BMC Psychiatry,
Journal Year:
2024,
Volume and Issue:
24(1)
Published: July 17, 2024
Abstract
Background
Developmental
dyslexia,
a
complex
neurodevelopmental
disorder,
not
only
affects
children’s
academic
performance
but
is
also
associated
with
increased
healthcare
costs,
lower
employment
rates,
and
reduced
productivity.
The
pathogenesis
of
dyslexia
remains
unclear
it
generally
considered
to
be
caused
by
the
overlap
genetic
environmental
factors.
Systematically
exploring
close
relationship
between
exposure
compounds
susceptibility
genes
in
development
currently
lacking
high
necessary.
Methods
In
this
study,
we
systematically
compiled
131
publicly
reported
for
sourced
from
DisGeNET,
OMIM,
GeneCards
databases.
Comparative
Toxicogenomics
Database
database
was
used
explore
95
compounds,
including
metals,
persistent
organic
pollutants,
polycyclic
aromatic
hydrocarbons,
pesticides.
Chemical
bias
towards
risk
taken
into
account
observation/expectation
ratios
>
1
corresponding
P
value
obtained
hypergeometric
probability
test.
Results
Our
study
found
that
number
targeted
each
chemical
varied
109.
A
total
35
chemicals
were
involved
reactions
dyslexia-associated
genes,
significant
enrichment
values
(observed/expected
genes)
ranging
1.147
(Atrazine)
66.901
(Dibenzo(a,
h)pyrene).
Conclusion
results
indicated
implicated
certain
reactions.
However,
these
findings
are
exploratory,
further
research
involving
animal
or
cellular
experiments
needed.
Environmental Health,
Journal Year:
2024,
Volume and Issue:
23(1)
Published: June 27, 2024
Abstract
Background
The
prevalence
of
metabolic
syndrome
(MetS)
in
American
adults
increased
from
37.6%
the
2011–12
period
to
41.8%
2017–2018.
Environmental
exposure,
particularly
common
compounds
such
as
glyphosate,
has
drawn
increasing
attention
a
potential
risk
factor.
Methods
We
employed
three
cycles
data
(2013–2018)
National
Health
and
Nutrition
Examination
Survey
(NHANES)
cross-sectional
study
examine
associations
between
urine
glyphosate
measurements
MetS
incidence.
first
created
score
using
exploratory
factor
analysis
(EFA)
International
Diabetes
Federation
(IDF)
criteria
for
MetS,
with
2013–2018
NHANES
cycles,
validated
this
independently
on
an
additional
associated
metric,
albumin-to-creatinine
(ACR)
ratio.
was
via
machine
learning
approach
predicting
ACR
binary
classification
then
used
multivariable
regression
test
association
quartile-categorized
exposure
score.
Results
In
adjusted
regressions,
regressions
showed
significant
inverted
U-shaped
or
saturating
dose‒response
profile,
often
largest
effect
exposures
quartile
3.
Exploration
modification
by
sex,
race,
age
category
revealed
differences
race
age,
older
people
(aged
>
65
years)
non-Hispanic
African
participants
showing
larger
sizes
all
quartiles.
Conclusions
found
that
urinary
concentration
is
significantly
statistical
designed
predict
status
dose–response
coefficient
nonlinear,
advanced
American,
Mexican
other
Hispanic
exhibiting
greater
sizes.
Pharmacia,
Journal Year:
2025,
Volume and Issue:
72, P. 1 - 12
Published: Feb. 27, 2025
The
major
production
of
artisanal
and
industrial
wines
is
elaborate
in
the
Ica
Valley,
Peru.
objective
was
to
evaluate
antioxidant
activity
polyphenols
permissible
values
glyphosate
from
Pisco
Routes
Samples:
six
coded
two
commercial
brands
as
references
(60088
60089).
Total
polyphenol
content
(TPC)
found
between
107.90
±
0.30
(60091)
234.73
0.61
mg
GAE/100
mL
(60084);
total
flavonoid
(TFC)
9.70
16.83
0.25
QE/100
(60084).
Antioxidant
activity:
DPPH
34.9
0.44
55.6
mM
TEAC/100
(60085).
FRAP
42.50
0.36
117.3
Correlation
relationship:
TPC/DPPH
(mM
mL)
for
60086
(r
=
0.7302,
R
2
0.5332),
60091
0.8029,
0.6447),
60085
-0.9820,
0.9643),
reference
60089
-0.9960,
0.9932).
TPC/FRAP
0.8096,
0.6554);
60088
presents
an
inverse
strong
correlation
with
a
100%
relationship
at
linear
level
both
variables.
TFC/DPPH
-1.0,
1.0),
60084
-0.9934,
0.9868),
60090
0.9586,
0.9190).
TFC/FRAP
60087
-0.9798,
0.9601)
0.9750,
0.9506)
higher
compared
60089.
It
concluded
that
samples
have
same
would
be
due
their
polyphenolic
compounds,
below
maximum
limit
(0.1
mg/L).
Journal of Agricultural and Food Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 17, 2025
In
this
article,
a
dual-signal
sensor
for
the
fluorescence
and
colorimetric
detection
of
glyphosate
(Gly)
is
developed
based
on
DNAzyme-mediated
click
chemistry
DNAzyme-regulated
CeO2
peroxidase-like
activity.
DNAzyme
can
bind
to
Cu+,
triggering
reaction
between
3-Azido-7-hydroxycoumarin
(AHC)
3-ethyn-1-ol
(BOL),
thus
generating
strong
signal
at
475
nm.
Due
coordination
Gly
Cu2+,
amount
reduced
Cu+
decreases,
resulting
in
weakening
fluorescence.
addition,
inhibit
catalytic
site
enzyme
activity,
while
DNAzyme,
which
does
not
participate
reaction,
be
adsorbed
by
CeO2,
further
inhibiting
activity
reducing
oxidation
color
change
3,3′,5,5′-tetramethylbenzidine
(TMB).
The
limit
dual-mode
sensing
platform
0.15
μg/mL,
0.19
μg/mL.
This
method
has
been
successfully
applied
tap
water
soybeans,
promising
application
pesticide
residue
detection.
