiple cancers. However, primary or acquired OXA resistance remains an emerging challenge for its clinical application. Ferroptosis iron-dependent mode cell death that has been demonstrated to play essential role chemoresistance many drugs, including OXA. In particular, dysregulation SLC7A11-GPX4, one major antioxidant systems ferroptosis, was found colorectal cancer (CRC) and hepatocellular carcinoma (HCC). addition, Nrf2, upstream regulator GPX4 other factors, also involved CRC HCC. Inhibition SLC7A11-GPX4 Nrf2 by genetic deletion pharmaceutical inhibition could significantly reverse resistance. Long noncoding RNA (lncRNA) participates ferroptosis cells. Specifically, LINC01134 promotes recruitment promoter GPX4, thereby exerting transcriptional regulation which eventually increases sensitivity HCC through upregulation ferroptosis. On hand, a novel lncRNA DACT3-AS1 sensitizes gastric cells miR-181a-5p/sirtuin 1(SIRT1)-mediated Therapies based on combination enhancers provide new therapeutic insights overcome present review, we current understanding ferroptosis-related resistance, highlight pathogenesis chemoresistance, summarize available therapies target enhancing

Language: Английский

Citations

5
PM2.5 exposure deteriorates Th1/Th2 balance in pediatric asthma by downregulating ALKBH5 and enhancing SRSF1 m6A methylation DOI

Chunhua Ye,

Yi‐fu Chen, Hua Liu

et al.

International Journal of Biometeorology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Language: Английский

Citations

0
Epigenetic changes in childhood asthma: a path to precision medicine DOI
Pankaj Soni,

Ignatius Edwin D'Souza

Epigenetics Insights, Journal Year: 2025, Volume and Issue: 18(1), P. 0 - 0

Published: Jan. 1, 2025

Language: Английский

Citations

0
High-Resolution Tracking of Aging-Related Small Molecules: Bridging Pollutant Exposure, Brain Aging Mechanisms, and Detection Innovations DOI Creative Commons

Keying Yu,

Soo In Yang,

H.-P. Song

et al.

Biosensors, Journal Year: 2025, Volume and Issue: 15(4), P. 242 - 242

Published: April 11, 2025

Brain aging is a complex process regulated by genetic, environmental, and metabolic factors, increasing evidence suggests that environmental pollutants can significantly accelerate this interfering with oxidative stress, neuroinflammation, mitochondrial function-related signaling pathways. Traditional studies have focused on the direct damage of macromolecules (e.g., proteins, DNA), while central role senescence-associated small molecules ROS, PGE2, lactate) in early regulatory mechanisms has been long neglected. In study, we innovatively proposed cascade framework "small molecule imbalance-signaling pathway dysregulation-macromolecule collapse", which reveals exacerbate dynamics brain through activation NLRP3 inflammatory vesicles inhibition HIF-1α. Meanwhile, to address technical bottleneck spatiotemporal monitoring, paper systematically reviews cutting-edge detection tools such as electrochemical sensors, genetically encoded fluorescent probes antioxidant quantum dots (AQDs). Among them, AQDs show unique advantages real-time monitoring ROS fluctuations intervention virtue their ultra-high specific surface area, controllable modification, free radical scavenging ability. By integrating multimodal techniques mechanism studies, work provides new perspective for analyzing pollutant-induced lays methodological foundation strategies based networks.

Language: Английский

Citations

0
Environmental pollutants exposure-derived extracellular vesicles: crucial players in respiratory disorders DOI

Haoran Shen,

Rui Zheng, Mulong Du

et al.

Thorax, Journal Year: 2024, Volume and Issue: 79(7), P. 680 - 691

Published: April 17, 2024

Individual exposure to environmental pollutants, as one of the most influential drivers respiratory disorders, has received considerable attention due its preventability and controllability. Considering that extracellular vesicle (EV) was an emerging intercellular communication medium, recent studies have highlighted crucial role pollutants derived EVs (EPE-EVs) in disorders.

Language: Английский

Citations

1
Epigenetic remodeling under oxidative stress: Mechanisms driving tumor metastasis DOI Creative Commons

Peilan Peng,

Siyuan Qin, Lei Li

et al.

MedComm – Oncology, Journal Year: 2024, Volume and Issue: 3(4)

Published: Nov. 14, 2024

Abstract Tumor metastasis is a multistep, inefficient process orchestrated by diverse signaling pathways. Compared to primary tumor cells, disseminated cells inevitably encounter higher oxidative stress in foreign environments. The levels of reactive oxygen species (ROS) fluctuate dynamically during different metastatic stages, adding complexity the regulation progression. Numerous studies suggest that epigenetic remodeling, key reversible mechanism gene regulation, plays critical role responding and controlling expression profiles drive metastasis. Despite extensive research, comprehensive understanding how impacts through modifications remains elusive, such as DNA methylation, histone modification, ncRNAs, m 6 A modification. Epigenetic therapeutic strategies, DNMT inhibitors, HDAC inhibitors (HDACis), miRNA mimics, have shown promise, yet challenges related immunogenicity, specificity, delivery also exist. Furthermore, due limited understanding, some drugs targeting modification be explored. In this review, we provided an overview influences behavior, summarized mechanisms involved these processes, reviewed latest advancements epigenetic‐targeted therapies, which may pave way develop novel strategy for preventing or treating

Language: Английский

Citations

1
Plasma extracellular vesicles regulate the Functions of Th2 and ILC2 cells via miRNA-150-5p in patients with allergic rhinitis DOI

Shu‐Bin Fang,

Zhi‐Rou Zhou,

Qi Sun

et al.

International Immunopharmacology, Journal Year: 2024, Volume and Issue: 144, P. 113644 - 113644

Published: Nov. 23, 2024

Language: Английский

Citations

1
Implications of DNA damage in chronic lung disease DOI Creative Commons
Dingning Zhang, Tong Sun, Jiguang Bao

et al.

Frontiers in Cell and Developmental Biology, Journal Year: 2024, Volume and Issue: 12

Published: Oct. 31, 2024

DNA plays an indispensable role in ensuring the perpetuation of life and safeguarding genetic stability living organisms. The emergence diseases linked to a wide spectrum responses damage has garnered increasing attention within scientific community. There is growing evidence that patterns response lungs are associated with onset, progression, treatment chronic lung such as obstructive pulmonary disease (COPD), asthma, bronchopulmonary dysplasia (BPD). Currently, some studies have analyzed mechanisms by which environmental factors induce damage. In this article, we summarize inducible damage, current indicators, methods for diagnosing explore repair after including nonhomologous end-joining homology-directed end joining pathways. Additionally, drug treatments may reduce or promote it occurs briefly described. general, more accurate assessment degree caused various needed further elucidate mechanism so search potential therapeutic targets.

Language: Английский

Citations

0
m6A Ribonucleic Acid Methylation in Fibrotic Diseases of Visceral Organs DOI Creative Commons

Xiaoniu Dai,

Yusi Cheng, Wei Luo

et al.

Small Science, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Fibrosis is a pathological process characterized by the excessive deposition of extracellular matrix in tissue's space, leading to structural injury and organ dysfunction, even failure, posing threat human life. Despite mounting evidence suggesting that fibrosis reversible, effective treatments for fibrotic diseases are lacking. Accumulating has elucidated ribonucleic acid (RNA) modifications have emerged as novel mechanisms regulating gene expression. N6‐methyladenosine (m6A) modification well‐known prevalent RNA posttranscriptional participates essential biological processes such splicing, translation, degradation. It tightly implicated wide range cellular various diseases, particularly fibrosis. The m6A dynamic reversible regulated methylases, commonly known “writers,” demethylases referred “erasers,” while recognized “readers.” suggests on RNAs associated with visceral organs including lungs, heart, liver, kidney. In this review, recent advances impact methylation highlighted potential prospects therapy treating discussed.

Language: Английский

Citations

0