European Urology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 1, 2024
While
prostate
cancer
(PCa)
incidence
and
mortality
rates
continue
to
rise,
early
detection
of
PCa
remains
highly
controversial,
the
research
landscape
is
rapidly
evolving.
Existing
systematic
reviews
(SRs)
meta-analyses
(MAs)
provide
valuable
insights,
but
often
focus
on
single
aspects
detection,
hindering
a
comprehensive
understanding
topic.
We
aim
fill
this
gap
by
providing
SR
contemporary
SRs
covering
different
in
European
Union
(EU)
UK.
Annals of Medicine,
Journal Year:
2024,
Volume and Issue:
56(1)
Published: March 5, 2024
This
comprehensive
review
aims
to
explore
the
potential
applications
of
Gastrin-releasing
peptide
receptor
(GRPR)
in
diagnosis
and
treatment
prostate
cancer.
Additionally,
study
investigates
role
GRPR
prognostic
assessment
for
individuals
afflicted
with
JAMA Network Open,
Journal Year:
2024,
Volume and Issue:
7(7), P. e2420034 - e2420034
Published: July 3, 2024
Importance
Prostate
cancer,
a
leading
cause
of
cancer
death
among
men,
urgently
requires
new
prevention
strategies,
which
may
involve
targeting
men
with
an
underlying
genetic
susceptibility.
Objective
To
explore
differences
in
risk
early
prostate
higher
vs
lower
to
inform
efforts.
Design,
Setting,
and
Participants
This
cohort
study
used
combined
analysis
genotyped
without
at
inclusion
lifestyle
data
2
prospective
studies
Sweden
the
US,
Malmö
Diet
Cancer
Study
(MDCS)
Health
Professionals
Follow-Up
(HPFS),
followed
up
from
1991
2019.
Data
were
analyzed
between
April
2023
2024.
Exposures
Men
categorized
according
modifiable
behaviors
risk.
A
polygenic
score
above
median
or
family
history
defined
(67%
population);
remaining
as
being
Main
Outcomes
Measures
using
time-to-event
estimating
hazard
ratios
(HR),
absolute
risks,
preventable
deaths
by
age.
Results
Among
19
607
included
for
analysis,
(IQR)
age
was
59.0
(53.0-64.7)
years
65.1
(58.0-71.8)
(HPFS).
During
follow-up,
107
(by
75
years)
337
late
(after
observed.
Compared
risk,
had
increased
rates
both
(HR,
3.26;
95%
CI,
1.82-5.84)
2.26;
1.70-3.01)
death,
lifetime
risks
(3.1%
1.3%
[MDCS]
2.3%
0.6%
[HPFS]).
accounted
94
(88%),
36%
(95%
12%-60%)
estimated
be
through
adherence
associated
healthy
(not
smoking,
weight,
high
physical
activity,
diet).
Conclusions
Relevance
In
this
20-year
follow-up
study,
predisposition
vast
majority
deaths,
one-third
preventable.
suggests
that
should
targeted
strategies.
European Urology,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 1, 2024
While
prostate
cancer
(PCa)
incidence
and
mortality
rates
continue
to
rise,
early
detection
of
PCa
remains
highly
controversial,
the
research
landscape
is
rapidly
evolving.
Existing
systematic
reviews
(SRs)
meta-analyses
(MAs)
provide
valuable
insights,
but
often
focus
on
single
aspects
detection,
hindering
a
comprehensive
understanding
topic.
We
aim
fill
this
gap
by
providing
SR
contemporary
SRs
covering
different
in
European
Union
(EU)
UK.
