Riluzole Reverses Blood–Testis Barrier Loss to Rescue Chemotherapy–Induced Male Infertility by Binding to TRPC DOI Creative Commons
Rufei Huang, Huan Xia,

Wanqing Lin

et al.

Cells, Journal Year: 2024, Volume and Issue: 13(23), P. 2016 - 2016

Published: Dec. 6, 2024

Cancer treatments, including cytotoxic therapy, often result in male infertility, necessitating the development of safe and effective strategies to preserve reproductive potential during chemotherapy. Notably, our study uncovers repurposing riluzole, an FDA-approved drug for amyotrophic lateral sclerosis (ALS), enhancing spermatogenesis. Hence, this research aims explore feasibility utilizing riluzole alleviate infertility induced by busulfan (BSF), a commonly used chemotherapy drug. We established BSF-induced oligospermia model 4-week-old mice found that could effectively counter detrimental effects BSF on sperm production with oligospermia. By restoring blood-testis barrier (BTB) functionality, improves quality reduces testicular atrophy. Through transcriptomic molecular docking analyses, we identify transient receptor canonical subfamily member 5 (TRPC5) as target riluzole-mediated regulation function. These findings propose promising therapeutic option chemotherapy-induced thereby addressing fertility challenges associated cancer treatments. Moreover, streamline process, providing cost-effective approach reduced risk compared developing entirely new drugs.

Language: Английский

Endocrine disrupting chemicals and male fertility: from physiological to molecular effects DOI Creative Commons
Marwa Lahimer,

Maria Abou Diwan,

Debbie Montjean

et al.

Frontiers in Public Health, Journal Year: 2023, Volume and Issue: 11

Published: Oct. 10, 2023

The deleterious effects of chemical or non-chemical endocrine disruptors (EDs) on male fertility potential is well documented but still not fully elucidated. For example, the detection industrial chemicals' metabolites in seminal plasma and follicular fluid can affect efficiency gametogenesis, maturation competency gametes has guided scientists to hypothesize that disrupting chemicals (EDCs) may disrupt hormonal homoeostasis by leading a wide range control impairments. EDCs exposure reproductive health are highly dependent factors including type EDCs, duration exposure, individual susceptibility, presence other co-factors. Research continue study these complex interactions. aim this review summarize literature better understand risks France.

Language: Английский

Citations

29
Association between dietary intake estimated levels of PCDD/Fs and human sperm quality DOI
María Ángeles Martínez, Albert Salas‐Huetos, María Fernández de la Puente

et al.

Reproductive Toxicology, Journal Year: 2025, Volume and Issue: unknown, P. 108831 - 108831

Published: Jan. 1, 2025

Language: Английский

Citations

1
Dermal exposure to bisphenols in pregnant women's and baby clothes: Risk characterization DOI
Marta Herrero, Marília Cristina Oliveira Souza, Neus González

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 878, P. 163122 - 163122

Published: March 29, 2023

Language: Английский

Citations

17
Ultra-processed food consumption and semen quality parameters in the Led-Fertyl study DOI Creative Commons
Cristina Valle‐Hita, Albert Salas‐Huetos, María Fernández de la Puente

et al.

Human Reproduction Open, Journal Year: 2024, Volume and Issue: 2024(1)

Published: Jan. 1, 2024

Abstract STUDY QUESTION Is ultra-processed food (UPF) consumption associated with semen quality parameters? SUMMARY ANSWER Higher UPF was inversely total sperm count, concentration, and motility in men of reproductive age. WHAT IS KNOWN ALREADY The UPF, which has been rising during the last decades, demonstrated to be positively several chronic diseases such as diabetes or cardiovascular diseases. However, scientific evidence on its potential impact remains notably limited. DESIGN, SIZE, DURATION A cross-sectional analysis conducted using data from 200 healthy (mean age 28.4 ± 5.5 years) enrolled Led-Fertyl (Lifestyle Environmental Determinants Seminogram Other Male Fertility-Related Parameters) study between February 2021 April 2023. PARTICIPANTS/MATERIALS, SETTING, METHODS (% energy UPF) estimated according NOVA classification system a validated 143-item semi-quantitative frequency questionnaire. Total vitality, motility, progressive normal forms were set main outcomes. Microscopic parameters analyzed phase-contrast microscope computer-assisted (CASA) system. Semen samples collected tested World Health Organization 2010 standards. Multivariable linear regression models fitted estimate associations tertile parameters. MAIN RESULTS AND THE ROLE OF CHANCE Sperm concentration (β: −1.42 × 106 spz./ml; 95% CI: −2.72 −0.12) −7.83%; −15.16 −0.51) lower participants highest compared lowest. similar association observed for count when per 10% increment −1.50 spz.; −2.83 −0.17). Theoretically replacing unprocessed minimally processed higher forms. LIMITATIONS, REASONS FOR CAUTION Cross-sectional studies do not permit drawing causal inferences. Measurement errors reporting bias cannot entirely ruled out. WIDER IMPLICATIONS FINDINGS This work suggests that may have an certain Furthermore, opting foods instead UPFs could potentially benefit quality. If these results are replicated future epidemiological different long-term designs, novel findings provide valuable insights updating even designing preventive interventional programs address infertility among FUNDING/COMPETING INTEREST(S) supported by Spanish government’s official funding agency biomedical research, ISCIII, through Fondo de Investigación para la Salud (FIS), European Union ERDF/ESF, ‘A way make Europe’/‘Investing your future’ [PI21/01447], Diputació Tarragona (2021/11-No.Exp. 8004330008-2021-0022642). J.S.-S. gratefully acknowledges financial support ICREA under Academia program. C.V.-H. received predoctoral grant Generalitat Catalunya (2022 FI_B100108). M.Á.M. Sara Borrell postdoctoral fellowship (CD21/00045—Instituto Carlos III (ISCIII)). M.F.d.l.P. Rovira i Virgili University (2020-PMF-PIPF-8). All authors no conflict interest declare. TRIAL REGISTRATION NUMBER N/A.

Language: Английский

Citations

6
Influence of maternal endocrine disrupting chemicals exposure on adverse pregnancy outcomes: A systematic review and meta-analysis DOI Creative Commons
Bin Liu, Xiaoling Lü,

Antong Jiang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 270, P. 115851 - 115851

Published: Dec. 28, 2023

Maternal endocrine disrupting chemicals (EDCs) exposure, the common environmental pollutants, was capable of involving in adverse pregnancy outcomes. However, evidence their connection is not consistent. Our goal to comprehensively explore risk EDCs related One hundred and one studies were included from two databases before 2023 association between outcomes including miscarriage, small for gestational age (SGA), low birth weight (LBW) preterm (PTB). We found that maternal PFASs exposure positively correlated with PTB (OR:1.13, 95% CI:1.04–1.23), SGA (OR:1.10, CI:1.04–1.16) miscarriage (OR:1.09, CI:1.00–1.19). The pooled estimates also showed PAEs linked (OR:1.16, CI:1.11–1.21), (OR:1.20, CI:1.07–1.35) (OR:1.55, CI:1.33–1.81). In addition, some specific class PFOS, MBP, MEHP, DEHP, BPA associated PTB. PFOA, PFHpA SGA. LBW. MMP, MEHHP, MEOHP, miscarriage. PFASs, may increase according our study. limited number on dose-response hampered further explanation causal association.

Language: Английский

Citations

11
Multiclass Determination of Endocrine-Disrupting Chemicals in Meconium: First Evidence of Perfluoroalkyl Substances in This Biological Compartment DOI Creative Commons
Aritz Domínguez-Liste, Teresa de Haro-Romero, Raquel Quesada-Jiménez

et al.

Toxics, Journal Year: 2024, Volume and Issue: 12(1), P. 75 - 75

Published: Jan. 15, 2024

Major concerns have been raised about human exposure to endocrine-disrupting chemicals (EDCs) during pregnancy. Effective methodologies for the assessment of this are needed support implementation preventive measures and prediction negative health effects. Meconium has proven a valuable non-invasive matrix evaluating cumulative xenobiotics last two trimesters The study objective was develop novel method determine presence in meconium perfluoroalkyl substances (PFASs), bisphenols, parabens, benzophenones, EDCs that widely used manufacture numerous consumer goods personal care products, including cosmetics. Ten PFASs, four benzophenones were measured samples prepared by using combination Captiva Enhanced Matrix Removal (EMR) lipid cartridges with salt-assisted liquid–liquid extraction (SALLE) dispersive microextraction (DLLME) before application liquid chromatography–tandem mass spectrometry (LC–MS/MS). Experimental parameters optimized applying different chemometric techniques. Limits detection ranged from 0.05 0.1 ng g−1, between-day variabilities (relative standard deviations) 6.5% 14.5%. validated matrix-matched calibration followed recovery assay spiked samples, obtaining percentage recoveries 89.9% 114.8%. then employed measure compounds not previously studied 20 samples. proposed analytical procedure yields information on utero selected EDCs.

Language: Английский

Citations

4
Investigating the spatiotemporal associations between meteorological conditions and air pollution in the federal state Baden-Württemberg (Germany) DOI Creative Commons
Leona Hoffmann, Lorenza Gilardi, Marie‐Therese Schmitz

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 12, 2024

Abstract When analyzing health data in relation to environmental stressors, it is crucial identify which variables include the statistical model exclude dependencies among variables. Four meteorological parameters: temperature, ultraviolet radiation, precipitation, and vapor pressure four outdoor air pollution ozone ( $$\text{O}_3$$ O 3 ), nitrogen dioxide $$\text{NO}_2$$ NO 2 particulate matter $$PM_{2.5}$$ P M 2.5 , $$PM_{10}$$ 10 ) were studied on a daily basis for Baden-Württemberg (Germany). This federal state covers urban rural compartments including mountainous river areas. A temporal spatial analysis of internal relationships was performed using (a) cross-correlations, both grand ensemble as well within subsets, (b) Local Indications Spatial Association (LISA) method. Meteorological strongly correlated themselves time space. We found strong interaction between ozone, with correlation coefficients varying over time. The ranged from negative correlations January (−0.84), April (−0.47), October (−0.54) positive July (0.45). cross-correlation plot showed noticeable change direction . Spatially, concentrations significantly higher than regions. For this effect reversed. LISA confirmed distinct hot cold spots stressors. work examined quantified spatio-temporal relationship conditions recommended prioritize future impact analyses. results are line underlying physico-chemical atmospheric processes. It also identified postal code areas dominant stressors further studies.

Language: Английский

Citations

4
High seminal BPA in IVF patients correlates with lower sperm count and up-regulated miR-21 and miR-130a DOI Creative Commons

Ola S. Davis,

Olivia L M Scandlan,

Reem Sabry

et al.

Reproductive Toxicology, Journal Year: 2024, Volume and Issue: 128, P. 108651 - 108651

Published: June 24, 2024

Bisphenol A (BPA) is a widespread industrial chemical, used as the key monomer of polycarbonate plastics and epoxy resins. BPA has been detected in human seminal fluid correlated with changes sperm parameters, crucial determining male fertility. In this study, semen samples were collected from 100 patients aged 29-47 years undergoing fertility assessment between 2021 2023 analyzed according to WHO guidelines. levels plasma then measured through an enzyme-linked immunosorbent assay (ELISA) compared quality metrics. The relative mRNA/miRNA expression genes associated reproduction, including androgen receptor, miR-34c, miR-21, miR-130a, was quantified groups high or low content. Our results revealed that increased age negatively counts (p<0.05). negative correlation remained significant when age-matched. No other relationships motility, morphology DNA fragmentation observed. qPCR analysis showed receptor mRNA significantly greater Moreover, we found miR-21 miR-130a also upregulated higher group These display relationship content provide insights into molecular mechanisms which may be affecting reproductive capability. Ultimately, research can potentially drive guidelines exposure limits for exposure.

Language: Английский

Citations

4
Climate change, microplastics, and male infertility DOI

Danesha Daniels,

Alexandra Berger Eberhardt

Current Opinion in Urology, Journal Year: 2024, Volume and Issue: 34(5), P. 366 - 370

Published: June 26, 2024

Semen quality is on the decline. While etiology unknown, recent literature suggests there may be a relationship between climate change, environmental toxins and male fertility. This review relays new information regarding associations our environment infertility.

Language: Английский

Citations

4
Bisphenol F induces spermatogenic cell ferroptosis via FTO-mediated m6A regulation of FTH1 DOI

Shimeng Zhou,

Yu Shi,

Jiang-ying Li

et al.

Free Radical Biology and Medicine, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0