Progressive cancer targeting by programmable aptamer‐tethered nanostructures DOI Creative Commons
Fatemeh Mohammadi, Hamed Zahraee,

Farkhonde Zibadi

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(11)

Published: Oct. 20, 2024

Abstract Scientific research in recent decades has affirmed an increase cancer incidence as a cause of death globally. Cancer can be considered plurality various diseases rather than single disease, which multifaceted problem. Hence, therapy techniques acquired more accelerated and urgent approvals compared to other therapeutic approaches. Radiotherapy, chemotherapy, immunotherapy, surgery have been widely adopted routine treatment strategies suppress disease progression metastasis. These approaches lengthened the longevity countless patients. Nonetheless, some inherent limitations restricted their application, including insignificant efficacy, toxicity, negligible targeting, non‐specific distribution, multidrug resistance. The development oligomer nanoconstructs with advantages chemical solid‐phase synthesis, programmable design, precise adjustment is crucial for advancing smart targeted drug nanocarriers. This review focuses on significance different aptamer‐assembled multifunctional nucleic acid oligomeric nanoskeletons efficient delivery. We discuss advancements design utilization aptamer‐tethered nanostructures enhance efficacy treatment. Valuably, this comprehensive highlights self‐assembled aptamers exceptionally intelligent nano‐biomaterials delivery based superior stability, high specificity, excellent recoverability, biocompatibility, versatile functions.

Language: Английский

Unlocking the Potential of RGD-Conjugated Gold Nanoparticles: A New Frontier in Targeted Cancer Therapy, Imaging, and Metastasis Inhibition DOI
Hossein Javid, Mahsa Akbari Oryani,

Nastaran Rezagholinejad

et al.

Journal of Materials Chemistry B, Journal Year: 2024, Volume and Issue: 12(42), P. 10786 - 10817

Published: Jan. 1, 2024

The review highlights the potential of RGD-conjugated AuNPs in cancer diagnosis and treatment, including breast cancer. It emphasizes need for further research to fully realize this technology’s inspire future investigations.

Language: Английский

Citations

5
RGD-based self-assembling nanodrugs for improved tumor therapy DOI Creative Commons
Bin Wang, Dongmei Tang,

Jianqiao Cui

et al.

Frontiers in Pharmacology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 1, 2024

RGD-based self-assembling nanodrugs are a promising advancement in targeted cancer therapy, combining the specificity of RGD peptides with benefits nanotechnology. These enhance tumor targeting and cellular uptake while reducing off-target effects. facilitate self-assembly stable nanostructures, ensuring efficient drug delivery. Despite their potential, challenges such as immunogenicity, stability, heterogeneity, manufacturing scalability need to be addressed. Future research should focus on improving biocompatibility, advanced strategies, personalized medicine approaches, innovative techniques. Overcoming these will pave way for successful clinical translation nanodrugs, offering more effective safer treatments.

Language: Английский

Citations

2
Progressive cancer targeting by programmable aptamer‐tethered nanostructures DOI Creative Commons
Fatemeh Mohammadi, Hamed Zahraee,

Farkhonde Zibadi

et al.

MedComm, Journal Year: 2024, Volume and Issue: 5(11)

Published: Oct. 20, 2024

Abstract Scientific research in recent decades has affirmed an increase cancer incidence as a cause of death globally. Cancer can be considered plurality various diseases rather than single disease, which multifaceted problem. Hence, therapy techniques acquired more accelerated and urgent approvals compared to other therapeutic approaches. Radiotherapy, chemotherapy, immunotherapy, surgery have been widely adopted routine treatment strategies suppress disease progression metastasis. These approaches lengthened the longevity countless patients. Nonetheless, some inherent limitations restricted their application, including insignificant efficacy, toxicity, negligible targeting, non‐specific distribution, multidrug resistance. The development oligomer nanoconstructs with advantages chemical solid‐phase synthesis, programmable design, precise adjustment is crucial for advancing smart targeted drug nanocarriers. This review focuses on significance different aptamer‐assembled multifunctional nucleic acid oligomeric nanoskeletons efficient delivery. We discuss advancements design utilization aptamer‐tethered nanostructures enhance efficacy treatment. Valuably, this comprehensive highlights self‐assembled aptamers exceptionally intelligent nano‐biomaterials delivery based superior stability, high specificity, excellent recoverability, biocompatibility, versatile functions.

Language: Английский

Citations

2