Mediterranean diet and osteoarthritis: an update DOI Creative Commons
Nicola Veronese, Francesco Saverio Ragusa, Ligia J. Domínguez

et al.

Aging Clinical and Experimental Research, Journal Year: 2024, Volume and Issue: 36(1)

Published: Dec. 3, 2024

Abstract The Mediterranean diet has gained significant attention for its potential health benefits on diverse pathological conditions including osteoarthritis (OA), a prevalent degenerative joint disease characterized by cartilage breakdown and inflammation. Numerous observational studies have suggested that adherence to the diet, may protective effects against OA. abundance of antioxidants anti-inflammatory compounds omega-3 fatty acids, among components is believed contribute beneficial Research investigating association between OA shown promising results. Several reported associated with reduced risk developing lower severity symptoms. Additionally, intervention demonstrated improvements in pain, function, quality life patients following intervention. Furthermore, emerging evidence suggests mechanisms underlying OA, ability reduce inflammation, oxidative stress, degradation. However, further well-designed randomized controlled trials mechanistic are needed elucidate precise establish causality. In conclusion, appears be dietary approach prevention management Its rich array nutrients bioactive exert development progression, although more research warranted confirm these findings mechanisms. Graphical abstract

Language: Английский

Mediterranean diet in the targeted prevention and personalized treatment of chronic diseases: evidence, potential mechanisms, and prospects DOI

Yuji Xiao,

Xuefei Xiao,

Xue Zhang

et al.

The EPMA Journal, Journal Year: 2024, Volume and Issue: 15(2), P. 207 - 220

Published: April 16, 2024

Language: Английский

Citations

21
The role of the Mediterranean diet in reducing the risk of cognitive impairement, dementia, and Alzheimer’s disease: a meta-analysis DOI Creative Commons
Mónika Fekete, Péter Varga, Zoltán Ungvári

et al.

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 11, 2025

Abstract Age-related cognitive impairment and dementia pose a significant global health, social, economic challenge. While Alzheimer’s disease (AD) has historically been viewed as the leading cause of dementia, recent evidence reveals considerable impact vascular (VCID), which now accounts for nearly half all cases. The Mediterranean diet—characterized by high consumption fruits, vegetables, whole grains, fish, olive oil—has widely recognized its cardiovascular benefits may also reduce risk decline dementia. To investigate protective effects diet on we conducted systematic literature review using PubMed, Web Science, Google Scholar, focusing studies published between 2000 2024. included in meta-nalysis examined adherence to incidence AD. We applied random-effects model calculate pooled hazard ratios (HRs) with 95% confidence intervals (CIs) assessed heterogeneity through I -square statistics. Forest plots, funnel Z -score plots were used visualize study outcomes. Of 324 full-text records reviewed, 23 met inclusion criteria. combined HR among those adhering was 0.82 (95% CI 0.75–0.89); 0.89 0.83–0.95); AD, 0.70 0.60–0.82), indicating substantial effects. Significant observed across studies, though suggested sufficient sample sizes support reliable conclusions each condition. In conclusion, this meta-analysis confirms that is associated an 11–30% reduction age-related disorders, including impairment, These findings underscore diet’s potential central element neuroprotective public health strategies mitigate promote healthier aging.

Language: Английский

Citations

6
Impact of adherence to the Mediterranean diet on stroke risk DOI Creative Commons
Zoltán Ungvári, Mónika Fekete, Péter Varga

et al.

GeroScience, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 7, 2025

Abstract Stroke is a leading cause of morbidity and mortality worldwide, dietary patterns have emerged as significant modifiable factor in stroke prevention. The Mediterranean diet, characterized by high intake fruits, vegetables, whole grains, nuts, olive oil, fish, has been widely recognized for its cardiovascular benefits. However, specific impact on risk requires further elucidation. We conducted comprehensive meta-analysis 30 studies, including both cohort case–control designs, to evaluate the relationship between adherence diet stroke. A systematic search was performed across multiple databases, random-effects model used estimate pooled hazard ratios (HRs) with 95% confidence intervals (CIs). Heterogeneity assessed using I 2 statistic, publication bias examined through funnel plots Egger’s regression test. Additionally, trial sequential analysis determine adequacy sample size. revealed reduction among individuals adhering HR 0.88 (95% CI: 0.84–0.91). Notably, heterogeneity detected ( = 34%). Z-score plot from confirmed that sizes were sufficient draw definitive conclusions. potential identified. studies highly effect (HR 0.54, 0.4–0.73). settings hinted at presence bias, supported Our findings provide robust evidence supporting protective against Despite some cumulative suggests promoting could serve an effective public health strategy Further research recommended explore underlying mechanisms assess diet’s diverse populations.

Language: Английский

Citations

2
Associations of Prenatal Mercury Exposure and PUFA with Telomere Length and mtDNA Copy Number in 7-Year-Old Children in the Seychelles Child Development Nutrition Cohort 2 DOI Creative Commons

Anja Stajnko,

Daniela Pineda, Jonathan K. Klus

et al.

Environmental Health Perspectives, Journal Year: 2025, Volume and Issue: 133(2)

Published: Feb. 1, 2025

Telomere length (TL) and mitochondrial DNA copy number (mtDNAcn) variations are linked to age-related diseases associated with environmental exposure nutritional status. Limited data, however, exist on the associations mercury exposure, particularly early in life.

Language: Английский

Citations

1
Adherence to the Mediterranean diet and its protective effects against colorectal cancer: a meta-analysis of 26 studies with 2,217,404 participants DOI Creative Commons
Zoltán Ungvári, Mónika Fekete, János Tibor Fekete

et al.

GeroScience, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 1, 2024

Abstract Colorectal cancer (CRC) is a major global health concern and represents significant public challenge in Hungary, where it exhibits some of the highest morbidity mortality rates European Union. The Mediterranean diet has been suggested to reduce incidence CRC, but comprehensive evidence from diverse study designs needed substantiate this effect. A systematic literature search was conducted PubMed, ClinicalTrials.gov, CENTRAL, Web Science identify randomized controlled trials human clinical 2008 2024 relevant studies. Statistical analysis performed using https://metaanalysisonline.com web application random effects model estimate pooled hazard (HRs). Forest plots, funnel Z -score plots were utilized visualize results. We identified 15 9 case–control studies, encompassing total 2,217,404 subjects. indicated that adherence significantly reduced prevalence CRC (HR = 0.84, 95% CI 0.78–0.91, p < 0.01). This protective effect consistent across sexes, with HRs 0.85 (95% 0.75–0.97, 0.01) for males 0.88 0.79–0.99, 0.03) females. Case–control studies specifically showed substantial 0.51, 0.38–0.68, Notable heterogeneity observed yet priori information size substantially below cumulative sample size, ensuring sufficient data reliable conclusions. findings meta-analysis reinforce role against CRC. results will inform dietary interventions designed mitigate risk, which are within framework Semmelweis Study, an ongoing cohort at University, explore multifaceted causes unhealthy aging Hungary. These aim practical patterns reducing among Hungarian population.

Language: Английский

Citations

8
Effects of carotenoids on mitochondrial dysfunction DOI Creative Commons
Opeyemi Stella Ademowo, Olubukola T. Oyebode,

Roshita Edward

et al.

Biochemical Society Transactions, Journal Year: 2024, Volume and Issue: 52(1), P. 65 - 74

Published: Feb. 22, 2024

Oxidative stress, an imbalance between pro-oxidant and antioxidant status, favouring the state is a result of increased production reactive oxygen species (ROS) or inadequate protection. ROS are produced through several mechanisms in cells including during mitochondrial oxidative phosphorylation. Increased mitochondrial-derived associated with dysfunction, early event age-related diseases such as Alzheimer's (ADs) metabolic disorders diabetes. AD post-mortem investigations affected brain regions have shown accumulation damage to macromolecules, stress has been considered important contributor disease pathology. An increase which leads levels superoxide, hydrogen peroxide other potentially vicious cycle both causative consequence dysfunction. Mitochondrial dysfunction may be ameliorated by molecules capacities that accumulate mitochondria carotenoids. However, role carotenoids mitigating not fully understood. A better understanding antioxidants function promising lead towards development novel effective treatment strategies for diseases. This review evaluates summarises some latest developments insights into effects on focus properties The mitochondria-protective key therapeutic targeting emerging drug

Language: Английский

Citations

5
An unbiased, sustainable, evidence-informed Universal Food Guide: a timely template for national food guides DOI Creative Commons
Elizabeth Dean,

Xu Jia,

Alice Jones

et al.

Nutrition Journal, Journal Year: 2024, Volume and Issue: 23(1)

Published: Oct. 18, 2024

Language: Английский

Citations

5
The Optic Nerve at Stake: Update on Environmental Factors Modulating Expression of Leber’s Hereditary Optic Neuropathy DOI Creative Commons
Pierre Layrolle, Christophe Orssaud,

Maryse Leleu

et al.

Biomedicines, Journal Year: 2024, Volume and Issue: 12(3), P. 584 - 584

Published: March 6, 2024

Optic neuropathies are characterized by the degeneration of optic nerves and represent a considerable individual societal burden. Notably, Leber's hereditary neuropathy (LHON) is devastating vision disease caused mitochondrial gene mutations that hinder oxidative phosphorylation increase stress, leading to loss retinal ganglion neurons axons. Loss rapid severe, predominantly in young adults. Penetrance incomplete, time onset unpredictable. Recent findings revealed incidence genetic LHON susceptibility around 1 1000, much higher than believed till now. Environmental factors critical triggering or severity. Families at risk have very strong demand for how prevent limit severity disease. Here, we review recent knowledge extrinsic determinants expression, including lifestyle, dietary supplements, common chemicals, drugs.

Language: Английский

Citations

4
Associations Between Adherence to the Mediterranean Diet and Incident Sarcopenia in Prospective Cohort Studies DOI Open Access
Ligia J. Domínguez, Nicola Veronese, Lee Smith

et al.

Nutrients, Journal Year: 2025, Volume and Issue: 17(2), P. 313 - 313

Published: Jan. 16, 2025

The loss of skeletal muscle mass and strength, known as sarcopenia, is prevalent in older adults linked to an increased risk disability, frailty, early mortality. Muscle health crucial for the functionality independence adults. As aging population continuously grows, finding cost-effective strategies preventing treating sarcopenia important public priority. While nutrition recognized a key factor development its role condition still under investigation. In recent decades, nutritional research has shifted from focus on individual nutrients or healthy foods examining combination dietary patterns, along with their potential synergistic antagonistic effects. A balanced diet regular participation physical activity are essential maintaining musculoskeletal health. One eating patterns greatest evidence multiple benefits Mediterranean diet, which also been positive effects function observational studies. However, there lack intervention This review explores updated longitudinal prospective studies associations between adherence order promote preventive aging.

Language: Английский

Citations

0
Impact of Diet and Exercise on Mitochondrial Quality and Mitophagy in Alzheimer's disease DOI
Jangampalli Adi Pradeepkiran, Md. Ariful Islam,

Ujala Sehar

et al.

Ageing Research Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 102734 - 102734

Published: March 1, 2025

Language: Английский

Citations

0