Capturing temporal variation in aquatic ecotoxicological risks: Chemical- versus effect-based assessment

The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 967, P. 178797 - 178797

Published: Feb. 12, 2025

The integration of effect-based and chemical profiling has been advocated to assess the potential ecotoxicological risks posed by mixtures present in aquatic ecosystems. However, concentrations contaminants surface waters can vary greatly over time space, making it challenging ensure risk assessment. Although first results are promising, not yet proven that these combined approaches also capable capturing temporal variation risks. study aimed test this combining passive time-integrative sampling with chemical-analytical techniques agricultural waterways. Silicone rubber sheets polar organic integrative samplers (POCIS) were deployed four water bodies consecutive six-week periods. Passive sampler extracts analysed using a battery 22 vitro vivo bioassays tandem extensive target analysis 225 compounds. induced fluctuating bioassay responses for all locations during periods, highlighting presence spatial toxic pressure. A range compounds, primarily fungicides herbicides, detected periods at variable concentrations, persistent but pressure regions. toxicity observed could solely be attributed chemicals 6 % cases those explaining only 1-16.9 effects, indicating predominantly caused undetected chemicals. Risk assessments based on revealed frequent exceedances trigger values It is concluded better capture variations than traditional analyses, advanced needed explain bioanalytical response profiles.

Language: Английский

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Advancing the Effect-Directed Identification in Combined Pollution: Using Pathways to Link Effects and Toxicants

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(42), P. 18642 - 18653

Published: Oct. 11, 2024

The difficulty in associating diverse pollutants with mixture effects has led to significant challenges identifying toxicants combined pollution. In this study, pathways were used link and toxicants. By evaluated by the concentration-dependent transcriptome, individual extended molecular mechanisms encompassing 135 corresponding 6 biological processes. Accordingly, mechanism-based identification of was achieved constructing a pathway toxicant database containing 2413 chemical–pathway interactions active fragments 72 pathways. developed method applied two different wastewaters, industrial wastewater OB municipal HL. Although lethality teratogenesis both observed at level, revealed pathways, cardiotoxicity- genotoxicity-related significantly enriched OB, neurotoxicity- environmental information processing-related Further suspect nontargeted screening generated 59 86 causative HL, respectively, among which 29 confirmed, that interacted over 90% contributed 50% effects. After upgrading treatments based on toxicants, consistent removal effects, observed. Mediation enables identification, supporting assessment management

Language: Английский

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Identifying and prioritizing organic toxicants in treated flowback and produced water from shale gas exploitation sites using an integrative effect-directed analysis and nontarget screening method

Water Research, Journal Year: 2025, Volume and Issue: unknown, P. 123311 - 123311

Published: Feb. 1, 2025

Language: Английский

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Estrogens and Progestogens in Environmental Waters: Analytical Chemistry and Biosensing Perspectives on Methods, Challenges, and Trends

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 21, 2025

Language: Английский

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Priorities to inform research on tire particles and their chemical leachates: A collective perspective

Environmental Research, Journal Year: 2024, Volume and Issue: unknown, P. 120222 - 120222

Published: Oct. 1, 2024

Language: Английский

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