Artificial Light at Night Disrupts Pain Behavior and Cerebrovascular Structure in Mice DOI Open Access
Jacob R. Bumgarner

Published: Jan. 1, 2023

Circadian rhythms are intrinsic biological processes that fluctuate in function with a period of approximately 24 hours. These precisely synchronized to the 24- hour day Earth by external rhythmic signaling cues. Solar light-dark cycles most potent environmental cue for terrestrial organisms align internal day. Proper alignment and synchrony circadian essential health optimal function.

Language: Английский

Light at night exposure and risk of dementia conversion from mild cognitive impairment in a Northern Italy population DOI Creative Commons
Tommaso Filippini, Sofia Costanzini, Annalisa Chiari

et al.

International Journal of Health Geographics, Journal Year: 2024, Volume and Issue: 23(1)

Published: Nov. 23, 2024

Abstract Background A few studies have suggested that light at night (LAN) exposure, i.e. lighting during hours, may increase dementia risk. We evaluated such association in a cohort of subjects diagnosed with mild cognitive impairment (MCI). Methods recruited study participants between 2008 and 2014 the Cognitive Neurology Clinic Modena Hospital, Northern Italy followed them for conversion to up 2021. collected their residential history we assessed outdoor artificial LAN exposure subjects’ residences using satellite imagery data available from Visible Infrared Imaging Radiometer Suite (VIIRS) period 2014–2022. relation cerebrospinal fluid biomarkers. used Cox-proportional hazards model compute hazard ratio (HR) 95% confidence interval (CI) according increasing through linear, categorical, non-linear restricted-cubic spline models, adjusting by relevant confounders. Results Out 53 subjects, 34 converted any type 26 Alzheimer’s dementia. Higher levels were positively associated biomarkers tau pathology, as well lower concentrations amyloid β 1−42 baseline. was linear regression (HR 1.04, CI 1.01–1.07 1-unit increase). Using reference lowest tertile, both intermediate highest tertiles showed increased risk (HRs 2.53, 0.99–6.50, 3.61, 1.34–9.74). In analysis, linearly above 30 nW/cm 2 /sr exposure. Adding potential confounders including traffic-related particulate matter, smoking status, chronic diseases, apolipoprotein E status multivariable model, or removing cases onset within first year follow-up did not substantially alter results. Conclusion Our findings suggest conversion, especially /sr, although limited sample size suggests caution interpretation results, be confirmed larger investigations.

Language: Английский

Citations

2
Association of outdoor artificial light at night with metabolic syndrome and the modifying effect of tree and grass cover DOI Creative Commons

Weizhuo Yi,

Weiqiang Wang, Zhiwei Xu

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 264, P. 115452 - 115452

Published: Sept. 9, 2023

Epidemiological studies show that outdoor artificial light at night (ALAN) is linked to metabolic hazards, but its association with syndrome (MetS) remains unclear. We aimed investigate the of ALAN MetS in middle-aged and elderly Chinese.From 2017-2020, we conducted a cross-sectional study total 109,452 participants living ten cities eastern China. was defined by fasting blood glucose (FG), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), pressure (BP), waist circumference (WC). In 2021, followed up 4395 without baseline. Each participant's five-year average exposure ALAN, as well their green space type, were measured through matching address. Generalized linear models used assess associations MetS. Stratified analyses performed sex, age, region, physical activity, space.In study, compared first quantile (Q1) exposure, odds ratios (ORs) 1.156 [95 % confidence interval (CI): 1.111-1.203] 1.073 (95 %CI: 1.021-1.128) respectively third fourth quantiles (Q3, Q4) exposure. The follow-up found that, OR Q4 1.204 1.019-1.422). Adverse components, including high FG, TG, obesity, also found. Greater males, elderly, urban residents, those low frequency areas levels grass cover tree cover.Outdoor associated an increased risk, especially lacking lower cover.

Language: Английский

Citations

6
Association of time spent in outdoor light and genetic susceptibility with the risk of type 2 diabetes DOI
Jing Lin, Hongxi Yang, Yuan Zhang

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 888, P. 164253 - 164253

Published: May 16, 2023

Language: Английский

Citations

5
Associations of nighttime light exposure during pregnancy with maternal and neonatal gut microbiota: A cohort study DOI
Ni Wu, Yu Sun,

Tianlai Qiu

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 908, P. 168292 - 168292

Published: Nov. 3, 2023

Language: Английский

Citations

5
Outdoor artificial light at night exposure and gestational diabetes mellitus: a case–control study DOI Creative Commons
Qi Sun, Fang Ye, Jing Liu

et al.

Frontiers in Public Health, Journal Year: 2024, Volume and Issue: 12

Published: April 10, 2024

This study aims to explore the association between outdoor artificial light at night (ALAN) exposure and gestational diabetes mellitus (GDM).

Language: Английский

Citations

1
Postnatal nighttime light exposure and infant temperament at age 12 months: mediating role of genus Akkermansia DOI

Tianlai Qiu,

Qingbo Fang,

Xuqi Tian

et al.

European Child & Adolescent Psychiatry, Journal Year: 2024, Volume and Issue: 33(7), P. 2413 - 2425

Published: April 30, 2024

Language: Английский

Citations

1
Outdoor light at night, air pollution and risk of incident type 2 diabetes DOI

Yonghao Wu,

Jiao Ye, Peng Shen

et al.

Environmental Research, Journal Year: 2024, Volume and Issue: 263, P. 120055 - 120055

Published: Sept. 23, 2024

Language: Английский

Citations

1
Sleeplessness and incident diabetes above the Arctic circle: a secondary analysis of cohort data from the Tromsø Study DOI Creative Commons
Nick Chindanai Uthaikhaifar, Olena Iakunchykova, Sarah Cook

et al.

BMJ Public Health, Journal Year: 2024, Volume and Issue: 2(1), P. e000644 - e000644

Published: Jan. 1, 2024

Circadian misalignment and sleep quality are intertwined processes that both associated with diabetes. The association between incident diabetes has not been previously investigated in populations living at polar latitudes who experience extreme seasonal daylight variation may be greater risk of circadian misalignment. Using data from adult residents Tromsø, Norway, this study investigates the poor quality, as indicated by self-reported sleeplessness, above Arctic circle. Secondary analysis cohort Tromsø Study. consists adults attended fourth (Tromsø4) seventh (Tromsø7) surveys conducted 1995 2016, respectively. Only individuals complete were included. Multivariable logistic regression was used to examine sleeplessness measured Tromsø4 participants followed up Tromsø7, adjusted for other factors. Among 10 875 (mean 41 years age baseline, 53.6% women), 21.2% (n=2302) reported experiencing baseline. Diabetes incidence over follow-up (20 years) 7.2% (n=784); among reporting 8.8%, compared 6.8% unexposed individuals. After adjustment, sleeplessness-exposed found have 23% odds (ORadj 1.23, 95% CI 1.03 1.47, p=0.022) Sleep is a population direction strength consistent findings geographical regions.

Language: Английский

Citations

0
Artificial light at night alters progression of cold neuropathy in a sex-dependent manner in a mouse model of type II diabetes mellitus DOI Creative Commons
Jacob R. Bumgarner,

Rhett C. White,

Jordan A. Brown

et al.

Frontiers in Photonics, Journal Year: 2024, Volume and Issue: 5

Published: Feb. 6, 2024

Artificial light at night (ALAN) is a pervasive circadian rhythm disruptor. Exposure to ALAN associated with detrimental effects on physiology and behavior, including disrupted metabolism, immune function, endocrine pain behavior. Given the of other disruptors pain, we sought understand how may alter progression severity diabetic neuropathy. To do this, used previously reported high-fat diet streptozotocin injection protocol induce type II phenotype in ∼8 week old female male mice then exposed either control or lighting conditions 14:10 h light-dark cycles for 4 weeks. Male housed exhibited reduced responsiveness cold pain; contrast, blunted this effect mice. exposure also elevated blood glucose altered body mass loss These were not present The results study highlight need consider sex as biological variable risk factors treatment mitigation pain.

Language: Английский

Citations

0
Exposure to light at night (LAN) and risk of overweight/obesity, hypertension, and diabetes: a systematic review and meta-analysis DOI

Bin Mao,

Chuhong Luo,

Shengnan Li

et al.

International Journal of Environmental Health Research, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 15

Published: July 16, 2024

Current studies have presented conflicting findings regarding the associations between light at night (LAN) exposure and risk of overweight/obesity, hypertension, diabetes. Our study systematically summarized evidence association LAN We searched five databases (PubMed, Web Science, Embase, Scopus, Cochrane) for observational published up to 1 August 2023. The pooled odds ratio (ORs) 95% confidence intervals (CIs) were estimated by random-effects models association. Eighteen included in meta-analysis. Compared with group lowest level LAN, highest is associated an increased overweight/obesity (pooled OR = 1.19, 95%CI: 1.13-1.26), hypertension OR: 1.86, CI:1.28-2.72), diabetes 1.21, 1.07-1.31). meta-analysis demonstrated

Language: Английский

Citations

0