Environmental Science and Pollution Research,
Journal Year:
2022,
Volume and Issue:
29(22), P. 32631 - 32650
Published: Feb. 24, 2022
Abstract
Bisphenol
A
(BPA)
is
one
of
the
most
widely
studied
endocrine
disrupting
chemicals
because
its
structural
similarity
to
17-β
estradiol;
ability
bind
as
an
agonist/antagonist
estrogen
receptors
elicits
adverse
effects
on
functioning
metabolic
and
endocrinal
system.
Therefore,
BPA
has
been
thoroughly
scrutinized
concerning
disruption
pathways
like
lipid
metabolism,
steroidogenesis,
insulin
signaling,
inflammation.
This
resulted
in
reports
correlation
with
various
aspects
cardiovascular
diseases,
obesity,
diabetes,
male
female
reproductive
disorders,
dysfunctions.
Among
these,
occurrence
polycystic
ovarian
syndrome
(PCOS)
premenopausal
women
great
concern.
PCOS
a
highly
prevalent
disorder
affecting
their
age
clinically
characterized
by
hyperandrogenism,
ovulatory
dysfunction,
morphology,
along
metabolism-related
dysfunctions
hyperinsulinemia,
resistance.
In
this
review,
we
analyzed
certain
researched
BPA,
while
focusing
alter
expression
significant
genes
GnRH
,
AdipoQ
ESR1
StAR
CYP11A1
CYP19A1
many
more
involved
regulation,
whose
commonly
associated
clinical
manifestations
PCOS.
Cell Communication and Signaling,
Journal Year:
2024,
Volume and Issue:
22(1)
Published: Jan. 10, 2024
Abstract
Background
Bisphenol
A
(BPA)
levels
are
high
in
women
with
polycystic
ovary
syndrome
(PCOS).
The
mechanism
by
which
BPA
induces
abnormal
glucose
metabolism
PCOS
patients
is
largely
unknown.
Methods
Serum
and
urine
samples
were
collected
from
without
(control)
at
the
reproductive
medicine
center
informed
consent.
Non-PCOS
who
received
vitro
fertilization
recruited
for
collection
of
ovarian
follicular
fluid
granular
cells.
Wild-type
C57BL/6
AhR
−/−
mice
used
to
verify
effects
on
PCOS.
Real-time
PCR,
western
blotting,
ELISA
conducted
analyze
function
BPA.
Chip-qPCR
verified
role
GLUT4
transcription.
Flow
cytometry
was
performed
determine
uptake.
Results
positive
correlation
observed
between
concentration
serum
patients.
aggravated
changes
metabolism,
impaired
fertility,
increased
body
fat.
Mechanistically,
we
showed
that
activated
led
decreased
transport
via
downregulation
Therefore,
use
inhibitors
or
knockout
could
effectively
rescue
BPA-induced
metabolic
disorders
mice.
Conclusions
Our
results
revealed
suppressed
expression
induced
activating
AhR,
causing
insulin
resistance,
thus
a
potential
contributor
development
be
new
therapeutic
target
International Journal of Toxicology,
Journal Year:
2024,
Volume and Issue:
43(3), P. 253 - 290
Published: Jan. 10, 2024
The
ten
key
characteristics
(KCs)
of
carcinogens
are
based
on
known
human
and
encompass
many
types
endpoints.
We
propose
that
an
objective
review
the
large
amount
cancer
mechanistic
evidence
for
chemical
bisphenol
A
(BPA)
can
be
achieved
through
use
these
KCs.
search
metabolic
data
relevant
to
carcinogenicity
BPA
was
conducted
web-based
software
tools
were
used
screen
organize
results.
applied
KCs
systematically
identify,
organize,
summarize
information
BPA,
bring
carcinogenic
mechanisms
into
focus.
For
some
with
very
sets,
we
utilized
reviews
focused
specific
Over
3000
studies
from
various
streams
(exposed
humans,
animals,
in
vitro
cell-free
systems)
identified.
Mechanistic
each
identified,
receptor-mediated
effects,
epigenetic
alterations,
oxidative
stress,
cell
proliferation
being
especially
rich.
Reactive
bioactive
metabolites
also
associated
a
number
This
demonstrates
how
evaluate
data,
data-rich
chemicals.
While
individual
entities
may
have
different
approaches
incorporation
hazard
identification,
provide
practical
framework
conducting
examination
available
without
priori
assumptions
mode
action.
analysis
suggests
multiple
inter-connected
which
this
act.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(2), P. 1083 - 1083
Published: Jan. 5, 2023
Obesogenic
endocrine-disrupting
chemicals
(EDCs)
belong
to
the
group
of
environmental
contaminants,
which
can
adversely
affect
human
health.
A
growing
body
evidence
supports
that
chronic
exposure
EDCs
contribute
a
rapid
increase
in
obesity
among
adults
and
children,
especially
wealthy
industrialized
countries
with
high
production
widely
used
industrial
such
as
plasticizers
(bisphenols
phthalates),
parabens,
flame
retardants,
pesticides.
The
main
source
obesogenic
is
through
diet,
particularly
consumption
contaminated
food
meat,
fish,
fruit,
vegetables,
milk,
dairy
products.
promote
by
stimulating
adipo-
lipogenesis
target
cells
adipocytes
hepatocytes,
disrupting
glucose
metabolism
insulin
secretion,
impacting
hormonal
appetite/satiety
regulation.
In
vitro
models
still
play
an
essential
role
investigating
potential
obesogens.
review
aimed
provide
information
on
currently
available
two-dimensional
(2D)
animal
cell
applied
for
studying
mechanisms
action
various
contaminants.
advantages
limitations
representing
crucial
endocrine
tissue
(adipose
tissue)
organs
(liver
pancreas)
involved
etiology
metabolic
diseases,
are
evaluate
effects
their
disruption
activity,
were
thoroughly
critically
discussed.
Molecules,
Journal Year:
2023,
Volume and Issue:
28(15), P. 5865 - 5865
Published: Aug. 3, 2023
The
aim
of
this
study
was
to
investigate
the
disruptions
metabolic
pathways
induced
by
bisphenol
A
(BPA)
and
explore
potential
therapeutic
intervention
provided
resveratrol
(RSV)
in
mitigating
these
through
modulation
biochemical
pathways.
Wistar
albino
rats
were
divided
into
three
groups:
group
1
served
as
control,
2
received
70
mg/Kg
BPA,
3
mg/kg
BPA
along
with
100
RSV.
After
treatment
period,
various
biomarkers
gene
expressions
measured
assess
effects
protective
results
revealed
that
exposure
significantly
increased
serum
levels
α-amylase,
α-glucosidase,
G6PC,
insulin,
HbA1c,
HMG-CoA
reductase,
FFAs,
TGs,
DPP-4,
MDA,
proinflammatory
cytokines
such
TNF-α
IL-6.
Concurrently,
led
a
reduction
antioxidant
enzymes
catalase
(CAT),
glutathione
peroxidase
(GPx),
superoxide
dismutase
(SOD),
well
GLUT4
HDL
cholesterol.
However,
administration
RSV
ameliorated
alterations
biomarker
exposure.
effectively
reduced
elevated
cytokines,
while
increasing
enzymes,
GLUT4,
Furthermore,
suppressed
mRNA
expression
glucokinase
(GCK),
insulin-like
growth
factor
(IGF-1),
glucose
transporter
(GLUT2)
up-regulated
uncoupling
protein
(UCP2),
which
are
all
critical
involved
metabolism
insulin
regulation.
In
contrast,
restored
altered
biomarkers,
indicating
its
modulate
transcriptional
restore
normal
function.
conclusion,
findings
strongly
suggest
holds
promise
for
BPA-induced
disorders.
By
modulating
related
regulation,
shows
restoring
function
counteracting
adverse
further
research
is
necessary
fully
understand
underlying
mechanisms
optimize
dosage
duration
maximum
benefits.
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(3), P. 2023 - 2023
Published: Jan. 19, 2023
Diabetes
is
a
metabolic
disease
that
currently
affects
nearly
half
billion
people
worldwide.
β-cells
dysfunction
one
of
the
main
causes
diabetes.
Exposure
to
endocrine-disrupting
chemicals
correlated
with
increased
diabetes
incidence.
We
hypothesized
treatment
bisphenol
A
(BPA)
induces
endoplasmic
reticulum
(ER)
stress
activates
unfolded
protein
response
(UPR),
leading
impaired
function
β-cells,
which
over
time,
can
cause
In
this
study,
we
aimed
evaluate
UPR
pathways
activation
under
BPA
in
and
possible
recovery
ER
homeostasis.
MIN6
cells
(mouse
insulinoma
cell
line)
isolated
pancreatic
islets
from
NOR
(non-obese
resistant)
mice
were
treated
BPA.
analyzed
impact
on
β-cell
viability,
architecture
early
secretory
pathway,
synthesis
processing
insulin
sensors
effectors.
found
addition
chemical
chaperone
TUDCA
rescues
deleterious
effects
BPA,
resulting
improved
morphology
β-cells.
conclusion,
propose
modulators
be
used
as
therapeutic
interventions
targeted
towards
regaining
