Gallic acid: a dietary metabolite’s therapeutic potential in the management of atherosclerotic cardiovascular disease

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 15

Published: Jan. 7, 2025

Atherosclerotic cardiovascular disease (ASCVD) causes significant morbidity and mortality globally. Most of the chemicals specifically target certain pathways minimally impact other diseases associated with ASCVD. Moreover, interactions these drugs can cause toxic reactions. Consequently, exploration multi-targeted safe medications for treating preventing ASCVD has become an increasingly popular trend. Gallic acid (GA), a natural secondary metabolite found in various fruits, plants, nuts, demonstrated potentials ASCVD, addition to its known antioxidant anti-inflammatory effects. It alleviates entire process atherosclerosis (AS) by reducing oxidative stress, improving endothelial dysfunction, inhibiting platelet activation aggregation. Additionally, GA treat ASCVD-related diseases, such as coronary heart (CHD) cerebral ischemia. However, pharmacological actions prevention treatment have not been comprehensively reviewed, which limits clinical development. This review primarily summarizes vitro vivo on related risk factors AS, it provides comprehensive overview toxicity, extraction, synthesis, pharmacokinetics, pharmaceutics GA,aimed enhance understanding applications further research

Language: Английский

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Zinc/aluminum-layered double hydroxide-gallic acid doped carboxymethyl cellulose nanocomposite films for wound healing

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 260, P. 129556 - 129556

Published: Jan. 18, 2024

Language: Английский

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Recent Advancements in Gallic Acid-Based Drug Delivery: Applications, Clinical Trials, and Future Directions

Pharmaceutics, Journal Year: 2024, Volume and Issue: 16(9), P. 1202 - 1202

Published: Sept. 13, 2024

Gallic acid (GA) is a well-known herbal bioactive compound found in many herbs and foods like tea, wine, cashew nuts, hazelnuts, walnuts, plums, grapes, mangoes, blackberries, blueberries, strawberries. GA has been reported for several pharmacological activities, such as antioxidant, inflammatory, antineoplastic, antimicrobial, etc. Apart from its incredible therapeutic benefits, it associated with low permeability bioavailability issues, limiting their efficacy. belongs to BCS (Biopharmaceutics classification system) class III (high solubility probability). In this context, novel drug delivery approaches played vital role resolving these issues. Nanocarrier systems help improve moiety’s physical chemical stability by encapsulating them into lipidic or polymeric matrix core system. regard, researchers have developed wide range of nanocarrier GA, including liposomes, transfersomes, niosomes, dendrimers, phytosomes, micelles, nanoemulsions, metallic nanoparticles, solid lipid nanoparticles (SLNs), nanostructured carriers, polymer conjugates, the present review, different search engines Scopus, PubMed, ScienceDirect, Google Scholar referred acquiring recent information on theme work. Therefore, review paper aims emphasize systems, patents, clinical updates GA.

Language: Английский

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Hyaluronic acid engineered gallic acid embedded chitosan nanoparticle as an effective delivery system for treatment of psoriasis

Environmental Research, Journal Year: 2023, Volume and Issue: 238, P. 117086 - 117086

Published: Sept. 6, 2023

Language: Английский

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Recent Advancements and Trends of Topical Drug Delivery Systems in Psoriasis: A Review and Bibliometric Analysis

International Journal of Nanomedicine, Journal Year: 2024, Volume and Issue: Volume 19, P. 7631 - 7671

Published: July 1, 2024

Abstract: Psoriasis is an immune-mediated inflammatory skin disease where topical therapy crucial. While various dosage forms have enhanced the efficacy of current treatments, their limited permeability and lack targeted delivery to dermis epidermis remain challenges. We reviewed evolution therapies for psoriasis conducted a bibliometric analysis from 1993 2023 using predictive linear regression model. This included comprehensive statistical visual evaluation each model's validity, literature profiles, citation patterns, collaborations, assessing R variance mean squared error (MSE). Furthermore, we detailed structural features penetration pathways emerging drug systems treatment, such as lipid-based, polymer-based, metallic nanocarriers, nanocrystals, highlighting advantages. systematic overview indicates that future research should focus on developing novel characterized by stability, biocompatibility, drug-carrying capacity. Keywords: psoriasis, bibliometric, delivery, nanoparticle, nanocarriers

Language: Английский

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Nanocarriers and their Integrated Microneedle Systems-Mediated Drug Delivery for the Treatment of Moderate-Severe Dermatological Diseases: Recent Progress, Applications and Future Perspectives

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: 106, P. 106748 - 106748

Published: Feb. 22, 2025

Language: Английский

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Evaluation of the release kinetics of hydrophilic and lipophilic compounds from lipid–polymer hybrid nanoparticles

Nanoscale, Journal Year: 2024, Volume and Issue: 16(33), P. 15801 - 15814

Published: Jan. 1, 2024

Lipid/polymer hybrid nanoparticles (LPHNPs) embedded in gelatin aerogels, a larger vehicle enhancing concentration and uniform dispersion, effectively sustain the release of small drugs, both hydrophilic lipophilic.

Language: Английский

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