A Review of the Consequences of Gut Microbiota in Neurodegenerative Disorders and Aging
Brain Sciences,
Journal Year:
2024,
Volume and Issue:
14(12), P. 1224 - 1224
Published: Dec. 3, 2024
Age-associated
alterations
in
the
brain
lead
to
cognitive
deterioration
and
neurodegenerative
disorders
(NDDs).
This
review
with
a
particular
focus
on
Alzheimer’s
disease
(AD),
emphasizes
burgeoning
significance
of
gut
microbiota
(GMB)
neuroinflammation
its
impact
gut–brain
axis
(GBA),
communication
conduit
between
central
nervous
system
(CNS).
Changes
microbiome,
including
diminished
microbial
diversity
prevalence
pro-inflammatory
bacteria,
are
associated
AD
pathogenesis.
Promising
therapies,
such
as
fecal
transplantation
(FMT),
probiotics,
prebiotics,
may
restore
health
enhance
performance.
Clinical
data
remain
insufficient,
necessitating
further
research
elucidate
causes,
therapy,
consider
individual
variances.
integrative
approach
yield
innovative
therapies
aimed
at
GMB
improve
function
older
people.
Language: Английский
The characteristics of intestinal microflora in infants with rotavirus enteritis, changes in microflora before and after treatment and their clinical values
Qingpi Yan,
No information about this author
Yuanyuan Chen,
No information about this author
E‐Bin Gao
No information about this author
et al.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Feb. 5, 2025
Rotavirus
(RV)
is
a
leading
pathogen
causing
diarrhea
in
children.
In
this
study,
total
of
51
fecal
samples
from
children
with
RV
enteritis,
29
post-treatment
samples,
and
38
age-matched
healthy
controls
were
collected.
Microbial
DNA
was
isolated
the
followed
by
high
throughput
Illumina
sequencing
targeting
16
S
rRNA
gene.
Compared
to
group,
RV-infected
group
exhibited
reduced
microbial
diversity.
Both
groups
shared
Firmicutes
as
dominant
phylum.
Additionally,
abundance
Proteobacteria
increased
significantly
group.
At
genus
level,
among
top
50
most
abundant
genera,
34
showed
significant
differences,
these
differential
genera
correlating
certain
clinical
indicators
such
dehydration
levels
C-reactive
protein
(CRP).
Notably,
there
no
differences
microbiota
before
after
treatment
Only
8.82%
(3/34)
recovery
trend
towards
state.
This
study
enhances
understanding
how
infection
alters
gut
structure
provides
scientific
basis
for
improving
diagnosis
strategies.
Language: Английский
The Neonatal Microbiome: Implications for Amyotrophic Lateral Sclerosis and Other Neurodegenerations
Brain Sciences,
Journal Year:
2025,
Volume and Issue:
15(2), P. 195 - 195
Published: Feb. 14, 2025
Most
brain
development
occurs
in
the
"first
1000
days",
a
critical
period
from
conception
to
child's
second
birthday.
Critical
processes
that
occur
during
this
time
include
synaptogenesis,
myelination,
neural
pruning,
and
formation
of
functioning
neuronal
circuits.
Perturbations
first
days
likely
contribute
later-life
neurodegenerative
disease,
including
sporadic
amyotrophic
lateral
sclerosis
(ALS).
Neurodevelopment
is
determined
by
many
events,
maturation
colonization
infant
microbiome
its
metabolites,
specifically
neurotransmitters,
immune
modulators,
vitamins,
short-chain
fatty
acids.
Successful
gut-brain
axis
function
depend
on
maternal
factors
(stress
exposure
toxins
pregnancy),
mode
delivery,
quality
postnatal
environment,
diet
after
weaning
breast
milk,
nutritional
deficiencies.
While
neonatal
highly
plastic,
it
remains
prone
dysbiosis
which,
once
established,
may
persist
into
adulthood,
thereby
inducing
chronic
inflammation
abnormal
excitatory/inhibitory
balance,
resulting
excitation.
Both
are
recognized
as
key
pathophysiological
ALS.
Language: Английский
Interplay Between Gut Microbiota and Exosome Dynamics in Sleep Apnea
R.R Hicks,
No information about this author
David Gozal,
No information about this author
Sadia Ahmed
No information about this author
et al.
Sleep Medicine,
Journal Year:
2025,
Volume and Issue:
unknown, P. 106493 - 106493
Published: April 1, 2025
Language: Английский
Influence of Microbiome Interactions on Antibiotic Resistance Development in the ICU Environment: Insights and Opportunities with Machine Learning
Deleted Journal,
Journal Year:
2025,
Volume and Issue:
70(2), P. 14 - 14
Published: April 9, 2025
Antibiotic
resistance
is
a
global
health
crisis
exacerbated
by
the
misuse
of
antibiotics
in
healthcare,
agriculture,
and
environment.
In
an
intensive
care
unit
(ICU),
where
high
antibiotic
usage,
invasive
procedures,
immunocompromised
patients
converge,
risks
are
amplified,
leading
to
multidrug-resistant
organisms
(MDROs)
poor
patient
outcomes.
The
human
microbiome
plays
crucial
role
development
dissemination
genes
(ARGs)
through
mechanisms
like
horizontal
gene
transfer,
biofilm
formation,
quorum
sensing.
Disruptions
balance,
or
dysbiosis,
further
exacerbate
resistance,
particularly
high-risk
ICU
environments.
This
study
explores
interactions
ICU,
highlighting
machine
learning
(ML)
as
transformative
tool.
Machine
algorithms
analyze
high-dimensional
data,
predict
patterns,
identify
novel
therapeutic
targets.
By
integrating
genomic,
microbiome,
clinical
these
models
support
personalized
treatment
strategies
enhance
infection
control
measures.
results
demonstrate
potential
improve
stewardship
outcomes,
emphasizing
its
utility
ICU-specific
interventions.
conclusion,
addressing
requires
multidisciplinary
approach
combining
advanced
computational
methods,
research,
expertise.
Enhanced
surveillance,
targeted
interventions,
collaboration
essential
mitigate
care.
Language: Английский
Photobiomodulation and the oral-gut microbiome axis: therapeutic potential and challenges
Neda Hakimiha,
No information about this author
Somayeh Jahani Sherafat,
No information about this author
E‐Liisa Laakso
No information about this author
et al.
Frontiers in Medicine,
Journal Year:
2025,
Volume and Issue:
12
Published: April 9, 2025
This
Perspective
article
explores
the
challenges
associated
with
direct
application
of
photobiomodulation
(PBM)
to
gut
and
presents
a
novel
hypothesis
for
indirect
health
modulation
through
oral
microbiome
alteration.
Given
difficulties
in
delivering
PBM
effectively
deep
gastrointestinal
tissues,
an
alternative
approach
involves
targeting
microbiome,
which
has
demonstrated
relationship
microbiome.
Research
indicates
that
applied
cavity
could
selectively
alter
microbial
composition.
alteration
may,
via
oral-gut
axis,
indirectly
impact
health.
hypothesis,
supported
by
preliminary
studies,
suggests
offer
promising
non-invasive
strategy
managing
gut-related
disorders.
Furthermore,
there
may
be
link
between
brain
diseases.
proximity
brain,
PBM-induced
changes
microbiota
help
prevent
neurological
However,
further
investigation
is
necessary
comprehensively
elucidate
underlying
mechanisms
therapeutic
implications
this
approach.
Language: Английский
Gut microbiota dysbiosis and metabolic shifts in pediatric norovirus infection: a metagenomic study in Northeast China
Z.-X. Wang,
No information about this author
Xinhong Wei,
No information about this author
Li-Zhen Piao
No information about this author
et al.
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2025,
Volume and Issue:
15
Published: May 22, 2025
Norovirus
(NoV)
is
a
leading
cause
of
acute
gastroenteritis
in
pediatric
populations
worldwide.
However,
the
role
gut
microbiota
NoV
pathogenesis
remains
poorly
understood.
We
conducted
longitudinal
metagenomic
analysis
fecal
samples
from
12
NoV-infected
children
and
13
age-matched
healthy
controls
Northeast
China.
Microbial
composition
functional
pathways
were
assessed
using
high-throughput
shotgun
sequencing
bioinformatic
profiling.
infection
was
associated
with
significant
microbial
dysbiosis,
including
increased
alpha
diversity
distinct
taxonomic
shifts.
Notably,
Bacteroides
uniformis,
Veillonella
spp.,
Carjivirus
communis
enriched
infected
individuals.
Functional
revealed
upregulation
metabolic
involved
carbohydrate
lipid
processing.
These
alterations
persisted
over
time
correlated
disease
severity.
Our
findings
reveal
novel
associations
between
particularly
enrichment
which
may
influence
host-pathogen
interactions
via
or
immune
mechanisms.
The
identified
signatures
offer
potential
biomarkers
for
diagnosis
targets
microbiota-based
therapeutic
strategies
infection.
Language: Английский
Long-term alterations in gut microbiota following mild COVID-19 recovery: bacterial and fungal community shifts
Da Li,
No information about this author
Daya Zhang,
No information about this author
Shi-Ju Chen
No information about this author
et al.
Frontiers in Cellular and Infection Microbiology,
Journal Year:
2025,
Volume and Issue:
15
Published: May 26, 2025
Objective
COVID-19
has
had
a
profound
impact
on
public
health
globally.
However,
most
studies
have
focused
patients
with
long
COVID
or
those
in
the
acute
phase
of
infection,
limited
research
individuals
who
recovered
from
mild
COVID-19.
This
study
investigates
long-term
changes
bacterial
and
fungal
communities
recovering
their
clinical
relevance.
Methods
Healthy
Hainan
Province
were
enrolled
before
outbreak,
along
at
3
months
6
post-recovery.
Stool,
blood
samples,
metadata
collected.
Metagenomic
sequencing
Internal
Transcribed
Spacer
(ITS)
analysis
characterized
communities,
while
bacterial-fungal
co-occurrence
networks
constructed.
A
random
forest
model
evaluated
predictive
capacity
key
taxa.
Results
The
gut
microbiota
recoverees
differed
significantly
that
healthy
individuals.
At
post-recovery,
probiotics
(e.g.,
Blautia
massiliensis
Kluyveromyces
spp.)
enriched,
linked
to
improved
metabolism,
months,
partial
recovery
Acidaminococcus
Asterotremella
was
observed
alongside
persistent
pathogens
Streptococcus
equinus
Gibberella
spp.).
Dynamic
observed,
enriched
both
baseline
but
absent
months.
Co-occurrence
network
revealed
synergies
between
(
Rothia
Coprinopsis
taxa,
suggesting
potential
roles
restoration.
(10
taxa)
outperformed
(8
predicting
status
(AUC
=
0.99
vs.
0.80).
Conclusion
These
findings
highlight
significant
impacts
microbiota,
taxa
influencing
metabolism
immune
regulation,
supporting
microbiome-based
strategies
for
management.
Language: Английский
Overview of Microorganisms: Bacterial Microbiome, Mycobiome, Virome Identified Using Next-Generation Sequencing, and Their Application to Ophthalmic Diseases
Microorganisms,
Journal Year:
2025,
Volume and Issue:
13(6), P. 1300 - 1300
Published: June 3, 2025
This
review
outlines
technological
advances
in
pathogen
identification
and
describes
the
development
evolution
of
next-generation
sequencers
that
can
be
applied
to
ocular
microbiome.
Traditional
methods
such
as
culture
PCR
have
limitations
detecting
full
spectrum
resident
microorganisms,
prompting
a
transition
toward
metagenomic
analysis.
As
microbiome
research
expands
across
body
systems,
comprehensive
bacteria,
fungi,
viruses
has
become
possible.
The
commensal
may
influence
disease
through
changes
immune
system
environment.
Next-generation
sequencing
enables
detailed
microbial
profiling,
aiding
diagnosis
treatment
selection.
Alterations
also
induce
metabolic
changes,
offering
insights
into
novel
methods.
technology,
summarizes
current
knowledge
microorganisms
found
on
surface
intraocular
fluid,
discusses
future
challenges
prospects.
However,
large
volume
data
obtained
must
interpreted
with
caution
due
possible
analytical
biases.
Furthermore,
determining
whether
is
truly
pathogenic
requires
interpretation
beyond
clinical
findings
results
traditional
Language: Английский