Cited by Association between glyphosate exposure and cardiovascular health using “Life’s Essential 8” metrics in US adults

Sex differences in the mediation of the MASLD - Depression association by fat distribution in U.S. adults DOI

Chang He,

Linling Zhou,

Tianming Gao

et al.

Acta Psychologica, Journal Year: 2025, Volume and Issue: 256, P. 105041 - 105041

Published: April 29, 2025

Language: Английский

Citations

Serum neurofilament light chain and cognition decline in US elderly: A cross‐sectional study DOI

X. Liu, Jun Chen,

Chen Meng

et al.

Annals of Clinical and Translational Neurology, Journal Year: 2023, Volume and Issue: 11(1), P. 17 - 29

Published: Oct. 30, 2023

Abstract Objective Early identification of cognitive impairment in neurodegenerative diseases like Alzheimer's disease (AD) is crucial. Neurofilament, a potential biomarker for neurological disorders, has gained attention. Our study aims to investigate the relationship between serum neurofilament light (sNfL) levels and function elderly individuals United States. Methods This cross‐sectional analyzed data from participants aged 60 above National Health Nutrition Examination Survey (2013–2014). We collected sNfL levels, tests, sociodemographic characteristics, comorbidities, other variables. Weighted multiple linear regression models examined ln(sNfL) scores. Restricted cubic spline (RCS) visualization explored nonlinear relationships. The stratified analysis subgroups' association. Results included 446 (47.73% male). Participants with 2.58 2.81 pg/mL (second quintile) performed relatively well tests. After adjusting factors, were negatively correlated function, adjusted β (95% CI) as follows: immediate recall test (IRT): −0.763 (−1.301 −0.224), delayed (DRT): −0.308 (−0.576 −0.04), animal fluency (AFT): −1.616 (−2.639 −0.594), digit symbol substitution (DSST): −2.790 (−4.369 −1.21). RCS curves showed relationships DRT, AFT, inflection points around 2.7 pg/mL. revealed negative correlation cognition specific subgroups distinct features, an interaction diabetes ln(sNfL). Interpretation Higher are associated poorer population shows promise early decline.

Language: Английский

Citations

Glyphosate exposure, muscular health and functional limitations in middle-aged and older adults DOI

Sara Jauregui-Zunzunegui,

Fernando Rodríguez‐Artalejo, María Téllez-Plaza

et al.

Environmental Research, Journal Year: 2024, Volume and Issue: 251, P. 118547 - 118547

Published: March 6, 2024

Glyphosate is the most widely used herbicide worldwide, both in domestic and industrial settings. Experimental research animal models has demonstrated changes muscle physiology reduced contractile strength associated with glyphosate exposure, while epidemiological studies have shown associations between exposure adverse health outcomes critical biological systems affecting function. This study data from a nationally representative survey of non-institutionalized U.S. general population (NHANES, n = 2132). Urine concentrations were determined by ion chromatography tandem mass spectrometry. Hand grip (HGS) was measured using Takei Dynamometer, relative estimated as ratio HGS dominant hand appendicular lean (ALM) to body index (ALMBMI) ratio. Low low defined 1 sex-, age- race-specific SD below mean. Physical function limitations identified significant difficulty or incapacity various activities. In fully-adjusted models, Mean Differences (MD) 95% confidence intervals [95%CI] per doubling increase −0.55 [-1.09, −0.01] kg for hand, −0.90 [-1.58. −0.21] HGS/ALMBMI. The Odds Ratios (OR) [95% CI] HGS, functional 1.27 [1.03, 1.57] HGS; 1.43 [1.05; 1.94] 1.33 [1.08, 1.63] stooping, crouching kneeling difficulty; 1.17 [0.91, 1.50] lifting carrying items weighting up 10 pounds 1.21 [1.01, 1.40] standing armless chair 1.47 [1.05, 2.29] ascending ten steps without pause difficulty. may be risk factor decreased increased physical limitations. More investigating influence this other environmental pollutants on aging are needed.

Language: Английский

Citations

Urinary glyphosate levels and association with mortality in the 2013–16 National Health and Nutrition Examination Survey DOI

Matthew Untalan,

Tara Ivic‐Pavlicic,

Emanuela Taioli

et al.

Carcinogenesis, Journal Year: 2023, Volume and Issue: 45(3), P. 163 - 169

Published: Dec. 2, 2023

Abstract Objectives Glyphosate is the most commonly used herbicide in USA; however, its safety still under debate. We assessed glyphosate levels and their association with overall mortality a representative sample of US adult population from 2013 to 2016 National Health Nutrition Examination Survey. Methods extracted data on urinary (N = 2910) measured by ion chromatography isotope-dilution tandem mass spectrometry. Associations between concentrations demographic, lifestyle other exposures were analyzed. Data linked public-use Mortality Files for 2019. Results The mean (STD) level was 0.53 (0.59) ng/ml, 25.7% subjects having at or below detection limit. At multivariate analysis, age creatinine associated (both P < 0.0001). There borderline (HRadj 1.33; 95% CI 0.99–1.77 0.06). When 3,5,6-trichloropyridinol excluded Cox model, exhibits significant 1.00–1.77; 0.0532). Conclusions These nationally suggest that recent exposure could be increased mortality. More studies are necessary understand population-level risk product, given widespread use agriculture.

Language: Английский

Citations

Redox imbalance and inflammation: A link to depression risk in brazilian pesticide-exposed farmers DOI

Mariane Magalhães Zanchi,

Filomena Marafon, Katiuska Marins

et al.

Toxicology, Journal Year: 2023, Volume and Issue: 501, P. 153706 - 153706

Published: Dec. 12, 2023

Language: Английский

Citations

Association of urinary glyphosate levels with iron homeostasis among a representative sample of US adults: NHANES 2013–2018 DOI

Pei‐Lun Chu,

Chia-Sung Wang,

Chikang Wang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 284, P. 116962 - 116962

Published: Aug. 28, 2024

Glyphosate and glyphosate-based herbicides (GBH), widely used globally, were initially considered harmless to humans. Experimental studies have suggested that these substances can disrupt iron homeostasis by interfering with uptake or triggering inflammatory responses. However, their potential impact on human remains underexplored.

Language: Английский

Citations

Glyphosate and AMPA in saliva and other traditional human matrices. New findings for less invasive biomonitoring to the exposure to pesticides DOI

Iohanna Filippi, Pilar Fernández, Joan O. Grimalt

et al.

Environmental Advances, Journal Year: 2023, Volume and Issue: 15, P. 100474 - 100474

Published: Dec. 23, 2023

Human biomonitoring of the exposure to pesticides is usually performed in biological matrices such as urine and plasma. However, possibility using less invasive allows screening large number subjects. The objective this study was evaluate body burden most widely used herbicide, Glyphosate (GLY), its main metabolite, aminomethylphosphonic acid (AMPA), different populations from province Córdoba (Argentina), propose saliva a matrix for possible implementation pesticides. AMPA concentrations were evaluated urine, plasma, subjects occupationally environmentally exposed one important agricultural areas Argentina. Gas chromatography coupled tandem mass spectrometry (MS/MS) identification quantification analytes. Both GLY quantified all with higher detection frequency (DF) group than non-occupationally individuals. Among matrices, highest DF concentration levels found saliva. Moreover, only statistical difference between groups saliva, indicating use non-invasive human scenarios exposure. No significant correlation traditional (urine blood) measure This first report presence samples. Results present are relevant future GLY, but also general. Saliva deserved further investigation an alternative, easy, economical involving methods screenings populations.

Language: Английский

Citations

Correlation of Urinary Glyphosate Levels with Whole Blood Selenium Levels among a Representative Sample of US Adults: NHANES 2013-2018 DOI

Pei‐Lun Chu, Ching-Chung Hsiao, Chikang Wang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 3, 2024

Abstract Purpose: Glyphosate and glyphosate-based herbicides (GBH), extensively utilized as worldwide, have been associated with numerous health issues. Previous experimental studies indicated their potential to disrupt selenium homeostasis by either interfering uptake or increasing oxidative stress. However, there is a significant research gap concerning the connection between glyphosate exposure status in epidemiological studies, particularly within nationally representative samples. Methods: In this study, we examined data from 2013-2018 National Health Nutrition Examination Survey (NHANES), involving 3011 participants aged 3 above. Our main objective was examine urinary levels, whole blood selenium, intake. Results: Our analysis did not uncover an association Nevertheless, observed negative correlation levels ß coefficient of -1.984, S.E. = 0.639, P 0.003 final model. We also reported notable decrease average concentrations tertiles increased, P-values for trend 0.033. Furthermore, prominent among females, non-Hispanic whites, individuals lower Conclusions: thorough examination NHANES data, our study uncovers possible detrimental levels. These findings underscore importance further investigation into consequences its influence on status, thereby raising awareness implications public health.

Language: Английский

Citations

An update of the impact of pesticide exposure on memory and learning DOI

Karol Ferreira Honatel, Bruno Dutra Arbo, Mirna Bainy Leal

et al.

Deleted Journal, Journal Year: 2024, Volume and Issue: 1(1)

Published: Nov. 11, 2024

The dependence on the use of pesticides in agribusiness leads to an increase human exposure these chemical compounds through occupational activity, contamination environment, food and water. nervous system is target most insecticidal when are poorly selective, they can harm non-target species, including humans. This work aimed investigate effects pesticide memory learning. Articles published PubMed database between 2015 2024 were reviewed. One hundred sixty-one articles included this review, which one thirty two preclinical studies twenty-nine studies. Among studies, organophosphates, pyrethroids, neonicotinoids, carbamates, addition herbicides, fungicides mixed exposures was associated with learning deficits animals such as bees, mosquitoes, fishes, mice, rats, bats. Olfactory, associative aversive learning, well capacity affected by pesticides. Most evaluated environmental organophosphate pesticides, pyrethroids carbamates outcomes interest. Living close application areas having parents working agriculture worse scores childhood adolescence. Prenatal insecticides has already been poorer attention skills attention-deficit/hyperactivity disorder (ADHD) symptoms, intellectual disability, autism spectrum disorder, motor delays, problems. In adults, during activity also performance. evidence found review suggests that different mechanisms action able cause some cognitive impairment. Developmental exposure, chronic contribute performance, especially memory.

Language: Английский

Citations

Association between glyphosate exposure and cardiovascular health using “Life’s Essential 8” metrics in US adults DOI

Yali Zhu,

Zhenlin Yang, Yuhao Chen

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 290, P. 117559 - 117559

Published: Dec. 17, 2024

Language: Английский

Citations