Geraniin Alleviates Mouse Laser‐Induced Choroidal Neovascularisation by Inhibiting Choroidal Endothelial Cell ACE2/Ang‐(1–7)/MasR/IL‐10 Pathway DOI Creative Commons

Hongyi Lu,

Qi Cai, Lele Li

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(23)

Published: Dec. 1, 2024

ABSTRACT Anti‐vascular endothelial growth factor (VEGF) drugs suppress choroidal neovascularisation (CNV), thus improving vision. However, some patients may have a poor response or develop resistance to anti‐VEGF drugs. Geraniin (GE), polyphenol isolated from an herb called Phyllanthus amarus , possesses anti‐angiogenic properties. This study aimed explore the mechanism of action GE in CNV. was found activate angiotensin‐converting enzyme 2 (ACE2)/angiotensin 1–7 (Ang‐[1–7])/MAS1 proto‐oncogene, G protein‐coupled receptor (MasR)/interleukin‐10 (IL‐10) pathway hypoxic human cells (HCECs) vitro and mouse models laser‐induced CNV vivo. Activation ACE2/Ang‐(1–7)/MasR/IL‐10 by attenuated proliferative, migratory, tube‐forming abilities HCECs prevented development mice. Notably, did not cause ocular systemic toxicity mice with These findings suggest that alleviates activating (CECs).

Language: Английский

Geraniin Alleviates Mouse Laser‐Induced Choroidal Neovascularisation by Inhibiting Choroidal Endothelial Cell ACE2/Ang‐(1–7)/MasR/IL‐10 Pathway DOI Creative Commons

Hongyi Lu,

Qi Cai, Lele Li

et al.

Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(23)

Published: Dec. 1, 2024

ABSTRACT Anti‐vascular endothelial growth factor (VEGF) drugs suppress choroidal neovascularisation (CNV), thus improving vision. However, some patients may have a poor response or develop resistance to anti‐VEGF drugs. Geraniin (GE), polyphenol isolated from an herb called Phyllanthus amarus , possesses anti‐angiogenic properties. This study aimed explore the mechanism of action GE in CNV. was found activate angiotensin‐converting enzyme 2 (ACE2)/angiotensin 1–7 (Ang‐[1–7])/MAS1 proto‐oncogene, G protein‐coupled receptor (MasR)/interleukin‐10 (IL‐10) pathway hypoxic human cells (HCECs) vitro and mouse models laser‐induced CNV vivo. Activation ACE2/Ang‐(1–7)/MasR/IL‐10 by attenuated proliferative, migratory, tube‐forming abilities HCECs prevented development mice. Notably, did not cause ocular systemic toxicity mice with These findings suggest that alleviates activating (CECs).

Language: Английский

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