Comparative Risk Assessment of Phthalate Diesters (Dehp, Dbp) in Lactating Mothers and Breastfed Babies by Monitoring of Breast Milk, Cow's Milk, and Infant Formula DOI

Duck Soo Lim,

Eun Young Han, Seul Min Choi

et al.

Published: Jan. 1, 2024

Language: Английский

Endocrine disrupting chemicals and obesity prevention: scoping review DOI Creative Commons

M. Amon,

Tina Kek,

Irma Virant‐Klun

et al.

Journal of Health Population and Nutrition, Journal Year: 2024, Volume and Issue: 43(1)

Published: Sept. 3, 2024

Exposure to endocrine disrupting chemicals (EDCs) can result in alterations of natural hormones the body. The aim this review article is highlight knowledge about EDCs and obesity. A scoping electronic literature was performed using PubMed platform for studies on obesity published between years 2013–2023. total 10 systematic reviews meta-analysis met our inclusion criteria more prominent focusing mainly bisphenols, including parabens, triclosan, phthalates, their association with Scoping review. EDCs, mostly bisphenols are related health effects, while there less information impact parabens triclosan. series negative physiological effects involving obesogenic, diabetogenic, carcinogenic, inflammatory mechanisms as well epigenetic microbiota modulations a prolonged exposure. profound research particular pollutants required illuminate accelerating mixtures or metabolites mechanism development Considering characteristics heterogeneity studies, it necessary design specific effect tracking and, particular, education daily preventive exposure preservation long-term public health.

Language: Английский

Citations

2
Association of serum phthalates exposure with incident type 2 diabetes risk in Chinese population: A nested case-control study DOI Creative Commons
Shiyang Zhang, Cheng Xu,

Chengyong Jia

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 265, P. 115493 - 115493

Published: Sept. 18, 2023

Prospective epidemiological evidence was lacking on the association of phthalates (PAEs) exposure with incident type 2 diabetes mellitus (T2DM) risk. In present nested case-control study, we identified 1006 T2DM cases and matched controls based Dongfeng-Tongji cohort 6 PAEs were detected in baseline serum. The conditional logistic regression model, Bayesian kernel machine (BKMR) model Quantile-based g-computation applied to evaluate associations determined PAEs, either as individuals or a mixture, Subgroup analysis conducted identify potential sensitive population effects T2DM. After multiple adjustment, no statistically significant observed between single mixture risk whole population. However, serum levels Di-n-butyl phthalate (DnBP) [OR= 2.06; 95% CI: (1.11-3.96)], Σdibutyl (ΣDBP) 1.96; (1.06-3.76)], Σlow-molecular- weight (ΣLMW) 2.27; (1.17-4.57)] significantly associated current drinker group. Moreover, interactions among Di-iso-butyl (DiBP), DnBP, Butyl-benzyl (BBP), ΣDBP, ΣLMW drinking status (P for interaction = 0.036, 0.005, 0.049. 0.010, 0.005). We did not find alcohol drinkers expose higher had

Language: Английский

Citations

6
Are the new phthalates safe? Evaluation of Diisononilphtalate (DINP) effects in porcine ovarian cell cultures DOI Creative Commons
Giuseppina Basini,

Simona Bussolati,

Stefano Grolli

et al.

Environmental Toxicology and Pharmacology, Journal Year: 2024, Volume and Issue: 106, P. 104384 - 104384

Published: Feb. 6, 2024

Phthalates are plasticizing chemicals, widely used in packaging materials and consumer products for several decades. These molecules have raised concerns because of their toxicity use been restricted countries. Therefore, novel phthalates introduced. Among these, diisononilphtalate (DINP) is employed. However, its safety has not properly addressed. using a well validated granulosa cell model, collected from swine ovaries with translational value, we studied potential DINP effects on important cellular functional parameters. In particular, growth, steroidogenesis redox status. Collected data showed that stimulates (p<0.05) increases estrogen inhibits progesterone production (P < 0.05), disrupts balance stimulating free radicals while reducing scavenger activities (P<0.05). Taken together, DINP's impact cultured cells provide cause concern regarding adverse reproductive endocrine functions.

Language: Английский

Citations

1
Influence of the interaction between genetic factors and breastfeeding on children's weight status: A systematic review DOI Creative Commons
Zhe Yang, Na Li,

Hong Cui

et al.

Advances in Nutrition, Journal Year: 2024, Volume and Issue: 15(11), P. 100312 - 100312

Published: Oct. 9, 2024

Breastfeeding may interact with other risk factors and have a combined influence on child growth. This systematic review aimed to examine the interaction between genetic breastfeeding how their combination is associated children weight status. Four databases were searched until August 2024, 8 eligible studies identified. The fat mass obesity (FTO) peroxisome proliferator-activated receptor γ2 (PPARG2) genes most examined genes. Although results of interactions genetics children's status inconsistent, some reported that or exclusive attenuated disadvantageous association alleles (higher obesity-specific score for multiple-gene study) overdevelopment body weight. These findings support WHO recommendations prolonged further suggest interventions prevent childhood be more effective in populations predisposition. was registered PROSPERO as CRD42023448365.

Language: Английский

Citations

1
The fungicide propiconazole induces hepatic steatosis and activates PXR in a mouse model of diet-induced obesity DOI
Brecht Attema, Outi Kummu,

Mária Krutáková

et al.

Archives of Toxicology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 24, 2024

Language: Английский

Citations

1
Science evolves but outdated testing and static risk management in the US delay protection to human health DOI Creative Commons
Maricel V. Maffini, Laura N. Vandenberg

Frontiers in Toxicology, Journal Year: 2024, Volume and Issue: 6

Published: Aug. 13, 2024

Science evolves but outdated testing and static risk management in the US delay protection to human health

Language: Английский

Citations

0
The Mediating Role of Oxidative Stress in the Association Between Phthalate Exposure and Body Mass Index Among Adults: A Cross-Sectional Analysis Using NHANES Data DOI
Rezaul Karim Ripon

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 3, 2024

Abstract Background The study investigates the mediating role of oxidative stress in relationship between phthalate exposure, measured via urinary Bisphenol A (BPA) levels, and Body Mass Index (BMI) adults. Given global prevalence obesity widespread exposure to phthalates, understanding this is critical. Methods: Data were derived from National Health Nutrition Examination Survey (NHANES), focusing on adult participants. Key variables included BPA levels (independent variable), BMI (dependent indicators (mediator), covariates such as age, serum creatinine, poverty index, race/ethnicity. Descriptive statistics summarized baseline characteristics, mediation analysis quantified direct, indirect, total effects BMI. Results: sample comprised 19,022 adults, with a nearly equal distribution males females. median differed significantly by gender. Mediation revealed that mediated approximately 19% effect Average Causal Effect (ACME) was − 0.000976 (95% CI: -0.001147 0.001, p < 0.001), Direct (ADE) 0.004155 -0.008239 = 0.016). 0.005132 -0.008997 0.004). Conclusions: This highlights significant findings suggest strategies reduce could mitigate obesogenic underscoring need for regulatory policies limit public health interventions targeting stress. Future research should explore longitudinal data broader range exposures further elucidate these relationships.

Language: Английский

Citations

0
Individual Inhalation Exposure to Phthalates and Their Associations with Anthropometric and Physiological Indices in Primary School Children in Jinan, China DOI Creative Commons
Haoming Yang, Lixin Wang, Yuchen Wang

et al.

Buildings, Journal Year: 2024, Volume and Issue: 14(11), P. 3397 - 3397

Published: Oct. 25, 2024

Phthalates are commonly found in indoor environments. Consequently, children may be exposed to phthalates through the air, potentially causing health issues. We collected 72 air samples from 60 households and 12 classrooms Jinan, surveyed health-examined children, assessed their phthalate inhalation exposure, analyzed associations between exposure levels children’s anthropometric physiological indicators. Eight were detected classrooms, with detection frequencies ranging 91.6% 100%. Di-iso-butyl (DiBP), di-n-butyl (DnBP), di (2-ethylhexyl) (DEHP) predominant phthalates. Children’s ranged 8.90 147 ng/(kg·day), DEHP being main inhaled phthalate. The non-carcinogenic risks of environments where live within acceptable limits. has a low carcinogenic risk. Di-n-octyl (DnOP) was associated decrease body mass index z-score, waist circumference, hip circumference. Additionally, negatively waist-to-hip ratio. DiBP systolic blood pressure while DnOP diastolic z-score. Furthermore, positively fractional exhaled nitric oxide findings this study suggest that substantially affect various metrics including index, pressure, increase risk respiratory tract inflammation.

Language: Английский

Citations

0
Comparative Risk Assessment of Phthalate Diesters (Dehp, Dbp) in Lactating Mothers and Breastfed Babies by Monitoring of Breast Milk, Cow's Milk, and Infant Formula DOI

Duck Soo Lim,

Eun Young Han, Seul Min Choi

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

0