Association between exposure to per- and polyfluoroalkyl substances (PFAS) and chronic cough in American adults: Results from NHANES 2003–2012

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 291, P. 117901 - 117901

Published: Feb. 1, 2025

Chronic cough, which affects approximately 10 % of the global population, is recognized as a significant health issue, especially among females. Recent research suggests that chronic cough may be an independent disease rather than merely symptom other conditions. This study focuses on potential role exposure to perfluoroalkyl and polyfluoroalkyl substances (PFAS) in development noting PFAS has been linked various adverse outcomes. We aimed explore association between risk U.S. analyzing data from National Health Nutrition Examination Survey (NHANES) 2003 2012 examining sex-based differences. Our findings reveal several factors independently associated with increased incidence including elevated levels serum perfluorobutane sulfonic acid (PFBS) perfluoroheptanoic (PFHP). The multi-pollutant models consistently demonstrated positive correlation higher adult males, PFBS PFHP primary contributors. However, due cross-sectional design NHANES study, further necessary elucidate precise mechanisms by contribute cough.

Language: Английский

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Association between per- and polyfluoroalkyl substances exposure and prevalence of chronic obstructive pulmonary disease: The mediating role of serum albumin

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 925, P. 171742 - 171742

Published: March 15, 2024

No study has examined the association between per- and polyfluoroalkyl substances (PFAS) exposure chronic obstructive pulmonary disease (COPD) risk. This aims to explore this relationship. enrolled 4541 individuals who had unavailable data on PFAS, COPD, covariates from NHANES 2007–2018. Serum PFAS including perfluorohexane sulfonate (PFHxS), perfluorononanoic acid (PFNA), perfluorooctanoic (PFOA), perfluorooctane sulfonic (PFOS) were analyzed, because of high detective rates. Considering skew distribution levels, natural logarithm-transformed (Ln-PFAS) was used. Logistic regression analysis, restricted cubic spline (RCS), weighted quantile sum (WQS) performed single, nonlinear, mixed effects. A mediating analysis used evaluate mediated effects albumin. Individuals with COPD higher levels PFHxS, PFNA, PFOA, PFOS compared those without COPD. Ln-PFNA (OR males: 1.92, 95 % CI:1.31 2.80, P: <0.001; OR females: 1.07, CI: 0.81 1.40, 0.636) ln-PFOA 2.17, CI:1.38 3.41, 1.49, 1.08 2.05, 0.016) associated risk especially in males. The interaction PFNA sex significant (P interaction: <0.001). RCS curve demonstrated nonlinear relationship nonlinear:0.001), ln-PFNA nonlinear:0.045), WQS showed correlated males (OR: 1.44, CI:1.18 1.75, Albumin PFOA (mediated proportion: −17.94 %). concludes are linked a males, serum albumin plays role Thess findings beneficial for prevention Further studies required potential mechanisms.

Language: Английский

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Sex- and trimester-specific impact of gestational co-exposure to organophosphate esters and phthalates on insulin action among preschoolers: Findings from the Ma’anshan birth cohort

Environment International, Journal Year: 2025, Volume and Issue: 196, P. 109287 - 109287

Published: Jan. 18, 2025

Prenatal exposure to organophosphate esters (OPEs) and phthalic acid (PAEs) is ubiquitous among pregnant individuals. However, research exploring the relationship between prenatal co-exposure OPEs PAEs childhood insulin function remains limited. In this study, utilizing data from 2,246 maternal-fetal dyads in Ma'anshan Birth Cohort, associations action were analyzed. Repeated measures of tris (2-chloroethyl) phosphate, six OPE metabolites, seven PAE metabolites collected maternal urine. Homeostasis model assessment resistance (HOMA-IR) index (IAI) served as outcome measures. After adjusting for potential confounders, effects repeated on evaluated using generalized estimating equations, while mixture assessed through BayesianKernel Machine Regression Quantile-Based G-Computation. The average age children at time study was 5.33 years. analysis revealed that MEP positively associated with increased HOMA-IR (β, 0.027; 95 % CI: 0.002, 0.053), IAI inversely correlated rising levels 0.025; -0.046, -0.004) MEHHP -0.128; -0.218, -0.037). Mixed modeling further indicated linked 0.058; 0.001, 0.114) negatively -0.054; -0.097, -0.010), stronger observed during second trimester. Notably, association more pronounced female compared males. This provides first epidemiological evidence highlighting pregnancy- sex-specific links action.

Language: Английский

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Associations between co-exposure to per- and polyfluoroalkyl substances and metabolic diseases: The mediating roles of inflammation and oxidative stress

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 953, P. 176187 - 176187

Published: Sept. 10, 2024

Language: Английский

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Association between per- and poly-fluoroalkyl substances and nonalcoholic fatty liver disease: A nested case-control study in northwest China

Environmental Pollution, Journal Year: 2024, Volume and Issue: 350, P. 123937 - 123937

Published: April 15, 2024

Language: Английский

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A column-switching two-dimensional liquid chromatography - high resolution/triple quadrupole dual mass spectrometry system for simultaneously untargeted metabolome and targeted exposome analyses

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

Metabolome-exposome association studies (mEWAS) demands high-coverage and high-sensitivity analytical methods for metabolites exposures with diverse chemical properties concentrations. Here, we present an integrated column-switching two-dimensional liquid chromatography (2DLC) - high resolution/triple quadrupole dual mass spectrometry (MS) method, achieving simultaneously untargeted metabolome targeted exposome analyses including 598 in a single run. Polar non-polar compounds log P ranging from -8 to 15 were separated without unretained the dead time. Benchmarked against biological matrices, analyte coverage increased by 35-104% over one-dimensional LC method. Highly sensitive limits of detection 0.001-1 μg/mL >90% ng/mL obtained, matching concentration difference between human blood. The method was demonstrated patients chronic diseases, showing feasibility establishing mEWAS integrating 2DLC-dual MS techniques.

Language: Английский

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Association Between Per- and Polyfluoroalkyl Substances and All-Cause Mortality in Diabetic Patients: Insights from a National Cohort Study and Toxicogenomic Analysis

Toxics, Journal Year: 2025, Volume and Issue: 13(3), P. 168 - 168

Published: Feb. 27, 2025

Per- and polyfluoroalkyl substances (PFAS) are a group of environmental contaminants associated with various health risks; however, their relationship all-cause mortality in individuals diabetes remains unclear. A total 1256 participants from the National Health Nutrition Examination Survey (NHANES) were included to explore association between seven PFAS compounds diabetic patients. Preliminary logistic regression identified three (perfluorooctanoic acid [PFOA], perfluorooctane sulfonic [PFOS], 2-(N-methyl-PFOSA) acetate [MPAH]) as significantly population. The optimal cut-off values for PFOS, PFOA, MPAH determined using X-tile algorithm, categorized into high- low-exposure groups. Kaplan–Meier survival curves multivariable Cox proportional hazards models used assess levels risk. results showed that high PFOS increased risk patients (hazard ratio [HR]: 1.55, 95% confidence interval [CI]: 1.06–2.29), while PFOA no significant associations. To mechanisms underlying PFOS–mortality link, toxicogenomic analysis 95 overlapping genes exposure diabetes-related Comparative Toxicogenomics Database (CTD) GeneCards. Functional enrichment revealed key biological processes, such glucose homeostasis response peptide hormone, pathways including longevity regulating pathway, apoptosis, p53 signaling pathway. Protein–protein interaction network 10 hub genes, was found upregulate or downregulate mRNA expression, protein activity, notable effects on levels. These findings suggest contributes through related metabolism, cellular signaling. Our study provides new insights diabetes, highlighting need large-scale cohort studies further vivo vitro experiments validate these findings.

Language: Английский

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Per- and polyfluoroalkyl substances exposures are associated with non-alcoholic fatty liver disease, particularly fibrosis

Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 126085 - 126085

Published: March 1, 2025

Language: Английский

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Overview of foodborne hazards associated with inflammation and metabolic health

BMC Global and Public Health, Journal Year: 2025, Volume and Issue: 3(1)

Published: April 8, 2025

Access to safe and nutritious food is key ensuring health well-being critical meeting the United Nations' Sustainable Development Goals. However, a synthesis of associations between foodborne illness malnutrition, such as metabolic health, remains gap in literature base. In this review, we summarized existing evidence on impacts biological chemical hazards nutrition-related outcomes, specifically overweight obesity, inflammation, disease, thyroid function, cancer development, adverse birth examining physiological mechanisms, epidemiological associations, animal studies. Mechanisms some hazards, H. pylori, pregnancy e.g., gestational diabetes mellitus, or nitrates impaired are relatively well-studied. effects many other human limited: for example, while arsenic exposure associated with limited availability dose-response studies challenges limit ascertaining its causal role. Untangling these mechanisms high relevance both high- well low- middle-income countries. Emerging technologies novel assessment techniques needed improve detection understanding understudied complex diseases, particularly those arising from hazards. These gaps highlighted need establishing surveillance systems monitoring diseases outcomes across populations.

Language: Английский

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Systemic immune-inflammation mediates the association between Klotho protein and metabolic syndrome: findings from a large-scale population-based study

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: Nov. 5, 2024

This study utilized large-scale population data from the National Health and Nutrition Examination Survey (NHANES) to elucidate relationship between Klotho protein metabolic syndrome along with its components. We further investigated possible mediating effect of inflammation on these relationships. Our objective was identify biomarkers for risk stratification potential therapeutic targets syndrome. enrolled 13,119 participants aged 40–79 years, spanning five NHANES cycles 2007 2016, complete information protein. The definition followed criteria Cholesterol Education Program-Adult Treatment Panel III. Survey-weighted logistic regression subgroup analysis were used explore associations serum levels syndrome, Mediation performed investigate effects inflammation-related markers, including white blood cells, neutrophils, lymphocytes, monocytes, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), systemic immune-inflammation index (SII) monocyte-to-HDL (MHR), aim elucidating how influences onset progression had an average age 56.06 years (95% CI: 55.76–56.37), a concentration 798.10 pg/ml 656.50–980.50) 43.77% prevalence (n = 5742). In crude model, negatively correlated components, central obesity, hypertension, hypertriglyceridemia. After adjusting all confounding factors, demonstrated be associated only (OR: 0.82, 95% 0.70–0.97), hypertension 0.83, 0.70–0.98), hypertriglyceridemia 0.78, 0.67–0.91). Subgroup interaction analyses revealed significant interactions age, sex, race/ethnicity, body mass index, Klotho. Additionally, mediation that leukocytes, neutrophils monocytes accounted 34.78%, 31.91% 7.13%, respectively, being partly mediated by immune inflammation. findings this research may valuable biomarker target

Language: Английский

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