Protective effects of Y-27632 against cisplatin-induced ototoxicity: A zebrafish model Y-27632 and cisplatin-induced ototoxicity

Food and Chemical Toxicology, Journal Year: 2024, Volume and Issue: 190, P. 114792 - 114792

Published: June 6, 2024

Language: Английский

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Protective Effects of Fasudil Against Cisplatin-Induced Ototoxicity in Zebrafish: An In Vivo Study

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(24), P. 13363 - 13363

Published: Dec. 13, 2024

While cisplatin is an effective anti-tumor treatment, it induces ototoxicity through mechanisms involving DNA damage, oxidative stress, and programmed cell death. Rho-associated coiled-coil-containing protein kinase (ROCK) essential for numerous cellular processes, including apoptosis regulation. Studies have suggested that ROCK inhibitors could prevent promote regeneration. We aimed to investigate the protective effects of inhibitor fasudil against cisplatin-induced in a zebrafish model. The larvae were exposed 1 mM alone or co-administered with varying concentrations 4 h. surviving hair counts, apoptosis, reactive oxygen species (ROS) levels, mitochondrial membrane potential (ΔΨm), caspase 3 activity, autophagy activation assessed. Rheotaxis behavior was also examined. Cisplatin reduced counts; increased ROS production, ΔΨm loss; activated autophagy. Fasudil (100 500 µM) mitigated loss, inhibited activation. preserved by co-administration cisplatin. zebrafish, whereas promising agent ototoxicity.

Language: Английский

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Measuring Optokinetic Reflex and Vestibulo-Ocular Reflex in Unilateral Vestibular Organ Damage Model of Zebrafish

Journal of the Association for Research in Otolaryngology, Journal Year: 2024, Volume and Issue: 25(2), P. 167 - 177

Published: Feb. 15, 2024

Language: Английский

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Meeting Pattern Detection from Trajectories in Road Network

Lecture notes in computer science, Journal Year: 2024, Volume and Issue: unknown, P. 405 - 420

Published: Jan. 1, 2024

Language: Английский

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