Mediation of association between semen microcystin exposure and semen quality by sex hormones in Chinese men DOI
Yang Luo, Dihui Xu, Yuhan Ma

et al.

Reproductive Toxicology, Journal Year: 2023, Volume and Issue: 124, P. 108529 - 108529

Published: Dec. 28, 2023

Language: Английский

Ecological Consequences of Antibiotics Pollution in Sub-Saharan Africa: Understanding Sources, Pathways, and Potential Implications DOI Creative Commons
Asha Ripanda, Mwemezi J. Rwiza, Elias C. Nyanza

et al.

Emerging contaminants, Journal Year: 2025, Volume and Issue: unknown, P. 100475 - 100475

Published: Jan. 1, 2025

Language: Английский

Citations

2
Freshwater Cyanobacterial Toxins, Cyanopeptides and Neurodegenerative Diseases DOI Creative Commons
Galina Nugumanova, Eugene D. Ponomarev, Sholpan Askarova

et al.

Toxins, Journal Year: 2023, Volume and Issue: 15(3), P. 233 - 233

Published: March 21, 2023

Cyanobacteria produce a wide range of structurally diverse cyanotoxins and bioactive cyanopeptides in freshwater, marine, terrestrial ecosystems. The health significance these metabolites, which include genotoxic- neurotoxic agents, is confirmed by continued associations between the occurrence animal human acute toxic events and, long term, cyanobacteria neurodegenerative diseases. Major mechanisms related to neurotoxicity compounds (1) blocking key proteins channels; (2) inhibition essential enzymes mammalian cells such as protein phosphatases phosphoprotein well new molecular targets toll-like receptors 4 8. One widely discussed implicated includes misincorporation cyanobacterial non-proteogenic amino acids. Recent research provides evidence that non-proteinogenic acid BMAA produced have multiple effects on translation process bypasses proof-reading ability aminoacyl-tRNA-synthetase. Aberrant generated non-canonical may be factor neuronal death neurodegeneration. We hypothesize production acids more general mechanism, leading mistranslation, affecting homeostasis, targeting mitochondria eukaryotic cells. It can evolutionarily ancient initially developed control phytoplankton communities during algal blooms. Outcompeting gut symbiotic microorganisms lead dysbiosis, increased permeability, shift blood-brain-barrier functionality, eventually, mitochondrial dysfunction high-energy demanding neurons. A better understanding interaction metabolism nervous system will crucial target or prevent

Language: Английский

Citations

23
Gender-specific effects of polystyrene nanoplastic exposure on triclosan-induced reproductive toxicity in zebrafish (Danio rerio) DOI
Zhiming Li,

Hongyi Xian,

Rongyi Ye

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 932, P. 172876 - 172876

Published: April 29, 2024

Language: Английский

Citations

13
Biological activity and molecular mechanism of inactivation of Microcystis aeruginosa by ultrasound irradiation DOI
Yazhou Peng, X.L. Xiao, Bozhi Ren

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 468, P. 133742 - 133742

Published: Feb. 7, 2024

Language: Английский

Citations

6
Transmission of Microcystins in Natural Systems and Resource Processes: A Review of Potential Risks to Humans Health DOI Creative Commons
Xueli Ren,

Yuting Wang,

Kenian Zhang

et al.

Toxins, Journal Year: 2023, Volume and Issue: 15(7), P. 448 - 448

Published: July 6, 2023

The rapid rise of microcystins (MCs) poses a serious threat to global freshwater ecosystems and has become an important issue public health. MCs have considerable stability are the most widely distributed hepatotoxins. It cannot only accumulate in aquatic organisms transfer higher nutrients levels, but also be degraded or transferred during resource utilization cyanobacteria. No matter which enrichment method, it will lead risk human exposure. This review summarizes research status MCs, introduces distribution different components ecosystems. was summarized, potential risks environment safety were summarized. polluted all areas In order protect life from health threats caused by this paper proposes some future directions promote control reduce exposure MCs.

Language: Английский

Citations

15
Nodding syndrome: A role for environmental biotoxins that dysregulate MECP2 expression? DOI Creative Commons
Peter S. Spencer, Raquel Valdes Angues,

Valerie S. Palmer

et al.

Journal of the Neurological Sciences, Journal Year: 2024, Volume and Issue: 462, P. 123077 - 123077

Published: June 2, 2024

Language: Английский

Citations

5
Toxicological Effects of Naturally Occurring Endocrine Disruptors on Various Human Health Targets: A Rapid Review DOI Creative Commons
Sara Virtuoso, Carla Raggi, Antonella Maugliani

et al.

Toxics, Journal Year: 2024, Volume and Issue: 12(4), P. 256 - 256

Published: March 29, 2024

Endocrine-disrupting compounds are chemicals that alter the normal functioning of endocrine system living organisms. They can be natural (N-EDCs) or synthetic (S-EDCs). N-EDCs belong to different groups, such as phytoestrogens (PEs), including flavonoids, mycotoxins originating from plants fungi, and cyanotoxins, derived bacteria. Humans encounter these substances in their daily lives. The aim this rapid review (RR) is provide a fine mapping toxicological effects on human health terms various medical conditions adverse consequences. This work based an extensive literature search follows rigorous step-by-step approach (search strategy, analysis strategy data extraction), select eligible papers published between 2019 2023 PubMed database, define set aspects characterizing target systems. Of identified RR, flavonoids most representative class. Male female reproductive systems were targets affected by N-EDCs, followed endocrine, nervous, bone cardiovascular In addition, perinatal, pubertal pregnancy periods found particularly susceptible disruptors. Considering current use, more research required.

Language: Английский

Citations

4
Impact of copper nanoparticles (CuNPs) on hypothalamic GnRH and pituitary gonadotropins secretions in a male mouse: An immunohistochemical study DOI

Vanrohlu Nicy,

Guruswami Gurusubramanian, Vikas Kumar Roy

et al.

The Journal of Steroid Biochemistry and Molecular Biology, Journal Year: 2025, Volume and Issue: unknown, P. 106700 - 106700

Published: Feb. 1, 2025

Language: Английский

Citations

0
Perfluorobutanesulfonate Induces Hypothalamic–Pituitary–Gonadal Axis Disruption and Gonadal Dysplasia of Lithobates catesbeianus Tadpoles DOI
Yilin Shu, Liyuan Zhang, Jun He

et al.

Chemical Research in Toxicology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 21, 2025

It is uncertain whether exposure to environmental concentrations of perfluorobutanesulfonate (PFBS) disrupts the reproductive endocrine system in amphibian tadpoles. In this study, tadpoles (Lithobates catesbeianus) G26 stage were treated with different levels PFBS (0, 1, 3, and 10 μg/L) for 60 days investigate how affects gonadal development Tadpole testes exhibited structural damage germ cells significantly fewer spermatogonia following exposure, but sex ratio remained unaffected. Further, downregulated transcripts genes associated ovarian (figla nobox) testicular (sox9 dmrt1) Encoding gonadotropin hormone transcriptionally upregulated pituitary, serum gonadotropins (FSH LH) elevated. Genes related testosterone synthesis upregulated, raised. The transcription cyp19a1 gene, which involved estradiol (E2), was downregulated, leading decreased E2. Furthermore, transcript level vitellogenin gene liver. Thus, appears disrupt hypothalamic-pituitary-gonadal-liver axis tadpoles, subsequently impacting development. findings study indicate that threaten amphibians first time. This provides important insights further investigation into risk poses stability population.

Language: Английский

Citations

0
Chlorophenols suppress gametogenesis by disrupting sex hormone signaling through DNA methylation in zebrafish DOI

Rongjian Liu,

Dongqiong Wei,

Xuan Ma

et al.

Environmental Pollution, Journal Year: 2025, Volume and Issue: unknown, P. 126221 - 126221

Published: April 1, 2025

Language: Английский

Citations

0