Frontiers in Endocrinology,
Journal Year:
2023,
Volume and Issue:
13
Published: Jan. 18, 2023
Anuran
metamorphosis
is
characterized
by
profound
morphological
changes
including
remodeling
of
tissues
and
organs.
This
transition
initiated
thyroid
hormones
(THs).
However,
the
current
knowledge
changing
levels
THs
during
relies
on
pooled
samples
using
methods
known
for
high
variability
with
sparse
reporting
measured
variation.
Moreover,
establishing
a
clear
linkage
between
key
gene
expression
bioindicators
TH
throughout
metamorphic
process
needed.
Using
state-of-the-art
ultra-high
performance
liquid
chromatography
isotope-dilution
tandem
mass
spectrometry,
we
targeted
12
metabolites
in
serum
Rana
[Lithobates]
catesbeiana
(n=5-10)
across
seven
distinct
postembryonic
stages
beginning
premetamorphic
tadpoles
(Gosner
stage
31-33)
continuing
through
to
juvenile
frog
46).
were
related
TH-relevant
transcripts
(thra,
thrb,
thibz)
back
skin
same
individual
animals.
Significant
increases
from
basal
observed
thyroxine
(T4)
3,3',5-triiodothyronine
(T3)
at
Gosner
41,
reaching
maximal
44
(28
±
10
2.3
0.5
ng/mL,
respectively),
decreasing
frogs.
In
contrast,
3,5-diiodothyronine
(T2)
increased
significantly
40
was
maintained
elevated
until
44.
While
thra
transcript
remained
constant
then
decreased
end
climax,
thrb
thibz
induced
followed
decrease
froglet.
exemplifies
exquisite
timing
events
as
classic
early
response
genes
are
transcribed
anticipation
peak
concentrations.
The
T2
concentration
profile
suggests
biological
role
this
biomolecule
anuran
development
an
additional
aspect
that
may
be
target
anthropogenic
chemicals
can
disrupt
signalling.
Hence,
second
aim
study,
set
out
find
metamorphosis,
which
aid
future
investigations
developmental
disruption.
sensitive
nanoLC-Orbitrap
system
untargeted
analysis
workflow
applied.
Among
6,062
endogenous
metabolites,
421
showed
metamorphosis-dependent
dynamics.
These
potential
included
several
carnitines,
prostaglandins
some
steroid
hormones.
Water,
Journal Year:
2021,
Volume and Issue:
13(22), P. 3258 - 3258
Published: Nov. 17, 2021
Emerging
pollutants
(EPs),
also
known
as
micropollutants,
have
been
a
major
issue
for
the
global
population
in
recent
years
result
of
potential
threats
they
bring
to
environment
and
human
health.
Pharmaceuticals
personal
care
products
(PPCPs),
antibiotics,
hormones
that
are
used
great
demand
health
cosmetic
purposes
rapidly
culminated
emergence
environmental
pollutants.
EPs
impact
variety
ways.
originate
from
animal
or
sources,
either
directly
discharged
into
waterbodies
slowly
leached
via
soils.
As
result,
water
quality
will
deteriorate,
drinking
sources
be
contaminated,
issues
arise.
Since
treatment
plants
rely
on
resources,
prevalence
this
contamination
aquatic
environments,
particularly
surface
water,
is
severe
problem.
The
review
looks
several
related
environment,
including
methods
removing
EPs.
Despite
its
benefits
downsides,
processes
comprise
approaches
such
physico-chemical,
biological,
advanced
oxidation
processes.
Nonetheless,
one
membrane-based
filtration
methods,
ultrafiltration,
considered
technologies
promises
best
micropollutant
removal
water.
With
interesting
properties
moderate
operating
manner
selectivity,
approach
more
popular
than
conventional
ones.
This
study
presents
comprehensive
summary
EP’s
existence
toxicological
consequences
health,
strategies.
Case Studies in Chemical and Environmental Engineering,
Journal Year:
2023,
Volume and Issue:
8, P. 100424 - 100424
Published: July 22, 2023
Water
quality
in
rivers
is
deteriorating
urban
and
rural
areas
due
to
natural
anthropogenic
factors.
Understanding
how
changes
factors
affect
river
water
crucial
for
managing
basins.
This
review
focuses
on
analyzing
key
affecting
quality,
the
temporal
spatial
variations
of
flowing
areas.
Natural
processes
such
as
weathering
rocks,
evapotranspiration,
atmospheric
deposition,
climate
change,
disasters
cause
water.
Anthropogenic
could
stem
from
industrial
effluents,
domestic
activities,
agricultural
activities
application
fertilizers,
manures,
pesticides,
animal
husbandry
irrigation
practices,
deforestation,
aquaculture.
The
seasonal
are
discussed,
land
use
or
cover
parameters
a
negative
positive
way.
In
addition
traditional
contaminants
biodegradable
organic
matter,
heavy
metals,
pathogens,
emerging
persistent
pollutants
organochlorine
pesticides
(OCPs),
polycyclic
aromatic
hydrocarbons
(PAHs),
polychlorinated
biphenyls
(PCBs),
perfluoroalkyl
polyfluoroalkyl
substances
(PFASs),
phamaceutic
active
compounds
(PhACs)
has
been
found
many
rivers,
which
pose
threat
human
health.
comparison
also
clarified,
provides
authorities
policymakers
with
deep
understanding
supports
decision-making
sustainable
management.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(6), P. 5342 - 5342
Published: March 10, 2023
Endocrine-disrupting
chemicals
(EDCs)
have
significant
impacts
on
biological
systems,
and
been
shown
to
interfere
with
physiological
especially
by
disrupting
the
hormone
balance.
During
last
few
decades,
EDCs
affect
reproductive,
neurological,
metabolic
development
function
even
stimulate
tumor
growth.
EDC
exposure
during
can
disrupt
normal
patterns
alter
susceptibility
disease.
Many
endocrine-disrupting
properties,
including
bisphenol
A,
organochlorines,
polybrominated
flame
retardants,
alkylphenols,
phthalates.
These
compounds
gradually
elucidated
as
risk
factors
for
many
diseases,
such
neural,
diseases
cancers.
Endocrine
disruption
has
spread
wildlife
species
that
are
connected
food
chains.
Dietary
uptake
represents
an
important
source
of
exposure.
Although
represent
a
public
health
concern,
relationship
specific
mechanism
between
remain
unclear.
This
review
focuses
disease-EDC
disease
endpoints
associated
endocrine
better
understanding
EDCs-disease
elucidates
new
prevention/treatment
opportunities
screening
methods.
Environmental Research,
Journal Year:
2021,
Volume and Issue:
204, P. 112063 - 112063
Published: Sept. 22, 2021
A
wide
range
of
chemicals
have
been
identified
as
endocrine
disrupting
(EDCs)
in
vertebrate
species.
Most
studies
EDCs
focused
on
exposure
both
male
and
female
adults
to
these
chemicals;
however,
there
is
clear
evidence
that
dramatic
effects
when
mature
or
developing
gametes
are
exposed,
consequently
associated
with
multigenerational
transgenerational
effects.
Several
publications
reviewed
such
actions
subgroups
species,
e.g.,
fish
rodents.
In
this
review,
we
take
a
holistic
approach
synthesizing
knowledge
the
across
including
fish,
anurans,
birds,
mammals,
discuss
potential
mechanism(s)
mediating
multi-
We
also
propose
series
recommendations
aimed
at
moving
field
forward
structured
coherent
manner.
Journal of Endocrinological Investigation,
Journal Year:
2024,
Volume and Issue:
47(8), P. 1863 - 1879
Published: March 24, 2024
Abstract
Background
The
family
of
perfluoroalkyl
and
polyfluoroalkyl
substances
(PFAS)
raised
concern
for
their
proven
bioaccumulation
persistence
in
the
environment
animals
as
well
hazardous
health
effects.
As
a
result,
new
congeners
PFAS
have
rapidly
replaced
so-called
“old
long-chain
PFAS”
(mainly
PFOA
PFOS),
currently
out-of-law
banned
by
most
countries.
These
compounds
derive
from
original
structure
PFAS”,
cutting
or
making
little
conformational
changes
to
structure,
thus
obtaining
molecules
with
similar
industrial
applications.
were
designed
obtain
"safer"
compounds.
Indeed,
old-long-chain
reported
exert
thyroid
disruptive
effects
vitro,
vivo
humans.
However,
shreds
evidence
accumulated
so
far
indicate
that
“restyling”
old
leads
production
compounds,
not
only
functionally
previous
ones
but
also
potentially
free
adverse
bioaccumulation.
Studies
aimed
at
characterizing
new-PFAS
on
function
some
these
showed
Purpose
present
review
is
providing
an
overview
recent
data
regarding
novel
alternatives
function.
Results
conclusions
An
extensive
current
legislation
obtained
vitro
studies
evaluating
exposure
PFOS
alternatives,
mixture
will
be
provided.
Environmental Research,
Journal Year:
2021,
Volume and Issue:
204, P. 111904 - 111904
Published: Aug. 19, 2021
Endocrine
disrupting
chemicals
(EDCs)
are
ubiquitous
in
the
environment
and
involve
diverse
chemical-receptor
interactions
that
can
perturb
hormone
signaling.
The
Organization
for
Economic
Co-operation
Development
has
validated
several
EDC-receptor
bioassays
to
detect
endocrine
active
established
guidelines
regulatory
testing
of
EDCs.
Focus
on
over
past
decade
been
initially
directed
EATS
modalities
(estrogen,
androgen,
thyroid,
steroidogenesis)
tests
exert
effects
through
non-EATS
less
established.
Due
recognition
EDCs
vast
their
mechanisms
action,
novel
needed
capture
full
scope
activity.
Here,
we
highlight
need
assays
discuss
major
international
efforts
underway
develop
such
tools
purposes,
focusing
high
concern
(i.e.,
retinoic
acid,
aryl
hydrocarbon
receptor,
peroxisome
proliferator-activated
glucocorticoid
signaling).
Two
case
studies
presented
with
strong
evidence
amongst
animals
human
disruption
associations
wildlife
disease.
This
includes
metabolic
syndrome
insulin
signaling
(case
study
1)
impact
cardiovascular
system
2).
is
relevant
as
obesity
disease
represent
two
most
significant
health-related
crises
our
time.
Lastly,
emerging
topics
related
discussed,
including
crosstalk
between
axis,
complex
mixtures
containing
a
variety
EDCs,
adverse
outcome
pathways
acting
mechanisms,
models
chemicals.
Recommendations
considerations
evaluating
proposed.
Moving
forward,
improved
understanding
will
lead
integrated
strategies
be
used
bodies
protect
environmental,
animal,
health
from
harmful
environmental
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(2), P. 1083 - 1083
Published: Jan. 5, 2023
Obesogenic
endocrine-disrupting
chemicals
(EDCs)
belong
to
the
group
of
environmental
contaminants,
which
can
adversely
affect
human
health.
A
growing
body
evidence
supports
that
chronic
exposure
EDCs
contribute
a
rapid
increase
in
obesity
among
adults
and
children,
especially
wealthy
industrialized
countries
with
high
production
widely
used
industrial
such
as
plasticizers
(bisphenols
phthalates),
parabens,
flame
retardants,
pesticides.
The
main
source
obesogenic
is
through
diet,
particularly
consumption
contaminated
food
meat,
fish,
fruit,
vegetables,
milk,
dairy
products.
promote
by
stimulating
adipo-
lipogenesis
target
cells
adipocytes
hepatocytes,
disrupting
glucose
metabolism
insulin
secretion,
impacting
hormonal
appetite/satiety
regulation.
In
vitro
models
still
play
an
essential
role
investigating
potential
obesogens.
review
aimed
provide
information
on
currently
available
two-dimensional
(2D)
animal
cell
applied
for
studying
mechanisms
action
various
contaminants.
advantages
limitations
representing
crucial
endocrine
tissue
(adipose
tissue)
organs
(liver
pancreas)
involved
etiology
metabolic
diseases,
are
evaluate
effects
their
disruption
activity,
were
thoroughly
critically
discussed.