Alzheimer’s disease: the role of extrinsic factors in its development, an investigation of the environmental enigma

Frontiers in Neurology, Journal Year: 2023, Volume and Issue: 14

Published: Dec. 6, 2023

In the realm of Alzheimer's disease, most prevalent form dementia, impact environmental factors has ignited intense curiosity due to its substantial burden on global health. Recent investigations have unveiled these as key contributors, shedding new light their profound influence. Notably, emerging evidence highlights detrimental role various contaminants in incidence and progression disease. These encompass a broad spectrum, including air pollutants laden with ozone, neurotoxic metals like lead, aluminum, manganese, cadmium, pesticides insidious effects, ubiquitous presence plastics microplastics. By meticulously delving into intricate web connecting this devastating neurological disorder, comprehensive chapter takes deep dive involvement significant risk for Furthermore, it explores underlying molecular mechanisms through which exert influence, aiming unravel complex interactions that drive pathogenesis Additionally, proposes potential strategies mitigate effects brain health, ultimate goal restoring preserving typical cognitive function. Through exploration, we aim enhance our understanding multifaceted relationship between neurotoxins providing solid foundation developing innovative in-vivo models advancing knowledge pathological processes debilitating condition.

Language: Английский

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Ozone-induced lung injury and inflammation: Pathways and therapeutic targets for pulmonary diseases caused by air pollutants

Environment International, Journal Year: 2025, Volume and Issue: unknown, P. 109391 - 109391

Published: March 1, 2025

Language: Английский

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Bisphenol A exposure links to exacerbation of memory and cognitive impairment: A systematic review of the literature

Neuroscience & Biobehavioral Reviews, Journal Year: 2022, Volume and Issue: 143, P. 104939 - 104939

Published: Nov. 1, 2022

Language: Английский

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Ozone-induced neurotoxicity: In vitro and in vivo evidence

Ageing Research Reviews, Journal Year: 2023, Volume and Issue: 91, P. 102045 - 102045

Published: Aug. 29, 2023

Language: Английский

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Sleep matters: Neurodegeneration spectrum heterogeneity, combustion and friction ultrafine particles, industrial nanoparticle pollution, and sleep disorders—Denial is not an option

Frontiers in Neurology, Journal Year: 2023, Volume and Issue: 14

Published: Feb. 27, 2023

Sustained exposures to ubiquitous outdoor/indoor fine particulate matter (PM 2.5 ), including combustion and friction ultrafine PM (UFPM) industrial nanoparticles (NPs) starting in utero , are linked early pediatric young adulthood aberrant neural protein accumulation, hyperphosphorylated tau (p-tau), beta-amyloid (Aβ 1 − 42 α-synuclein (α syn) TAR DNA-binding 43 (TDP-43), hallmarks of Alzheimer's (AD), Parkinson's disease (PD), frontotemporal lobar degeneration (FTLD), amyotrophic lateral sclerosis (ALS). UFPM from anthropogenic natural sources NPs enter the brain through nasal/olfactory pathway, lung, gastrointestinal (GI) tract, skin, placental barriers. On a global scale, most important outdoor motor traffic emissions. This study focuses on neuropathology heterogeneity overlap AD, PD, FTLD, ALS older adults, their similarities with young, highly exposed urbanites, strong link sleep disorders. Critical information includes how this cross all biological barriers, interact soluble proteins key organelles, result oxidative, endoplasmic reticulum, mitochondrial stress, neuroinflammation, DNA damage, aggregation misfolding, faulty complex quality control. The toxicity makes them powerful candidates for development progression fatal common neurodegenerative diseases, having disturbances. A detailed residential history, proximity high-traffic roads, occupational histories, high-emission (i.e., factories, burning pits, forest fires, airports), indoor (tobacco, wood winter, cooking fumes, microplastics house dust), consumption NPs, along neurocognitive neuropsychiatric critical. Environmental pollution is ubiquitous, early, cumulative risk factor neurodegeneration Prevention deadly neurological diseases associated air should be public health priority.

Language: Английский

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Restoring Impaired Neurogenesis and Alleviating Oxidative Stress by Cyanidin against Bisphenol A-induced Neurotoxicity: In Vivo and In Vitro Evidence

Current Drug Discovery Technologies, Journal Year: 2024, Volume and Issue: 21(2)

Published: Jan. 26, 2024

Background: Bisphenol A (BPA) is a known neurotoxic compound with potentially harmful effects on the nervous system. Cyanidin (CYN) has shown promise as neuroprotective agent. Objective: The current study aims to determine efficacy of CYN against BPA-induced neuropathology. Methods: In vitro experiments utilized PC12 cells were pre-treated gradient doses and further stimulated 10ng/ml BPA. DPPH radical scavenging activity, catalase total ROS nitric oxide activity done. vivo assessments employed doublecortin immunohistochemistry brain in BPA-exposed Sprague-Dawley rats. Further, silico molecular docking all proteins involved canonical Wnt signaling was performed using Autodock v4.2 tool BIOVIA Discovery Studio Visualizer. Results: IC50 values ascorbic acid determined dose-response curves, it found be 24.68 ± 0.563µg/ml 20.69 1.591µg/ml, respectively. BPA-stimulated pretreated showed comparable (p=0.0287). reactive species production by CYN-treated significantly decreased compared (p<0.0001). Moreover, inhibited BPA control vivo, positively affected immature neuron quantity, correlating dosage. During analysis, exhibited binding affinity > -7Kcal/mol key associated Wnt/β-catenin cascade. Conclusion: Conclusively, our finding suggests that counteracting BPAinduced oxidative stress, improving compromised neurogenesis hippocampal cortical regions, displaying notable interactions proteins. Thereby, could render its potential neuropathology

Language: Английский

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Environmental Toxins and Alzheimer’s Disease: a Comprehensive Analysis of Pathogenic Mechanisms and Therapeutic Modulation

Molecular Neurobiology, Journal Year: 2023, Volume and Issue: 61(6), P. 3657 - 3677

Published: Nov. 25, 2023

Language: Английский

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Alkaloid-rich fraction from Luffa cylindrica Linn fruit enhances memory and mitigates oxidative stress in hippocampus of ozone-exposed sprague Dawley rat via LCMS and network pharmacology approach

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 289, P. 117686 - 117686

Published: Jan. 1, 2025

Luffa cylindrica (L.), is a medicinal plant aimed to investigate the efficacy of alkaloid-rich fraction (ARF) extracted from L. cylindrica. The study employed behavioural analysis rat using Morris water maze (MWM), biochemical apoptotic proteins, Immunohistochemistry caspase 3 protein and network pharmacology approach. ozone-induced group exhibited complex behavioral changes. Western blot revealed altered expression SOD2, Caspase 3, Cytochrome C which play integral roles in oxidative stress, apoptosis, mitochondrial function. Histopathological hippocampus further supported neuroprotective potential cylindrica, demonstrating reduction neuropathological lesions improved memory processes. Network Pharmacology showed implication GSK3β neuronal damage. ARF promise preventing In summary, this comprehensive sheds light on its applications by vivo molecular analyses. It provides holistic understanding properties ARF, encouraging exploration for therapeutic interventions neurological diseases.

Language: Английский

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EnvironMental Health: A Framework for an Emerging Field at the Intersection of the Environment and Mental Health Crises

GeoHealth, Journal Year: 2025, Volume and Issue: 9(2)

Published: Feb. 1, 2025

Abstract Understanding how the environment shapes our mental and cognitive health is imperative to support efforts that promote healthy sustainable living conditions. The etiology of conditions remains often unclear, social factors have received more scrutiny than natural or built environments. We present a conceptual framework illustrating emerging intersection between neuropsychological health, intended structure guide research funding, as well public environmental initiatives. conducted scoping review reviews existing evidence on impacts health. found an extensive body work was focused chemical hazards their associations with neurological including attention‐deficit/hyperactivity disorder (ADHD), autism, dementia, mood. identified areas intersecting such air, water, light, green space schizophrenia behavioral Our analysis intersections allows for identification knowledge clusters gaps, contextualizing needs opportunities future funding strategies. These significant connections showcase importance understanding relationships With this work, we assert protection its integration into healthcare can bring cascading benefits synergies well‐being address economic burden crises.

Language: Английский

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Network Toxicology and Molecular Docking Strategy for Analyzing the Toxicity and Mechanisms of Bisphenol A in Alzheimer's Disease

Journal of Biochemical and Molecular Toxicology, Journal Year: 2025, Volume and Issue: 39(4)

Published: April 1, 2025

ABSTRACT Alzheimer's disease (AD) is a chronic and progressive neurodegenerative disorder marked by memory deterioration cognitive impairment. Bisphenol A (BPA), common environmental pollutant, has been linked to neurotoxicity may contribute AD development. This study aims uncover potential toxicological targets molecular mechanisms of BPA‐induced AD. BPA's neurotoxic effects were predicted using ProTox ADMETlab. Target prediction for BPA was conducted through the STITCH Swiss Prediction platforms, while AD‐related compiled from GeneCards, OMIM, Therapeutic Database (TTD). Protein‐protein interaction (PPI) networks constructed STRING visualized in Cytoscape, gene ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) pathway analyses performed. Molecular docking employed evaluate binding interactions between identified core targets. Through systematic bioinformatics analyses, 137 candidate BPA‐elicited identified. Screening via PPI network analysis highlighted five key targets: STAT3, AKT1, INS, EGFR, PTEN. GO KEGG enrichment revealed significant involvement oxidative stress, neuronal apoptosis, processes, pathways such as PI3K/AKT, MAPK, lipid atherosclerosis, signaling. simulations confirmed strong affinities these sheds light on underlying context provides foundation further research into preventive therapeutic strategies. The integration toxicology offers robust framework unraveling toxic uncharacterized chemical agents.

Language: Английский

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