Emerging Targets and Treatments for Sarcopenia: A Narrative Review

Nutrients, Journal Year: 2024, Volume and Issue: 16(19), P. 3271 - 3271

Published: Sept. 27, 2024

Sarcopenia is characterized by the progressive loss of skeletal muscle mass, strength, and function, significantly impacting overall health quality life in older adults. This narrative review explores emerging targets potential treatments for sarcopenia, aiming to provide a comprehensive overview current prospective interventions.

Language: Английский

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Mitochondria in skeletal system-related diseases

Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 181, P. 117505 - 117505

Published: Nov. 4, 2024

Language: Английский

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Amber (Succinite) Extract Enhances Glucose Uptake through the Up-Regulation of ATP and Down-Regulation of ROS in Mouse C2C12 Cells

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(5), P. 586 - 586

Published: May 3, 2024

Traditionally, amber (Succinite) has been used to alleviate all types of pain, skin allergies, and headaches. However, no studies have conducted on its antidiabetic antioxidant effects. In this study, differentiated skeletal muscle C2C12 cells were demonstrate the protective effects (AMB) against H2O2-induced cell death. addition, AMB glucose uptake ATP production investigated. Our results showed that at 10, 25, 50 μg/mL suppressed elevation ROS induced by H2O2 in a dose-dependent manner. Moreover, enhanced utilization through improvement an increase PGC-1α gene expression resulting amelioration mitochondrial activity. On other hand, significantly increased transporters GLUT4 GLUT1. finding suggests can be as natural supplement for diabetes treatment promotion function.

Language: Английский

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USP2 Mitigates Reactive Oxygen Species-Induced Mitochondrial Damage via UCP2 Expression in Myoblasts

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(22), P. 11936 - 11936

Published: Nov. 6, 2024

Ubiquitin-specific protease 2 (USP2) maintains mitochondrial integrity in culture myoblasts. In this study, we investigated the molecular mechanisms underlying protective role of USP2 mitochondria. The knockout (KO)

Language: Английский

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