European Journal of Preventive Cardiology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 30, 2024
Journal
Article
Accepted
manuscript
Rethinking
Cholesterol:
The
Role
of
Lipophilic
Pollutants
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access
Duk-Hee
Lee,
Lee
Department
Preventive
Medicine,
School
Kyungpook
National
University,
Daegu,
Korea
Corresponding
author:
M.D.,
Ph.D.,
101
Dongin-dong,
Jung-gu,
700-422,
Telephone:
+82-53-420-6960,
Fax:
+82-53-425-2447,
E-mail:
[email protected]
https://orcid.org/0000-0003-1596-9968
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author
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David
R
Jacobs,
Jr,
Jr
Division
Epidemiology
and
Community
Health,
Public
University
Minnesota,
Minneapolis,
USA
P
Monica
Lind,
Lind
Medical
Sciences,
Occupational
Environmental
Uppsala
Uppsala,
Sweden
Lars
Clinical
Epidemiology,
https://orcid.org/0000-0003-2335-8542
European
Cardiology,
zwae350,
https://doi.org/10.1093/eurjpc/zwae350
Published:
30
October
2024
history
Received:
07
Revision
received:
15
Accepted:
28
Archives of Toxicology,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 22, 2025
Abstract
In
humans
as
well
in
animals,
the
toxic
contaminant
2,3,7,8-tetrachlorodibenzo-
p-
dioxin
(TCDD)
stimulates
immunosuppression
and
increases
responsiveness
to
infectious
diseases.
The
relationship
between
environmental
contaminants
different
diseases,
including
COVID-19,
has
been
described.
Nevertheless,
reports
about
potential
impact
of
TCDD
on
coronaviruses
(CoVs)
are
limited.
this
study,
(0–100
pg/mL)
was
assessed
during
infection
vitro
with
canine
coronavirus
(CCoV-II),
alphaCoV
causing
moderate
enteric
disease
dogs,
although
genetic
alterations
may
surprisingly
generate
new
dangerous
strains.
For
instance,
outbreaks
lethal
infections
dogs
were
related
highly
virulent
CCoV
strains,
cases
pneumonia
malaise
associated
canine–feline
recombinant
strains
CCoV,
underlining
cross-species
spread
capability
CoVs.
Herein,
infection,
induced
a
substantial
growth
virus
yield
expression
viral
nucleocapsid
protein
infected
groups.
Infected
cells
exhibited
cell
morphology,
extensively
enhanced
by
TCDD.
Moreover,
modulated
levels
aryl
hydrocarbon
receptor
(AHR),
signaling
responsive
both
CoVs
infections.
Overall,
our
findings
showed
that
TCDD,
playing
role
AHR
signaling,
worsen
infection.
Antioxidants,
Journal Year:
2024,
Volume and Issue:
13(4), P. 445 - 445
Published: April 10, 2024
2,2′,4,4′-Tetrabrominated
biphenyl
ether
(BDE-47)
is
a
polybrominated
diphenyl
(PBDE)
homologue
that
ubiquitous
in
biological
samples
and
highly
toxic
to
humans
other
organisms.
Prior
research
has
confirmed
BDE-47
can
induce
oxidative
damage
RAW264.7
cells,
resulting
apoptosis
impaired
immune
function.
The
current
study
mainly
focused
on
how
Isoliquiritigenin
(ISL)
Licochalcone
B
(LCB)
might
protect
against
BDE-47’s
immunotoxic
effects
cells.
results
show
ISL
LCB
could
increase
phagocytosis,
the
production
of
MHC-II,
decrease
inflammatory
factors
(TNF-α,
IL-6,
IL-1β)
co-stimulatory
(CD40,
CD80,
CD86),
alleviating
function
impairment
caused
by
BDE-47.
Secondly,
both
reduce
expressions
proteins
Bax
Caspase-3,
promote
expression
protein
Bcl-2,
apoptotic
rate,
initiated
Additionally,
levels
antioxidant
substances
(SOD,
CAT,
GSH)
reactive
oxygen
species
(ROS),
thereby
counteracting
stress
induced
Ultimately,
suppress
NF-κB
pathway
down-regulating
IKBKB
up-regulating
IκB-Alpha
addition
activating
Nrf2
promoting
HO-1
NQO1.
To
summarize,
causes
be
mitigated
through
activation
inhibition
pathway,
which
turn
prevents
apoptosis.
These
findings
enrich
understanding
toxicological
molecular
mechanism
detoxification
licorice.
Lipids in Health and Disease,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: March 27, 2025
Exposure
to
brominated
flame
retardants
(BFRs)
has
been
linked
alterations
in
human
metabolism
and
disease
processes.
However,
the
relationship
between
BFR
exposure
blood
lipid
levels
remains
unclear.
This
study
aimed
investigate
potential
association
profiles
American
adults.
A
cross-sectional
was
conducted
using
data
from
National
Health
Nutrition
Examination
Survey
(NHANES)
2005–2016.
Serum
concentrations
of
twelve
BFRs,
PBB153
eleven
polybrominated
diphenyl
ethers
(PBDEs),
were
quantified
isotope
dilution
gas
chromatography/high-resolution
mass
spectrometry
(GC/HRMS).
Blood
levels,
including
total
cholesterol
(TC)
high-density
lipoprotein
(HDL-C)
measured
enzymatically.
The
Friedewald
equation
used
determine
low-density
(LDL-C):
[LDL-C]
=
[TC]
−
[HDL-C]
[TG/5].
Remnant
(RC)
calculated
formula:
[RC]
[LDL-C].
Multivariable
regression
analyses
applied
examine
associations
individual
BFRs
TC,
HDL-C,
LDL-C,
RC.
overall
mixtures
with
lipids
evaluated
quantile
g-computation
(QGC)
weighted
sum
(WQS)
regression.
In
order
identify
gender-specific
differences,
stratified
mixture
performed
by
gender.
3,154
eligible
participants
included.
Nine
a
detection
rate
greater
than
70%
included
analysis.
Individually,
PBB153,
PBDE209,
PBDE153,
PBDE28
positively
associated
TC
RC
after
adjusted
all
covariates.
Furthermore,
PBDE153
LDL-C.
No
found
HDL-C.
WQS
QGC
confirmed
that
demonstrates
is
increased
RC,
indicating
an
elevated
risk
dyslipidemia
cardiovascular
diseases.
