EUROPEAN JOURNAL OF ENVIRONMENTAL SCIENCES,
Journal Year:
2024,
Volume and Issue:
14(1), P. 49 - 58
Published: June 24, 2024
This
survey
focused
on
a
detailed
analysis
of
the
ability
fluvial
Quaternary
sediments
to
remove
pharmaceuticals
and
personal
care
products
(PPCPs)
from
drinking
water.
Thirty-eight
PPCPs
were
detected
in
Jizera
River,
which
is
used
after
infiltration
produce
water
by
Káraný
waterworks.
Several
occurred
at
concentrations
exceeding
100
ng/l,
some
are
not
possible
(oxypurinol,
acesulfame).
The
presence
was
monitored
during
passage
through
sandy
gravels
receiving
well
(total
distance
180
m)
monthly
intervals
2022–2023.
can
be
divided
into
different
groups
based
results.
Iohexol,
iopromide,
metoprolol,
cetirizine,
valsartan
clarithromycin
already
below
established
threshold
passing
60
m
gravel.
Other
substances
gradually
attenuated
diverse
group
remained
groundwater
even
subsoil.
Surprisingly,
PPCP
with
high
degree
attenuation,
such
as
metformin,
whose
concentration
drops
original
value
677
ng/l
16
this
group.
member
lowest
attenuation
sulfamethoxazole
9%.
Five
(benzotriazole,
propylparaben,
bisphenol
S,
hydrochlorothiazide,
ibuprofen-2-hydroxy)
identified
most
problematic
since
they
passed
quaternary
aquifer
practically
unchanged
process
qualitative
treatment
using
artificial
appears
ineffective.
Frontiers in Endocrinology,
Journal Year:
2024,
Volume and Issue:
15
Published: Aug. 15, 2024
Diabetes
and
its
complications
significantly
affect
individuals’
quality
of
life.
The
etiology
diabetes
mellitus
associated
is
complex
not
yet
fully
understood.
There
an
increasing
emphasis
on
investigating
the
effects
endocrine
disruptors
diabetes,
as
these
substances
can
impact
cellular
processes,
energy
production,
utilization,
ultimately
leading
to
disturbances
in
homeostasis.
Mitochondria
play
a
crucial
role
generation,
any
impairment
organelles
increase
susceptibility
diabetes.
This
review
examines
most
recent
epidemiological
pathogenic
evidence
concerning
link
between
including
complications.
analysis
suggests
that
disruptor-induced
mitochondrial
dysfunction—characterized
by
disruptions
electron
transport
chain,
dysregulation
calcium
ions
(Ca
2+
),
overproduction
reactive
oxygen
species
(ROS),
initiation
signaling
pathways
related
apoptosis—may
be
key
mechanisms
connecting
development
Current Nutrition Reports,
Journal Year:
2025,
Volume and Issue:
14(1)
Published: Jan. 8, 2025
Abstract
Purpose
of
Review
Endocrine
disruptors
(EDs)
can
mimic
or
interfere
with
hormones
in
the
body,
leading
to
non-communicable
diseases,
such
as
obesity,
diabetes,
and
metabolic
syndrome.
Susceptibility
EDs
increases
during
prenatal
postnatal
life,
a
critical
time
window.
This
review
aims
summarize
latest
evidence
on
relation
early
life
exposure
some
obesity
other
disorders.
Recent
Findings
There
is
increasing
that
may
impair
adipogenesis
by
number
size
adipocytes,
thereby
susceptibility
childhood.
It
stated
period
raise
risk
type
2
diabetes
adulthood
disrupting
glucose,
lipid,
insulin
homeostasis
offspring.
They
also
accelerate
development
1
through
various
mechanisms,
like
immunomodulation,
gut
microbiota,
vitamin
D
pathways.
Summary
growing
understanding
ED
stages
could
play
an
important
role
We
suggest
setting
national
goals,
global
standards,
policies
reduce
environmental
pregnant
lactating
women,
babies,
considered
sensitive
populations.
Journal of Xenobiotics,
Journal Year:
2025,
Volume and Issue:
15(1), P. 13 - 13
Published: Jan. 17, 2025
Endocrine-disrupting
chemicals
(EDCs)
are
natural
or
synthetic
substances
that
able
to
interfere
with
hormonal
systems
and
alter
their
physiological
signaling.
EDCs
have
been
recognized
as
a
public
health
issue
due
widespread
use,
environmental
persistence
the
potential
levels
of
long-term
exposure
implications
in
multiple
pathological
conditions.
Their
reported
adverse
effects
pose
critical
concerns
about
warranting
strict
regulation.
This
is
case
bisphenol
A
(BPA),
well-known
EDC
whose
tolerable
daily
intake
(TDI)
was
re-evaluated
2023
by
European
Food
Safety
Authority
(EFSA),
immune
system
has
identified
most
sensitive
BPA
exposure.
Increasing
scientific
evidence
indicates
can
several
hormone
receptors,
pathways
interacting
proteins,
resulting
complex,
cell
context-dependent
response
may
differ
among
tissues.
In
this
regard,
neuronal
important
targets
signaling
now
emerging
players
endocrine
disruption.
Here,
we
use
its
analogs
proof-of-concept
address
detrimental
on
nervous
highlight
complex
interrelationships
within
immune-neuroendocrine
network
(INEN).
Finally,
propose
Receptor
for
Activated
C
Kinase
1
(RACK1),
an
target
valuable
screening
tool,
could
serve
central
hub
our
toxicology
model
explain
bisphenol-mediated
INEN.
Journal of Xenobiotics,
Journal Year:
2025,
Volume and Issue:
15(1), P. 14 - 14
Published: Jan. 17, 2025
Dietary
exposure
to
the
plasticiser
bisphenol
A
(BPA),
an
obesogenic
and
endocrine
disruptor
from
plastic
epoxy
resin
industries,
remains
prevalent
despite
regulatory
restriction
food
safety
efforts.
BPA
can
be
accumulated
in
humans
animals,
potentially
exerting
differential
health
effects
based
on
individual
metabolic
capacity.
This
pilot
study
examines
impact
of
direct
ex
vivo
gut
microbiota
obese
normal-weight
children,
using
16S
rRNA
amplicon
sequencing
anaerobic
culturing
combined
methods.
Results
showed
that
xenobiotic
induced
modifications
microbial
taxa
relative
abundance,
community
structure,
diversity.
Specifically,
reduced
abundance
bacteria
belonging
phylum
Bacteroidota,
while
Actinomycetota
were
promoted.
Consistently,
Bacteroides
species
classified
as
sensitive
BPA,
whereas
class
Clostridia
identified
resistant
our
culturomics
analysis.
Some
altered
bacterial
patterns
common
for
both
BPA-exposed
groups
non-exposed
group
study.
These
findings
also
corroborated
a
larger
cohort
children.
Future
research
will
essential
evaluate
these
potential
biomarkers
biomonitoring
effect
its
role
substance
Polymers for Advanced Technologies,
Journal Year:
2025,
Volume and Issue:
36(1)
Published: Jan. 1, 2025
ABSTRACT
In
the
present
study,
hexagonal
boron
nitride
(h‐BN)
nanosheets
were
first
functionalized
with
hydroxyl
groups
(h‐BN‐OH),
and
then
phosphonic
acid
grafted
onto
h‐BN
surface
(BNP)
using
aminotris(methylenephosphonic
acid)
(ATMP)
through
a
condensation
reaction.
The
BNP
was
incorporated
into
polyvinyl
chloride
(PVC)
matrix
to
prepare
PVC/BNP
composites.
Thermogravimetric
analysis
showed
an
increase
in
thermal
stability,
BNP/PVC
composites
exhibiting
greater
resistance
degradation
at
elevated
temperatures.
addition
of
improved
dispersion
interfacial
adhesion
within
PVC
matrix,
as
confirmed
by
Scanning
Electron
Microscopy
(SEM).
Furthermore,
exhibited
22.5%
tensile
strength
(21.2
MPa)
82%
improvement
elongation
break
(464%)
compared
pristine
composites,
which
17.3
MPa
255%.
Moreover,
notably
conductivity
from
0.18
1.50
W/m
K
content
increased
BNP‐0
BNP‐4.
These
improvements
stability
mechanical
strength,
well
excellent
migration
resistance,
make
highly
promising
for
advanced
applications.
Frontiers in Endocrinology,
Journal Year:
2025,
Volume and Issue:
16
Published: Jan. 24, 2025
G
Protein-Coupled
Estrogen
Receptor
1
(GPER-1)
is
a
membrane
estrogen
receptor
that
has
emerged
as
key
player
in
breast
cancer
development
and
progression.
In
addition
to
its
direct
influence
on
signaling,
crucial
interaction
between
GPER-1
the
hypothalamic-pituitary-gonadal
(HPG)
axis
been
evidenced.
The
novel
complex
relationship
HPG
implies
hormonal
regulation
with
important
homeostatic
effects
general
organ
reproductive
tissues,
but
also
pathophysiology
of
cancer,
especially
cancer.
Recent
research
points
great
versatility
GPER-1,
interacting
classical
receptors
signaling
pathways
related
inflammation.
Importantly,
through
activation
by
environmental
synthetic
estrogens,
associated
hormone
therapy
resistance
These
findings
open
new
perspectives
understanding
tumor
raise
possibility
future
applications
design
more
personalized
effective
therapeutic
approaches.
BIO Web of Conferences,
Journal Year:
2025,
Volume and Issue:
155, P. 10001 - 10001
Published: Jan. 1, 2025
Bisphenol
A
(BPA)
is
increasingly
released
into
water,
soil,
and
air,
becoming
an
environmental
pollutant.
Since
BPA
persistent
in
the
environment,
it
remains
there
for
a
considerable
amount
of
time
allows
bioaccumulation,
potentially
affecting
ecosystems
human
health.
For
that
reason,
detection
environment
essential.
In
this
study,
we
develop
electrochemical
sensor
simple
rapid
water
environment.
The
was
developed
using
glassy
carbon
electrode
(GCE)
modified
with
conductive
materials.
carried
out
based
on
oxidation
GCE
differential
pulse
voltammetry
technique.
performs
acceptable
analytical
performance
limit
0.5
μM
sensitivity
0.22
μA
-1
.
also
has
potency
samples.
