PeerJ,
Journal Year:
2023,
Volume and Issue:
11, P. e16472 - e16472
Published: Nov. 20, 2023
Amultigenerational
study
on
Ceriodaphnia
dubia
was
carried
out
by
exposing
three
subsequent
generations
to
pharmaceuticals
chlorpromazine
(CPZ)
and
diclofenac
(DCF),
two
lanthanide
chlorides,
gadolinium
as
GdCl3
europium
EuCl3.
As
the
treatments,
environmentally
relevant
concentrations
were
chosen
(0.001,
0.01
0.1
mg/L
for
CPZ;
0.1,
1
10
DCF;
0.425,
4.25
42.5
µg/L
Gd
0.41,
4.1
41
Eu).
Survival,
population
growth
reproduction
success
evaluated
at
21
30
days
of
exposure,
whole
observation
period
lasted
40
days.
The
least
sensitive
all
selected
substances
first
daphnid
generation
(F1).
Within
21-day
no
significant
effects
psychotropic
drug
CPZ
C.
survival
observed
in
F1-F3.
anti-inflammatory
DCF
did
not
affect
F1
generation;
however,
it
significantly
reduced
F3
1-10
mg/L.
Both
lanthanides
F2
but
considerably
decreased
4-42
µg/L.
stimulated
generation,
while
inhibition
occurred
highest
tested
F3.
inhibitory
effect
reproductive
resembled
that
DCF.
dynamics
adverse
during
21-30-day
revealed
despite
increased
mortality
controls
(up
30%),
used
minified,
most
instances,
aggravated
dubia.
Our
data
suggest
a
test
organism
can
be
multigenerational
investigations,
especially
when
testing
close
environmental
concentrations.
In
this
respect,
standard
chronic
toxicity
assay
seems
limited
since
prolonged
observations
several
daphnids
are
required
obtain
reliable
information
risk
assessment
potentially
aggressive
chemicals.
Chemosphere,
Journal Year:
2023,
Volume and Issue:
350, P. 141079 - 141079
Published: Dec. 29, 2023
The
antipsychotic
chlorpromazine
(Cpz)
has
raised
concern
as
a
pharmaceutical
effluent
due
to
its
wide
medical
applications.
Moreover,
potent
pro-oxidant
properties
and
impact
on
the
cell
viability
of
marine
mollusc
Mytilus
galloprovincialis,
even
at
low
concentrations
(ng/L),
have
been
noted.
Based
this
evidence,
in
study,
we
investigated
physiological
effects
Cpz
M.
elucidate
fate
within
organism,
terms
bioaccumulation,
biotransformation,
byssus
changes
stress
responses
cellular
thiolome.
Histological
indicators
vitality
analyses
were
also
performed
better
evaluate
influence
drug
morphology
digestive
gland.
To
end,
two
different
(Cpz
I
(12
ng/L
or
37
pM)
II
μg/L
nM))
administered
mussels
over
14
days.
accumulation
gland
significantly
increased
with
water
concentration
(BCF
II).
Biochemical
indicated
lysosomal
dysfunction,
reflected
elevated
total
Cathepsin
D
activity
compromised
membrane
stability.
Stress-related
metal-buffering
proteins
(GST
metallothionein)
responded
both
concentrations.
induced
phase
biotransformation
(CYP450-dependent
EROD),
while
triggered
caspase-3
activation,
indicative
detoxification
overload.
analysis
revealed
atrophy,
epithelial
thinning,
haemocyte
infiltration,
brown
presence.
Byssus
showed
significant
alterations.
In
conclusion,
our
study
underscores
Cpz-induced
histological
posing
potential
implications
for
mussel
health
confirming
utilisation
an
indication
ecotoxicity.
Environmental Science & Technology,
Journal Year:
2024,
Volume and Issue:
58(3), P. 1473 - 1483
Published: Jan. 11, 2024
Though
toxins
produced
during
harmful
blooms
of
cyanobacteria
present
diverse
risks
to
public
health
and
the
environment,
surface
water
quality
surveillance
cyanobacterial
is
inconsistent,
spatiotemporally
limited,
routinely
relies
on
ELISA
kits
estimate
total
microcystins
(MCs)
in
waters.
Here,
we
employed
liquid
chromatography
tandem
mass
spectrometry
examine
common
cyanotoxins,
including
five
microcystins,
three
anatoxins,
nodularin,
cylindrospermopsin,
saxitoxin
20
subtropical
reservoirs
spatially
distributed
across
a
pronounced
annual
rainfall
gradient.
Probabilistic
environmental
hazard
analyses
identified
whether
values
for
cyanotoxins
were
exceeded
if
these
exceedances
varied
spatiotemporally.
MC-LR
was
most
congener
detected,
but
it
not
consistently
observed
with
other
toxins,
MC-YR,
which
detected
at
highest
concentrations
spring
many
observations
above
California
human
recreation
guideline
(800
ng/L).
Cylindrospermopsin
also
quantitated
40%
eutrophic
reservoirs;
detections
did
exceed
US
Environmental
Protection
Agency
swimming/advisory
level
(15,000
Our
have
implications
routine
monitoring
practices,
traditionally
use
MC
levels
often
limit
collection
samples
summer
months
near
reservoir
impoundments,
further
indicate
that
spatiotemporal
efforts
are
necessary
understand
when
occur
throughout
year.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Feb. 12, 2024
Abstract
Maintaining
good
surface
water
quality
is
essential
to
protecting
ecosystems
and
human
health,
different
targeted
measures
for
polluted
areas
are
an
effective
way
maintain
quality.
This
paper
takes
Henan
as
example
study
the
spatial
dependence
of
explore
its
clustering
pattern,
find
out
main
driving
factors
affecting
analyze
sources
heavily
by
random
forest.
The
results
indicate
that
pollution
pattern
in
Province
can
be
roughly
categorized
insignificant
northern
part,
heavy
central
light
southern
part.
mainly
located
Zhengzhou,
Luoyang
Kaifeng
cities.
indicators
NH
3
-N,
COD
Mn
TP.
causes
deterioration
region
urban
sewage
industrial
wastewater
discharges.
not
only
provide
a
scientific
basis
systematic
management
Province,
but
also
new
method
regional
management.
