Relationship between serum thyroid hormones and their associated metabolites, and gene expression bioindicators in the back skin of Rana [Lithobates] catesbeiana tadpoles and frogs during metamorphosis DOI Creative Commons
Rikke Poulsen,

Shireen H. Jackman,

Martin Hansen

et al.

Frontiers in Endocrinology, Journal Year: 2023, Volume and Issue: 13

Published: Jan. 18, 2023

Anuran metamorphosis is characterized by profound morphological changes including remodeling of tissues and organs. This transition initiated thyroid hormones (THs). However, the current knowledge changing levels THs during relies on pooled samples using methods known for high variability with sparse reporting measured variation. Moreover, establishing a clear linkage between key gene expression bioindicators TH throughout metamorphic process needed. Using state-of-the-art ultra-high performance liquid chromatography isotope-dilution tandem mass spectrometry, we targeted 12 metabolites in serum Rana [Lithobates] catesbeiana (n=5-10) across seven distinct postembryonic stages beginning premetamorphic tadpoles (Gosner stage 31-33) continuing through to juvenile frog 46). were related TH-relevant transcripts (thra, thrb, thibz) back skin same individual animals. Significant increases from basal observed thyroxine (T4) 3,3',5-triiodothyronine (T3) at Gosner 41, reaching maximal 44 (28 ± 10 2.3 0.5 ng/mL, respectively), decreasing frogs. In contrast, 3,5-diiodothyronine (T2) increased significantly 40 was maintained elevated until 44. While thra transcript remained constant then decreased end climax, thrb thibz induced followed decrease froglet. exemplifies exquisite timing events as classic early response genes are transcribed anticipation peak concentrations. The T2 concentration profile suggests biological role this biomolecule anuran development an additional aspect that may be target anthropogenic chemicals can disrupt signalling. Hence, second aim study, set out find metamorphosis, which aid future investigations developmental disruption. sensitive nanoLC-Orbitrap system untargeted analysis workflow applied. Among 6,062 endogenous metabolites, 421 showed metamorphosis-dependent dynamics. These potential included several carnitines, prostaglandins some steroid hormones.

Language: Английский

A Review on Emerging Pollutants in the Water Environment: Existences, Health Effects and Treatment Processes DOI Open Access

Nor Zaiha Arman,

Salmiati Salmiati,

Azmi Aris

et al.

Water, Journal Year: 2021, Volume and Issue: 13(22), P. 3258 - 3258

Published: Nov. 17, 2021

Emerging pollutants (EPs), also known as micropollutants, have been a major issue for the global population in recent years result of potential threats they bring to environment and human health. Pharmaceuticals personal care products (PPCPs), antibiotics, hormones that are used great demand health cosmetic purposes rapidly culminated emergence environmental pollutants. EPs impact variety ways. originate from animal or sources, either directly discharged into waterbodies slowly leached via soils. As result, water quality will deteriorate, drinking sources be contaminated, issues arise. Since treatment plants rely on resources, prevalence this contamination aquatic environments, particularly surface water, is severe problem. The review looks several related environment, including methods removing EPs. Despite its benefits downsides, processes comprise approaches such physico-chemical, biological, advanced oxidation processes. Nonetheless, one membrane-based filtration methods, ultrafiltration, considered technologies promises best micropollutant removal water. With interesting properties moderate operating manner selectivity, approach more popular than conventional ones. This study presents comprehensive summary EP’s existence toxicological consequences health, strategies.

Language: Английский

Citations

190

Influences of key factors on river water quality in urban and rural areas: A review DOI Creative Commons
Nguyễn Tuấn Anh,

Le Duy Can,

Nguyễn Thị Hồng Nhân

et al.

Case Studies in Chemical and Environmental Engineering, Journal Year: 2023, Volume and Issue: 8, P. 100424 - 100424

Published: July 22, 2023

Water quality in rivers is deteriorating urban and rural areas due to natural anthropogenic factors. Understanding how changes factors affect river water crucial for managing basins. This review focuses on analyzing key affecting quality, the temporal spatial variations of flowing areas. Natural processes such as weathering rocks, evapotranspiration, atmospheric deposition, climate change, disasters cause water. Anthropogenic could stem from industrial effluents, domestic activities, agricultural activities application fertilizers, manures, pesticides, animal husbandry irrigation practices, deforestation, aquaculture. The seasonal are discussed, land use or cover parameters a negative positive way. In addition traditional contaminants biodegradable organic matter, heavy metals, pathogens, emerging persistent pollutants organochlorine pesticides (OCPs), polycyclic aromatic hydrocarbons (PAHs), polychlorinated biphenyls (PCBs), perfluoroalkyl polyfluoroalkyl substances (PFASs), phamaceutic active compounds (PhACs) has been found many rivers, which pose threat human health. comparison also clarified, provides authorities policymakers with deep understanding supports decision-making sustainable management.

Language: Английский

Citations

98

Endocrine-Disrupting Chemicals and Disease Endpoints DOI Open Access
Changhwan Ahn, Eui‐Bae Jeung

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(6), P. 5342 - 5342

Published: March 10, 2023

Endocrine-disrupting chemicals (EDCs) have significant impacts on biological systems, and been shown to interfere with physiological especially by disrupting the hormone balance. During last few decades, EDCs affect reproductive, neurological, metabolic development function even stimulate tumor growth. EDC exposure during can disrupt normal patterns alter susceptibility disease. Many endocrine-disrupting properties, including bisphenol A, organochlorines, polybrominated flame retardants, alkylphenols, phthalates. These compounds gradually elucidated as risk factors for many diseases, such neural, diseases cancers. Endocrine disruption has spread wildlife species that are connected food chains. Dietary uptake represents an important source of exposure. Although represent a public health concern, relationship specific mechanism between remain unclear. This review focuses disease-EDC disease endpoints associated endocrine better understanding EDCs-disease elucidates new prevention/treatment opportunities screening methods.

Language: Английский

Citations

85

Harnessing the power of bacterial laccases for xenobiotic degradation in water: A 10-year overview DOI
Mujeeb Ur Rahman, Muhammad Wajid Ullah, Junaid Ali Shah

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 918, P. 170498 - 170498

Published: Feb. 1, 2024

Language: Английский

Citations

18

Endocrine disrupting chemicals and their effects on the reproductive health in men DOI
Aswin Thacharodi, Saqib Hassan,

Gururaj Acharya

et al.

Environmental Research, Journal Year: 2023, Volume and Issue: 236, P. 116825 - 116825

Published: Aug. 5, 2023

Language: Английский

Citations

32

A cross-species comparative approach to assessing multi- and transgenerational effects of endocrine disrupting chemicals DOI Creative Commons
Bernard Robaire, Géraldine Delbès, Jessica Head

et al.

Environmental Research, Journal Year: 2021, Volume and Issue: 204, P. 112063 - 112063

Published: Sept. 22, 2021

A wide range of chemicals have been identified as endocrine disrupting (EDCs) in vertebrate species. Most studies EDCs focused on exposure both male and female adults to these chemicals; however, there is clear evidence that dramatic effects when mature or developing gametes are exposed, consequently associated with multigenerational transgenerational effects. Several publications reviewed such actions subgroups species, e.g., fish rodents. In this review, we take a holistic approach synthesizing knowledge the across including fish, anurans, birds, mammals, discuss potential mechanism(s) mediating multi- We also propose series recommendations aimed at moving field forward structured coherent manner.

Language: Английский

Citations

49

Changing the structure of PFOA and PFOS: a chemical industry strategy or a solution to avoid thyroid-disrupting effects? DOI Creative Commons
Francesca Coperchini, Antonio Greco, Mario Rotondi

et al.

Journal of Endocrinological Investigation, Journal Year: 2024, Volume and Issue: 47(8), P. 1863 - 1879

Published: March 24, 2024

Abstract Background The family of perfluoroalkyl and polyfluoroalkyl substances (PFAS) raised concern for their proven bioaccumulation persistence in the environment animals as well hazardous health effects. As a result, new congeners PFAS have rapidly replaced so-called “old long-chain PFAS” (mainly PFOA PFOS), currently out-of-law banned by most countries. These compounds derive from original structure PFAS”, cutting or making little conformational changes to structure, thus obtaining molecules with similar industrial applications. were designed obtain "safer" compounds. Indeed, old-long-chain reported exert thyroid disruptive effects vitro, vivo humans. However, shreds evidence accumulated so far indicate that “restyling” old leads production compounds, not only functionally previous ones but also potentially free adverse bioaccumulation. Studies aimed at characterizing new-PFAS on function some these showed Purpose present review is providing an overview recent data regarding novel alternatives function. Results conclusions An extensive current legislation obtained vitro studies evaluating exposure PFOS alternatives, mixture will be provided.

Language: Английский

Citations

8

Emerging concepts and opportunities for endocrine disruptor screening of the non-EATS modalities DOI Creative Commons
Christopher J. Martyniuk, Rubén Martínez, Laia Navarro‐Martín

et al.

Environmental Research, Journal Year: 2021, Volume and Issue: 204, P. 111904 - 111904

Published: Aug. 19, 2021

Endocrine disrupting chemicals (EDCs) are ubiquitous in the environment and involve diverse chemical-receptor interactions that can perturb hormone signaling. The Organization for Economic Co-operation Development has validated several EDC-receptor bioassays to detect endocrine active established guidelines regulatory testing of EDCs. Focus on over past decade been initially directed EATS modalities (estrogen, androgen, thyroid, steroidogenesis) tests exert effects through non-EATS less established. Due recognition EDCs vast their mechanisms action, novel needed capture full scope activity. Here, we highlight need assays discuss major international efforts underway develop such tools purposes, focusing high concern (i.e., retinoic acid, aryl hydrocarbon receptor, peroxisome proliferator-activated glucocorticoid signaling). Two case studies presented with strong evidence amongst animals human disruption associations wildlife disease. This includes metabolic syndrome insulin signaling (case study 1) impact cardiovascular system 2). is relevant as obesity disease represent two most significant health-related crises our time. Lastly, emerging topics related discussed, including crosstalk between axis, complex mixtures containing a variety EDCs, adverse outcome pathways acting mechanisms, models chemicals. Recommendations considerations evaluating proposed. Moving forward, improved understanding will lead integrated strategies be used bodies protect environmental, animal, health from harmful environmental

Language: Английский

Citations

39

Acute exposure to microcystins affects hypothalamic-pituitary axes of male rats DOI
Ting Shi, Linlin Xu, Liang Chen

et al.

Environmental Pollution, Journal Year: 2022, Volume and Issue: 318, P. 120843 - 120843

Published: Dec. 9, 2022

Language: Английский

Citations

23

Application of In Vitro Models for Studying the Mechanisms Underlying the Obesogenic Action of Endocrine-Disrupting Chemicals (EDCs) as Food Contaminants—A Review DOI Open Access
Monika Kowalczyk, Jakub P. Piwowarski, Artur Wardaszka

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(2), P. 1083 - 1083

Published: Jan. 5, 2023

Obesogenic endocrine-disrupting chemicals (EDCs) belong to the group of environmental contaminants, which can adversely affect human health. A growing body evidence supports that chronic exposure EDCs contribute a rapid increase in obesity among adults and children, especially wealthy industrialized countries with high production widely used industrial such as plasticizers (bisphenols phthalates), parabens, flame retardants, pesticides. The main source obesogenic is through diet, particularly consumption contaminated food meat, fish, fruit, vegetables, milk, dairy products. promote by stimulating adipo- lipogenesis target cells adipocytes hepatocytes, disrupting glucose metabolism insulin secretion, impacting hormonal appetite/satiety regulation. In vitro models still play an essential role investigating potential obesogens. review aimed provide information on currently available two-dimensional (2D) animal cell applied for studying mechanisms action various contaminants. advantages limitations representing crucial endocrine tissue (adipose tissue) organs (liver pancreas) involved etiology metabolic diseases, are evaluate effects their disruption activity, were thoroughly critically discussed.

Language: Английский

Citations

15