Anticancer Potential of Natural Chalcones: In Vitro and In Vivo Evidence DOI Open Access
Radka Michalková, Ladislav Mirossay, Martin Kello

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(12), P. 10354 - 10354

Published: June 19, 2023

There is no doubt that significant progress has been made in tumor therapy the past decades. However, discovery of new molecules with potential antitumor properties still remains one most challenges field anticancer therapy. Nature, especially plants, a rich source phytochemicals pleiotropic biological activities. Among plethora phytochemicals, chalcones, bioprecursors flavonoid and isoflavonoids synthesis higher have attracted attention due to broad spectrum activities clinical applications. Regarding antiproliferative effects multiple mechanisms action including cell cycle arrest, induction different forms death modulation various signaling pathways documented. This review summarizes current knowledge related natural chalcones types malignancies breast cancers, cancers gastrointestinal tract, lung renal bladder melanoma.

Language: Английский

2022 Update on Prostate Cancer Epidemiology and Risk Factors—A Systematic Review DOI Creative Commons
Oskar Bergengren, Kelly Pekala, Konstantina Matsoukas

et al.

European Urology, Journal Year: 2023, Volume and Issue: 84(2), P. 191 - 206

Published: May 17, 2023

Language: Английский

Citations

366
Liquid Biopsy in Prostate Cancer Management—Current Challenges and Future Perspectives DOI Open Access
Felice Crocetto, Gianluca Russo, Erika Di Zazzo

et al.

Cancers, Journal Year: 2022, Volume and Issue: 14(13), P. 3272 - 3272

Published: July 4, 2022

Although appreciable attempts in screening and diagnostic approaches have been achieved, prostate cancer (PCa) remains a widespread malignancy, representing the second leading cause of cancer-related death men. Drugs currently used PCa therapy initially show potent anti-tumor effect, but frequently induce resistance progresses toward metastatic castration-resistant forms (mCRPC), virtually incurable. Liquid biopsy has emerged as an attractive promising strategy complementary to invasive tissue guide diagnosis treatment. shows ability represent tumor microenvironment, allow comprehensive information follow-up progression tumor, enabling development different treatment strategies well permitting monitoring response. biopsy, indeed, is endowed with significant potential modify management. Several blood biomarkers could be analyzed for diagnostic, prognostic predictive purposes, including circulating cells (CTCs), extracellular vesicles (EVs), DNA (ctDNA) RNA (ctRNA). In addition, several other body fluids may adopted (i.e., urine, sperm, etc.) beyond blood. This review dissects recent advancements future perspectives liquid biopsies, highlighting their strength weaknesses

Language: Английский

Citations

78
Underlying Features of Prostate Cancer—Statistics, Risk Factors, and Emerging Methods for Its Diagnosis DOI Creative Commons
Cristina V. Berenguer,

Ferdinando Pereira,

José S. Câmara

et al.

Current Oncology, Journal Year: 2023, Volume and Issue: 30(2), P. 2300 - 2321

Published: Feb. 15, 2023

Prostate cancer (PCa) is the most frequently occurring type of malignant tumor and a leading cause oncological death in men. PCa very heterogeneous terms grade, phenotypes, genetics, displaying complex features. This often has indolent growth, not compromising patient’s quality life, while its more aggressive forms can manifest rapid growth with progression to adjacent organs spread lymph nodes bones. Nevertheless, overtreatment patients leads important physical, mental, economic burdens, which be avoided careful monitoring. Early detection, even cases locally advanced metastatic tumors, provides higher chance cure, thus go through less treatments fewer side effects. Furthermore, it offer knowledge about how modifiable risk factors an effective method for reducing risk. Innovations diagnostics therapy are still required overcome some limitations current screening techniques, specificity sensitivity. In this context, review brief overview statistics, reporting incidence mortality rates worldwide, factors, emerging strategies.

Language: Английский

Citations

58
Exploring pharmacological active ingredients of traditional Chinese medicine by pharmacotranscriptomic map in ITCM DOI
Sai Tian, Jinbo Zhang,

Shunling Yuan

et al.

Briefings in Bioinformatics, Journal Year: 2023, Volume and Issue: 24(2)

Published: Jan. 31, 2023

With the emergence of high-throughput technologies, computational screening based on gene expression profiles has become one most effective methods for drug discovery. More importantly, profile-based approaches remarkably enhance novel drug-disease pair discovery without relying drug- or disease-specific prior knowledge, which been widely used in modern medicine. However, systematic active ingredients traditional Chinese medicine (TCM) scarcely performed due to inadequate pharmacotranscriptomic data. Here, we develop largest-to-date online TCM ingredients-based platform integrated (ITCM) ingredients. First, unified experiments and constructed largest data repository 496 representative ingredients, was five times larger than previous built by our team. The transcriptome-based multi-scale analysis also elucidate their mechanism. Then, developed six state-of-art signature search screen determine optimal size all methods. Moreover, them into a strategy, TCM-Query, identify potential special disease. In addition, comprehensively collected TCM-related resource literature mining. Finally, applied ITCM an ingredient bavachinin, two diseases, including prostate cancer COVID-19, demonstrate power aimed explore boost studies pharmacological action is available at http://itcm.biotcm.net.

Language: Английский

Citations

57
Evodiamine impairs HIF1A histone lactylation to inhibit Sema3A-mediated angiogenesis and PD-L1 by inducing ferroptosis in prostate cancer DOI
Ying Yu,

Xing Huang,

Chaoqi Liang

et al.

European Journal of Pharmacology, Journal Year: 2023, Volume and Issue: 957, P. 176007 - 176007

Published: Aug. 21, 2023

Language: Английский

Citations

51
Global Burden of Prostate Cancer and Association with Socioeconomic Status, 1990–2019: A Systematic Analysis from the Global Burden of Disease Study DOI Creative Commons
Weiyu Zhang, Guiying Cao, Feng Wu

et al.

Journal of Epidemiology and Global Health, Journal Year: 2023, Volume and Issue: 13(3), P. 407 - 421

Published: May 6, 2023

Both the morbidity and mortality of prostate cancer are increasing worldwide. Updated evaluations burden its global, regional national patterns essential for formulating effective preventive strategies. To investigate incidence, mortality, disability-adjusted life years (DALYs) between 1990 2019 to facilitate measures control planning. Annual incident cases, deaths, DALYs, age-standardized incidence rates (ASIRs), (ASMRs), DALYs (ASDRs) were derived from Global Burden Diseases study 2019. Percentage changes in deaths estimated annual percentage (EAPCs) ASIRs, ASMRs ASDRs calculated quantify temporal trends. Correlations EAPCs socio-demographic index (SDI) universal health coverage (UHCI) evaluated by Pearson correlation analyses. Globally, number increased 116.11%, 108.94%, 98.25% 2019, respectively. The ASIR an average 0.26% (95% CI: 0.14%, 0.37%) per year while ASMR ASDR decreased - 0.75% 0.84%, 0.67%) 0.71% 0.78%, 0.63%) this period, Epidemic trends burdens not uniform throughout different groups SDI or geography. varied across regions, with trend ASIR, ASMR, low low-middle regions A significant positive EAPC UHCI was observed countries a < 70 (ρ = 0.37, p 0.001). Prostate remains major global due increase past three decades. These increases likely continue as population ages, which indicates potential talent gap trained healthcare workforce. diversity development models implies importance specific local strategies tailored each country's risk factor profile. Prevention, early detection more treatment essential.

Language: Английский

Citations

49
A review of the carcinogenic potential of human papillomavirus (HPV) in urological cancers DOI Creative Commons

Ehsan Zolfi,

Farhood Khaleghi mehr,

Nikoo Emtiazi

et al.

Virology Journal, Journal Year: 2025, Volume and Issue: 22(1)

Published: Feb. 28, 2025

Direct skin-to-skin contact during intimate sexual with a human papillomavirus (HPV)-positive individual is often the cause of HPV infection. In addition, many studies have been written up to date that look at role in growth other types tumors. Not all urological cancers are associated HPV. However, penile cancer (PC) caused by HPV, especially high-risk types. HPV-16 has most frequent (68.3%), followed HPV-6 (8.1%) and HPV-18 (6.9%). An increased risk getting certain urinary like prostate, bladder, testicular, kidney also linked these infections. Additionally, may play part continuous inflammation progression different organs tissues. So, making vaccine programs available more people male sex around world could significantly lower number The critical effects on urologic (UCs), such as penile, cancer, importance vaccination seen this study.

Language: Английский

Citations

3
Long-term exposure to ambient air pollutants and risk of prostate cancer: a prospective cohort study DOI

Yu Chen,

Siru Yang,

Jiahao Lin

et al.

Environmental Research, Journal Year: 2025, Volume and Issue: unknown, P. 121020 - 121020

Published: Feb. 1, 2025

Language: Английский

Citations

2
Endocrine-disrupting chemicals (EDCs) and cancer: new perspectives on an old relationship DOI
Roberta Modica, Elio Benevento, Annamaria Colao

et al.

Journal of Endocrinological Investigation, Journal Year: 2022, Volume and Issue: 46(4), P. 667 - 677

Published: Dec. 16, 2022

Language: Английский

Citations

48
The Role of Isoflavones in the Prevention of Breast Cancer and Prostate Cancer DOI Creative Commons
T. Pejcic, Milica Zeković, Uroš Bumbaširević

et al.

Antioxidants, Journal Year: 2023, Volume and Issue: 12(2), P. 368 - 368

Published: Feb. 3, 2023

This narrative review summarizes epidemiological studies on breast cancer and prostate with an overview of their global incidence distribution to investigate the relationship between these diseases diet. The biological properties, mechanisms action, available data supporting potential role isoflavones in prevention are discussed. Studies evaluating effects tissue cultures normal malignant cells, as well current body research regarding attained through multiple modifications cellular molecular signaling pathways control oxidative stress, summarized. Furthermore, this compiles literature sources reporting following: (1) levels estrogen tissue; (2) organs European Asian populations; (3) average concentrations secretion (milk semen). Finally, particular emphasis is placed investigating effect tissues via receptors (ER).

Language: Английский

Citations

35