A Review of the Consequences of Gut Microbiota in Neurodegenerative Disorders and Aging

Brain Sciences, Journal Year: 2024, Volume and Issue: 14(12), P. 1224 - 1224

Published: Dec. 3, 2024

Age-associated alterations in the brain lead to cognitive deterioration and neurodegenerative disorders (NDDs). This review with a particular focus on Alzheimer’s disease (AD), emphasizes burgeoning significance of gut microbiota (GMB) neuroinflammation its impact gut–brain axis (GBA), communication conduit between central nervous system (CNS). Changes microbiome, including diminished microbial diversity prevalence pro-inflammatory bacteria, are associated AD pathogenesis. Promising therapies, such as fecal transplantation (FMT), probiotics, prebiotics, may restore health enhance performance. Clinical data remain insufficient, necessitating further research elucidate causes, therapy, consider individual variances. integrative approach yield innovative therapies aimed at GMB improve function older people.

Language: Английский

---

The characteristics of intestinal microflora in infants with rotavirus enteritis, changes in microflora before and after treatment and their clinical values

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: Feb. 5, 2025

Rotavirus (RV) is a leading pathogen causing diarrhea in children. In this study, total of 51 fecal samples from children with RV enteritis, 29 post-treatment samples, and 38 age-matched healthy controls were collected. Microbial DNA was isolated the followed by high throughput Illumina sequencing targeting 16 S rRNA gene. Compared to group, RV-infected group exhibited reduced microbial diversity. Both groups shared Firmicutes as dominant phylum. Additionally, abundance Proteobacteria increased significantly group. At genus level, among top 50 most abundant genera, 34 showed significant differences, these differential genera correlating certain clinical indicators such dehydration levels C-reactive protein (CRP). Notably, there no differences microbiota before after treatment Only 8.82% (3/34) recovery trend towards state. This study enhances understanding how infection alters gut structure provides scientific basis for improving diagnosis strategies.

Language: Английский

---

The Neonatal Microbiome: Implications for Amyotrophic Lateral Sclerosis and Other Neurodegenerations

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(2), P. 195 - 195

Published: Feb. 14, 2025

Most brain development occurs in the "first 1000 days", a critical period from conception to child's second birthday. Critical processes that occur during this time include synaptogenesis, myelination, neural pruning, and formation of functioning neuronal circuits. Perturbations first days likely contribute later-life neurodegenerative disease, including sporadic amyotrophic lateral sclerosis (ALS). Neurodevelopment is determined by many events, maturation colonization infant microbiome its metabolites, specifically neurotransmitters, immune modulators, vitamins, short-chain fatty acids. Successful gut-brain axis function depend on maternal factors (stress exposure toxins pregnancy), mode delivery, quality postnatal environment, diet after weaning breast milk, nutritional deficiencies. While neonatal highly plastic, it remains prone dysbiosis which, once established, may persist into adulthood, thereby inducing chronic inflammation abnormal excitatory/inhibitory balance, resulting excitation. Both are recognized as key pathophysiological ALS.

Language: Английский

---

Interplay Between Gut Microbiota and Exosome Dynamics in Sleep Apnea

Sleep Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 106493 - 106493

Published: April 1, 2025

Language: Английский

---

Influence of Microbiome Interactions on Antibiotic Resistance Development in the ICU Environment: Insights and Opportunities with Machine Learning

Deleted Journal, Journal Year: 2025, Volume and Issue: 70(2), P. 14 - 14

Published: April 9, 2025

Antibiotic resistance is a global health crisis exacerbated by the misuse of antibiotics in healthcare, agriculture, and environment. In an intensive care unit (ICU), where high antibiotic usage, invasive procedures, immunocompromised patients converge, risks are amplified, leading to multidrug-resistant organisms (MDROs) poor patient outcomes. The human microbiome plays crucial role development dissemination genes (ARGs) through mechanisms like horizontal gene transfer, biofilm formation, quorum sensing. Disruptions balance, or dysbiosis, further exacerbate resistance, particularly high-risk ICU environments. This study explores interactions ICU, highlighting machine learning (ML) as transformative tool. Machine algorithms analyze high-dimensional data, predict patterns, identify novel therapeutic targets. By integrating genomic, microbiome, clinical these models support personalized treatment strategies enhance infection control measures. results demonstrate potential improve stewardship outcomes, emphasizing its utility ICU-specific interventions. conclusion, addressing requires multidisciplinary approach combining advanced computational methods, research, expertise. Enhanced surveillance, targeted interventions, collaboration essential mitigate care.

Language: Английский

---

Photobiomodulation and the oral-gut microbiome axis: therapeutic potential and challenges

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: April 9, 2025

This Perspective article explores the challenges associated with direct application of photobiomodulation (PBM) to gut and presents a novel hypothesis for indirect health modulation through oral microbiome alteration. Given difficulties in delivering PBM effectively deep gastrointestinal tissues, an alternative approach involves targeting microbiome, which has demonstrated relationship microbiome. Research indicates that applied cavity could selectively alter microbial composition. alteration may, via oral-gut axis, indirectly impact health. hypothesis, supported by preliminary studies, suggests offer promising non-invasive strategy managing gut-related disorders. Furthermore, there may be link between brain diseases. proximity brain, PBM-induced changes microbiota help prevent neurological However, further investigation is necessary comprehensively elucidate underlying mechanisms therapeutic implications this approach.

Language: Английский

---

Gut microbiota dysbiosis and metabolic shifts in pediatric norovirus infection: a metagenomic study in Northeast China

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: May 22, 2025

Norovirus (NoV) is a leading cause of acute gastroenteritis in pediatric populations worldwide. However, the role gut microbiota NoV pathogenesis remains poorly understood. We conducted longitudinal metagenomic analysis fecal samples from 12 NoV-infected children and 13 age-matched healthy controls Northeast China. Microbial composition functional pathways were assessed using high-throughput shotgun sequencing bioinformatic profiling. infection was associated with significant microbial dysbiosis, including increased alpha diversity distinct taxonomic shifts. Notably, Bacteroides uniformis, Veillonella spp., Carjivirus communis enriched infected individuals. Functional revealed upregulation metabolic involved carbohydrate lipid processing. These alterations persisted over time correlated disease severity. Our findings reveal novel associations between particularly enrichment which may influence host-pathogen interactions via or immune mechanisms. The identified signatures offer potential biomarkers for diagnosis targets microbiota-based therapeutic strategies infection.

Language: Английский

---

Long-term alterations in gut microbiota following mild COVID-19 recovery: bacterial and fungal community shifts

Frontiers in Cellular and Infection Microbiology, Journal Year: 2025, Volume and Issue: 15

Published: May 26, 2025

Objective COVID-19 has had a profound impact on public health globally. However, most studies have focused patients with long COVID or those in the acute phase of infection, limited research individuals who recovered from mild COVID-19. This study investigates long-term changes bacterial and fungal communities recovering their clinical relevance. Methods Healthy Hainan Province were enrolled before outbreak, along at 3 months 6 post-recovery. Stool, blood samples, metadata collected. Metagenomic sequencing Internal Transcribed Spacer (ITS) analysis characterized communities, while bacterial-fungal co-occurrence networks constructed. A random forest model evaluated predictive capacity key taxa. Results The gut microbiota recoverees differed significantly that healthy individuals. At post-recovery, probiotics (e.g., Blautia massiliensis Kluyveromyces spp.) enriched, linked to improved metabolism, months, partial recovery Acidaminococcus Asterotremella was observed alongside persistent pathogens Streptococcus equinus Gibberella spp.). Dynamic observed, enriched both baseline but absent months. Co-occurrence network revealed synergies between ( Rothia Coprinopsis taxa, suggesting potential roles restoration. (10 taxa) outperformed (8 predicting status (AUC = 0.99 vs. 0.80). Conclusion These findings highlight significant impacts microbiota, taxa influencing metabolism immune regulation, supporting microbiome-based strategies for management.

Language: Английский

---

Overview of Microorganisms: Bacterial Microbiome, Mycobiome, Virome Identified Using Next-Generation Sequencing, and Their Application to Ophthalmic Diseases

Microorganisms, Journal Year: 2025, Volume and Issue: 13(6), P. 1300 - 1300

Published: June 3, 2025

This review outlines technological advances in pathogen identification and describes the development evolution of next-generation sequencers that can be applied to ocular microbiome. Traditional methods such as culture PCR have limitations detecting full spectrum resident microorganisms, prompting a transition toward metagenomic analysis. As microbiome research expands across body systems, comprehensive bacteria, fungi, viruses has become possible. The commensal may influence disease through changes immune system environment. Next-generation sequencing enables detailed microbial profiling, aiding diagnosis treatment selection. Alterations also induce metabolic changes, offering insights into novel methods. technology, summarizes current knowledge microorganisms found on surface intraocular fluid, discusses future challenges prospects. However, large volume data obtained must interpreted with caution due possible analytical biases. Furthermore, determining whether is truly pathogenic requires interpretation beyond clinical findings results traditional

Language: Английский

---