Materials Today Bio,
Journal Year:
2023,
Volume and Issue:
22, P. 100789 - 100789
Published: Sept. 1, 2023
Alzheimer's
disease
(AD)
is
a
progressive
neurodegenerative
disorder,
which
not
just
confined
to
the
older
population.
Although
developments
have
been
made
in
AD
treatment,
various
limitations
remain
be
addressed.
These
are
partly
contributed
by
biological
hurdles,
such
as
blood–brain
barrier
and
peripheral
side
effects,
well
lack
of
carriers
that
can
efficiently
deliver
therapeutics
brain
while
preserving
their
therapeutic
efficacy.
The
increasing
prevalence
unavailability
effective
treatments
encouraged
researchers
develop
improved,
convenient,
affordable
therapies.
Functional
materials
based
on
primitive
cells
nanotechnology
emerging
attractive
treatment.
Cell
primitives
possess
distinct
functions,
including
long-term
circulation,
lesion
site
targeting,
immune
suppression.
This
review
summarizes
challenges
delivery
drugs
recent
advances
cell
primitive–based
for
Various
primitives,
cells,
extracellular
vesicles,
membranes,
presented
together
with
distinctive
functions
construction
strategies.
Moreover,
future
research
directions
discussed
basis
foreseeable
perspectives.
International Journal of Molecular Sciences,
Journal Year:
2024,
Volume and Issue:
25(21), P. 11720 - 11720
Published: Oct. 31, 2024
Alzheimer's
disease
(AD)
presents
a
public
health
challenge
due
to
its
progressive
neurodegeneration,
cognitive
decline,
and
memory
loss.
The
amyloid
cascade
hypothesis,
which
postulates
that
the
accumulation
of
amyloid-beta
(Aβ)
peptides
initiates
leading
AD,
has
dominated
research
therapeutic
strategies.
failure
recent
Aβ-targeted
therapies
yield
conclusive
benefits
necessitates
further
exploration
AD
pathology.
This
review
proposes
Mitochondrial-Neurovascular-Metabolic
(MNM)
integrates
mitochondrial
dysfunction,
impaired
neurovascular
regulation,
systemic
metabolic
disturbances
as
interrelated
contributors
pathogenesis.
Mitochondrial
hallmark
leads
oxidative
stress
bioenergetic
failure.
Concurrently,
breakdown
blood-brain
barrier
(BBB)
cerebral
blood
flow,
characterize
dysregulation,
accelerate
neurodegeneration.
Metabolic
such
glucose
hypometabolism
insulin
resistance
impair
neuronal
function
survival.
hypothesis
highlights
interconnectedness
these
pathways
suggests
strategies
targeting
health,
integrity,
regulation
may
offer
more
effective
interventions.
MNM
addresses
multifaceted
aspects
providing
comprehensive
framework
for
understanding
progression
developing
novel
approaches.
approach
paves
way
innovative
could
significantly
improve
outcomes
millions
affected
worldwide.
Genes,
Journal Year:
2022,
Volume and Issue:
13(10), P. 1789 - 1789
Published: Oct. 3, 2022
Alzheimer’s
Disease
(AD)
is
the
most
prevalent
form
of
dementia
and
characterized
by
progressive
memory
loss
cognitive
decline.
The
underlying
mechanism
AD
has
not
been
fully
understood.
At
present
there
no
method
to
detect
at
its
early
stage.
Recent
studies
indicate
that
mitochondria
dysfunction
related
pathogenesis.
Altered
functions
are
found
in
influence
both
amyloid-β
(Aβ)
tau
pathology.
Variations
DNA
(mtDNA)
lead
a
change
energy
metabolism
brain
contribute
AD.
MtDNA
can
reflect
status
therefore
play
an
essential
role
In
this
review,
we
summarize
changes
mtDNA
mutations
patients
discuss
possibility
being
biomarker
for
diagnosis
Frontiers in Cell and Developmental Biology,
Journal Year:
2023,
Volume and Issue:
11
Published: May 18, 2023
Cholinergic
Receptor
Muscarinic
1
(CHRM1)
is
a
G
protein-coupled
acetylcholine
(ACh)
receptor
predominantly
expressed
in
the
cerebral
cortex.
In
retrospective
Materials Today Bio,
Journal Year:
2023,
Volume and Issue:
22, P. 100789 - 100789
Published: Sept. 1, 2023
Alzheimer's
disease
(AD)
is
a
progressive
neurodegenerative
disorder,
which
not
just
confined
to
the
older
population.
Although
developments
have
been
made
in
AD
treatment,
various
limitations
remain
be
addressed.
These
are
partly
contributed
by
biological
hurdles,
such
as
blood–brain
barrier
and
peripheral
side
effects,
well
lack
of
carriers
that
can
efficiently
deliver
therapeutics
brain
while
preserving
their
therapeutic
efficacy.
The
increasing
prevalence
unavailability
effective
treatments
encouraged
researchers
develop
improved,
convenient,
affordable
therapies.
Functional
materials
based
on
primitive
cells
nanotechnology
emerging
attractive
treatment.
Cell
primitives
possess
distinct
functions,
including
long-term
circulation,
lesion
site
targeting,
immune
suppression.
This
review
summarizes
challenges
delivery
drugs
recent
advances
cell
primitive–based
for
Various
primitives,
cells,
extracellular
vesicles,
membranes,
presented
together
with
distinctive
functions
construction
strategies.
Moreover,
future
research
directions
discussed
basis
foreseeable
perspectives.
