Prenatal Perfluorooctanoic Acid (PFOA) exposure causes reproductive toxicity by disrupting the formation of transzonal projections (TZPs) and down-regulating Wnt4/β-catenin signaling pathway in progeny

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 291, P. 117816 - 117816

Published: Jan. 31, 2025

Language: Английский

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Kidney function mediates the association of per- and poly-fluoroalkyl substances (PFAS) and heavy metals with hepatic fibrosis risk

Environmental Research, Journal Year: 2024, Volume and Issue: unknown, P. 120092 - 120092

Published: Sept. 1, 2024

Language: Английский

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Serum albumin and liver dysfunction mediate the associations between organophosphorus pesticide exposure and hypertension among US adults

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 948, P. 174748 - 174748

Published: Oct. 1, 2024

Language: Английский

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Epidemiological characteristics of asthma-COPD overlap, its association with all-cause mortality, and the mediating role of depressive symptoms: evidence from NHANES 2005–2018

BMC Public Health, Journal Year: 2024, Volume and Issue: 24(1)

Published: May 28, 2024

Abstract Background Asthma-COPD overlap (ACO) is a distinct and intricate respiratory condition that requires specific attention management. The objective of this cohort study was to examine the epidemiological characteristics ACO, explore association between ACO all-cause mortality, investigate potential mediating role depressive symptoms in association. Methods This retrospective used data from National Health Nutrition Examination Survey (NHANES) 2005–2018 Death Index (NDI) 2019. A total 22,745 participants were included: 705 with 2352 asthma-only, 853 COPD-only, 18,835 without asthma or COPD. non-ACO group ( N = 22,040) referred individuals ACO. Statistical tests employed assess differences some other groups. Cox proportional hazards models applied evaluate relationship estimating hazard ratios (HR) 95% confidence intervals. Mediation analysis conducted effects on mortality. Results prevalence 3.10% our population. Compared participants, exhibited significantly different characteristics, including higher age, lower family income-to-poverty ratio, body mass index, rates comorbidities i.e., hypertension, diabetes, hyperlipidemia, cardiovascular disease, cancer, poorer dietary habits, rate disorders. significant increase mortality (HR 1.908, 95%CI 1.578–1.307, p < 0.001). proportions mediated by for -associated 8.13% (CI: 4.22%-14.00%, Conclusions revealed strong uncovered psychological mechanism underlying relationship. Our indicates possible necessity offering comprehensive care patients, encompassing early detection, lifestyle guidance, mental health support. Nevertheless, due limitations design dataset, results should be interpreted caution.

Language: Английский

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Association between exposure to per- and polyfluoroalkyl substances (PFAS) and chronic cough in American adults: Results from NHANES 2003–2012

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 291, P. 117901 - 117901

Published: Feb. 1, 2025

Chronic cough, which affects approximately 10 % of the global population, is recognized as a significant health issue, especially among females. Recent research suggests that chronic cough may be an independent disease rather than merely symptom other conditions. This study focuses on potential role exposure to perfluoroalkyl and polyfluoroalkyl substances (PFAS) in development noting PFAS has been linked various adverse outcomes. We aimed explore association between risk U.S. analyzing data from National Health Nutrition Examination Survey (NHANES) 2003 2012 examining sex-based differences. Our findings reveal several factors independently associated with increased incidence including elevated levels serum perfluorobutane sulfonic acid (PFBS) perfluoroheptanoic (PFHP). The multi-pollutant models consistently demonstrated positive correlation higher adult males, PFBS PFHP primary contributors. However, due cross-sectional design NHANES study, further necessary elucidate precise mechanisms by contribute cough.

Language: Английский

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Relationship between novel inflammatory markers derived from high-sensitivity C-reactive protein and heart failure: a cross-sectional study

BMC Cardiovascular Disorders, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 18, 2025

High-sensitivity C-reactive protein to HDL-C ratio (HCHR) and high-sensitivity lymphocyte count (HCLR) are two novel inflammatory indicators, heart failure (HF) is linked chronic inflammation. This study sought evaluate the link between HCHR, HCLR, HF. We carried out a cross-sectional investigation using National Health Nutrition Examination Survey (NHANES, 2015–2018). used multivariate logistic regression determine association HF, followed by smoothed curve fitting threshold effect analysis, as well subgroup analyses of underlying demographic variables investigate potential impacts. The receiver operating characteristic curves were employed examine correlation each index included 8751 subjects, after Ln conversion for HCHR HCLR showed that subjects in highest tertile Ln(HCHR) had significantly higher risk 45% than those lowest fully adjusted model 3 (OR = 1.45, 95% CI 1.02–2.07; P trend 0.0269), whereas Ln(HCLR) 52% 1.52, 1.07–2.17; 0.0184) tertile. HF exhibited nonlinear relationship, with an inflection point -2.71 log-likelihood 0.024. Subgroup revealed no significant interactions Ln(HCHR), Ln(HCLR), specific subgroups (all > 0.05). ROC indicated greatest diagnostic efficacy (AUC: 0.638, 0.607–0.669), succeeded 0.620, 0.589–0.652). Our findings indicate positively prevalence among US adults. Specifically, levels demonstrated featuring at -2.71.

Language: Английский

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Investigating the correlation between blood manganese concentrations and anemia in U.S. adults: a nationally representative study

Hematology, Journal Year: 2025, Volume and Issue: 30(1)

Published: Feb. 20, 2025

The health implications of trace elements have become increasingly concerning, yet the connection between blood manganese levels and anemia remains insufficiently examined. This research endeavors to explore potential linkage concentrations anemia. Utilizing data from National Health Nutrition Examination Survey (NHANES) 2011 2018, this study examines correlation among U.S. adults, offering a comprehensive national perspective. included 11,300 adults aged 20 above, with both hemoglobin measured. Generalized Additive Model (GAM) was applied delineate smooth curves, threshold effect analysis performed identify inflection points these curves. Subsequently, unconditional logistic regression employed assess risk. Our involved total individuals, which 1,143 (10.1%) were identified curve fitting indicated U-shaped relationship risk Specifically, when below 8.69 µg/L, increasing linked decreased anemia, an adjusted OR 0.838 (95% CI: 0.735-0.954), indicating protective level against Conversely, at or above further elevations strongly associated increased rising 1.160 1.124-1.196), suggesting that excessively high significantly raised developing provides novel insights into association Further extensive, population-based cohort studies are necessary validate causality uncover intrinsic toxicological mechanisms.

Language: Английский

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Associations of exposure to individual polyfluoroalkyl substances and their mixtures with vitamin D biomarkers in postmenopausal women

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 294, P. 118103 - 118103

Published: March 29, 2025

Language: Английский

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Association between urinary exposures and the risk of chronic obstructive pulmonary disease in smokers: results from NHANES 2007–2016

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: April 4, 2025

Objective This study aims to shed light on the connection of urinary exposures with risk chronic obstructive pulmonary disease (COPD) among smokers, thereby providing scientific evidence for prevention and intervention COPD. Methods Data National Health Nutrition Examination Survey (NHANES) 2007–2016 were utilized, including 3,973 smokers aged 20 or older. We employed weighted multivariate logistic quantile sum (WQS) regression models delve into link concentrations COPD risk. Additionally, restricted cubic spline was utilized examine dose–response relationship between biomarker The stability associations across different participant characteristics evaluated through subgroup mediation analyses. Results Our encompassed a total participants, whom 472 diagnosed Regression analyses revealed inverse association benzophenone-3 (BP-3) propyl paraben (PrP) Higher quartiles BP-3 PrP exhibited lower incidence [BP-3: odds ratio (OR) = 0.64, 95% confidence interval (95%CI) (0.47, 0.89), p 0.007; PrP: OR 0.56, 95%CI (0.36, 0.86), 0.008]. Significant synergistic interactions observed [WQS: 0.75, (0.65, 0.88), 0.026], contributing 40.31 40.01% analysis, respectively. Mediation analysis proved that inflammatory markers, such as white blood cell (WBC) count neutrophil-to-lymphocyte (NLR), significantly mediated BP-3, PrP, (all -values &lt;0.05). Conclusion in environmental exposure have an correlation risk, WBC NLR partially mediating this association.

Language: Английский

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Unveiling the Hidden Threat: Per- and Polyfluoroalkyl Substance Pollution’s Distinct Traits and Crucial Impacts on Lung Function in Chinese Plateau Populations

Environment & Health, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 14, 2025

Language: Английский

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