BPA
is
used
in
a
wide
range
of
consumer
products
with
very
concern
toxicological
properties.
The
European
Union
has
restricted
its
use
to
protect
human
health.
Industry
substituted
by
analogues.
However,
there
lack
knowledge
about
their
impacts.
In
this
work,
and
5
analogues
(BPS,
BPAP,
BPAF,
BPFL
BPC)
have
been
studied
classical
SH-SY5Y
the
alternative
3D
vitro
models
after
24
96
h
exposure.
Cell
viability,
percentage
ROS,
cell
cycle
phases
as
well
morphology
spheroids
were
measured.
2D
model
was
more
sensitive
than
differences
viability
higher
60%
exposure,
different
mechanisms
ROS
production.
After
chronic
both
affected
comparison
recovery
time
(96
h),
exposed
2.5-40
µM
able
recover
morphology.
Among
BPs
tested,
BPFL>BPAF>BPAP
>BPC
revealed
effects,
while
BPS
only
one
lower
effects
BPA.
To
conclude,
suitable
candidate
perform
reliable
neurotoxicity
tests.
Scientific Reports,
Journal Year:
2024,
Volume and Issue:
14(1)
Published: April 5, 2024
Abstract
Bisphenol-A
(BPA)
is
widely
used
in
food
packaging
and
household
products,
leading
to
daily
human
exposure
potential
health
risks
including
metabolic
diseases
like
type
2
diabetes
mellitus
(T2DM).
Understanding
BPA's
mechanisms
developing
intervention
strategies
urgent.
Centella
asiatica
,
a
traditional
herbal
medicine
containing
pentacyclic
triterpenoids,
shows
promise
due
its
antioxidant
anti-inflammatory
properties,
utilized
for
centuries
Ayurvedic
therapy.
We
investigated
the
effect
of
(CA)
ethanol
extract
on
BPA-induced
pancreatic
islet
toxicity
male
Swiss
albino
mice.
BPA
administration
(10
100
μg/kg
body
weight,
twice
daily)
21
days
caused
glucose
homeostasis
disturbances,
insulin
resistance,
dysfunction,
which
were
partially
mitigated
by
CA
supplementation
(200
400
mg/kg
weight).
Additionally,
heightened
oxidative
stress,
elevated
levels
proinflammatory
cytokines,
loss
mitochondrial
membrane
(MMP),
abnormal
cell
cycle,
increased
apoptosis
implicated
detrimental
impact
endocrine
pancreas
effectively
counteracted
supplementation.
In
summary,
demonstrated
significant
ability
mitigate
apoptosis,
modulate
redox
homeostasis,
alleviate
inflammation,
preserve
MMP,
regulate
cycle.
As
result,
emerged
as
potent
agent
neutralizing
diabetogenic
effects
considerable
extent.
Heliyon,
Journal Year:
2024,
Volume and Issue:
10(11), P. e31667 - e31667
Published: May 23, 2024
Bisphenol
A
(BPA)
is
a
common
environmental
endocrine
disruptor
that
negatively
impairs
male
reproductive
ability.
This
study
aimed
to
explore
the
alterations
in
serum
metabolomics
occur
following
BPA
exposure
and
mechanism
via
which
induces
death
of
testicular
cells
mouse
model.
AMB Express,
Journal Year:
2025,
Volume and Issue:
15(1)
Published: Jan. 8, 2025
Abstract
Nonylphenol
(NP)
is
a
ubiquitous
environmental
endocrine
disrupting
chemical
and
oxidative
stress
inducer
in
biological
systems.
Resveratrol
(RES)
Naringenin
(NG)
are
phytochemicals
possessing
antioxidant
properties
estrogenic
activity.
This
study
was
conducted
to
investigate
the
toxicity
of
NP
mitigating
effects
RES
NG
on
rats.
Thirty
male
rats
were
classified
into
5
groups
as
follows:
1-
Normal
control
(NC),
2-
Dimethyl
sulfoxide
(DMSO)
group,
3-
4-
+
5-
NG.
Results
revealed
that
treatment
significantly
decreased
activities
superoxide
dismutase,
Catalase,
Glutathione
peroxidase
content
blood,
liver
kidney
compared
NC
DMSO
groups.
Conversely,
activity
Glutathione-s-transferase
elevated
blood
kidney.
Moreover,
significant
escalation
observed
levels
Malondialdehyde.
Also,
led
decrease
serum
total
testosterone
testis
weight,
accompanied
with
concurrent
elevation
estradiol
level
All
recorded
induced
by
effectively
countered
co-treatment
or
In
addition,
molecular
docking
studies
carried
out
reveal
interactions
between
NP,
RES,
estrogen
receptor
beta
which
provide
possible
mechanism
for
their
potential
Overall,
our
gives
deeper
understanding
toxic
effect
capacity
functions
well
therapeutic
utility
alleviating
these
adverse
effects.
Clinical Phytoscience,
Journal Year:
2025,
Volume and Issue:
11(1)
Published: Jan. 9, 2025
Abstract
Background
Bisphenol-A
(BPA),
a
chemical
impregnated
into
plastic
bottles
which
has
been
linked
to
obesity
and
its
associated
health
problems,
was
used
induce
in
this
study.
The
cost
reported
limitations
side
effects
of
orthodox
medications
employed
for
weight
management,
have
necessitated
shift
attention
medicinal
plants,
given
their
comparative
advantage
the
common
belief
amongst
locals
that
plants
are
free
from
negative
effects.
One
plant
found
application
loss
local
population
Nigeria
is
Alchornea
cordifolia
commonly
grows
Africa
confirmed
possess
numerous
properties
including
anti-inflammatory,
anti-diarrheal,
hepaprotective,
antiviral,
anti-diabetic
Objective
To
evaluate
attenuation
effect
ethanol
extract
(ACEE)
other
macrovascular
risks
BPA-induced
rat
model.
Methods
Thirty
(30)
young
male
Wistar
rats
(80–100
g)
divided
five
groups
six
each,
were
administered
BPA
(50
mg/kg),
once
day,
p.o
.
four
weeks
order
obesity.
Afterwards,
using
anthropometric
indicators,
animals
treated
another
as
follows:
Group
1
(Normal
control)
received
drug/extract
reconstitution
solvent,
olive
oil,
2
(obese
50
mg/kg
BPA,
3
conventional
anti-obesity
drug,
Orlistat
(30
4
ACEE
(500
5
(1000
mg/kg).
At
end
study,
indicators
relevant
serum
biochemical
determined
standard
procedures.
Results
results
obtained
showed
oral
administration
caused
i.e.
increased
body
weight,
Lee’s
Index
waist
circumference,
compared
normal
control
(
p
<
0.05).
Moreover,
treatment
alter
measured
(FBG,
lipid
profile,
liver
kidney
function
indicators)
regulating
enzymes
(pancreatic
lipase
HMG-CoA
reductase
activities),
relative
However,
upon
4-week
at
500
1000
b.w.,
there
observed
significant
indices,
indices
metabolizing
studied
Conclusion
Together,
study
scientifically
validated
traditional
use
leaves
control,
hence
suggest
may
natural
products
useful
management
related
complications.
Environment International,
Journal Year:
2025,
Volume and Issue:
unknown, P. 109299 - 109299
Published: Jan. 1, 2025
Bisphenol
A
(BPA)
is
a
ubiquitous
environmental
pollutant
with
endocrine-disrupting
functions.
Identifying
protective
drugs
and
exploring
the
mechanisms
against
BPA
are
crucial
in
healthcare.
Natural
products
exhibiting
antioxidant
properties
considered
to
be
able
protect
toxicity.
Although
BPA-modulated
targets
miRNAs
have
been
individually
reported,
their
connections
natural
were
rarely
organized.
With
help
of
protein-protein
interaction
database
(STRING),
relationship
between
individual
was
interconnected
provide
systemic
view.
In
this
review,
BPA-downregulated
-upregulated
classified,
interactive
network
innovatively
analyzed
using
bioinformatic
(STRING).
also
retrieved
ingeniously
connected
targets.
Moreover,
novel
connection
BPA-countering
integrated
into
All
these
targets-associated
and/or
incorporated
STRING
network,
providing
relationships.
Overall,
target-miRNA-protecting
product
axis
constructed,
straightforward
direction
for
effects
products.
Toxicology,
Journal Year:
2024,
Volume and Issue:
502, P. 153715 - 153715
Published: Jan. 9, 2024
BPA
is
used
in
a
wide
range
of
consumer
products
with
very
concern
toxicological
properties.
The
European
Union
has
restricted
its
use
to
protect
human
health.
Industry
substituted
by
analogues.
However,
there
lack
knowledge
about
their
impacts.
In
this
work,
and
5
analogues
(BPS,
BPAP,
BPAF,
BPFL
BPC)
have
been
studied
classical
SH-SY5Y
the
alternative
3D
vitro
models
after
24
96
h
exposure.
Cell
viability,
percentage
ROS,
cell
cycle
phases
as
well
morphology
spheroids
were
measured.
2D
model
was
more
sensitive
than
differences
viability
higher
60%
exposure,
different
mechanisms
ROS
production.
After
chronic
both
affected
comparison
recovery
time
(96
h),
exposed
2.5-40
µM
able
recover
morphology.
Among
BPs
tested,
BPFL>BPAF>BPAP
>BPC
revealed
effects,
while
BPS
only
one
lower
effects
BPA.
To
conclude,
suitable
candidate
perform
reliable
neurotoxicity
tests.
Reproductive Toxicology,
Journal Year:
2024,
Volume and Issue:
128, P. 108628 - 108628
Published: June 5, 2024
Bisphenol
A
(BPA),
a
widespread
environmental
contaminant,
poses
concerns
due
to
its
disruptive
effects
on
physiological
functions
of
the
uterine
endometrium.
In
contrast,
melatonin
(MT)
and
Resveratrol
(RSV)
are
under
scrutiny
for
their
potential
protective
roles
against
BPA-induced
damage.
For
efficacy
ethical
in
animal
test,
endometrial
organoids,
three-dimensional
models
mimicking
endometrium,
serve
as
crucial
tools
unraveling
impact
factors
reproductive
health.
This
study
aimed
comprehensively
characterize
morphological,
molecular
metabolic
responses
porcine
organoids
BPA
assess
MT
RSV.
Porcine
uteri
were
prepared,
digested
with
collagenase,
mixed
Matrigel,
incubated
at
38°C
5
%
CO
Journal of Xenobiotics,
Journal Year:
2024,
Volume and Issue:
14(4), P. 1378 - 1405
Published: Oct. 2, 2024
Endocrine-disrupting
chemicals
(EDCs)
are
chemical
substances
that
can
interfere
with
any
hormone
action.
They
categorized
according
to
origin
and
use,
such
as
industrial
like
polychlorinated
biphenyls
(PCBs)
polybrominated
(PBBs),
plastics
bisphenol
A
(BPA),
plasticizers
phthalates,
pesticides
dichlorodiphenyltrichloroethane
(DDT),
fungicides
vinclozolin,
pharmaceuticals
diethylstilbestrol
(DES).
Natural
EDCs,
phytoestrogens,
present
in
the
diet
of
both
humans
animals.
Polyphenols
a
large
group
natural
compounds
derived
from
plants
found
beverages
food.
grouped
based
on
their
structure
into
flavonoids
nonflavonoids
reported
have
many
beneficial
effects
health,
including,
but
not
limited
to,
anticancer,
antioxidant,
anti-inflammatory
effects.
Moreover,
polyphenols
pro-
antioxidant
characteristics,
due
potential,
they
presumably
protective
effect
against
damage
induced
by
EDCs.
However,
may
act
In
this
review,
we
report
regulate
activity
having
positive
negative
Hence,
better
understanding
associations
between
EDCs
will
allow
establishment
improved
approaches
protect
human
health
Toxics,
Journal Year:
2024,
Volume and Issue:
12(11), P. 810 - 810
Published: Nov. 11, 2024
This
study
explores
the
neuroprotective
effects
of
resveratrol
(Resv)
against
tri-o-cresyl
phosphate
(TOCP)-induced
neurotoxicity
in
spinal
cord
adult
hens.
It
is
well
documented
that
TOCP
exposure
causes
significant
neurodegeneration
via
mechanisms
involve
endoplasmic
reticulum
(ER)
stress
and
impaired
autophagy.
In
this
experiment,
hens
were
assigned
to
one
four
groups:
Control,
Resv,
TOCP,
+
Resv.
The
tissues
examined
through
transmission
electron
microscopy,
hematoxylin
eosin
(HE)
staining,
Nissl
Western
blotting
evaluate
key
proteins
associated
with
ER
Additionally,
RT-qPCR
immunofluorescence
employed
measure
sirtuin1
(SIRT1)
expression.
findings
revealed
induced
severe
ultrastructural
damage,
including
disrupted
myelin
sheaths,
dilated
ER,
extensive
neurodegeneration,
as
confirmed
by
histological
evaluations.
expression
levels
GRP78,
p-PERK,
p-eIF2α,
ATF4,
CHOP,
Beclin-1,
P62,
LC3-II
also
significantly
elevated
TOCP.
However,
Resv
treatment
markedly
attenuated
these
pathological
changes
reducing
stress,
restoring
autophagic
flux,
upregulating
SIRT1
expression,
preserving
integrity.
These
results
indicate
can
effectively
counteract
TOCP-induced
modulating
autophagy,
underscoring
its
potential
a
therapeutic
agent
for
neuroprotection.
