Plastics derived endocrine‐disrupting compounds and their effects on early development

Birth Defects Research, Journal Year: 2020, Volume and Issue: 112(17), P. 1308 - 1325

Published: June 1, 2020

Abstract Despite the fact that estrogenic effects of bisphenols were first described 80 years ago, recent data about its potential negative impact on birth outcome parameters raises a strong rationale to investigate further. The adverse health plastics recommend measure impacts endocrine‐disrupting compounds (EDCs) such as (BPA, BPS, BPF), bis(2‐ethylhexyl) phthalate, and dibutyl phthalate (DBP) in human health. Exposure these utero may program diseases testis, prostate, kidney abnormalities immune system, cause tumors, uterine hemorrhage during pregnancy polycystic ovary. These also control processes epigenetic transgenerational inheritance adult‐onset by modulating DNA methylation epimutations reproductive cells. early developmental stage is most susceptible window for genomic programming. critical stages events normal lie between many transitions occurring spermatogenesis, egg fertilization fully formed fetus. As cells begin grow differentiate, there are balances hormones, protein synthesis. Data emerging how plastic‐derived affect embryogenesis, placentation feto‐placental development since pregnant women unborn fetuses often exposed factors preconception throughout gestation. Impaired ultimately influences fetal outcomes at center disorders contributes an independent risk factor adult chronic diseases. This review will summarize current status exposure plastic derived EDCs growth, gene expression, angiogenic activities process their possible outcomes.

Language: Английский

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Synthesis of porphyrin porous organic polymers and their application of water pollution treatment: A review

Environmental Technology & Innovation, Journal Year: 2022, Volume and Issue: 29, P. 102972 - 102972

Published: Nov. 25, 2022

With the advance of society and industrialization, a large number organic inorganic pollutants in water cause harm to humans environment. Therefore, development effective pollutant removal methods materials is urgently needed. Porous polymers (POPs) are emerging porous formed by polymerization different structured building blocks. Adjustable pore size structure, specific surface area, high porosity for POPs provide platform study water. The thermal stability insoluble skeleton make them highly stable water, not easily decomposed, produce secondary degradation products. Porphyrins have conjugation systems their molecular centers strongly coordinated with metal ions, which been widely studied applied recent years. Porphyrin (Py-POPs) combine advantages porphyrins photosensitivity. Based on above, researchers enthusiastically working Py-POPs. In this review, we summarized research progress Py-POPs Firstly, introduced structures linkage bonds that up preparation Then application field adsorption green photocatalytic was presented. Finally, prospects challenges further were discussed.

Language: Английский

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Critical Overview on Endocrine Disruptors in Diabetes Mellitus

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(5), P. 4537 - 4537

Published: Feb. 25, 2023

Diabetes mellitus is a major public health problem in all countries due to its high human and economic burden. Major metabolic alterations are associated with the chronic hyperglycemia that characterizes diabetes causes devastating complications, including retinopathy, kidney failure, coronary disease increased cardiovascular mortality. The most common form type 2 (T2D) accounting for 90 95% of cases. These disorders heterogeneous which genetic factors contribute, but so do prenatal postnatal life environmental sedentary lifestyle, overweight, obesity. However, these classical risk alone cannot explain rapid evolution prevalence T2D 1 particular areas. Among factors, we fact exposed growing amount chemical molecules produced by our industries or way life. In this narrative review, aim give critical overview role pollutants can interfere endocrine system, so-called endocrine-disrupting chemicals (EDCs), pathophysiology disorders.

Language: Английский

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BPS‐induced ovarian dysfunction: Protective actions of melatonin via modulation of SIRT‐1/Nrf2/NFĸB and IR/PI3K/pAkt/GLUT‐4 expressions in adult golden hamster

Journal of Pineal Research, Journal Year: 2023, Volume and Issue: 75(1)

Published: April 1, 2023

Abstract Ever‐increasing occurrence of plastic‐manufacturing industries leads to environmental pollution that has been associated with declined human health and increased incidence compromised reproductive health. Female subfertility/infertility is a complex phenomenon toxicants as well lifestyle factors have crucial role play. Bisphenol S (BPS) was believed be “safer” replacement bisphenol A (BPA) but recent data documented its neurotoxic, hepatotoxic, nephrotoxic, reprotoxic attributes. Hence based on the scarcity reports, we investigated molecular insights into BPS‐induced ovarian dysfunction protective actions melatonin against it in adult golden hamsters, Mesocricetus auratus . Hamsters were administered (3 mg/kg BW i.p. alternate days) BPS (150 orally every day) for 28 days. treatment disrupted hypothalamo–pituitary–ovarian (HPO) axis evident by reduced gonadotropins such luteinizing hormone (LH) follicle‐stimulating (FSH), steroids estradiol (E2) progesterone (P4), thyroid hormones namely triiodothyronine (T3) thyroxine (T4) levels along their respective receptors (ERα, TRα, MT‐1) thereby reducing folliculogenesis. exposure also led oxidative stress/inflammation increasing reactive oxygen species metabolic disturbances. However, supplementation restored folliculogenesis/steroidogenesis indicated number growing follicles/corpora lutea E2/P4 levels. Further, stimulated key redox/survival markers silent information regulator transcript‐1 (SIRT‐1), forkhead box O‐1 (FOXO‐1), nuclear factor E2‐related factor‐2 (Nrf2), phosphoinositide 3‐kinase/protein kinase B (PI3K/pAkt) expressions enhanced antioxidant capacity. Moreover, inflammatory load including kappa‐B (NFĸB), cyclooxygenase‐2 (COX‐2), inducible nitric oxide synthase (iNOS) expressions, serum tumor necrosis α (TNFα), C‐reactive protein (CRP) nitrite–nitrate upregulated insulin receptor (IR), glucose uptake transporter‐4 (GLUT‐4), connexin‐43, proliferating cell antigen (PCNA) ovary ameliorating alterations due BPS. In conclusion, found severe deleterious impact while protected physiology from these detrimental changes suggesting potential preemptive candidate toxicant‐compromised female

Language: Английский

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Chronic exposure of bisphenol A impairs carbohydrate and lipid metabolism by altering corresponding enzymatic and metabolic pathways

Environmental Toxicology and Pharmacology, Journal Year: 2020, Volume and Issue: 78, P. 103387 - 103387

Published: April 14, 2020

Language: Английский

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New insights into bisphenols induced obesity in zebrafish (Danio rerio): Activation of cannabinoid receptor CB1

Journal of Hazardous Materials, Journal Year: 2021, Volume and Issue: 418, P. 126100 - 126100

Published: May 24, 2021

Language: Английский

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Bisphenol A Induces Histopathological, Hematobiochemical Alterations, Oxidative Stress, and Genotoxicity in Common Carp (Cyprinus carpio L.)

Oxidative Medicine and Cellular Longevity, Journal Year: 2022, Volume and Issue: 2022, P. 1 - 14

Published: Jan. 28, 2022

Bisphenol A (BPA) is one of the environmental endocrine disrupting toxicants and widely used in industry involving plastics, polycarbonate, epoxy resins. This study was designed to investigate toxicological effects BPA on hematology, serum biochemistry, histopathology different organs common carp (

Language: Английский

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Bisphenol A induces testicular oxidative stress in mice leading to ferroptosis

Asian Journal of Andrology, Journal Year: 2022, Volume and Issue: 25(3), P. 375 - 381

Published: Sept. 23, 2022

Bisphenol A is a common environmental factor and endocrine disruptor that exerts negative impact on male reproductive ability. By exploring bisphenol A-induced testicular cell death using the Institute of Cancer Research (ICR) mouse model, we found ferroptosis phenomenon may exist. Mice were divided into six groups administered different doses via intragastric gavage once daily for 45 consecutive days. Serum was then collected to determine levels superoxide dismutase malondialdehyde. Epididymal sperm also semen analysis, tissue ferritin content determination, electron microscope observation mitochondrial morphology, immunohistochemistry, real-time quantitative polymerase chain reaction, western blot analysis. Exposure decrease quality cause oxidative damage, iron accumulation, damage in testes mice. In addition, confirmed affect expression ferroptosis-related genes, glutathione peroxidase 4 (GPX4), heavy 1 (FTH1), cyclooxygenase 2 (COX2), acyl-CoA synthetase (ACSL4) tissues. Accordingly, speculate induces stress, which leads cells. Overall, inhibition be potential strategy reduce toxicity caused by A.

Language: Английский

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Natural Products in Mitigation of Bisphenol A Toxicity: Future Therapeutic Use

Molecules, Journal Year: 2022, Volume and Issue: 27(17), P. 5384 - 5384

Published: Aug. 24, 2022

Bisphenol A (BPA) is a ubiquitous environmental toxin with deleterious endocrine-disrupting effects. It widely used in producing epoxy resins, polycarbonate plastics, and polyvinyl chloride plastics. Human beings are regularly exposed to BPA through inhalation, ingestion, topical absorption routes. The prevalence of exposure has considerably increased over the past decades. Previous research studies have found plethora evidence BPA's harmful Interestingly, even at lower concentration, this industrial product was be cellular tissue levels, affecting various body functions. noble possible treatment could made plausible by using natural products (NPs). In review, we highlight existing experimental NPs against exposure-induced adverse effects, which involve body's reproductive, neurological, hepatic, renal, cardiovascular, endocrine systems. review also focuses on targeted signaling pathways involved BPA-induced toxicity. Although potential molecular mechanisms underlying toxicity been investigated, there currently no specific for Hence, considered future therapeutic use effects exposure.

Language: Английский

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A vision for safer food contact materials: Public health concerns as drivers for improved testing

Environment International, Journal Year: 2023, Volume and Issue: 180, P. 108161 - 108161

Published: Sept. 26, 2023

Food contact materials (FCMs) and food articles are ubiquitous in today's globalized system. Chemicals migrate from FCMs into foodstuffs, so called chemicals (FCCs), but current regulatory requirements do not sufficiently protect public health hazardous FCCs because only individual substances used to make tested mostly for genotoxicity while endocrine disruption other hazard properties disregarded. Indeed, a known source of wide range chemicals, they likely contribute highly prevalent non-communicable diseases. can also include non-intentionally added (NIAS), which often unknown therefore subject risk assessment. To address these important shortcomings, we outline how the safety may be improved by (1) testing overall migrate, including (unknown) NIAS, finished articles, (2) expanding toxicological beyond multiple endpoints associated with diseases relevant human health. identify mechanistic testing, group chronic outcomes chemical exposure Six Clusters Disease (SCOD) propose that should their impacts on SCOD. Research focus developing robust, relevant, sensitive in-vitro assays based information linked SCOD, e.g., through Adverse Outcome Pathways (AOPs) or Key Characteristics Toxicants. Implementing this vision will improve prevention exposures, FCMs.

Language: Английский

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