Exposure to 6-PPD quinone causes ferroptosis activation associated with induction of reproductive toxicity in Caenorhabditis elegans

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 471, P. 134356 - 134356

Published: April 19, 2024

Language: Английский

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Environmental profiles, hazard identification, and toxicological hallmarks of emerging tire rubber-related contaminants 6PPD and 6PPD-quinone

Environment International, Journal Year: 2024, Volume and Issue: 187, P. 108677 - 108677

Published: April 21, 2024

N-(1,3-dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD) is commonly used in rubber compounds as antioxidants to protect against degradation from heat, oxygen, and ozone exposure. This practice extends the lifespan of products, including tires, by preventing cracking, aging, deterioration. However, environmental consequences waste generated during product use, particularly formation 6PPD-quinone (6PPD-Q) through reaction 6PPD with ozone, have raised significant concerns due their detrimental effects on ecosystems. Extensive research has revealed widespread occurrence its derivate 6PPD-Q various compartments, air, water, soil. The emerging substance been shown pose acute mortality long-term hazards aquatic terrestrial organisms at concentrations below environmentally relevant levels. Studies demonstrated toxic a range organisms, zebrafish, nematodes, mammals. These include neurobehavioral changes, reproductive dysfunction, digestive damage exposure pathways. Mechanistic insights suggest that mitochondrial stress, DNA adduct formation, disruption lipid metabolism contribute toxicity induced 6PPD-Q. Recent findings human samples, such blood, urine, cerebrospinal fluid, underscore importance further public health toxicological implications these compounds. distribution, fate, biological effects, underlying mechanisms environment highlight urgent need for additional understand address impacts

Language: Английский

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Potential human health risk of the emerging environmental contaminant 6-PPD quinone

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 949, P. 175057 - 175057

Published: July 26, 2024

Language: Английский

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Environmental fate of tire-rubber related pollutants 6PPD and 6PPD-Q: A review

Environmental Research, Journal Year: 2024, Volume and Issue: 258, P. 119492 - 119492

Published: June 25, 2024

Language: Английский

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Exposure to 6-PPD quinone disrupts glucose metabolism associated with lifespan reduction by affecting insulin and AMPK signals in Caenorhabditis elegans

Chemosphere, Journal Year: 2024, Volume and Issue: 363, P. 142975 - 142975

Published: July 29, 2024

Language: Английский

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Neurotoxicity from long-term exposure to 6-PPDQ: Recent advances

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 282, P. 116689 - 116689

Published: July 15, 2024

The recent acceleration of industrialization and urbanization has brought significant attention to N-(1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine quinone (6-PPDQ), an emerging environmental pollutant from tire wear, due its long-term effects on the environment organisms. Recent studies suggest that 6-PPDQ can disrupt neurotransmitter synthesis release, impact receptor function, alter signaling pathways, potentially causing oxidative stress, inflammation, apoptosis. This review investigates potential neurotoxic prolonged exposure, mechanisms underlying cytotoxicity, associated health risks. We emphasize need for future research, including precise exposure assessments, identification individual differences, development risk assessments intervention strategies. article provides a comprehensive overview 6-PPDQ's behavior, impact, neurotoxicity in environment, highlighting key areas challenges research.

Language: Английский

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Typical Tire Additives in River Water: Leaching, Transformation, and Environmental Risk Assessment

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(42), P. 18940 - 18949

Published: Oct. 9, 2024

Tire wear particles (TWPs) released during vehicle driving can enter water bodies, leading to leaching of tire additives (TAs) in aquatic environments. However, the transformation behavior and related ecological impacts TAs their products (TPs) remain unclear. In this study, laboratory-based simulation experiments field investigations were conducted explore mechanisms risks TAs. After being placed river for 24 h, about 7–95% 12 investigated TWPs leached. Forty-eight TPs from eight tentatively identified along with different pathways via suspect screening by high-resolution mass spectrometry. Semiquantitative results indicated that derived N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylene-diamine (6PPD) predominant leachates, while aryl hydrolysis quinone main pathways. Field on urban surface samples 16 sites Hong Kong revealed occurrence 17 1 TP, concentrations ranging 13.9 2230 ng/L (median ± standard deviation: 226 534 ng/L). Sixteen six additionally screening. It is estimated 6PPD-quinone seven could pose medium high risk, N-(1,3-dimethylbutyl)-N′-phenyl-p-quinonediimine, a frequently detected was as persistent-bioaccumulative-toxic substance.

Language: Английский

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Tire rubber-derived contaminants 6PPD and 6PPD-quinone reduce attachment and outgrowth of trophoblast spheroids onto endometrial epithelial cells

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 290, P. 117744 - 117744

Published: Jan. 1, 2025

N-(1,3-Dimethylbutyl)-N'-phenyl-p-phenylenediamine (6PPD), a synthetic additive widely used in the rubber industry, and its oxidized product 6PPD-quinone (6PPDQ), have garnered widespread attention as an emerging hazardous chemicals owing to their potential detrimental effects on aquatic ecosystem human health. The of 6PPD 6PPDq female reproductive tract, especially embryo implantation, remain unknown were investigated this study. We spheroid attachment outgrowth models BeWo trophoblastic spheroids Ishikawa cells surrogates for blastocyst endometrial epithelium, respectively. Treatment with up 48 h decreased viability dose- cell line-dependent manner (20-100 μM 10-100 6PPDQ both lines). At noncytotoxic concentration, exposure 1 10 reduced further inhibited invasion epithelial monolayer. A similar result was observed 6PPDQ-exposed groups. Gene expression profiling 6PPD- revealed that differentially regulated panel transcript markers toward overall downregulation receptivity invasion. study provides first proof adverse trophoblast during window warranting need vivo clinical studies.

Language: Английский

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p-Phenylenediamines and their derived quinones: A review of their environmental fate, human exposure, and biological toxicity

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 488, P. 137373 - 137373

Published: Jan. 25, 2025

Language: Английский

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Comparative effects of 6PPD and 6PPD-Quinone at environmentally relevant concentrations on hepatotoxicity, glucolipid metabolism and ferroptotic response in adult zebrafish

Environmental Research, Journal Year: 2025, Volume and Issue: 275, P. 121386 - 121386

Published: March 12, 2025

Language: Английский

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