ChemistrySelect,
Journal Year:
2024,
Volume and Issue:
9(41)
Published: Oct. 28, 2024
Abstract
Sugars,
as
cryoprotectants,
can
be
added
to
NP
formulations
before
lyophilization
ensure
that
NPs
retain
their
size
during
long‐term
storage.
In
this
study,
mannitol,
glucose,
and
sucrose
were
used
at
different
concentrations
extend
the
storage
time
of
doxorubicin
(DOX)‐loaded
PLGA‐NPs
prepared
using
two
copolymer
ratios
(75
:
25
50
50)
temperatures
(−20,
+4,
+25
°C).
After
lyophilization,
a
glucose
or
concentration
only
5
%
for
DOX‐PLGA‐75
25‐NP
10
DOX‐PLGA‐50
50‐NP
found
prevent
agglomeration
up
4
months
−20
°C.
It
is
noteworthy
after
°C
months,
was
prevented
in
content
both
types.
On
other
hand,
expected,
no
sugar
type
could
The
sizes
encapsulation
efficiencies
(EE%)
221.8±2.20
45.4
221.5±1.31
48.7
25‐NP,
respectively.
Furthermore,
release
profiles
DOX
investigated
by
UV‐Vis
analyses.
DSC
analysis
revealed
present
free
form
amorphous
NPs.
Consequently,
PLGA
have
an
impact
on
stability
loaded
lyophilizates,
DOX‐loaded
with
75
stored
+4
when
combined
appropriate
contents
concentrations,
demonstrating
versatility
these
materials.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2023,
Volume and Issue:
11
Published: Nov. 1, 2023
Cancer
presents
a
formidable
threat
to
human
health,
with
the
majority
of
cases
currently
lacking
complete
cure.
Frequently,
chemotherapy
drugs
are
required
impede
its
progression.
However,
these
frequently
suffer
from
drawbacks
such
as
poor
selectivity,
limited
water
solubility,
low
bioavailability,
and
propensity
for
causing
organ
toxicity.
Consequently,
concerted
effort
has
been
made
seek
improved
drug
delivery
systems.
Nano-drug
systems
based
on
biodegradable
polyesters
have
emerged
subject
widespread
interest
in
this
pursuit.
Extensive
research
demonstrated
their
potential
offering
high
effective
encapsulation,
controlled
release,
minimal
Notably,
poly
(ε-caprolactone)
(PCL),
(lactic-co-glycolic
acid)
(PLGA),
polylactic
acid
(PLA)
gained
prominence
most
widely
utilized
options
carriers
nano
system.
This
paper
comprehensively
reviews
recent
materials
nano-carriers
delivering
chemotherapeutic
drugs,
summarizing
latest
advancements,
acknowledging
limitations,
forecasting
future
directions.
Journal of Macromolecular Science Part B,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 16
Published: Jan. 3, 2025
This
article
reviews
how
pH-sensitive
polymeric
nanoparticles
are
designed
to
deliver
drugs,
specifically
colon
cancer.
The
acidic
tumor
microenvironment
(TME)
plays
a
vital
role
in
activating
innovative
drug
delivery
systems,
improving
release
and
reducing
overall
toxicity.
discussion
focuses
on
polymer
composition,
particle
size,
surface
charge
crosslinking
degree
affect
release,
stability
targeting
efficiency.
discusses
polymers
like
chitosan
poly
(lactic-co-glycolic
acid)
(PLGA)
can
enhance
by
utilizing
mechanisms.
show
promising
results
laboratory
animal
tests
accurately
they
drugs
cancer
cells
while
side
effects
healthy
tissues.
Challenges,
scaling
up
nanoparticle
production,
dealing
with
heterogeneity
overcoming
resistance
addressed.
Future
advancements
discussed,
including
multifunctional
personalized
treatments
tailored
individual
patients.
Overall,
we
propose
believe
ongoing
improvements
could
significantly
improve
treatment,
making
it
more
effective
safer.
AAPS PharmSciTech,
Journal Year:
2025,
Volume and Issue:
26(1)
Published: Jan. 16, 2025
Abstract
Lung
inflammation
is
a
hallmark
of
several
respiratory
diseases.
Despite
the
great
effectiveness
synthetic
antiinflammatory
agents,
they
cause
potential
side
effects.
Polydatin
(PD),
natural
phytomedicine,
has
antioxidant
and
Its
clinical
applications
are
hindered
due
to
poor
aqueous
solubility,
low
bioavailability,
rapid
metabolism
by
first-pass
effect.
Herein,
we
report
development
novel
chitosan
oligosaccharide-coated
PD-loaded
Poly
dl-lactide-co-glycolide
nanoparticles
(COS-coated
PD/PLGA
NPs)
against
bleomycin-induced
pulmonary
in
rat
model.
The
NPs
exhibited
small
particle
size
188.57
±
5.68
nm
high
zeta
+
18.13
2.75
mV
with
spherical
architecture
sustained
release
pattern
PD.
In
vivo
studies
lung
model
revealed
superior
prophylactic
activity
COS-coated
over
free
drug
(PD)
as
demonstrated
histopathological
immunohistochemical
analyses,
alongside
biochemical
assays
evaluating
oxidative
stress
biomarkers
inflammatory
cytokine
levels.
Overall,
optimized
formulation
offers
promising
platform
many
Graphical
Journal of Physics Conference Series,
Journal Year:
2025,
Volume and Issue:
2980(1), P. 012024 - 012024
Published: April 1, 2025
Abstract
Silica/zinc
ferrite
nanocomposite
was
prepared
using
the
coprecipitation
method
to
be
applied
as
a
candidate
for
drug
delivery
agents.
The
success
of
synthesis
evidenced
by
presence
an
amorphous
silica
phase
and
zinc
in
X-ray
diffraction
pattern.
In
addition,
FTIR
characterization,
main
functional
groups,
Si-O,
Si-O-Fe,
Zn-O,
were
detected.
Based
on
SEM
morphology
silica/zinc
tended
form
spherical
shape
with
average
particle
size
38.2
nm.
magnetic
character
evaluated
characterization
VSM,
showing
superparamagnetic
curve
saturation
magnetization
3.5
emu/g.
loading
performance
showed
absorption
peak
at
wavelength
251
nm,
confirming
doxorubicin
drug.
Furthermore,
effectiveness
release
demonstrated
controlled
starting
45
minutes
total
160
minutes.
