Cited by Copper oxide nanoparticles induce non-alcoholic fatty liver disease by disrupting bile acid homeostasis and perturbing the intestinal microbial homeostasis

The micro(nano)plastics perspective: exploring cancer development and therapy DOI

Xiangying Deng,

Yajun Gui,

Lin Zhao

et al.

Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)

Published: Jan. 24, 2025

Microplastics, as an emerging environmental pollutant, have received widespread attention for their potential impact on ecosystems and human health. Microplastics are defined plastic particles less than 5 millimeters in diameter can be categorized primary secondary microplastics. Primary microplastics usually originate directly from industrial production, while formed by the degradation of larger items. capable triggering cytotoxicity chronic inflammation, may promote cancer through mechanisms such pro-inflammatory responses, oxidative stress endocrine disruption. In addition, improved bring new perspectives to therapy, studies drug carriers underway, showing high targeting bioavailability. Although current suggest association between certain cancers (e.g., lung, liver, breast cancers), long-term effects specific still need studied. This review aimed at exploring carcinogenicity promising applications therapy provides important directions future research emphasizes multidisciplinary collaboration address this global health challenge.

Language: Английский

Citations

Polypropylene durable amphiphilicity through interfacial macromolecular implantation DOI

Shunzhong Cai,

Renhai Zhao,

Ruilong Liu

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 161428 - 161428

Published: March 1, 2025

Language: Английский

Citations

The efficient prediction of inflammatory osteolysis caused by polylactic acid through network toxicology and molecular docking strategy DOI

Zichen Cui, He Tian, Shuo Zhang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 291, P. 117876 - 117876

Published: Feb. 1, 2025

Polylactic acid (PLA), as a bioplastic, is extensively utilized in bone tissue engineering for its biocompatibility, adaptability and affordability. However, the toxicological research of PLA still limited. The hydrolysis products induced inflammatory response which caused osteolysis mediated by oxidative damage through recruitment macrophages accumulation foreign body multinucleated giant cells, ultimately leading to failure regeneration. lack effective treatments highlights importance finding new therapies. This study systematically investigated potential molecular mechanisms PLA-induced employing network toxicology docking techniques. We first conducted toxicology-based assessment according structure PLA. result from integrating screening targets multiple databases identified 126 associated with osteolysis, then an interaction diagram was constructed. Gene ontology (GO)/KEGG enrichment analysis clarified that may cause via metabolic pathways cancer, well lipid atherosclerosis. Further STRING Cytoscape software screened 25 core including HSP90AA1, AKT1, SRC, STAT1 FYN. found enriched highly correlated covered 18 targets, supporting scientific hypothesis induces osteolysis. Moreover, results confirmed displayed strong binding ability formed stable binding. Taken together, this not only revealed biological mechanism but also provided evidence future prevention treatment inflammation.

Language: Английский

Citations

Exploring Environmental Behaviors and Health Impacts of Biodegradable Microplastics DOI

Yuhao Yan, Jun Cheng, Jie Gao

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: March 21, 2025

Biodegradable plastics (BPs) are promoted as eco-friendly alternatives to conventional plastics. However, compared microplastics (MPs), they degrade rapidly into biodegradable (BMPs), which may lead a more significant accumulation of BMPs in the environment. This review systematically compares and MPs, summarizes current knowledge on their environmental behaviors impacts ecosystems human health, offers recommendations for future research. detected water, sediments, indoor dust, food, marine organisms, samples. Compared prone transformations, such photodegradation biodegradation, results shorter migration distance across different matrices. Like can adsorb pollutants transport them enhancing toxicity health risks through Trojan horse effect. Studies indicate that negatively impact terrestrial aquatic than MPs by disrupting nutrient cycling inhibiting plant animal growth. In vivo vitro research also shows BMP degradation products increase bioavailability, exacerbating neurotoxicity overall toxicity. findings BMPs' effects remain inconsistent. Further evaluation trade-offs between biodegradability is needed address these uncertainties.

Language: Английский

Citations

Integrated transcriptomics and metabolomics reveal the mechanism of polystyrene nanoplastics toxicity to mice DOI

Shi Jian-zhou,

Xianyi Yu,

Jinbing Zhao

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 284, P. 116925 - 116925

Published: Aug. 27, 2024

Microplastic (MP) are an emerging environmental pollutant, which has toxic effects on organisms, and it received extensive attention currently. Studying the transcriptomic metabolic responses of mice to nanoplastic-contaminated water is critical for understanding molecular-level toxicity nanoplastics (NPs), but there few studies this topic. To analyze different concentrations polystyrene (PS) at transcriptome metabolism spleens study molecular toxicity. Here, testing histopathology spleen female was performed after drinking containing 0.1 μm PS-NPs (1 mg/mL 50 mg/mL) 49 days, respectively. The tissue samples were subjected metabolome sequencing. Four differentially expressed genes randomly chosen qRT-PCR confirm correctness Common Kyoto encyclopedia genomes (KEGG) pathway analysis showed that a large number differential metabolites mainly focused immune, inflammation, neurodegenerative disease, cardiovascular nervous, etc. in organism systems module; lipid, amino acid, taurine hypotaurine metabolisms, signaling translation, molecules interaction, neuroactive ligand-receptor information processing. results levels confirmed immune system affected contaminated with nanoplastics.

Language: Английский

Citations

Hazard assessment of airborne and foodborne biodegradable polyhydroxyalkanoates microplastics and non-biodegradable polypropylene microplastics DOI

Hua Zha, Shengjie Li,

Aoxiang Zhuge

et al.

Environment International, Journal Year: 2025, Volume and Issue: unknown, P. 109311 - 109311

Published: Jan. 1, 2025

Language: Английский

Citations

Nanoplastics and microplastics released from an enzyme-embedded biodegradable polyester during hydrolysis DOI

Nyuk Ling,

Zi-Yang Fan,

Wen-Qian Lian

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 489, P. 137640 - 137640

Published: Feb. 16, 2025

Language: Английский

Citations

A novel approach for rapid quantification and length distribution of microfibers released during domestic laundry DOI

Qiyang Han,

Xiongying Wu,

Xuemei Ding

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 137638 - 137638

Published: Feb. 1, 2025

Language: Английский

Citations

Encapsulation and delivery systems based on natural biological macromolecules: Focusing on nutrients in infant formula DOI

Runze Li, Shihang Li, Chen Chen

et al.

Trends in Food Science & Technology, Journal Year: 2025, Volume and Issue: unknown, P. 104974 - 104974

Published: March 1, 2025

Language: Английский

Citations

In vivo and in vitro degradation and biological toxicity studies of polyesters with varying degradation rates DOI

Ze-Yang Zhang,

Wei-Zhen Zheng,

Zhi‐Chao Zhen

et al.

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 492, P. 138196 - 138196

Published: April 17, 2025

Language: Английский

Citations