Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 483 - 496
Published: June 13, 2024
Language: Английский
The Egyptian Journal of Internal Medicine, Journal Year: 2025, Volume and Issue: 37(1)
Published: Jan. 24, 2025
Abstract This narrative review explores the relationship between air pollution and neurodegenerative diseases (NDs). Historically, has been linked primarily to respiratory cardiovascular issues, but recent evidence suggests that it may also impact neurological health. With global increase in diseases, understanding environmental risk factors become crucial. The synthesizes findings from studies, highlighting potential role of pollutants—particularly fine particulate matter (PM2.5), ozone, nitrogen dioxide (NO2), heavy metals—in onset progression NDs. Key mechanisms under investigation include brain inflammation microglial activation, which are believed contribute processes. Animal human studies have shown correlations exposure increased cognitive decline disorders. Research indicates exacerbate neuroinflammation cause white abnormalities, disrupt neural communication function. Additionally, emerging like residential greenness climate action could mitigate some these adverse effects. Despite advancements, significant knowledge gaps remain, particularly regarding long-term chronic specific molecular pathways involved. shows need for further research clarify develop targeted interventions. Addressing pollution’s on requires comprehensive public health strategies, including stricter regulations awareness, alongside continued into preventive therapeutic measures.
Language: Английский
Citations
4
Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 266, P. 115565 - 115565
Published: Oct. 11, 2023
Exposure to particulate matter (PM) has been associated with a range of health impacts, including neurological abnormalities that affect neurodevelopment, neuroplasticity, and behavior. Recently, there growing interest in investigating the possible relationship between PM exposure onset progression neurodegenerative diseases, such as Alzheimer's disease, Parkinson's Huntington's multiple sclerosis. However, precise mechanism by which affects neurodegeneration is still unclear, even though several epidemiological animal model studies have provided mechanistic insights. This article presents review current research on neurotoxicity its impact diseases. summarizes findings from collected through searches Google Scholar, PubMed, Web Science, Scopus. paper also discusses reported effects central nervous system highlights gaps future directions. The information presented this may inform public policies aimed at reducing contribute development new treatments for Further therapeutic will be needed fully understand
Language: Английский
Citations
28
Frontiers in Human Neuroscience, Journal Year: 2024, Volume and Issue: 17
Published: Jan. 12, 2024
The neuropathological hallmarks of Alzheimer’s disease (AD), Parkinson’s (PD), frontotemporal lobar degeneration (FTLD), and amyotrophic lateral sclerosis (ALS) are present in urban children exposed to fine particulate matter (PM 2.5 ), combustion friction ultrafine PM (UFPM), industrial nanoparticles (NPs). Metropolitan Mexico City (MMC) forensic autopsies strongly suggest that anthropogenic UFPM NPs reach the brain through nasal/olfactory, lung, gastrointestinal tract, skin, placental barriers. Diesel-heavy unregulated vehicles a key source for 21.8 million MMC residents. We found hyperphosphorylated tau, beta amyloid 1-42 , α-synuclein, TAR DNA-binding protein-43 were associated with 186 (mean age 27.45 ± 11.89 years). neurovascular unit is an early anatomical target, first two decades life critical: 100% 57 aged 14.8 5.2 years had AD pathology; 25 (43.9%) AD+TDP-43; 11 (19.3%) + PD TDP-43; 2 (3.56%) +PD. Fe, Ti, Hg, Ni, Co, Cu, Zn, Cd, Al, Mg, Ag, Ce, La, Pr, W, Ca, Cl, K, Si, S, Na, C seen frontal temporal lobes, olfactory bulb, caudate, substantia nigra, locus coeruleus, medulla, cerebellum, and/or motor cortical spinal regions. Endothelial, neuronal, glial damages extensive, mitochondria, rough endoplasmic reticulum, Golgi apparatus, lysosomes. Autophagy, cell nuclear membrane damage, disruption pores heterochromatin, death present. Metals abrasion deterioration automobile catalysts electronic waste rare earth elements, i.e., lanthanum, cerium, praseodymium, entering young brains. Exposure environmental prime candidates initiating stages fatal neurodegenerative diseases. adults—surrogates polluted areas around world—exhibit AD, PD, FTLD, ALS forecasting serious health, social, economic, academic, judicial societal detrimental impact. Neurodegeneration prevention should be public health priority as problem human exposure particle pollution solvable. knowledgeable main emission sources technological options control them. What we waiting for?
Language: Английский
Citations
16
Heliyon, Journal Year: 2023, Volume and Issue: 9(7), P. e17837 - e17837
Published: June 30, 2023
BackgroundDementia is a neurological syndrome characterized by severe cognitive impairment with functional impact on everyday life. It can be classified as young onset dementia (EOD) in case of symptom before 65, and late (LOD). The purpose this study to assess the risk due light pollution, specifically outdoor artificial at night (LAN).MethodsUsing case-control design, we enrolled patients newly-diagnosed province Modena period 2017–2019 referent population from their caregivers. We geo-referenced address residence date recruitment, provided it was stable for previous five years. assessed LAN exposure through 2015 nighttime luminance satellite images Visible Infrared Imaging Radiometer Suite (VIIRS). Using logistic regression model adjusted age, sex, education, calculated associated increasing exposure, namely using <10 W/cm2/sr reference considering ≥10-<40 intermediate ≥40 high respectively also implemented non-linear assessment spline model.ResultsWe recruited 58 EOD cases, 34 LOD cases 54 controls. Average levels overlapped controls, while showed higher levels. Compared lowest (OR = 1.36, 95% CI 0.54–3.39, but not category 1.04, 0.32–3.34). In contrast, positively ORs 2.58 (95% IC 0.26–25.97) 3.50 0.32–38.87) categories, respectively. analysis substantial lack association between EOD, almost linear although highly imprecise emerged LOD.ConclusionsAlthough precision estimates affected limited sample size design did allow us exclude presence residual confounding, these results suggest possible role etiology dementia, particularly its late-onset form.
Language: Английский
Citations
11
Diagnostics, Journal Year: 2024, Volume and Issue: 14(21), P. 2408 - 2408
Published: Oct. 29, 2024
Objective: Neurofilament light chain proteins (NfLs) are considered a promising biomarker of neuroaxonal damage in several neurological diseases. Their measurement the serum and cerebrospinal fluid (CSF) patients with dementia may be especially useful. Our aim was to compare NfL performance two advanced technologies, specifically Ella™ microfluidic platform Lumipulse™ fully automated system, cognitive disorders. Methods: Thirty subjects neurodegenerative disorders (10 Alzheimer’s Disease, 10 Frontotemporal Dementia, non-progressive Mild Cognitive Impairment) seen at Neurology Clinic Modena University Hospital (Italy) underwent CSF both (Bio-Techne, Minneapolis, MN, USA)) system for CLEIA (Fujirebio Inc., Ghent, Belgium). Correlation regression analyses were applied assess association between concentrations obtained assays serum. The Passing–Bablok method employed evaluate agreement assays. Results: There high correlations (r = 0.976, 95% CI. 0.950–0.989 vs. r 0.923, CI 0.842–0.964 serum). A model estimated explain relationship assays, allowing us switch from one other when only assay available. Conclusions: We found good degree correlation methods neurocognitive also established that will allow comparisons results either technique, meta-analyses larger sample sizes.
Language: Английский
Citations
4
Journal of Toxicology and Environmental Health Part B, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 31
Published: Jan. 18, 2025
Particulate matter with an aerodynamic diameter of less than 2.5 µm (PM2.5) is one the criteria air pollutants that (1) serve as essential carrier airborne toxicants arising from combustion-related events including emissions industries, automobiles, and wildfires (2) play important role in transient to long-lasting cognitive dysfunction well several other neurological disorders. A systematic review was conducted address differences study design various biochemical molecular markers employed elucidate disorders PM2.5 -exposed humans animal models. Out 340,068 scientific publications screened 7 databases, 312 studies were identified targeted relationship between exposure dysfunction. Equivocal evidence pre-clinical (animal model) human contributes dementia, Parkinson disease, multiple sclerosis, stroke, depression, autism spectrum disorder, attention deficit hyperactivity neurodevelopment. In addition, there substantial also associated Alzheimer's anxiety, neuropathy, brain tumors. The exposome characterizing neurobehavioral anomalies opportunities available leverage neuroexposome initiative for conducting longitudinal discussed. Our provided some areas warrant consideration, which unraveling microbiome, climate change exposure-induced
Language: Английский
Citations
0
BMC Public Health, Journal Year: 2025, Volume and Issue: 25(1)
Published: April 5, 2025
There is growing evidence that exposure to particulate matter (PM) associated with impaired cognitive function. However, limited studies have specifically examined the relationship between PM and domain-specific This study involved 2,668 female participants from Lifestyle Healthy Aging of Chinese Square Dancer Study. Global function was assessed using a composite Z-score derived four tests: Auditory Verbal Learning Test (AVLT), Fluency (VFT), Digit Symbol Substitution (DSST), Trail Making Test-B (TMT-B). These tests evaluated specific subdomains: memory language attention executive concentrations were estimated Random Forest (RF) model, which calculated average over 1-year 3-year periods at high grid resolution 1 × km. Mixed linear regression employed explore association After adjusting for basic socio-demographic factors, 10 mg/m3 increase in PM10 significantly decrease DSST score by -0.05 (95% confidence interval [CI]: -0.11, 0) an TMT-B 0.05 CI: 0.01, 0.1). When further gaseous pollutants (SO₂, NO₂, O₃), even stronger associations observed either PM2.5 or performance both global cognition subdomains. Specifically, subdomain, µg/m³ -0.10 -0.15, -0.04). Age-stratified analyses indicated older consistently more vulnerable exposure. Notably, linked declines scores across middle-aged age groups. Ambient domains among females. Female populations 65 years old susceptible adverse effects PM10. Among subdomains, showed strongest exposure, earlier ages, suggesting may serve as early warning sign decline. Not applicable.
Language: Английский
Citations
0
NeuroToxicology, Journal Year: 2024, Volume and Issue: 105, P. 158 - 183
Published: Oct. 5, 2024
Language: Английский
Citations
2
International Journal of Health Geographics, Journal Year: 2024, Volume and Issue: 23(1)
Published: Nov. 23, 2024
Abstract Background A few studies have suggested that light at night (LAN) exposure, i.e. lighting during hours, may increase dementia risk. We evaluated such association in a cohort of subjects diagnosed with mild cognitive impairment (MCI). Methods recruited study participants between 2008 and 2014 the Cognitive Neurology Clinic Modena Hospital, Northern Italy followed them for conversion to up 2021. collected their residential history we assessed outdoor artificial LAN exposure subjects’ residences using satellite imagery data available from Visible Infrared Imaging Radiometer Suite (VIIRS) period 2014–2022. relation cerebrospinal fluid biomarkers. used Cox-proportional hazards model compute hazard ratio (HR) 95% confidence interval (CI) according increasing through linear, categorical, non-linear restricted-cubic spline models, adjusting by relevant confounders. Results Out 53 subjects, 34 converted any type 26 Alzheimer’s dementia. Higher levels were positively associated biomarkers tau pathology, as well lower concentrations amyloid β 1−42 baseline. was linear regression (HR 1.04, CI 1.01–1.07 1-unit increase). Using reference lowest tertile, both intermediate highest tertiles showed increased risk (HRs 2.53, 0.99–6.50, 3.61, 1.34–9.74). In analysis, linearly above 30 nW/cm 2 /sr exposure. Adding potential confounders including traffic-related particulate matter, smoking status, chronic diseases, apolipoprotein E status multivariable model, or removing cases onset within first year follow-up did not substantially alter results. Conclusion Our findings suggest conversion, especially /sr, although limited sample size suggests caution interpretation results, be confirmed larger investigations.
Language: Английский
Citations
2
Environmental Research, Journal Year: 2023, Volume and Issue: 242, P. 117652 - 117652
Published: Nov. 18, 2023
It is acknowledged that living in a green environment may help mental well-being and this be especially true for vulnerable people. However, the relationship between greenness neuropsychiatric symptoms dementia has not been studied/explored yet. We collected clinical, neuropsychiatric, residential data from subjects with province of Modena, Northern Italy. Neuropsychiatric were measured Neuropsychiatry Inventory, questionnaire administered to caregiver who assesses presence severity symptoms, including delusions, hallucinations, agitation/aggression, dysphoria/depression, anxiety, euphoria/elation, apathy/indifference, disinhibition, irritability/lability, aberrant motor behaviors, sleep disturbances, appetite/eating changes. Normalized Difference Vegetation Index (NDVI) was used as proxy greenness. Regression models constructed study association features. 155 patients recruited. found variably associated risk having symptoms. The apathy lower levels (OR = 0.42, 95% CI 0.19–0.91 NDVI below median value). psychosis higher but more imprecise values 1.34, 0.69–2.61). Our results suggest possible people dementia. If replicated larger samples, these findings will pave road identifying innovative greening strategies interventions can improve health
Language: Английский
Citations
4