CHARACTERIZATION AND IN VIVO TOXICITY ASSAY OF UNCOATED SILICON NANOPARTICLES DOI Open Access
K.V. Zolotarev

New Materials Compounds and Applications, Journal Year: 2024, Volume and Issue: 8(2), P. 162 - 170

Published: Aug. 8, 2024

Silicon nanoparticles (SiNPs) are highly promising for biological and biomedical applications, including bioimaging, due to their unique optical properties (i.e., strong fluorescence very high photostability). Their low or negligible in vitro toxicity has been reported, but vivo effects of SiNPs still uncertain. Uncoated were dispersed water via sonication rapid aggregation was observed (319.0 ± 2.4 nm particle size). In studied using Danio rerio embryos larvae. Rapid incubation medium observed; besides that, at 25 mg/L higher concentration induced swim bladder malformation and/or death the fish. The estimated LC50 value 7-day larvae 180 mg/L. This is first study uncoated unfunctionalized SiNPs. To achieve better stability media lower toxicity, should be covered with hydrophilic layers, absorption by cellular membranes may weaker this case.

Language: Английский

Inflammatory response of nanoparticles: Mechanisms, consequences, and strategies for mitigation DOI
Muhammad Summer,

Rimsha Ashraf,

Shaukat Ali

et al.

Chemosphere, Journal Year: 2024, Volume and Issue: 363, P. 142826 - 142826

Published: July 11, 2024

Language: Английский

Citations

31
Investigating Nanomaterials for Improved Barrier Properties in Food Packaging DOI Open Access
Alice Njolke Mafe, Great Iruoghene Edo, Patrick Othuke Akpoghelie

et al.

Deleted Journal, Journal Year: 2025, Volume and Issue: 2(2)

Published: Jan. 13, 2025

This review examines the potential of nanomaterials in revolutionizing food packaging, focusing on their role enhancing barrier properties and extending shelf life packaged foods. Traditional packaging materials often fall short effectively protecting against oxygen, moisture, UV light, resulting diminished quality shorter life. Nanomaterials, including nanoclays, metal oxide nanoparticles (e.g., ZnO, TiO₂), carbon-based graphene, carbon nanotubes), biodegradable options like cellulose nanocrystals, have emerged as promising solutions. These offer exceptional gas moisture properties, antimicrobial effects, protection capabilities. The provides an in-depth exploration various nanomaterials, highlighting distinctive mechanisms; such tortuosity which enhance performance by limiting permeability. It also discusses recent advancements integrating into both flexible rigid systems, well active intelligent that employs nanosensors for real-time monitoring freshness spoilage. Despite potential, challenges toxicity concerns, environmental impacts, economic constraints to large-scale adoption are addressed. emphasizes need future research dual-function can simultaneously improve enable sensing. innovations could transform technologies, promoting enhanced safety sustainability.

Language: Английский

Citations

6
Curcumin-Based Nanoparticles: Advancements and Challenges in Tumor Therapy DOI Creative Commons
Hicham Wahnou, Riad El Kebbaj, Bertrand Liagre

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(1), P. 114 - 114

Published: Jan. 15, 2025

Curcumin, a bioactive compound derived from the rhizome of Curcuma longa L., has garnered significant attention for its potent anticancer properties. Despite promising therapeutic potential, poor bioavailability, rapid metabolism, and low water solubility hinder curcumin’s clinical application. Nanotechnology offers viable solution to these challenges by enabling development curcumin-based nanoparticles (CNPs) that enhance bioavailability efficacy. This review provides comprehensive overview recent advancements in design synthesis CNPs cancer therapy. We discuss various NP formulations, including polymeric, lipid-based, inorganic nanoparticles, highlighting their role improving pharmacokinetic pharmacodynamic profiles. The mechanisms which exert effects, such as inducing apoptosis, inhibiting cell proliferation, modulating signaling pathways, are explored details. Furthermore, we examine preclinical studies have demonstrated efficacy treating different types tumors, breast, colorectal, pancreatic cancers. Finally, addresses current future perspectives translation CNPs, emphasizing need further research optimize targeted delivery outcomes. By synthesizing latest research, this underscores potential avenue advancing

Language: Английский

Citations

3
Nanocarriers for targeted drug delivery in the vascular system: focus on endothelium DOI Creative Commons

Xiuxiu Cong,

Zebin Zhang, He Li

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: Oct. 12, 2024

Endothelial cells (ECs) are pivotal in maintaining vascular health, regulating hemodynamics, and modulating inflammatory responses. Nanocarriers hold transformative potential for precise drug delivery within the system, particularly targeting ECs therapeutic purposes. However, complex interactions between nanocarriers present significant challenges development clinical translation of nanotherapeutics. This review assesses recent advancements key strategies employing to ECs. It suggested that through physicochemical design surface modifications, can enhance specificity improve internalization efficiency Additionally, we elaborated on applications specifically designed treatment cardiovascular diseases, cancer metastasis, disorders. Despite these advancements, safety concerns, complexity vivo processes, challenge achieving subcellular remain obstacles effective with nanocarriers. A comprehensive understanding endothelial cell biology its interaction is crucial realizing full targeted systems.

Language: Английский

Citations

9
Utilization of Nanoparticles for Treating Age-Related Macular Degeneration DOI Creative Commons
Anna Nikolaidou, Ellas Spyratou, Athanasia Sandali

et al.

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 162 - 162

Published: Jan. 25, 2025

Age-related macular degeneration (AMD) is a predominant cause of vision loss, posing significant challenges in its management despite advancements such as anti-vascular endothelial growth factor (anti-VEGF) therapy. Nanomedicine, with novel properties and capabilities, offers promising potential to transform the treatment paradigm for AMD. This review reports use diverse nanoparticles (NPs) AMD vitro, vivo, ex including liposomes, lipid nanoparticles, nanoceria, nanofibers, magnetic quantum dots, dendrimers, polymer delivered forms gels, eye drops, intravitreally, or intravenously. Drug delivery was most common NPs AMD, followed by photodynamic therapy dose enhancement, antioxidant function biomimetic activity, immune modulation. Innovative approaches arising included nanotechnology-based light-responsive controlled drug release, well gene transfer. Nanomedicine transformative approach applications. The integration nanotechnology not only provides innovative solutions overcome current therapeutic limitations but also shows enhancing outcomes patient quality life.

Language: Английский

Citations

1
A Review on Biosynthesis of Nanoparticles via Microalgal Technology and Their Biomedical Applications DOI

S. P. Ojha,

Ariba Khan, Chita Ranjan Sahoo

et al.

BioNanoScience, Journal Year: 2025, Volume and Issue: 15(2)

Published: Feb. 7, 2025

Language: Английский

Citations

1
DNA and gelatin—a cool aerogel mix DOI

Changyu Shen,

Xianhu Liu

Science, Journal Year: 2024, Volume and Issue: 385(6704), P. 30 - 30

Published: July 4, 2024

A degradable biopolymer is an effective radiative cooling material.

Language: Английский

Citations

7
Green synthesis of N, B co-doped TiO2 nanoparticles with enhanced photocatalytic and antioxidant activities DOI
A.M. Elbasiony, Abdullah Alamri, Usama A. Soliman

et al.

Journal of the Taiwan Institute of Chemical Engineers, Journal Year: 2024, Volume and Issue: unknown, P. 105626 - 105626

Published: June 1, 2024

Language: Английский

Citations

6
Silver nanoparticles induce liver inflammation through ferroptosis in zebrafish DOI
Yuansi Zheng, Jie Song, Qiuhui Qian

et al.

Chemosphere, Journal Year: 2024, Volume and Issue: 362, P. 142673 - 142673

Published: June 28, 2024

Language: Английский

Citations

6
ZnO NPs induce miR-342-5p mediated ferroptosis of spermatocytes through the NF-κB pathway in mice DOI Creative Commons
Guangyu Liu, Jing Lv, Yifan Wang

et al.

Journal of Nanobiotechnology, Journal Year: 2024, Volume and Issue: 22(1)

Published: July 3, 2024

Zinc oxide nanoparticle (ZnO NP) is one of the metal nanomaterials with extensive use in many fields such as feed additive and textile, which an emerging threat to human health due widely distributed environment. Thus, there urgent need understand toxic effects associated ZnO NPs. Although previous studies have found accumulation NPs testis, molecular mechanism dominated a decline male fertility not been elucidated.

Language: Английский

Citations

4