Health for the future: spatiotemporal CA-MC modeling and spatial pattern prediction via dendrochronological approach for nickel and lead deposition

Air Quality Atmosphere & Health, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Language: Английский

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Efficient adsorption and reduction of Cr(VI) from water using A. niger@kaolin flocs: Utilization of waste solid

Journal of Water Process Engineering, Journal Year: 2024, Volume and Issue: 63, P. 105466 - 105466

Published: May 13, 2024

Language: Английский

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Heavy Metal Interactions with Neuroglia and Gut Microbiota: Implications for Huntington’s Disease

Cells, Journal Year: 2024, Volume and Issue: 13(13), P. 1144 - 1144

Published: July 3, 2024

Huntington’s disease (HD) is a rare but progressive and devastating neurodegenerative characterized by involuntary movements, cognitive decline, executive dysfunction, neuropsychiatric conditions such as anxiety depression. It follows an autosomal dominant inheritance pattern. Thus, child who has parent with the mutated huntingtin (mHTT) gene 50% chance of developing disease. Since HTT protein involved in many critical cellular processes, including neurogenesis, brain development, energy metabolism, transcriptional regulation, synaptic activity, vesicle trafficking, cell signaling, autophagy, its aberrant aggregates lead to disruption numerous pathways neurodegeneration. Essential heavy metals are vital at low concentrations; however, higher concentrations, they can exacerbate HD disrupting glial–neuronal communication and/or causing dysbiosis (disturbance gut microbiota, GM), both which neuroinflammation further Here, we discuss detail interactions iron, manganese, copper glial–neuron GM indicate how this knowledge may pave way for development new generation disease-modifying therapies HD.

Language: Английский

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Heavy Metals in Spices and Herbs from Worldwide Markets: A Systematic Review and Health Risk Assessment

Environmental Pollution, Journal Year: 2024, Volume and Issue: unknown, P. 124999 - 124999

Published: Sept. 1, 2024

Language: Английский

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Unmasking Lead Exposure and Neurotoxicity: Epigenetics, Extracellular Vesicles, and the Gut-Brain Connection

Indian Journal of Clinical Biochemistry, Journal Year: 2025, Volume and Issue: 40(1), P. 1 - 3

Published: Jan. 1, 2025

Language: Английский

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Tannic acid as a green chemical for the removal of various heavy metals: A critical review of recent developments

Journal of Environmental Management, Journal Year: 2025, Volume and Issue: 375, P. 124390 - 124390

Published: Feb. 1, 2025

Language: Английский

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The Neurobehavioral Impact of Zinc Chloride Exposure in Zebrafish: Evaluating Cognitive Deficits and Probiotic Modulation

Toxics, Journal Year: 2025, Volume and Issue: 13(3), P. 193 - 193

Published: March 8, 2025

Zinc contamination in aquatic environments has become a growing concern due to its potential bioaccumulate and induce neurotoxic effects organisms. As an essential trace element, zinc plays crucial role various physiological processes, but excessive exposure can disrupt the gut–brain axis, leading cognitive behavioral impairments. Recent studies have suggested that probiotics may offer protective against environmental neurotoxins by modulating gut microbiota associated neurological functions. The zebrafish (Danio rerio) emerged as valuable model organism for studying biological mechanisms underlying neurotoxicity therapeutic interventions. This study aimed assess of on impairments induced chloride (ZnCl2) zebrafish. Specifically, were exposed ZnCl2 at concentrations 0.5 mg/L 1.0 96 h, followed 7-day post-exposure period (Bifidobacterium longum, Bifidobacterium animalis lactis, Lactobacillus rhamnosus). these is already known neuromotor deficits resembling Alzheimer’s disease-like symptoms models, making it suitable evaluating neuroprotective probiotics. Behavioral assessments including sociability tests along with short- long-term memory evaluations conducted using EthoVision XT 16 software. Memory demonstrated impaired functions, while probiotic treatment did not significantly ameliorate deficits. In social behavior test, resulted marked decrease sociability, whereas significant changes. However, administration following intoxication exhibited anxiolytic effect These findings suggest exhibit partial neurobehavioral benefits chloride-induced toxicity, particularly mitigating anxiety-like behaviors rather than Further investigations are needed elucidate precise which interact axis context heavy metal neurotoxicity.

Language: Английский

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Interaction of environmental fluoride exposure and gut microbes: potential implication in the development of fluorosis in human subjects

Food and Chemical Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 115388 - 115388

Published: March 1, 2025

Language: Английский

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The Western Diet and Atopic Dermatitis: The Potential Role of Nutrients, Contaminants, and Additives in Dysbiosis and Epithelial Barrier Dysfunction

Antioxidants, Journal Year: 2025, Volume and Issue: 14(4), P. 386 - 386

Published: March 25, 2025

Atopic dermatitis (AD) is a chronic inflammatory skin disorder influenced by both genetic and environmental factors, collectively termed the exposome. Among these determinants, diet emerges as pivotal component, with diverse nutrients, contaminants, additives shaping immune responses, microbiota composition, systemic status. This literature review aimed to elucidate interplay between dietary factors dysbiosis in AD, providing insights into how interactions may impact disease susceptibility progression. A comprehensive search of PubMed Scopus was conducted using relevant keywords medical subject headings (MeSH). Studies published English within past 25 years were included, encompassing vitro, vivo, ex vivo research, well reviews. Priority given frequently cited articles, reflecting significant contributions current understanding. Findings suggest that habits influence AD modulating gut microbiota, pathways, processes. These underscore importance considering broader exposome framework, paving way for targeted interventions improve management. Further research needed clarify mechanisms optimize nutritional strategies, potentially informing preventive therapeutic approaches AD.

Language: Английский

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Evaluation of Heavy Metals and Essential Minerals in the Hair of Children with Autism Spectrum Disorder and Their Association with Symptom Severity

Biological Trace Element Research, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

The exact cause of Autism spectrum disorder (ASD) remains unclear. accumulation heavy metals and the imbalance trace elements are believed to play a key role in pathogenesis ASD. This study aimed compare levels hair 1–16-year-old children with varying ASD severity. We included control group 57 children, as well 124 autism, consisting 53 mild moderate autism 71 severe autism. Questionnaires samples were collected, 21 chemical analyzed using inductively coupled plasma mass spectrometry (ICP-MS). Children showed significantly higher copper (Cu) vanadium (V), cobalt (Co), nickel (Ni), arsenic (As), cadmium (Cd), lead (Pb) their bodies compared group. Boys Cu, As, Cd, Pb group, while girls exhibited lower potassium (K) increased Pb. Severely autistic under 7 years old had Mn, V, Co, Ni, aged 7–16 typically Cu As. These findings underscore importance essential minerals environmental factors severity disease.

Language: Английский

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