Journal of Inorganic and Organometallic Polymers and Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 15, 2024
Language: Английский
Journal of Inorganic and Organometallic Polymers and Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 15, 2024
Language: Английский
Environmental Toxicology and Chemistry, Journal Year: 2024, Volume and Issue: 43(12), P. 2530 - 2544
Published: Sept. 18, 2024
The detection of pharmaceuticals in aquatic ecosystems has generated concern for wildlife and human health over the past several decades. β-adrenergic blocking agents are a class drugs designed to treat cardiovascular diseases high blood pressure. Metoprolol is second-generation β1-adrenergic receptor inhibitor detected effluent derived from sewage treatment plants. Our review presents an updated survey current state knowledge regarding sources, occurrence, toxicity metoprolol ecosystems. We further aimed summarize literature on presence various classes species consider trophic transfer these contaminants marine mammals. biological impacts have been reported 20 organisms, with primary focus cardiac function oxidative stress. reveals that concentrations cause above levels typical freshwater environments. Future studies should investigate effects at lower organisms. Other recommendations include (1) noncardiac endpoints, because computational assessments currently available molecular data identify gonadotropins, vitellogenin, collagen, cytokines as potential targets modulation, (2) development adverse outcome pathways dysfunction improve our understanding interactions outcomes following exposure. As next generation β-blockers developed, continued diligence needed assessing environmental determine their accumulation long-term humans. Environ Toxicol Chem 2024;43:2530-2544. © 2024 SETAC.
Language: Английский
Citations
1Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 482, P. 136628 - 136628
Published: Nov. 22, 2024
Language: Английский
Citations
1The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 904, P. 166378 - 166378
Published: Aug. 17, 2023
Language: Английский
Citations
3Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology, Journal Year: 2023, Volume and Issue: 276, P. 109812 - 109812
Published: Dec. 5, 2023
Language: Английский
Citations
3Marine Pollution Bulletin, Journal Year: 2024, Volume and Issue: 200, P. 116128 - 116128
Published: Feb. 19, 2024
Pharmaceuticals are recognised as environmental contaminants of emerging concern (CECs) due to their increasing presence in the aquatic environment, along with high bioactivity linked therapeutic use. Therefore, information on levels is urgently required. This study examined a range common pharmaceuticals oysters and mussels intended for human consumption from England Wales using stable isotope dilution tandem mass spectrometry. A compounds were detected bivalve tissue, Selective Serotonin Reuptake Inhibitor antidepressant sertraline being most abundant, reaching maximum concentration 22.1 ng/g wet weight shellfish tissue. Levels all showed seasonal geographical patterns. dietary risk assessment revealed that identified molluscs represent clear hazard, but not consumer. highlights requirement further monitoring other CECs molluscs.
Language: Английский
Citations
0Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 213 - 257
Published: Nov. 1, 2024
Language: Английский
Citations
0Journal of Inorganic and Organometallic Polymers and Materials, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 15, 2024
Language: Английский
Citations
0