The Effect of Black Cumin (Nigella Sativa) on Breastfeeding Mothers DOI Creative Commons

Rabia Zakaria,

Siti Choirul Dwi Astuti

JURNAL INFO KESEHATAN, Journal Year: 2022, Volume and Issue: 20(1), P. 29 - 40

Published: June 27, 2022

Breast milk is the best nutrient to reduce pain in nursing mothers and death infants. However, for mothers, too little volume cause of problems occurring during breastfeeding process. Thus, who breastfeed should consume foods that can increase breast volume. One food frequently consumed by honey. In fact, natural honey challenging discover, price also high which makes it as an obstacle. A more economical alternative required, one black cumin. It easy obtain affordable. Black cumin contains galactagogue prolactin influences production. The objective this study identify effect on milk. was a randomized controlled trial involving 60 divided into intervention groups control groups. group provided 15 grams brewed with 1000C boiling water much 200 ml, assigned pure ml. Intervention were administered second day completion after giving birth. They measuring instruments accustomed measure pumps. Bivariate analysis employing Wilcoxon Mann Whitney tests presented significant difference between (p = 0.001) This recommends application strategy mothers.

Language: Английский

Eco-friendly organic nanomaterials for multifunctional textiles: sources, applications, recent advances and future prospects towards sustainability DOI
Md. Shahadat Hossain Khan,

Mostafizur Rahaman,

Arnob Dhar Pranta

et al.

International Journal of Environmental Science and Technology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 8, 2025

Language: Английский

Citations

4
Bioinspired green synthesis of ZnO nanoparticles by marine-derived Streptomyces plicatus and its multifaceted biomedicinal properties DOI

Jeesha Soni,

Revathi Duraisamy,

Dhanraj Ganapathy

et al.

Microbial Pathogenesis, Journal Year: 2024, Volume and Issue: 193, P. 106758 - 106758

Published: June 19, 2024

Language: Английский

Citations

14
QSAR, Antimicrobial, and Antiproliferative Study of (R/S)-2-Thioxo-3,4-dihydropyrimidine-5-carboxanilides DOI Creative Commons
Mehul P. Parmar, Anwesha Das, Disha P. Vala

et al.

ACS Omega, Journal Year: 2025, Volume and Issue: 10(7), P. 7013 - 7026

Published: Feb. 10, 2025

Owing to the significant contribution of three-dimensional (3D) field-based QSAR toward hit optimization and accurately predicting activities small molecules, herein, 3D-QSAR, in vitro antimicrobial, molecular docking, pharmacophore modeling studies all isolated (R/S)-2-thioxo-DHPM-5-carboxanilides exhibiting antimicrobial activity were carried out. The screening process was performed using 46 compounds, best-scoring model with top statistical values considered for bacterial fungal targets Bacillus subtilis Candida albicans. As a result 3D-QSAR analysis, compound 4v-(S)- 4v-(R)-isomers found be more potent compared standard drugs tetracycline fluconazole, respectively. Furthermore, enantiomerically pure isomers 4q, 4d′, 4n, 4f′, 4v, 4q′, 4c, 4p′ than fluconazole inhibit growth against B. subtilis, Salinivibrio proteolyticus, C. albicans, Aspergillus niger, Molecular docking analysis shows that glide score −10.261 kcal/mol, 4v-(R)-isomer target albicans may 14-α demethylase fluconazole. compounds' antiproliferative results showed 4o′ exhibited GI50 between 8.8 34 μM six solid tumor cell lines. Following greater potential HeLa line, its kinetics study live imaging These outcomes highlight acceptance safety as well compounds effective antifungal agents.

Language: Английский

Citations

0
Unveiling the Antibacterial, Antifungal, and Cytotoxic Potential of Selenium Nanoparticles Synthesized with Syzygium cumini Leaf Extract DOI
Haorongbam Joldy Devi, Prathiba Gnanasekaran, Madan Kumar Arumugam

et al.

Journal of Cluster Science, Journal Year: 2025, Volume and Issue: 36(2)

Published: Feb. 22, 2025

Language: Английский

Citations

0
Quinazoline-2,4(1H,3H)-dione modulates STAT3 and FOXO3a signaling in HepG2 cells DOI
Suryaa Manoharan,

Krishnasanthiya Murugesan,

S. Gunasekaran

et al.

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: 157, P. 108304 - 108304

Published: Feb. 22, 2025

Language: Английский

Citations

0
The Emergence of N. sativa L. as a Green Antifungal Agent DOI
Raghvendra Pandey, Brijesh Pandey, Atul Bhargava

et al.

Mini-Reviews in Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 24(16), P. 1521 - 1534

Published: Feb. 27, 2024

L. has been widely used in the Unani, Ayurveda, Chinese, and Arabic medicine systems a long history of medicinal folk uses. Several phytoconstituents plant are reported to have excellent therapeutic properties.

Language: Английский

Citations

2
Potential health benefits of Nigella sativa on diabetes mellitus and its complications: A review from laboratory studies to clinical trials DOI Creative Commons
Siti Hajar Adam,

Noor Mohd Nasri,

Mohd Izhar Ariff Mohd Kashim

et al.

Frontiers in Nutrition, Journal Year: 2022, Volume and Issue: 9

Published: Nov. 10, 2022

This review aims to gather and summarize up-to-date information on the potential health benefits of Nigella sativa (NS) diabetes mellitus (DM) its complications from different animal models, clinical trials in vitro studies. DM is one most prevalent metabolic disorders resulting chronic hyperglycaemia due problems insulin secretion, action or both. It affects people regardless age, gender race. The main consequence development dysregulation glucose homeostasis. Current treatments for include pharmacological therapy, diabetic therapy targeting β cells. Some these therapeutic approaches are promising; however, their safety effectiveness remain elusive. Since ancient times, medicinal plants have been used proven effective against diseases. These believed be benefit physiological pathological processes, as they can prevent, reduce treat multiple Linn. an annual indigenous herbaceous plant belonging Ranunculaceae, buttercup family. NS exhibits multifactorial activities; it could ameliorate oxidative, inflammatory, apoptotic insulinotropic effects inhibit carbohydrate digestive enzymes. Thus, this demonstrates that a complement adjuvant management complications. However, future research should able replicate fill gaps study conducted introduce safely patients with DM.

Language: Английский

Citations

9
Novel thymohydroquinone gallate (THQG) derivative loaded ligand Modified quantum dots as pH-Sensitive Multi-Modal theragnostic agent for cancer treatment DOI

Ummama Saeed,

Rubaida Mahmood,

Batool Fatima

et al.

European Journal of Pharmaceutics and Biopharmaceutics, Journal Year: 2024, Volume and Issue: 200, P. 114312 - 114312

Published: May 11, 2024

Language: Английский

Citations

1
Nano-based formulations of thymoquinone are new approaches for psoriasis treatment: a literature review DOI Creative Commons
Amir Modarresi Chahardehi,

Hamid Reza Ojaghi,

Hossein Motedayyen

et al.

Frontiers in Immunology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 12, 2024

Psoriasis, a persistent immune-mediated inflammatory skin condition, affects approximately 2-3% of the global population. Current treatments for psoriasis are fraught with limitations, including adverse effects, high costs, and diminishing efficacy over time. Thymoquinone (TQ), derived from Nigella sativa seeds, exhibits promising anti-inflammatory, antioxidant, immunomodulatory properties that could prove beneficial in managing psoriasis. However, TQ’s hydrophobic nature poor bioavailability have hindered its usefulness as therapeutic agent. Recent research has strategically addressed these challenges by developing nano-thymoquinone (nano-TQ) formulations to enhance delivery treating Preclinical studies employing mouse models demonstrated nano-TQ effectively mitigates inflammation, erythema, scaling, epidermal thickness, cytokine levels psoriatic lesions. Various formulations, nanoemulsions, lipid vesicles, nanostructured carriers, ethosomes, been explored improve solubility, facilitate penetration, ensure sustained release, achieve site-specific targeting. Although clinical trials currently scarce, outcomes vitro animal promising. The potential co-delivery other anti-psoriatic agents also presents avenues further investigation.

Language: Английский

Citations

1
Anticancer Property of Digera muricata Leaf Extract: An In Vitro Study DOI Open Access

P. Varadarajan,

Anitha Roy,

D Jagadeswaran

et al.

Cureus, Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 23, 2023

Aim The aim was to evaluate the anticancer potential of Digera muricata ethanolicleaf extract on MG-63 osteosarcoma cell lines. Materials and methods anti-cancer properties ethanolic leaf were evaluated lines using 3- (4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, morphological changes in cells assessed after 24 hours microscopic observation. Additionally, fluorescence microscopy employed apoptotic acridine orange/ethidium (AO/EtBr) dual staining. Results MTT assay revealed a dose-dependent death. viability decreased with increase concentrations extract, 89.98 ± 4.89 percentage at 25 μg/ml 15.64 3.64 200 concentrations. A concentartion 116.95 showed 50% inhibition (IC50). staining studies also extract's effectiveness inducing apoptosis. Conclusion D. could impart good antiproliferative activity induce apoptosis hence, it may be considered as agent for development drug formulation treatment osteosarcoma.

Language: Английский

Citations

3