Influence of selected dosages of plastic microparticles on the porcine fecal microbiome

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Jan. 8, 2025

Abstract Studies conducted so far have shown that nano- and microplastic may disturb the intestinal microenvironment by interacting with epithelium gut microbiota. Depending on research model used, effect microbiome is different—an increase or decrease in selected taxa resulting development of dysbiosis. Dysbiosis be associated inflammation, mental disorders diabetes. The aim study was to analyze 15 gilts divided into 3 groups (n = 5; control group, receiving micropartices at a dose 0.1 g/day (LD) 1 (HD)). Feaces were collected before after 28 days exposure PET microplastics. analysis performed using next-generation sequencing. Alpha beta diversity indices compared, showing, repetition affected only abundance LD groups, but not HD group. relationships between number reads phylum, genus species level calculated statistical methods ( r -Pearson correlation, generalized regression model, variance). revealed, populations Family XIII AD3011 group , Coprococcus V9D2013 UCG-010 Sphaerochaeta increased increasing MP-PET dose. above-mentioned are mainly responsible for production short-chain fatty acids (SCFA). It assumed, SCFA one mechanisms involved response oral MP-PET.

Language: Английский

Unraveling the Role of the Human Gut Microbiome in Health and Diseases

Microorganisms, Journal Year: 2024, Volume and Issue: 12(11), P. 2333 - 2333

Published: Nov. 15, 2024

The human gut is a complex ecosystem that supports billions of living species, including bacteria, viruses, archaea, phages, fungi, and unicellular eukaryotes. Bacteria give genes enzymes for microbial host-produced compounds, establishing symbiotic link between the external environment host at both systemic levels. microbiome, which primarily made up commensal critical maintaining healthy host's immune system, aiding digestion, synthesizing essential nutrients, protecting against pathogenic as well influencing endocrine, neural, humoral, immunological functions metabolic pathways. Qualitative, quantitative, and/or topographic shifts can alter resulting in dysbiosis dysfunction, contribute to variety noncommunicable illnesses, hypertension, cardiovascular disease, obesity, diabetes, inflammatory bowel cancer, irritable syndrome. While most evidence date observational does not establish direct causation, ongoing clinical trials advanced genomic techniques are steadily enhancing our understanding these intricate interactions. This review will explore key aspects relationship microbiota, eubiosis, health highlighting emerging strategies microbiome engineering potential therapeutic approaches various conditions.

Language: Английский

The Microplastic-Crisis: Role of Bacteria in Fighting Microplastic-Effects in the Digestive System

Environmental Pollution, Journal Year: 2024, Volume and Issue: unknown, P. 125437 - 125437

Published: Dec. 1, 2024

Language: Английский