International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(1), P. 675 - 675
Published: Jan. 4, 2024
Excess
body
weight
constitutes
one
of
the
major
health
challenges
for
societies
and
healthcare
systems
worldwide.
Besides
type
diet,
calorie
intake
lack
physical
exercise,
recent
data
have
highlighted
a
possible
association
between
endocrine-disrupting
chemicals
(EDCs),
such
as
bisphenol
A,
phthalates
their
analogs,
obesity.
EDCs
represent
heterogeneous
group
that
may
influence
hormonal
regulation
mass
adipose
tissue
morphology.
Based
on
available
from
mechanistic,
animal
epidemiological
studies
including
meta-analyses,
evidence
points
towards
contribution
to
development
obesity,
associated
disorders
obesity-related
dysfunction
by
(1)
impacting
adipogenesis;
(2)
modulating
epigenetic
pathways
during
development,
enhancing
susceptibility
obesity;
(3)
influencing
neuroendocrine
signals
responsible
appetite
satiety;
(4)
promoting
proinflammatory
milieu
in
inducing
state
chronic
subclinical
inflammation;
(5)
dysregulating
gut
microbiome
immune
homeostasis;
(6)
thermogenic
tissue.
Critical
periods
exposure
obesogenic
are
prenatal,
neonatal,
pubertal
reproductive
periods.
Interestingly,
even
at
low
doses
promote
transgenerational
inheritance
adult
obesity
subsequent
generations.
The
aim
this
review
is
summarize
role
EDCs,
specifically
BPA
phthalate
plasticizers,
taking
into
account
vitro,
epidemiologic
studies;
discuss
mechanisms
linking
analyze
effects
critical
exposure;
present
interesting
perspectives,
preventive
measures
research
area.
Expert Review of Endocrinology & Metabolism,
Journal Year:
2024,
Volume and Issue:
19(4), P. 307 - 315
Published: May 18, 2024
The
environmental
spread
of
pollutants
has
led
to
a
persistent
exposure
living
beings
multiple
chemicals,
by
now
become
ubiquitous
in
the
surrounding
environment.
Environmental
these
substances
been
reported
cause
multi-
and/or
transgenerational
health
effects.
Per-
and
Polyfluorinated
Substances
(PFAS)
raise
great
concern,
given
their
known
effects
both
as
endocrine
disruptors
potential
carcinogens.
multi/trans-generational
different
have
investigated
several
studies,
harmful
observed
also
for
PFAS.
Cancers,
Journal Year:
2024,
Volume and Issue:
16(5), P. 983 - 983
Published: Feb. 28, 2024
This
exploratory
narrative
review
paper
delves
into
the
intricate
interplay
between
per-
and
polyfluoroalkyl
substances
(PFAS)
exposure,
sociodemographic
factors,
influence
of
stressors
in
context
endometrial
cancer.
PFAS,
ubiquitous
environmental
contaminants
notorious
for
their
persistence
ecosystem,
have
garnered
attention
potential
to
disrupt
endocrine
systems
provoke
immune
responses.
We
comprehensively
examine
various
sources
PFAS
encompassing
household
items,
water,
air,
soil,
thus
shedding
light
on
multifaceted
routes
through
which
individuals
encounter
these
compounds.
Furthermore,
we
explore
such
as
income,
education,
occupation,
ethnicity/race,
geographical
location
relationship
cancer
risk.
also
investigated
role
stress
exposure
The
results
revealed
a
significant
impact
factors
both
levels
Stress
emerged
notable
contributing
factor
influencing
development
cancer,
further
emphasizing
importance
management
practices
overall
well-being.
By
synthesizing
evidence
from
diverse
fields,
this
underscores
need
interdisciplinary
research
targeted
interventions
address
complex
stressors,
Advances in environmental engineering and green technologies book series,
Journal Year:
2025,
Volume and Issue:
unknown, P. 33 - 80
Published: Jan. 16, 2025
The
treatment
of
industrial
and
pharmaceutical
wastewater
is
a
serious
environmental
problem
because
these
contaminants
are
toxic
varied,
endangering
both
human
health
aquatic
ecosystems.
various
difficulties
involved
in
treating
complicated
effluents
examined
this
review
paper.
An
increasing
number
contaminants,
including
pharmaceuticals
endocrine-disrupting
chemicals,
emerging,
the
wastewater's
complex
chemical
compositions,
which
combine
organic
inorganic
materials,
major
issues.
By
using
microorganisms
to
break
down
pollutants,
bioremediation
has
become
more
effective
through
development
microbial
engineering.
analysis
accentuates
need
constant
efforts
towards
research
development,
dynamic
nature
legislative
regulatory
frameworks,
for
industry
government
organizations
collaborate
public
awareness.
This
thorough
emphasizes
how
urgently
research,
funding,
support
needed
create
efficient
sustainable
techniques.
Scientific Reports,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Feb. 3, 2025
Increasing
evidence
suggests
that
endocrine-disrupting
chemicals
(EDCs)
have
adverse
effects
on
breast
cancer
(BC).
The
aim
of
this
study
was
to
assess
the
association
between
exposure
prevalent
EDCs—phenols
and
parabens—and
risk
developing
BC.
Data
urinary
bisphenol
A
(BPA),
triclosan
(TRS),
benzophenone-3
(BP3),
methyl
paraben
(MPB),
ethyl
(EPB),
propyl
(PPB),
butyl
(BUP)
were
obtained
from
2005–2014
National
Health
Nutrition
Examination
Survey.
total
4455
subjects
included
in
cross-sectional
study.
results
weighted
multivariable
regression
models
indicated
elevated
concentrations
TRS
increased
BC
by
2.33
(Q2:
95%
CI
=
1.45–3.75,
p
<
0.001)
1.94
times
(Q3:
1.21–3.09,
0.006),
respectively.
nonlinear
statistically
significant
(P
0.007),
with
restricted
cubic
splines
(RCS)
curve
exhibiting
an
inverted
U
shape.
more
pronounced
among
overweight
individuals
(BMI
≥
25
kg/m2),
those
aged
60
years,
white
individuals.
Weighted
quantile
sum
(WQS)
Bayesian
Kernel
Machine
Regression
(BKMR)
analysis
revealed
no
overall
mixtures
phenol
metabolites
risk.
However,
most
influential,
higher
(both
continuous
categorical)
significantly
associated
risk,
particularly
