Lecture notes in computer science, Journal Year: 2024, Volume and Issue: unknown, P. 405 - 420
Published: Jan. 1, 2024
Language: Английский
Lecture notes in computer science, Journal Year: 2024, Volume and Issue: unknown, P. 405 - 420
Published: Jan. 1, 2024
Language: Английский
Food and Chemical Toxicology, Journal Year: 2024, Volume and Issue: 190, P. 114792 - 114792
Published: June 6, 2024
Language: Английский
Citations
3International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13363 - 13363
Published: Dec. 13, 2024
While cisplatin is an effective anti-tumor treatment, it induces ototoxicity through mechanisms involving DNA damage, oxidative stress, and programmed cell death. Rho-associated coiled-coil-containing protein kinase (ROCK) essential for numerous cellular processes, including apoptosis regulation. Studies have suggested that ROCK inhibitors could prevent promote regeneration. We aimed to investigate the protective effects of inhibitor fasudil against cisplatin-induced in a zebrafish model. The larvae were exposed 1 mM alone or co-administered with varying concentrations 4 h. surviving hair counts, apoptosis, reactive oxygen species (ROS) levels, mitochondrial membrane potential (ΔΨm), caspase 3 activity, autophagy activation assessed. Rheotaxis behavior was also examined. Cisplatin reduced counts; increased ROS production, ΔΨm loss; activated autophagy. Fasudil (100 500 µM) mitigated loss, inhibited activation. preserved by co-administration cisplatin. zebrafish, whereas promising agent ototoxicity.
Language: Английский
Citations
1Journal of the Association for Research in Otolaryngology, Journal Year: 2024, Volume and Issue: 25(2), P. 167 - 177
Published: Feb. 15, 2024
Language: Английский
Citations
0Lecture notes in computer science, Journal Year: 2024, Volume and Issue: unknown, P. 405 - 420
Published: Jan. 1, 2024
Language: Английский
Citations
0