Molecular Pharmaceutics,
Journal Year:
2024,
Volume and Issue:
21(4), P. 2012 - 2024
Published: March 18, 2024
The
nonviral
delivery
systems
that
combine
genes
with
photosensitizers
for
multimodal
tumor
gene/photodynamic
therapy
(PDT)
have
attracted
much
attention.
In
this
study,
a
series
of
ROS-sensitive
cationic
bola-lipids
were
applied
the
gene/photosensitizer
codelivery.
Zn-DPA
was
introduced
as
headgroup
to
enhance
DNA
binding,
while
hydrophobic
linking
chains
may
facilitate
formation
lipid
nanoparticles
(LNP)
and
encapsulation
photosensitizer
Ce6.
length
chain
played
an
important
role
in
gene
transfection
process,
14-TDZn
containing
longest
showed
better
condensation,
transfection,
cellular
uptake.
LNPs
could
well
load
Ce6
form
14-TDC
without
loss
efficiency.
used
codelivery
p53
achieve
enhanced
therapeutic
effects
on
cell
proliferation
inhibition
apoptosis.
Results
system
more
effective
than
individual
or
monotherapy.
Mechanism
studies
production
ROS
after
irradiation
increase
accumulation
protein
cells,
thereby
promoting
caspase-3
activation
inducing
apoptosis,
indicating
some
synergistic
effect.
These
results
demonstrated
serve
promising
nanocarrier
gene/PDT
combination
therapy.
Pharmaceuticals,
Journal Year:
2024,
Volume and Issue:
17(2), P. 195 - 195
Published: Feb. 1, 2024
Hypoxia-inducible
factor-1
(HIF-1)
is
a
key
regulator
for
balancing
oxygen
in
the
cells.
It
transcription
factor
that
regulates
expression
of
target
genes
involved
homeostasis
response
to
hypoxia.
Recently,
research
has
demonstrated
multiple
roles
HIF-1
pathophysiology
various
diseases,
including
cancer.
crucial
mediator
hypoxic
and
metabolism,
thus
contributing
tumor
development
progression.
Studies
showed
HIF-1α
subunit
significantly
upregulated
cancer
cells
promotes
survival
by
mechanisms.
In
addition,
potential
progression,
cell
division,
survival,
proliferation,
angiogenesis,
metastasis.
Moreover,
role
regulating
cellular
metabolic
pathways,
particularly
anaerobic
metabolism
glucose.
Given
its
significant
it
been
an
intriguing
therapeutic
research.
Several
compounds
targeting
HIF-1-associated
processes
are
now
being
used
treat
different
types
This
review
outlines
emerging
strategies
as
well
relevance
regulation
pathways
addresses
employment
nanotechnology
developing
these
promising
strategies.
Critical Reviews in Oncology/Hematology,
Journal Year:
2024,
Volume and Issue:
197, P. 104351 - 104351
Published: April 12, 2024
Breast
cancer
is
potentially
a
lethal
disease
and
leading
cause
of
death
in
women.
Chemotherapy
radiotherapy
are
the
most
frequently
used
treatment
options.
Drug
resistance
advanced
breast
limits
therapeutic
output
treatment.
The
endocrine
hormonal
imbalance,
particularly
triple
negative
HER2
positive
cancers.
efflux
drugs
due
to
p-gp's
activity
another
resistance.
resistant
protein
also
contributes
significantly.
Strategies
combat
include
use
nanoparticles
target
drug
delivery
by
co-delivery
chemotherapeutic
genes
(siRNA
miRNA)
that
help
down-regulate
causing
siRNA
specific
effectively
silences
p-gp
other
proteins
chemosensitizers
effective
overcoming
Chemo-sensitizers
sensitize
cells
effects
drugs.
Novel
anti-neoplastic
agents
such
as
antibody-drug
conjugates
mesenchymal
stem
tools
improve
response
cancer.
Similarly,
combination
photo/thermal
ablation
with
chemotherapy
can
act
overcome
In
this
review,
we
focus
on
mechanism
nanoparticle-based
strategies
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(27)
Published: March 7, 2024
Abstract
Nucleic
acid
drugs
are
widely
used
in
biomedical
fields.
However,
one
of
the
main
challenges
vivo
is
to
selectively
deliver
nucleic
subcellular
compartments.
To
solve
this
problem,
an
oncolytic
virus‐like
nanoparticle,
OV@FN,
constructed
that
can
directly
acids
cytoplasm
through
membrane
fusion
response
slightly
acidic
environment
tumor.
OV@FN
composed
a
nano‐core
(NA‐Zn@G)
accurately
release
high
concentrations
glutathione
tumor
cells
and
hybrid
vesicle
(FN)
expressing
virus
glycoprotein
(mVSV‐G).
The
study
findings
suggest
efficiently
delivers
cells,
as
compared
normal
cells.
Importantly,
FN
effectively
induces
form
syncytium,
thus
promoting
intracellular
drug
diffusion,
enhancing
gene
therapy
effect.
In
silencing
test
shows
OV
siR
@FN
has
significant
delivery
performance.
melanoma
model,
3pdsR
remarkable
ablation
ability
improves
immunosuppressive
microenvironment
site.
offers
novel
approach
designing
platforms.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(1), P. 658 - 658
Published: Jan. 4, 2024
High-throughput
genetic
screening
is
useful
for
discovering
critical
genes
or
gene
sequences
that
trigger
specific
cell
functions
and/or
phenotypes.
Loss-of-function
mainly
achieved
through
RNA
interference
(RNAi),
CRISPR
knock-out
(CRISPRko),
and
(CRISPRi)
technologies.
Gain-of-function
depends
on
the
overexpression
of
a
cDNA
library
activation
(CRISPRa).
Base
editing
can
perform
both
gain-
loss-of-function
screening.
This
review
discusses
techniques
based
Cas9
nuclease,
including
Cas9-mediated
genome
dCas9-based
interference.
We
compare
these
methods
with
previous
RNAi
propose
future
prospects
applications
PubMed,
Journal Year:
2024,
Volume and Issue:
18(2), P. 94 - 99
Published: Feb. 2, 2024
Some
failures
in
ovary
function,
like
folliculogenesis
and
oogenesis,
can
give
rise
to
various
infertility-associated
problems,
including
polycystic
syndrome
(PCOS)
premature
ovarian
insufficiency
(POI).
PCOS
influences
8
20%
of
women;
while
POI
occurs
at
least
1%
all
women.
Regrettably,
the
current
therapies
for
these
diseases
have
not
sufficiently
been
effective,
finding
a
suitable
strategy
is
still
puzzle.
One
helpful
strategies
managing
treating
disorders
understanding
contributing
pathogenesis
mechanisms.
Recently,
it
has
declared
that
abnormal
expression
microRNAs
(miRNAs),
as
subset
non-coding
RNAs,
involved
reproductive
diseases.
Among
miRNAs,
roles
miRNA-21
highlighted
some
documents;
hence,
purpose
this
mini-review
was
summarize
evidences
conjunction
with
functions
miRNA
other
effective
normal
or
(i.e.,
POI)
mechanistic
insight.
